LOCUS       NM_001415039            9275 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus roundabout guidance receptor 2 (Robo2), transcript
            variant 8, mRNA.
ACCESSION   NM_001415039
VERSION     NM_001415039.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9275)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 9275)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9275)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   4  (bases 1 to 9275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 9275)
  AUTHORS   Waters,B.J., Birman,Z.R., Wagner,M.R., Lemanski,J. and Blum,B.
  TITLE     Islet architecture in adult mice is actively maintained by Robo2
            expression in beta cells
  JOURNAL   Dev Biol 505, 122-129 (2024)
   PUBMED   37972678
  REMARK    GeneRIF: Islet architecture in adult mice is actively maintained by
            Robo2 expression in beta cells.
REFERENCE   6  (bases 1 to 9275)
  AUTHORS   Jimenez,D., Garcia,C., de Castro,F., Chedotal,A., Sotelo,C., de
            Carlos,J.A., Valverde,F. and Lopez-Mascaraque,L.
  TITLE     Evidence for intrinsic development of olfactory structures in Pax-6
            mutant mice
  JOURNAL   J Comp Neurol 428 (3), 511-526 (2000)
   PUBMED   11074448
REFERENCE   7  (bases 1 to 9275)
  AUTHORS   Erskine,L., Williams,S.E., Brose,K., Kidd,T., Rachel,R.A.,
            Goodman,C.S., Tessier-Lavigne,M. and Mason,C.A.
  TITLE     Retinal ganglion cell axon guidance in the mouse optic chiasm:
            expression and function of robos and slits
  JOURNAL   J Neurosci 20 (13), 4975-4982 (2000)
   PUBMED   10864955
REFERENCE   8  (bases 1 to 9275)
  AUTHORS   Niclou,S.P., Jia,L. and Raper,J.A.
  TITLE     Slit2 is a repellent for retinal ganglion cell axons
  JOURNAL   J Neurosci 20 (13), 4962-4974 (2000)
   PUBMED   10864954
REFERENCE   9  (bases 1 to 9275)
  AUTHORS   Piper,M., Georgas,K., Yamada,T. and Little,M.
  TITLE     Expression of the vertebrate Slit gene family and their putative
            receptors, the Robo genes, in the developing murine kidney
  JOURNAL   Mech Dev 94 (1-2), 213-217 (2000)
   PUBMED   10842075
REFERENCE   10 (bases 1 to 9275)
  AUTHORS   Murtra,P., Sheasby,A.M., Hunt,S.P. and De Felipe,C.
  TITLE     Rewarding effects of opiates are absent in mice lacking the
            receptor for substance P
  JOURNAL   Nature 405 (6783), 180-183 (2000)
   PUBMED   10821273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158234.2, AC112155.3, AC134452.4, AC122049.2 and AC162374.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-934               AC158234.2         109413-110346       c
            935-1261            AC158234.2         51112-51438         c
            1262-1419           AC112155.3         117746-117903
            1420-1540           AC112155.3         118741-118861
            1541-1679           AC112155.3         129560-129698
            1680-1807           AC112155.3         148685-148812
            1808-1819           AC134452.4         6209-6220
            1820-1944           AC134452.4         29283-29407
            1945-2116           AC134452.4         32843-33014
            2117-2322           AC134452.4         36382-36587
            2323-2404           AC134452.4         41209-41290
            2405-2567           AC134452.4         41680-41842
            2568-2734           AC134452.4         43775-43941
            2735-2856           AC134452.4         47106-47227
            2857-3088           AC134452.4         53085-53316
            3089-3213           AC122049.2         164791-164915       c
            3214-3385           AC122049.2         162975-163146       c
            3386-3568           AC122049.2         154690-154872       c
            3569-3611           AC122049.2         146743-146785       c
            3612-3739           AC122049.2         145218-145345       c
            3740-4021           AC162374.4         3045-3326
            4022-4175           AC162374.4         8736-8889
            4176-4436           AC162374.4         16119-16379
            4437-4642           AC162374.4         20610-20815
            4643-4816           AC162374.4         32357-32530
            4817-5089           AC162374.4         37729-38001
            5090-5281           AC162374.4         39706-39897
            5282-9275           AC162374.4         41083-45076
FEATURES             Location/Qualifiers
     source          1..9275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 42.17 cM"
     gene            1..9275
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="roundabout guidance receptor 2"
                     /db_xref="GeneID:268902"
                     /db_xref="MGI:MGI:1890110"
     exon            1..934
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     CDS             874..5286
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8; roundabout homolog 2"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform 8 precursor"
                     /protein_id="NP_001401968.1"
                     /db_xref="GeneID:268902"
                     /db_xref="MGI:MGI:1890110"
                     /translation="MNPLMFTLLLLFGFLCIQIDGSRLRQEDFPPRIVEHPSDVIVSK
                     GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK
                     PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH
                     PEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE
                     LTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDY
                     TLRIKKAMSTDEGTYVCIAENRVGKVEASATLTVRVRPVAPPQFVVRPRDQIVAQGRT
                     VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY
                     YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTALLKCKATGEPL
                     PVISWLKEGFTFLGRDPRATIQDQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD
                     VTESGATISKNYDMNDLPGPPSKPQVTDVSKNSVTLSWQPGTPGVLPASAYIIEAFSQ
                     SVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP
                     PAQGVDHRQVQKELGDVVVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL
                     QASTVWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAP
                     SAPPQSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFHINKTVDA
                     AIRSVVIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQI
                     TDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSR
                     PGLLNAGDPNYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATML
                     SDGAIYSSIDFTTKTTYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSVQQ
                     KTDLMGFGYSLPDQNKGNNGGKGGKKKKTKNSSKAQKNNGSTWANVPLPPPPVQPLPG
                     TELGHYAAEQENGYDSDSWCPPLPVQTYLHQGMEDELEEDEDRVPTPPVRGVASSPAI
                     SFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNTPPPQPPAPPL
                     GYVSGALISDLETDVPDEDADDEEEPLEIPRPLRALDQTPGSSMDNLDSSVTGKAFSS
                     SQRQRPTSPFSTDSNTSAAQNQSQRPRPTKKHKGGRMDPQPVLPHRREGMPDDLPPPP
                     DPPPGQGLRQQIGLSQHSGNVENSTERKGSSLERQQAANLEDTKSSLDCPAKTVLEWQ
                     RQTQDWINSTERQEETRKAPHKQGVGSEESLVPYSKPSFPSPGGHSSSGTSSSKGSTG
                     PRKADVLRGSHQRNANDLLDIGYVGSNSQGQFTE"
     exon            935..1261
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1419
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1540
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1679
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1807
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1819
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1944
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2116
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2322
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2404
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2567
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2734
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2856
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3088
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3213
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3385
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3568
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3611
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3739
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..4021
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4022..4175
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4436
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4642
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4816
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..5089
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            5090..5281
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            5282..9275
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6729..6734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAAA"
     polyA_site      6759
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="major polyA site"
     regulatory      9114..9119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAGA"
     polyA_site      9136
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
     regulatory      9247..9252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAAA"
     polyA_site      9275
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
ORIGIN      
        1 actactcccg gaggctggac cacgcgtgag catcctcagg gctcccaggt ccggagctcc
       61 tagatctggc ggtgctcgcc agcagcagct ggacgctaga tctctccggg gcggcccctc
      121 ccgggtggcc gcggcctcag ctcagcccct ccctcttccc ttgcttcttc tcctcgccct
      181 cctcctcgct ccctcaccac gtaggagttc ccattctcca cccaagccgt cctgccttcc
      241 ccttttcctt ccttttggaa accagagact ccgagggagg cgaccaggct gcggaggaga
      301 gggccggctc acaaagtgct gctttgacac atccttagga tggaagttaa gtgaaaacag
      361 aaccacacaa aacaaaactc cgcgaagtgg tgctgctacg gaggaaacca aggggagaaa
      421 aacccggtgg gcaggtcaat ggttgcttcg cagcgctttg gcaagtttgt ggaacacttt
      481 ctaggaatta ggtctttttt gtacccccat catcttcttg acttccgaag aaagaagttg
      541 tgtttggatt gcaatggagt ctaaggagac agggctagac gcacgtgaat agtcccgcca
      601 gctgggctga atttgtggga atttagaaag acagcctgtg gaagtgcaac gtctctgaag
      661 tcccctgggt tcattcggat ggcacctaac gcgtcccgtg acagacctct tcaccaacag
      721 cttccgatgt tgccattttg ctcttcttga ccttaattaa tctctaggaa agtctaaact
      781 tcggacctac ctcttttttt gatacttatt tttgtacttc tgctctctgg gattggtttc
      841 ttaaacaacc tggatccttt ttcatatgtc aaaatgaatc ctctgatgtt tacactatta
      901 ttgctctttg gatttctctg cattcagatt gatggatctc gtcttcgtca agaagacttt
      961 ccccccagga tcgtagaaca cccttctgat gtcatcgtct ccaagggaga gcccaccact
     1021 ctgaactgta aagcagaggg ccgacccacc cccaccattg aatggtacaa ggatggtgag
     1081 agggtggaga cagacaagga tgatcccagg tcccacagaa tgcttctgcc cagcggatct
     1141 ttattctttt tgcgaattgt tcatgggcgc agaagtaaac cggacgaagg gagttacgtt
     1201 tgtgttgcaa ggaactatct tggtgaagca gtgagtcgaa atgcatctct ggaagtggca
     1261 ttattgcgag atgacttccg gcaaaacccc acagatgtgg tagtcgcagc tggagagcct
     1321 gcaatcttgg agtgccagcc accacgggga cacccagaac caaccatcta ctggaaaaag
     1381 gacaaagtcc gaattgatga caaggaagag agaataagta tccgtggtgg gaagctgatg
     1441 atctctaata ctaggaaaag cgatgctggc atgtacacct gtgtgggaac caatatggtg
     1501 ggagaaaggg acagcgaccc tgcagagctc actgtctttg aacgacccac atttctcagg
     1561 aggccaatta accaggtggt gctagaggaa gaagctgtag aattccgttg tcaggtccaa
     1621 ggagatcccc agccaacggt gaggtggaaa aaagatgatg cagacttgcc gagaggaagg
     1681 tatgatatca aagatgacta cacgctgaga attaaaaagg ccatgagtac tgatgaaggt
     1741 acctatgtgt gtattgctga gaatcgggtg ggaaaagtgg aagcctctgc taccctcact
     1801 gtccgagttc gccctgttgc tcctccacag tttgtggtta ggccaagaga tcagatcgtt
     1861 gctcaaggcc gaacagtgac attcccctgt gaaactaaag gaaacccaca gccagctgtt
     1921 ttttggcaga aagaaggcag ccagaaccta cttttcccga atcaacctca gcagcccaac
     1981 agccgatgtt cagtgtcgcc cacgggggac ctcaccatca ccaacatcca gcgttcagat
     2041 gcgggttact acatctgcca ggccctaacc gtggcaggaa gcattttagc taaagcacag
     2101 ttggaagtta ctgacgtttt gacagataga cctccaccca taatcttgca aggaccaata
     2161 aaccaaacac ttgcagtaga cggtacagca ttgttgaagt gtaaagccac tggtgagcct
     2221 ctgcctgtaa ttagctggct aaaggagggc tttacttttc tggggagaga tccaagagcc
     2281 acgatccaag accaaggaac actgcagatt aagaatttac ggatatctga tactggcact
     2341 tatacttgtg tggctacaag ttccagtgga gagacttcct ggagtgcagt gctggatgta
     2401 acagaatctg gagcaacaat cagtaaaaat tatgatatga atgacctccc gggaccacca
     2461 tccaaacctc aggtcactga tgtttctaag aacagtgtca ccttatcctg gcagccaggt
     2521 acacctggcg ttcttcctgc aagcgcgtat atcattgagg ctttcagcca atcggtgagc
     2581 aatagctggc agacagtggc aaaccatgtt aagacaactc tgtatacagt aagggggctg
     2641 aggcccaaca caatctactt gtttatggtc agagcgatca acccacaagg tctcagtgat
     2701 ccaagtccta tgtcggatcc tgtacgcaca caagatatca gccccccagc acaaggagtg
     2761 gaccacagac aggtgcagaa ggaattaggt gatgtcgttg ttcgtctcca taatccagtt
     2821 gtcctgacac ctacaactgt tcaagtcaca tggacggtgg accgacaacc ccagtttatt
     2881 cagggctaca gagtgatgta ccgtcagact tcgggactac aagcctcaac tgtgtggcag
     2941 aatctagacg ccaaagtccc gactgagagg agtgctgtcc ttgtgaattt gaaaaagggg
     3001 gtgacttatg aaattaaagt ccggccgtat tttaacgagt tccaaggaat ggacagtgaa
     3061 tcgaaaacag tccgaaccac tgaggaagcc ccaagtgccc ctccccagtc tgtcactgtg
     3121 ctgacagttg gaagtcacaa cagcacaagc atcagtgttt cctgggatcc tccaccagcc
     3181 gaccaccaga atggaattat tcaggaatat aagatctggt gtctgggaaa cgaaacgcga
     3241 ttccatatca ataaaacggt ggatgcagcc attcgctctg tagtaatagg tggcttgttc
     3301 cctggaattc agtaccgggt agaagtggca gctagcacaa gtgcaggggt tggagtaaaa
     3361 agtgaaccac agccgataat aattggggga cgtaacgaag ttgtcattac tgaaaacaat
     3421 aacagcatca ctgagcaaat cacggatgtc gtgaagcaac cggcatttat agctggcatt
     3481 ggtggtgcct gctgggtaat tctgatgggt tttagcatct ggttgtactg gagaagaaag
     3541 aagagaaagg gactcagcaa ttatgctgta acatttcaaa gaggagatgg aggactaatg
     3601 agcaatggga gccgtccagg tcttctaaat gctggcgatc ccaattaccc atggcttgct
     3661 gattcttggc cagccacgag tttgccagtg aacaatagca atagtggccc aaatgaaatt
     3721 ggaaattttg ggcgtggaga tgtgctgcct ccggtgccag gccaagggga taaaacagcg
     3781 accatgctct cggatggagc catttatagc agcattgact tcactaccaa aaccacttac
     3841 aacagttcca gccaaataac acaggccacc ccatatgcca ctacacaaat cctgcattca
     3901 aacagcatcc acgaactggc agttgatctt cctgatccac agtggaaaag ctcagttcaa
     3961 cagaagacag acctcatggg atttggttat tcgctacctg atcagaacaa ggggaacaac
     4021 ggtgggaaag gtggaaaaaa gaagaaaact aaaaattctt cgaaagcgca gaaaaacaac
     4081 ggatccactt gggctaatgt ccctctacct cctcctcccg tccagcccct tcctggtaca
     4141 gagctgggcc actatgctgc ggaacaagaa aatggctatg acagtgacag ctggtgccca
     4201 ccattaccgg tgcaaacata cttgcatcag ggtatggaag atgagctgga agaagacgaa
     4261 gatcgggtcc caacacctcc tgttcgcggc gtggcctctt caccagctat ctcttttgga
     4321 cagcagtcca ctgccactct tactccatcc ccacgggaag agatgcaacc catgctgcaa
     4381 gctcacttgg atgagttgac aagggcctat cagtttgata tagcaaaaca aacatggcac
     4441 attcaaagca ataccccacc tccacaaccc ccagctccgc cattaggtta cgtgtccgga
     4501 gccttgattt ctgatttgga gacagatgtt ccagatgagg atgctgatga tgaagaggaa
     4561 ccattagaaa ttcccaggcc cctcagagca ctagaccaga cacctggatc cagtatggac
     4621 aatctagaca gctctgtcac aggaaaagcc tttagctcct ctcaaaggca gcggcccacc
     4681 agcccatttt ctacggacag taacaccagt gctgcccaga atcaaagcca gaggcctcgg
     4741 cccacgaaaa aacataaggg aggacggatg gacccacagc cagtgttacc tcatcggagg
     4801 gaagggatgc cagatgatct tcccccacca ccagatcccc caccaggtca gggtttaagg
     4861 cagcagatag gcctgagcca acactctggt aacgtggaaa actcaacaga gagaaaagga
     4921 agctctctag agagacaaca agcagccaac ttagaagaca caaagagctc attggattgt
     4981 ccagctaaaa ctgttctaga gtggcagcgt caaacccagg actggataaa ctctacagaa
     5041 cgccaagaag aaactcggaa agccccacac aaacaagggg ttggatcaga ggagtccctg
     5101 gtgccctaca gcaagcccag cttcccgtct cctggcgggc acagctcatc aggaacatct
     5161 tcctctaaag ggtccactgg ccctcggaag gctgacgtgc tgagaggcag ccaccagagg
     5221 aatgccaatg accttctcga cattggatat gtgggctcaa atagtcaagg acagtttaca
     5281 gagtaactga gaggggacat acaaagatgc tctgaggacc atcaggtcca aactcatgga
     5341 agtgataaca tttaacagtg caatgaacaa tttctttatt tatgtactat taaaaaaaaa
     5401 ctgtaaatgc aatgtaaaga cacacagcca cacatattcc acagttattt tcttgtgttc
     5461 ttctcttact tacaccaccc accttaactc tttcttgtca ggagtatata agaaaaagaa
     5521 agaaagcaaa actcaccctc caggaagaaa aggatttttc ctctgtatat aatttctttt
     5581 gtgcattgct atgcaagctc actcttttta actctgttca tattattgtc tgttctgatt
     5641 ggtctgttgt actatatgtg aattaatggg ctgtggtgcc atatattaac ttttaattgt
     5701 gtaacttttt atgtttaaat tttgcactgc gattttattt ggtgataagc acaaatctct
     5761 actcctcatg acatgaagaa aagattgaat gtgaagggag ttttctgtac tgtaagttag
     5821 gttggataat gctggtgtaa ccaatccagt tagatggttt tcagttgggg gtgtagaaat
     5881 aggaagatcg aaggaatgat ggtgttggca aagtcttctt gaaacaacag atattgagac
     5941 aattttaaga agcagaaaga tggatactat tgactaaagc aggggtcaaa agaagggggt
     6001 ttaagtctag acagagtatg taataaagta tggtggtagc aaagatgtac taacttgctt
     6061 taaaaatatt attaaagttt tatttagaat gaactttacc tgccattgta attaacccat
     6121 cttagaatta caatgagcaa aataaaaatc aaggtgtttc aagagatctg tatttatatt
     6181 acagcttttt aaaaacagca gttttgaata atcataatta atctctccaa ctcattaagt
     6241 cagactataa catggagttc cccaaggaaa caaacaaaaa aaatgaactc cagaaactct
     6301 agcaaatagt taaagaagca acttattctt cgagcatact cggctactct tgaatatgag
     6361 ctcaattgca atatcttgtt catctttcta atacatgtac agtacatatt agaggatgta
     6421 ggcacatcac ttaagttcat ttctttttaa aaaaaaaaag caaactaatg cattctgcat
     6481 acaattttgt gtttcttttg gttaaaatgt gaaatcgatg ccaccagatg tatagccaca
     6541 ttataagtgc ttaaaggcag tgctcacagt atgttcagtt tccagttagt agatttattg
     6601 gactcaatat tttctggtac attctcagaa attggctacc aactcaaatc tgtttgaccc
     6661 attttgaatg agtaaatcgg aaagaacagt caaaagggag aaaaaaatgc atgtttatac
     6721 actttttaaa taaaaccaaa tcttgtaagt ggacattaat aacagtgtcc tgcctcattt
     6781 gttttcacga ctctgagaac aaggagttgc tcaacatcca ttatgtatgc tcaagataaa
     6841 tgtgactttg aaatgtatgt tagctactgt acatgtatgt aagtcaagta gatgatagcc
     6901 ttcctgaaac taccactaat aatattttcc catgtgctac ttacacaagc ttaaattcta
     6961 gttcagcaaa tgtttttcat tattttttct tacggtttat tcaatagagg gtacctagaa
     7021 aaatattcag tgtgatggtc aacatattga gtgttcaagt aggggatatt tactttggca
     7081 atacatactg tgcattattg gttcagatgc caattcatga gacattatca taggaaatgg
     7141 ataatataag aacatggctc taagggtcct tctccacagg caagcataga atttgaggtt
     7201 cttcatgggt cccaaaactt gcttagtgtt atatacttaa cttccttcac tgaagtatca
     7261 agcaattcta acacaccgtt taacaacttt ctaccatcag tgcctgcatt ttattgaagt
     7321 ttgatgtctc tggtacaagg aaatagagaa agctgaacag tttctgttgg gagaaaaagt
     7381 ttctgtaatt attgtcaatt ctaagttgtg atgaatataa cttttcatct atacagttcc
     7441 ttactcatgg tctctattta aaagcatagg atcttttaag atatactttt agctgagtct
     7501 tcactgtatg ttcatgaata atataattta gtgaaaaact ttagtacatc atatgtatgg
     7561 taactgacat ttgcagatta ttatcaaacc aaatcataag aaataatatc ttcagatcac
     7621 atgatggctt accgaacaat ttcaggttat agcatgatgt ctttctgatt gtcttcagta
     7681 tatgatcata agcaattata ttgtgtccat acagtttaca tactgtgatt cccgcaaaat
     7741 cttgcatctg atatctacca tgaagatgaa ataatatgct atgaatttca ggcatagaca
     7801 tactatcagc aatagaaagc cttcatcatc tagatatctg gataaatcca ttcatcgtca
     7861 accatcagat tgttaactgg ggaacacgta cctccctcac aaatgctttc ttttcgtctt
     7921 gtagttgatt gaatgtgata ggaaatctgc tgagttgact cttctgtggg cctgagcaga
     7981 aacatgcata agccatcaga aggaagtctg gatgggaagg aaaccttgtc tttcactcgt
     8041 aggcaatact gctgtgtagt cacggcagac ccaagcacag cttctttcag aacatgcaaa
     8101 gtctccttat gaaatataca catcagtgcc caaactcagg tgtaccagtg taaagcgtag
     8161 ggtttgccta cccttttttc atatcatttt acataagcaa gttaggagac tacagggcta
     8221 tgaaaataaa tgtttcctta acaggatttg gagcaagttc acgggagtac ataggacagt
     8281 cgagcccagt gtaaacacta ccaaaggaaa ggacagcctt gcagaagcgt gagctccgac
     8341 taacagagcg gcttaagtat gctctgtgat acagcttaat gcactcccta ttcaaatccc
     8401 actgtcaatg ggatttaagt tgccagttta tatgtgattt catggaacac aaccaagttc
     8461 tacttaatac ctttatgcaa tttttttttc actgatgaaa aatcaatatc cacatcaatg
     8521 ggtgcccagc tgcggatcac ctctcctaaa aagcgatctt gtcagtattg aagaaatgta
     8581 gaaccataat tttcactact aatatcattt tgctcaacta cttctgtata ttgtggaaaa
     8641 aggggtgggg ccgggggaat gtgtgtttcc acattttctg agaggtgaaa atatttttgt
     8701 gttgctttgt cctaatgggt acttcaaatg aaacaccata caattttaaa tgacatgcaa
     8761 ttaacgaata ttttttactc tcataacatt aaaagcattt gttgtgattt tcaagtgtta
     8821 caagatagat ttttgtggtc gtgggtagac gttttatact ttgttttata gatggatttt
     8881 tttcccactg tcgtttactt gagtggacaa acagtatccc aagtctcaaa gtgtttcatt
     8941 ggatgttgtt agatcagcaa agaaattggc agaaaattga ttcatagtat tgtcaaagaa
     9001 ttgtgtattg tgtattcact gggaaaaata aaaaatatat tcacattcca attttgtaaa
     9061 aaaaaaaaca aaaagccatt tatgtaaaca aatttctctg tggacaaacc aaaaatagat
     9121 ccttgtgtca cttttaggac tctgtgacta ttttgtggcc caatattcat atttcttttt
     9181 ttctaattta aatatggatc agaagtgctt ggtaagaaat aatacatagt cataattaaa
     9241 gacagcaata aaggctgcaa gtatttgaaa ttata
//
