LOCUS       NM_001358493            9013 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus roundabout guidance receptor 2 (Robo2), transcript
            variant 1, mRNA.
ACCESSION   NM_001358493 XM_017317013
VERSION     NM_001358493.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9013)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 9013)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9013)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   4  (bases 1 to 9013)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 9013)
  AUTHORS   Waters,B.J., Birman,Z.R., Wagner,M.R., Lemanski,J. and Blum,B.
  TITLE     Islet architecture in adult mice is actively maintained by Robo2
            expression in beta cells
  JOURNAL   Dev Biol 505, 122-129 (2024)
   PUBMED   37972678
  REMARK    GeneRIF: Islet architecture in adult mice is actively maintained by
            Robo2 expression in beta cells.
REFERENCE   6  (bases 1 to 9013)
  AUTHORS   Jimenez,D., Garcia,C., de Castro,F., Chedotal,A., Sotelo,C., de
            Carlos,J.A., Valverde,F. and Lopez-Mascaraque,L.
  TITLE     Evidence for intrinsic development of olfactory structures in Pax-6
            mutant mice
  JOURNAL   J Comp Neurol 428 (3), 511-526 (2000)
   PUBMED   11074448
REFERENCE   7  (bases 1 to 9013)
  AUTHORS   Erskine,L., Williams,S.E., Brose,K., Kidd,T., Rachel,R.A.,
            Goodman,C.S., Tessier-Lavigne,M. and Mason,C.A.
  TITLE     Retinal ganglion cell axon guidance in the mouse optic chiasm:
            expression and function of robos and slits
  JOURNAL   J Neurosci 20 (13), 4975-4982 (2000)
   PUBMED   10864955
REFERENCE   8  (bases 1 to 9013)
  AUTHORS   Niclou,S.P., Jia,L. and Raper,J.A.
  TITLE     Slit2 is a repellent for retinal ganglion cell axons
  JOURNAL   J Neurosci 20 (13), 4962-4974 (2000)
   PUBMED   10864954
REFERENCE   9  (bases 1 to 9013)
  AUTHORS   Piper,M., Georgas,K., Yamada,T. and Little,M.
  TITLE     Expression of the vertebrate Slit gene family and their putative
            receptors, the Robo genes, in the developing murine kidney
  JOURNAL   Mech Dev 94 (1-2), 213-217 (2000)
   PUBMED   10842075
REFERENCE   10 (bases 1 to 9013)
  AUTHORS   Murtra,P., Sheasby,A.M., Hunt,S.P. and De Felipe,C.
  TITLE     Rewarding effects of opiates are absent in mice lacking the
            receptor for substance P
  JOURNAL   Nature 405 (6783), 180-183 (2000)
   PUBMED   10821273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115120.4, AC158234.2, AC112155.3, AC134452.4, AC122049.2 and
            AC162374.4.
            
            On Dec 20, 2022 this sequence version replaced NM_001358493.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               AC115120.4         156153-156698
            547-873             AC158234.2         51112-51438         c
            874-1031            AC112155.3         117746-117903
            1032-1152           AC112155.3         118741-118861
            1153-1291           AC112155.3         129560-129698
            1292-1419           AC112155.3         148685-148812
            1420-1431           AC134452.4         6209-6220
            1432-1556           AC134452.4         29283-29407
            1557-1728           AC134452.4         32843-33014
            1729-1934           AC134452.4         36382-36587
            1935-2016           AC134452.4         41209-41290
            2017-2179           AC134452.4         41680-41842
            2180-2346           AC134452.4         43775-43941
            2347-2468           AC134452.4         47106-47227
            2469-2700           AC134452.4         53085-53316
            2701-2825           AC122049.2         164791-164915       c
            2826-2997           AC122049.2         162975-163146       c
            2998-3180           AC122049.2         154690-154872       c
            3181-3223           AC122049.2         146743-146785       c
            3224-3351           AC122049.2         145218-145345       c
            3352-3633           AC162374.4         3045-3326
            3634-3759           AC162374.4         3742-3867
            3760-3913           AC162374.4         8736-8889
            3914-4174           AC162374.4         16119-16379
            4175-4380           AC162374.4         20610-20815
            4381-4554           AC162374.4         32357-32530
            4555-4827           AC162374.4         37729-38001
            4828-5019           AC162374.4         39706-39897
            5020-9013           AC162374.4         41083-45076
FEATURES             Location/Qualifiers
     source          1..9013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 42.17 cM"
     gene            1..9013
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="roundabout guidance receptor 2"
                     /db_xref="GeneID:268902"
                     /db_xref="MGI:MGI:1890110"
     exon            1..546
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..5024
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; roundabout homolog 2"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform 1 precursor"
                     /protein_id="NP_001345422.1"
                     /db_xref="GeneID:268902"
                     /db_xref="MGI:MGI:1890110"
                     /translation="MLSSEKVDKITRLELLFVLMLFFSGPTLGKLTRTPWKGKPWKGG
                     SRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPR
                     SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ
                     NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK
                     SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ
                     PTVRWKKDDADLPRGRYDIKDDYTLRIKKAMSTDEGTYVCIAENRVGKVEASATLTVR
                     VRPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN
                     SRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG
                     PINQTLAVDGTALLKCKATGEPLPVISWLKEGFTFLGRDPRATIQDQGTLQIKNLRIS
                     DTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDMNDLPGPPSKPQVTDVSKNSVT
                     LSWQPGTPGVLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRA
                     INPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVVVRLHNPVVLTPTTVQVT
                     WTVDRQPQFIQGYRVMYRQTSGLQASTVWQNLDAKVPTERSAVLVNLKKGVTYEIKVR
                     PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSHNSTSISVSWDPPPADHQNGI
                     IQEYKIWCLGNETRFHINKTVDAAIRSVVIGGLFPGIQYRVEVAASTSAGVGVKSEPQ
                     PIIIGGRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKR
                     KGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPNYPWLADSWPATSLPVNNSNSGPNEI
                     GNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTTYNSSSQITQATPYATTQIL
                     HSNSIHELAVDLPDPQWKSSVQQKTDLMGFGYSLPDQNKGNNALLYIPDYRLAEGLSN
                     RMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKKKKTKNSSKAQKNNGSTWANVPLPPP
                     PVQPLPGTELGHYAAEQENGYDSDSWCPPLPVQTYLHQGMEDELEEDEDRVPTPPVRG
                     VASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNTPPP
                     QPPAPPLGYVSGALISDLETDVPDEDADDEEEPLEIPRPLRALDQTPGSSMDNLDSSV
                     TGKAFSSSQRQRPTSPFSTDSNTSAAQNQSQRPRPTKKHKGGRMDPQPVLPHRREGMP
                     DDLPPPPDPPPGQGLRQQIGLSQHSGNVENSTERKGSSLERQQAANLEDTKSSLDCPA
                     KTVLEWQRQTQDWINSTERQEETRKAPHKQGVGSEESLVPYSKPSFPSPGGHSSSGTS
                     SSKGSTGPRKADVLRGSHQRNANDLLDIGYVGSNSQGQFTE"
     exon            547..873
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1031
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1152
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1291
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1419
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1431
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1556
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1728
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1934
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2016
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2179
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2346
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2468
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2700
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2825
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2997
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3180
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3223
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3351
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3633
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3759
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3913
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4174
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4380
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4381..4554
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4827
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..5019
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..9013
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6467..6472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAAA"
     polyA_site      6497
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="major polyA site"
     regulatory      8852..8857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAGA"
     polyA_site      8874
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
     regulatory      8985..8990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
                     /note="hexamer: AATAAA"
     polyA_site      9013
                     /gene="Robo2"
                     /gene_synonym="2600013A04Rik; 9430089E08Rik;
                     D230004I22Rik; mKIAA1568"
ORIGIN      
        1 attaggatca cacaggcagc ctgaaagctg tcagtacaac tgcttctcat cttttttttt
       61 ttttcacacg gtcctgacat ctcttctctt tttttctgct ggacacacat tcctgttttt
      121 atcattttca atcaagtgca cgcaggacgc tgaggaatat tcccactgaa agcaaagtgg
      181 agaacaggaa tgattttaca gctcttaaag tggaaacagt gctgactgcg ggctgagggg
      241 aaggagctgg agccgtgaga aatgtagctt ggctcagggc tacatcaggg agctgctcct
      301 tcagctgcta aagatggcaa aacaccacct acctccgact tctcaatgat caatgctacc
      361 ttcagaaccc ggagggaaga ggatgtgaga aatttttata aaattcactt gtggaaatgt
      421 tatcatccga gaaagtggac aaaattacta gactcgaact tctcttcgtt ttgatgttat
      481 tcttctcagg accaactcta ggcaagctga ccaggacccc ctggaagggc aaaccttgga
      541 aggggggatc tcgtcttcgt caagaagact ttccccccag gatcgtagaa cacccttctg
      601 atgtcatcgt ctccaaggga gagcccacca ctctgaactg taaagcagag ggccgaccca
      661 cccccaccat tgaatggtac aaggatggtg agagggtgga gacagacaag gatgatccca
      721 ggtcccacag aatgcttctg cccagcggat ctttattctt tttgcgaatt gttcatgggc
      781 gcagaagtaa accggacgaa gggagttacg tttgtgttgc aaggaactat cttggtgaag
      841 cagtgagtcg aaatgcatct ctggaagtgg cattattgcg agatgacttc cggcaaaacc
      901 ccacagatgt ggtagtcgca gctggagagc ctgcaatctt ggagtgccag ccaccacggg
      961 gacacccaga accaaccatc tactggaaaa aggacaaagt ccgaattgat gacaaggaag
     1021 agagaataag tatccgtggt gggaagctga tgatctctaa tactaggaaa agcgatgctg
     1081 gcatgtacac ctgtgtggga accaatatgg tgggagaaag ggacagcgac cctgcagagc
     1141 tcactgtctt tgaacgaccc acatttctca ggaggccaat taaccaggtg gtgctagagg
     1201 aagaagctgt agaattccgt tgtcaggtcc aaggagatcc ccagccaacg gtgaggtgga
     1261 aaaaagatga tgcagacttg ccgagaggaa ggtatgatat caaagatgac tacacgctga
     1321 gaattaaaaa ggccatgagt actgatgaag gtacctatgt gtgtattgct gagaatcggg
     1381 tgggaaaagt ggaagcctct gctaccctca ctgtccgagt tcgccctgtt gctcctccac
     1441 agtttgtggt taggccaaga gatcagatcg ttgctcaagg ccgaacagtg acattcccct
     1501 gtgaaactaa aggaaaccca cagccagctg ttttttggca gaaagaaggc agccagaacc
     1561 tacttttccc gaatcaacct cagcagccca acagccgatg ttcagtgtcg cccacggggg
     1621 acctcaccat caccaacatc cagcgttcag atgcgggtta ctacatctgc caggccctaa
     1681 ccgtggcagg aagcatttta gctaaagcac agttggaagt tactgacgtt ttgacagata
     1741 gacctccacc cataatcttg caaggaccaa taaaccaaac acttgcagta gacggtacag
     1801 cattgttgaa gtgtaaagcc actggtgagc ctctgcctgt aattagctgg ctaaaggagg
     1861 gctttacttt tctggggaga gatccaagag ccacgatcca agaccaagga acactgcaga
     1921 ttaagaattt acggatatct gatactggca cttatacttg tgtggctaca agttccagtg
     1981 gagagacttc ctggagtgca gtgctggatg taacagaatc tggagcaaca atcagtaaaa
     2041 attatgatat gaatgacctc ccgggaccac catccaaacc tcaggtcact gatgtttcta
     2101 agaacagtgt caccttatcc tggcagccag gtacacctgg cgttcttcct gcaagcgcgt
     2161 atatcattga ggctttcagc caatcggtga gcaatagctg gcagacagtg gcaaaccatg
     2221 ttaagacaac tctgtataca gtaagggggc tgaggcccaa cacaatctac ttgtttatgg
     2281 tcagagcgat caacccacaa ggtctcagtg atccaagtcc tatgtcggat cctgtacgca
     2341 cacaagatat cagcccccca gcacaaggag tggaccacag acaggtgcag aaggaattag
     2401 gtgatgtcgt tgttcgtctc cataatccag ttgtcctgac acctacaact gttcaagtca
     2461 catggacggt ggaccgacaa ccccagttta ttcagggcta cagagtgatg taccgtcaga
     2521 cttcgggact acaagcctca actgtgtggc agaatctaga cgccaaagtc ccgactgaga
     2581 ggagtgctgt ccttgtgaat ttgaaaaagg gggtgactta tgaaattaaa gtccggccgt
     2641 attttaacga gttccaagga atggacagtg aatcgaaaac agtccgaacc actgaggaag
     2701 ccccaagtgc ccctccccag tctgtcactg tgctgacagt tggaagtcac aacagcacaa
     2761 gcatcagtgt ttcctgggat cctccaccag ccgaccacca gaatggaatt attcaggaat
     2821 ataagatctg gtgtctggga aacgaaacgc gattccatat caataaaacg gtggatgcag
     2881 ccattcgctc tgtagtaata ggtggcttgt tccctggaat tcagtaccgg gtagaagtgg
     2941 cagctagcac aagtgcaggg gttggagtaa aaagtgaacc acagccgata ataattgggg
     3001 gacgtaacga agttgtcatt actgaaaaca ataacagcat cactgagcaa atcacggatg
     3061 tcgtgaagca accggcattt atagctggca ttggtggtgc ctgctgggta attctgatgg
     3121 gttttagcat ctggttgtac tggagaagaa agaagagaaa gggactcagc aattatgctg
     3181 taacatttca aagaggagat ggaggactaa tgagcaatgg gagccgtcca ggtcttctaa
     3241 atgctggcga tcccaattac ccatggcttg ctgattcttg gccagccacg agtttgccag
     3301 tgaacaatag caatagtggc ccaaatgaaa ttggaaattt tgggcgtgga gatgtgctgc
     3361 ctccggtgcc aggccaaggg gataaaacag cgaccatgct ctcggatgga gccatttata
     3421 gcagcattga cttcactacc aaaaccactt acaacagttc cagccaaata acacaggcca
     3481 ccccatatgc cactacacaa atcctgcatt caaacagcat ccacgaactg gcagttgatc
     3541 ttcctgatcc acagtggaaa agctcagttc aacagaagac agacctcatg ggatttggtt
     3601 attcgctacc tgatcagaac aaggggaaca acgccttact ttacatccct gactaccgat
     3661 tggctgaggg attgtctaat agaatgccac acaaccagtc acaggatttc agcaccacca
     3721 gctctcacaa cagctcagaa aggagtggca gtctctcagg tgggaaaggt ggaaaaaaga
     3781 agaaaactaa aaattcttcg aaagcgcaga aaaacaacgg atccacttgg gctaatgtcc
     3841 ctctacctcc tcctcccgtc cagccccttc ctggtacaga gctgggccac tatgctgcgg
     3901 aacaagaaaa tggctatgac agtgacagct ggtgcccacc attaccggtg caaacatact
     3961 tgcatcaggg tatggaagat gagctggaag aagacgaaga tcgggtccca acacctcctg
     4021 ttcgcggcgt ggcctcttca ccagctatct cttttggaca gcagtccact gccactctta
     4081 ctccatcccc acgggaagag atgcaaccca tgctgcaagc tcacttggat gagttgacaa
     4141 gggcctatca gtttgatata gcaaaacaaa catggcacat tcaaagcaat accccacctc
     4201 cacaaccccc agctccgcca ttaggttacg tgtccggagc cttgatttct gatttggaga
     4261 cagatgttcc agatgaggat gctgatgatg aagaggaacc attagaaatt cccaggcccc
     4321 tcagagcact agaccagaca cctggatcca gtatggacaa tctagacagc tctgtcacag
     4381 gaaaagcctt tagctcctct caaaggcagc ggcccaccag cccattttct acggacagta
     4441 acaccagtgc tgcccagaat caaagccaga ggcctcggcc cacgaaaaaa cataagggag
     4501 gacggatgga cccacagcca gtgttacctc atcggaggga agggatgcca gatgatcttc
     4561 ccccaccacc agatccccca ccaggtcagg gtttaaggca gcagataggc ctgagccaac
     4621 actctggtaa cgtggaaaac tcaacagaga gaaaaggaag ctctctagag agacaacaag
     4681 cagccaactt agaagacaca aagagctcat tggattgtcc agctaaaact gttctagagt
     4741 ggcagcgtca aacccaggac tggataaact ctacagaacg ccaagaagaa actcggaaag
     4801 ccccacacaa acaaggggtt ggatcagagg agtccctggt gccctacagc aagcccagct
     4861 tcccgtctcc tggcgggcac agctcatcag gaacatcttc ctctaaaggg tccactggcc
     4921 ctcggaaggc tgacgtgctg agaggcagcc accagaggaa tgccaatgac cttctcgaca
     4981 ttggatatgt gggctcaaat agtcaaggac agtttacaga gtaactgaga ggggacatac
     5041 aaagatgctc tgaggaccat caggtccaaa ctcatggaag tgataacatt taacagtgca
     5101 atgaacaatt tctttattta tgtactatta aaaaaaaact gtaaatgcaa tgtaaagaca
     5161 cacagccaca catattccac agttattttc ttgtgttctt ctcttactta caccacccac
     5221 cttaactctt tcttgtcagg agtatataag aaaaagaaag aaagcaaaac tcaccctcca
     5281 ggaagaaaag gatttttcct ctgtatataa tttcttttgt gcattgctat gcaagctcac
     5341 tctttttaac tctgttcata ttattgtctg ttctgattgg tctgttgtac tatatgtgaa
     5401 ttaatgggct gtggtgccat atattaactt ttaattgtgt aactttttat gtttaaattt
     5461 tgcactgcga ttttatttgg tgataagcac aaatctctac tcctcatgac atgaagaaaa
     5521 gattgaatgt gaagggagtt ttctgtactg taagttaggt tggataatgc tggtgtaacc
     5581 aatccagtta gatggttttc agttgggggt gtagaaatag gaagatcgaa ggaatgatgg
     5641 tgttggcaaa gtcttcttga aacaacagat attgagacaa ttttaagaag cagaaagatg
     5701 gatactattg actaaagcag gggtcaaaag aagggggttt aagtctagac agagtatgta
     5761 ataaagtatg gtggtagcaa agatgtacta acttgcttta aaaatattat taaagtttta
     5821 tttagaatga actttacctg ccattgtaat taacccatct tagaattaca atgagcaaaa
     5881 taaaaatcaa ggtgtttcaa gagatctgta tttatattac agctttttaa aaacagcagt
     5941 tttgaataat cataattaat ctctccaact cattaagtca gactataaca tggagttccc
     6001 caaggaaaca aacaaaaaaa atgaactcca gaaactctag caaatagtta aagaagcaac
     6061 ttattcttcg agcatactcg gctactcttg aatatgagct caattgcaat atcttgttca
     6121 tctttctaat acatgtacag tacatattag aggatgtagg cacatcactt aagttcattt
     6181 ctttttaaaa aaaaaaagca aactaatgca ttctgcatac aattttgtgt ttcttttggt
     6241 taaaatgtga aatcgatgcc accagatgta tagccacatt ataagtgctt aaaggcagtg
     6301 ctcacagtat gttcagtttc cagttagtag atttattgga ctcaatattt tctggtacat
     6361 tctcagaaat tggctaccaa ctcaaatctg tttgacccat tttgaatgag taaatcggaa
     6421 agaacagtca aaagggagaa aaaaatgcat gtttatacac tttttaaata aaaccaaatc
     6481 ttgtaagtgg acattaataa cagtgtcctg cctcatttgt tttcacgact ctgagaacaa
     6541 ggagttgctc aacatccatt atgtatgctc aagataaatg tgactttgaa atgtatgtta
     6601 gctactgtac atgtatgtaa gtcaagtaga tgatagcctt cctgaaacta ccactaataa
     6661 tattttccca tgtgctactt acacaagctt aaattctagt tcagcaaatg tttttcatta
     6721 ttttttctta cggtttattc aatagagggt acctagaaaa atattcagtg tgatggtcaa
     6781 catattgagt gttcaagtag gggatattta ctttggcaat acatactgtg cattattggt
     6841 tcagatgcca attcatgaga cattatcata ggaaatggat aatataagaa catggctcta
     6901 agggtccttc tccacaggca agcatagaat ttgaggttct tcatgggtcc caaaacttgc
     6961 ttagtgttat atacttaact tccttcactg aagtatcaag caattctaac acaccgttta
     7021 acaactttct accatcagtg cctgcatttt attgaagttt gatgtctctg gtacaaggaa
     7081 atagagaaag ctgaacagtt tctgttggga gaaaaagttt ctgtaattat tgtcaattct
     7141 aagttgtgat gaatataact tttcatctat acagttcctt actcatggtc tctatttaaa
     7201 agcataggat cttttaagat atacttttag ctgagtcttc actgtatgtt catgaataat
     7261 ataatttagt gaaaaacttt agtacatcat atgtatggta actgacattt gcagattatt
     7321 atcaaaccaa atcataagaa ataatatctt cagatcacat gatggcttac cgaacaattt
     7381 caggttatag catgatgtct ttctgattgt cttcagtata tgatcataag caattatatt
     7441 gtgtccatac agtttacata ctgtgattcc cgcaaaatct tgcatctgat atctaccatg
     7501 aagatgaaat aatatgctat gaatttcagg catagacata ctatcagcaa tagaaagcct
     7561 tcatcatcta gatatctgga taaatccatt catcgtcaac catcagattg ttaactgggg
     7621 aacacgtacc tccctcacaa atgctttctt ttcgtcttgt agttgattga atgtgatagg
     7681 aaatctgctg agttgactct tctgtgggcc tgagcagaaa catgcataag ccatcagaag
     7741 gaagtctgga tgggaaggaa accttgtctt tcactcgtag gcaatactgc tgtgtagtca
     7801 cggcagaccc aagcacagct tctttcagaa catgcaaagt ctccttatga aatatacaca
     7861 tcagtgccca aactcaggtg taccagtgta aagcgtaggg tttgcctacc cttttttcat
     7921 atcattttac ataagcaagt taggagacta cagggctatg aaaataaatg tttccttaac
     7981 aggatttgga gcaagttcac gggagtacat aggacagtcg agcccagtgt aaacactacc
     8041 aaaggaaagg acagccttgc agaagcgtga gctccgacta acagagcggc ttaagtatgc
     8101 tctgtgatac agcttaatgc actccctatt caaatcccac tgtcaatggg atttaagttg
     8161 ccagtttata tgtgatttca tggaacacaa ccaagttcta cttaatacct ttatgcaatt
     8221 tttttttcac tgatgaaaaa tcaatatcca catcaatggg tgcccagctg cggatcacct
     8281 ctcctaaaaa gcgatcttgt cagtattgaa gaaatgtaga accataattt tcactactaa
     8341 tatcattttg ctcaactact tctgtatatt gtggaaaaag gggtggggcc gggggaatgt
     8401 gtgtttccac attttctgag aggtgaaaat atttttgtgt tgctttgtcc taatgggtac
     8461 ttcaaatgaa acaccataca attttaaatg acatgcaatt aacgaatatt ttttactctc
     8521 ataacattaa aagcatttgt tgtgattttc aagtgttaca agatagattt ttgtggtcgt
     8581 gggtagacgt tttatacttt gttttataga tggatttttt tcccactgtc gtttacttga
     8641 gtggacaaac agtatcccaa gtctcaaagt gtttcattgg atgttgttag atcagcaaag
     8701 aaattggcag aaaattgatt catagtattg tcaaagaatt gtgtattgtg tattcactgg
     8761 gaaaaataaa aaatatattc acattccaat tttgtaaaaa aaaaaacaaa aagccattta
     8821 tgtaaacaaa tttctctgtg gacaaaccaa aaatagatcc ttgtgtcact tttaggactc
     8881 tgtgactatt ttgtggccca atattcatat ttcttttttt ctaatttaaa tatggatcag
     8941 aagtgcttgg taagaaataa tacatagtca taattaaaga cagcaataaa ggctgcaagt
     9001 atttgaaatt ata
//
