LOCUS       NM_001415010            8382 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus roundabout guidance receptor 1 (Robo1), transcript
            variant 1, mRNA.
ACCESSION   NM_001415010 XM_036159818
VERSION     NM_001415010.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8382)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 8382)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 8382)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8382)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8382)
  AUTHORS   Liu,L., Zhang,X., Geng,H.R., Qiao,Y.N., Gui,Y.H. and Zhao,J.Y.
  TITLE     High paternal homocysteine causes ventricular septal defects in
            mouse offspring
  JOURNAL   iScience 27 (4), 109447 (2024)
   PUBMED   38523790
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8382)
  AUTHORS   Niclou,S.P., Jia,L. and Raper,J.A.
  TITLE     Slit2 is a repellent for retinal ganglion cell axons
  JOURNAL   J Neurosci 20 (13), 4962-4974 (2000)
   PUBMED   10864954
REFERENCE   7  (bases 1 to 8382)
  AUTHORS   Piper,M., Georgas,K., Yamada,T. and Little,M.
  TITLE     Expression of the vertebrate Slit gene family and their putative
            receptors, the Robo genes, in the developing murine kidney
  JOURNAL   Mech Dev 94 (1-2), 213-217 (2000)
   PUBMED   10842075
REFERENCE   8  (bases 1 to 8382)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
REFERENCE   9  (bases 1 to 8382)
  AUTHORS   Li,H.S., Chen,J.H., Wu,W., Fagaly,T., Zhou,L., Yuan,W., Dupuis,S.,
            Jiang,Z.H., Nash,W., Gick,C., Ornitz,D.M., Wu,J.Y. and Rao,Y.
  TITLE     Vertebrate slit, a secreted ligand for the transmembrane protein
            roundabout, is a repellent for olfactory bulb axons
  JOURNAL   Cell 96 (6), 807-818 (1999)
   PUBMED   10102269
REFERENCE   10 (bases 1 to 8382)
  AUTHORS   Sundaresan,V., Roberts,I., Bateman,A., Bankier,A., Sheppard,M.,
            Hobbs,C., Xiong,J., Minna,J., Latif,F., Lerman,M. and Rabbitts,P.
  TITLE     The DUTT1 gene, a novel NCAM family member is expressed in
            developing murine neural tissues and has an unusually broad pattern
            of expression
  JOURNAL   Mol Cell Neurosci 11 (1-2), 29-35 (1998)
   PUBMED   9608531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025560.9, AC121890.3, AC124726.4 and AC164551.2.
            
            On Dec 20, 2022 this sequence version replaced XM_036159818.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.589704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               CT025560.9         26265-26514
            251-385             CT025560.9         144221-144355
            386-469             AC121890.3         113634-113717
            470-796             AC124726.4         22513-22839         c
            797-954             AC164551.2         26699-26856
            955-1075            AC164551.2         55282-55402
            1076-1214           AC164551.2         55743-55881
            1215-1342           AC164551.2         57728-57855
            1343-1467           AC164551.2         82150-82274
            1468-1639           AC164551.2         84223-84394
            1640-1845           AC164551.2         92236-92441
            1846-1927           AC164551.2         94049-94130
            1928-2096           AC164551.2         94277-94445
            2097-2263           AC164551.2         94540-94706
            2264-2385           AC164551.2         99755-99876
            2386-2617           AC164551.2         100629-100860
            2618-2739           AC164551.2         101914-102035
            2740-2911           AC164551.2         105778-105949
            2912-3109           AC164551.2         111668-111865
            3110-3136           AC164551.2         115736-115762
            3137-3179           AC164551.2         117186-117228
            3180-3334           AC164551.2         123988-124142
            3335-3670           AC164551.2         126479-126814
            3671-3778           AC164551.2         128893-129000
            3779-3923           AC164551.2         131681-131825
            3924-4172           AC164551.2         134944-135192
            4173-4579           AC164551.2         146201-146607
            4580-4732           AC164551.2         149826-149978
            4733-5041           AC164551.2         157728-158036
            5042-5238           AC164551.2         165060-165256
            5239-8382           AC164551.2         166417-169560
FEATURES             Location/Qualifiers
     source          1..8382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 41.08 cM"
     gene            1..8382
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="roundabout guidance receptor 1"
                     /db_xref="GeneID:19876"
                     /db_xref="MGI:MGI:1274781"
     exon            1..250
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            251..385
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..5253
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; roundabout homolog 1"
                     /codon_start=1
                     /product="roundabout homolog 1 isoform 1 precursor"
                     /protein_id="NP_001401939.1"
                     /db_xref="GeneID:19876"
                     /db_xref="MGI:MGI:1274781"
                     /translation="MGGIKMKWKHLPLLVISLLTLSRKQLLLAQLIPDPEDLERGNDN
                     GTPAPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT
                     IEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEA
                     VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK
                     DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA
                     VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTC
                     VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG
                     SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT
                     DVIADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVSTQDSRIKQ
                     LESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS
                     APSKPEVTDVSKNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTAAENVKTETFA
                     IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTSQGVDHKQVQRELGNVVL
                     HLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSV
                     VIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAI
                     LVTWQPPPEDTQNGMVQEYKVWCLGNETKYHINKTVDGSTFSVVIPSLVPGIRYSVEV
                     AASTGAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVRQPAFIAGIGAACWII
                     LMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNIS
                     EPATQPWLADTWPNTGNNHNDCSINCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNK
                     QTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLS
                     NNMNNGAGDSSEKHWKPPGQQKPEVAPIQYNIMEQNKLNKDYRANDTIPPTIPYNQSY
                     DQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSE
                     EYNMSVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQ
                     STATLTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISG
                     PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGW
                     GSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF
                     HASQCPRPTSPVSTDSNMSAVVIQKARPAKKQKHQPGHLRREAYADDLPPPPVPPPAI
                     KSPTVQSKAQLEVRPVMVPKLASIEARTDRSSDRKGGSYKGREALDGRQVTDLRTNPS
                     DPREAQEQPNDGKGRGTKAAKRDLPPAKTHLGQEDILPYCRPTFPTSNNPRDPSSSSS
                     MSSRGSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES"
     exon            386..469
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            470..796
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            797..954
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1075
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1214
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1342
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1467
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1639
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1845
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1927
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2096
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2263
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2385
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2617
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2739
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2911
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3109
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3136
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3179
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3334
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3670
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3778
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3923
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4172
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4579
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4732
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            4733..5041
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5238
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..8382
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6965..6970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="hexamer: ATTAAA"
     regulatory      6981..6986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="hexamer: AATACA"
     polyA_site      6986
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="major polyA site"
     polyA_site      7005
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
     regulatory      8362..8367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
                     /note="hexamer: AATAAA"
     polyA_site      8382
                     /gene="Robo1"
                     /gene_synonym="DUTT1; Gm310"
ORIGIN      
        1 gcattaatag taatacagat aacgggtatg aaagaattct ctactgaaga aggattgaat
       61 atttttccag gctgctgaga ccgagaggaa atctgactct tctctccctg cccctcactc
      121 atactggaaa aagtctcaga caggcttttg ctgcgtttaa actcgggagg ctgctctctg
      181 cagagcaaag ttggagggct gtgcctgcat cgcggagctg ctggatttct gaaaagaatc
      241 ttatggaagg ataacataca tctgtattgc tggctggtgt aatgtatggg agggataaag
      301 atgaaatgga aacaccttcc tcttctggtc atatctctcc tcactctatc aagaaaacag
      361 ctccttctgg cccagcttat cccagaccct gaggacctag agagggggaa cgacaacgga
      421 acgccagccc ccacctctga taacgatgac aattcgctgg gctacacagg ctcccgtctt
      481 cgtcaggaag attttccacc ccgcattgtt gaacaccctt cagacctgat cgtctccaaa
      541 ggagaacctg ccactctgaa ctgtaaagcc gaaggccgcc ccaccccgac gatagaatgg
      601 tacaaaggtg gggaaagagt ggagacggac aaagatgacc cgcgctcaca ccggatgctg
      661 ctgccaagcg ggtctttatt tttcttacgc atagtccatg gacggaagag taggcccgac
      721 gaaggggtct acatctgtgt ggctaggaat tacctcggag aggctgtgag ccacaacgca
      781 tcgctggagg tagctatact acgggatgac ttcagacaaa acccttcaga tgtcatggtg
      841 gcagtaggcg aacctgcagt catggaatgc cagcctccac ggggccatcc agagcccacc
      901 atctcctgga aaaaggatgg ctcacccctg gatgataaag atgaaagaat cactatacga
      961 ggaggaaaac tcatgatcac ttatacgcgt aaaagcgatg ctggcaagta tgtttgcgtt
     1021 ggcaccaaca tggtggggga acgggagagt gaagtcgcag agctaaccgt tttagagaga
     1081 ccatcgtttg tgaagagacc cagtaatttg gcagtgactg tggatgacag tgcagaattt
     1141 aaatgtgagg cccgaggaga ccctgtgcct acagttcgat ggaggaaaga tgacggagag
     1201 ctgcccaaat ccagatatga aatccgagat gatcatactt tgaaaattcg gaaggtgact
     1261 gctggcgaca tgggatcata cacttgtgtg gcagaaaata tggtcgggaa agctgaagct
     1321 tccgctactt tgacagttca agagccgcca catttcgttg taaaacctcg ggaccaggtg
     1381 gttgccttgg gaagaactgt gacgtttcag tgcgaagcaa ctggaaatcc tcaaccagct
     1441 atcttttgga ggagagaggg gagtcagaat ctacttttct cctaccagcc tccacagtcc
     1501 tctagccgat tttcagtttc gcagacagga gacctcacca ttacgaacgt ccagcggtct
     1561 gatgtcggct actacatctg tcagacttta aatgttgctg gaagtatcat cacaaaggcc
     1621 tatttggaag ttactgatgt gattgcagac cggcctcccc cagtcattcg gcaaggtcct
     1681 gtgaatcaga ctgtagcagt ggatggcact ttaatcctca gctgtgtggc cacaggcagt
     1741 ccagcaccca caattctgtg gaggaaggat ggagtccttg tttcaaccca agattctcgg
     1801 atcaaacagc tggagagtgg cgtgctgcag atccgctacg ctaagctggg tgacacgggt
     1861 cggtacacct gcaccgcatc gacccccagc ggtgaggcca cgtggagcgc ttacatcgaa
     1921 gtccaggaat ttggggttcc agttcaaccc ccaagaccca ccgaccccaa cttaatcccc
     1981 agcgccccct caaagcccga agttacagat gtcagcaaaa acacggtcac tttatcgtgg
     2041 cagccaaact tgaactcagg agcaacccca acatcttata ttatagaagc cttcagccat
     2101 gcatctggta gcagctggca gacggcggca gaaaatgtga aaacagaaac atttgccatc
     2161 aaaggactca aacctaacgc catttacctt ttcctggtga gggcagcaaa tgcctatgga
     2221 attagtgatc caagccaaat atcagatcca gtgaaaacgc aagatgtccc accaaccagc
     2281 caaggggtgg accacaagca ggtccaaaga gaactgggga atgttgtctt acatctgcac
     2341 aacccgacca tcctttcttc ctcctcagtc gaagtgcact ggacggtgga ccaacaatct
     2401 caatatattc aaggctataa aattctctac cgcccatctg gagccagcca tggtgaatcg
     2461 gagtggttag tttttgaagt gaggacgcca acgaaaaaca gcgtggtgat ccccgatctc
     2521 agaaaaggcg tcaactacga gattaaggct cgcccatttt ttaatgagtt tcaaggagca
     2581 gacagtgaaa tcaaatttgc caaaacctta gaagaagcac caagtgcccc tccccgaagt
     2641 gtaactgtat ccaagaatga tggaaatggg actgcaatcc tggtcacttg gcaaccgcct
     2701 cctgaagaca cacaaaatgg aatggtccaa gaatataagg tttggtgtct cggtaatgaa
     2761 acgaagtatc acataaacaa gacagtcgat ggctcgacct tctcggtggt catcccctct
     2821 ctggttcctg ggatccgata cagtgtggag gtggcagcga gcactggggc gggtcccggg
     2881 gtgaagagcg aacctcagtt catccagtta gattctcacg gaaaccccgt gtctcccgag
     2941 gaccaagtca gccttgctca gcagatctcc gacgtggtga ggcagccggc gttcattgca
     3001 ggcattgggg cagcctgttg gattatcctc atggtcttca gcatctggct ttacagacac
     3061 cgcaagaaga gaaacggact caccagcacg tatgcgggta tccggaaagt cccgtccttt
     3121 accttcacgc caacagtaac ttatcaaaga ggaggcgaag ccgtcagcag tggagggagg
     3181 ccgggactcc tcaacattag tgaacctgcc acgcagccat ggctggcaga cacgtggccc
     3241 aacacaggca acaaccacaa tgactgctcc atcaactgct gcacggccgg caatggcaac
     3301 agcgacagca acctgacaac ctacagtcgc ccagctgatt gtatagccaa ttataacaac
     3361 caactggata acaaacaaac aaatctgatg ctccctgagt caactgttta tggtgatgtg
     3421 gaccttagta acaaaatcaa tgagatgaaa accttcaata gcccaaatct gaaggacggg
     3481 cgttttgtca atccatcagg gcagcccact ccctatgcca ccactcaact catccaggcg
     3541 aacctcagca acaatatgaa taatggcgcc ggggactcca gcgagaagca ctggaagcct
     3601 ccgggacagc agaaaccgga agtggcacca attcagtata acatcatgga gcaaaacaag
     3661 ctgaacaaag attatcgggc aaatgacacg atccctccaa ccatcccata caaccagtcc
     3721 tatgaccaga acacaggagg gtcttataac agctcagatc ggggcagtag tacatccggg
     3781 agtcaaggcc acaagaaagg ggcacggaca ccaaaggcac ccaagcaggg tggcatgaac
     3841 tgggcagact tgctgccccc tcctccggcg catcctcccc cacatagcaa cagtgaagaa
     3901 tacaacatgt ccgtagatga aagctatgat caagaaatgc cctgtccagt gccacctgcg
     3961 cggatgtatt tgcaacagga tgaattagag gaagaggaag atgaaagagg ccccactccc
     4021 cctgtccggg gggcagcttc ttctccagct gctgtgtcct acagccacca atccacggcc
     4081 actctcaccc cttctcccca ggaagagctc cagcccatgt tacaggattg tccggaggac
     4141 ctcgggcaca tgccccaccc accagacagg aggcggcagc ccgtgagtcc tcctccaccg
     4201 ccacggccaa tttccccacc tcatacttac ggctacattt caggacccct tgtctcagat
     4261 atggataccg atgccccaga agaggaggag gacgaagctg acatggaagt tgccaaaatg
     4321 cagacccgaa ggctgttgtt acgtgggctg gagcagaccc cagcatccag tgttggggac
     4381 cttgagagct ccgtcactgg gtccatgatc aatggctggg gctcagcctc ggaagaggac
     4441 aacatttcca gtgggcgctc cagtgtcagt tcatccgatg gctccttttt cactgacgct
     4501 gattttgccc aggcagttgc tgcagctgcg gagtatgcgg gcctgaaagt ggctcgccgc
     4561 caaatgcaag atgctgctgg ccgccgccac ttccatgcct ctcagtgccc aaggcccacg
     4621 agtcctgtgt ccacagacag caacatgagt gctgttgtga tccagaaagc cagacccgcc
     4681 aagaagcaga aacaccagcc aggacatctg cgcagggaag cctacgcaga tgatcttcca
     4741 ccccctccag tgccaccacc tgctataaaa tcgcccactg tccagtccaa ggcacagctg
     4801 gaggtacggc ctgtcatggt gccaaaactc gcgtctatag aagcaaggac agatagatcg
     4861 tcagacagaa aaggaggcag ttacaagggg agagaagctc tggatggaag acaagtcact
     4921 gacctgcgaa caaatccaag tgaccccaga gaggcacagg aacagccaaa tgacgggaaa
     4981 ggccgaggaa caaaggcagc caagcgagac cttccaccag caaagacgca cctcggccaa
     5041 gaggatattc ttccgtactg tagacctact ttcccaacgt caaacaaccc tagagacccc
     5101 agttcctcca gctctatgtc atcaagagga tcagggagcc gacaaagaga gcaagcaaat
     5161 gtgggccgaa ggaatatggc agaaatgcaa gtacttgggg gatttgaaag aggagatgag
     5221 aataatgaag aattagagga aactgaaagc tgaagacaac cagagaggct tacgatgcta
     5281 atgtgaaaaa ccatcactca agaggcctcc tcccgtctga tgacacacaa taccagatga
     5341 aattgttcag tgcaatcaga atggacaagt tgccgttttt attcctcctg ttgggataac
     5401 attttttaaa agtttcttgg gtttttagtg ttgctgattg attgcctaac ccttaatgaa
     5461 cctccccctg ccgcgacgct gttacagccg ttatccttga cttccaacac tggaagtgtc
     5521 ttgaatgctt gcttcagcca tcagccagca aggaagaaca gaccaattct ttttgcgatt
     5581 tgcccctgag atatggcatt gcactgctta tatatcacgc taattgatag caaaatattg
     5641 atcaatgata taaaggtgat gactcaacct catgccaagg gctctcaaag tataattgtt
     5701 ctatgaccaa ctgctaaggc caattgaagc atacttcatt ttacatgatt ttaggatcag
     5761 tcttttatac caccctttgc tggcataaac taaaagtcta tcacatacag aactacagtc
     5821 taatttcaat ggggtagaag cattgtaaat atatactctt tgcaactcct ggtggtactt
     5881 tattttgtct ttatttcaac cattgaaata tattcttgga aatgtacttt tggataagta
     5941 gggctgagcc agttggacct ctggttgtct agtcattgtg agaagtaaac ctagcaaaaa
     6001 tcttgttcta tttttcaatc aaaaagcaac tacaaatgca tattccacgc aaatggatgt
     6061 ttttaacgac caattgagta aagacatccc tatcttaact ggcctaaatt tcttctggta
     6121 gtgtcagatc acctttcaga agtgccactt aaggaggttt gtttgatttt ttttgttgtt
     6181 gttgttgttg ttgttttttg taatgcactg tttttaatct tttttttttt ggttttaaaa
     6241 gcacaatcac taaactttat ttgtaaacca ttgtaactat taaccttttt tttcttattg
     6301 aagaaactgt tgagaagtgt ttctagcctg ttttgttaat gctctgtgtt tgtatttgca
     6361 atatttgaat ggtgacagct ggtgaggtca cgtacagact ttatcgtggg ctgtgaacca
     6421 aatggttcca atttttcctg gacttaaaaa aaaatttttt tgttctaagt ttttcgtggc
     6481 caatgttgaa tcttataaga tttccttaga agctcataag aggaattcca actcggaatt
     6541 gccaagtgat gctctgtgac tgtaggtttc tataattttt tttgacattt taagaatttc
     6601 attgacttta taattggtgc tatttgaaga aaacaaaatg aatctttagt catgcatagg
     6661 tatcaggctt gacccccaca aagccaaaca aaactgaact acaaaataaa taaataaata
     6721 aataaataaa taaataaata aaagcaaata aaaacaaaag gctggtattc acctaaaact
     6781 aagtgtattc atttagctaa tttgaagaag ccccatgtcc catagaaagg atgtgcagtt
     6841 ctaagggaac aatccacgtg attaatgttt tcattatgtt catgtaagaa acctctttat
     6901 ttttagccat acttttgcat actgaaaatt caataatcag aaaagtaatt ttgtcatatt
     6961 atttattaaa aatgttctca aatacatcat ccttccttgt gttgattttt tttttcattg
     7021 tatgactatc agatttattc cattaaatca caaagttgtt ttgtcttcgc atttcaccac
     7081 cacattatga aaacgaagga gttctcagtt ttcctaatga gcatccaggt tctactacca
     7141 agcaaaaaat tctcattgca gttgtgtgaa gtaagtggga gctgattctc aagttgaagt
     7201 tagctgtgtg gtcagagagc gactctgaaa ggtgtgctgt gtttggttct gtatgtgtat
     7261 ctgaatttca gttagcctgt ttctgaaatg atcaggatgc aactccagta aacctcattg
     7321 gtcaagcttg aaccacctat gttctgtcag taagaaagct tataaatccc attgcttgtc
     7381 agagaaaatt tgggctggca ctgatatacc aggttgcacg ctgtgatcag ttaaagcacc
     7441 atactgcaga atgtcacgtg gatggggtac catggctacc gtggcttgga aatgtcaaga
     7501 tccacagaat gtcctggagc ttagatccct gacacccacc cacccaccct gtgatataga
     7561 ttcttcttct tttacctaaa tttttgtgtt taccagaaaa gctgaagaaa tgaaacggaa
     7621 caatgaaggg cttaatttgg aatgtaattt tataaaagtg atgtgattat catcatctac
     7681 ttgatatata aacagaccta gaggtcaagg agctagtttc tttgttaaaa aacaaatcac
     7741 tgtgggttgg ggagggggga taaggaacat atgtaatgga cagattttct ttttctaggt
     7801 gggtgaacta ctaataagct actatctctc ttttatatta catgctgcag ttcacacaca
     7861 aaattctgta tatcagaagg ccgggacaag accggatcct ggctttgtcc cggttgtgtt
     7921 tctttggaca tgttacctaa cctctaagtc tcaggtactt cacctgtaaa gtcagtaata
     7981 cctacctcaa ggagcgattg tcatgattca gtgagttgat gtatctacac agactctgta
     8041 aactccacaa cggtattaag atattgttat ctttatggac tgaaattcac tacacatgca
     8101 gtctccatgt ttttcatccc tgatttgttc ctaaacattt gcatgagaga aaaagcataa
     8161 gtgtggtgta aggacgaggg tccttccatc tctggtaagt aaaactcact gtgaaattac
     8221 cccattgtgg aataaatgct tgctgttctt gttcgtttct ttgctttcga atgcaagggc
     8281 agtaaatgaa ttgctggcat tgtatttctg gtattttctt ctttgcacag ttggtaatac
     8341 agatatgtca cttgagttct caataaatgg atttagtgtc ta
//
