LOCUS       NM_013835               8736 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Ro60, Y RNA binding protein (Ro60), mRNA.
ACCESSION   NM_013835
VERSION     NM_013835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8736)
  AUTHORS   Song,Y., Wei,F., Liu,Y., Han,F., Ma,L., Zhuang,Y., Pan,C., Jia,Z.
            and Gong,A.
  TITLE     IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity
            in Cutaneous Lupus Erythematosus
  JOURNAL   Mediators Inflamm 2022, 4955761 (2022)
   PUBMED   35909659
  REMARK    GeneRIF: IL-33/ST2 Activation Is involved in Ro60-Regulated
            Photosensitivity in Cutaneous Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8736)
  AUTHORS   Yang,N., Zhang,Q., Ye,S., Lu,T., Sun,M., Wang,L., Wang,M.,
            Pan,Y.H., Dang,S. and Zhang,W.
  TITLE     Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult
            Mice
  JOURNAL   J Dent Res 101 (2), 226-234 (2022)
   PUBMED   34323105
REFERENCE   3  (bases 1 to 8736)
  AUTHORS   Kim,S.Y., Park,M.J., Kwon,J.E., Choi,S.Y., Seo,H.B., Jung,K.A.,
            Choi,J.W., Baek,J.A., Lee,H.H., Lee,B.I., Park,S.H. and Cho,M.L.
  TITLE     Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of
            Dextran Sulfate Sodium-Induced Colitis
  JOURNAL   Immunol Lett 201, 45-51 (2018)
   PUBMED   30395870
  REMARK    GeneRIF: Ro60 ameliorated the severity of dextran sodium sulfate
            -induced colitis in mice by repressing inflammation, fibrosis,
            angiogenesis, and the production of reactive oxygen species
            Erratum:[Immunol Lett. 2019 Aug;212:132. doi:
            10.1016/j.imlet.2019.01.001.. PMID: 30638737]
REFERENCE   4  (bases 1 to 8736)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   5  (bases 1 to 8736)
  AUTHORS   Maier-Moore,J.S., Kurien,B.T., D'Souza,A., Bockus,L., Asfa,S.,
            Dorri,Y., Hubbell,S., Yeliosof,O., Obeso,D., Schoeb,T.R.,
            Jonsson,R. and Scofield,R.H.
  TITLE     Passive transfer of antibodies to the linear epitope 60 kD Ro
            273-289 induces features of Sjogren's syndrome in naive mice
  JOURNAL   Clin Exp Immunol 180 (1), 19-27 (2015)
   PUBMED   25370295
  REMARK    GeneRIF: These data support the hypothesis that antibodies to Ro274
            deposit in salivary glands can enter intact salivary gland cells
            and are involved in the dysregulation of salivary flow in SS.
REFERENCE   6  (bases 1 to 8736)
  AUTHORS   Gordon,T.P., Kinoshita,G., Cavill,D., Keech,C., Farris,A.,
            Kaufman,K., McCluskey,J. and Purcell,A.
  TITLE     Restricted specificity of intermolecular spreading to endogenous La
            (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity
  JOURNAL   Scand J Immunol 56 (2), 168-173 (2002)
   PUBMED   12121436
  REMARK    GeneRIF: Restricted specificity of intermolecular spreading to
            endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental
            autoimmunity.
REFERENCE   7  (bases 1 to 8736)
  AUTHORS   Kaufman,K.M., Farris,A.D., Gross,J.K., Kirby,M.Y. and Harley,J.B.
  TITLE     Characterization and genomic sequence of the murine 60 kD Ro gene
  JOURNAL   Genes Immun 1 (4), 265-270 (2000)
   PUBMED   11196703
REFERENCE   8  (bases 1 to 8736)
  AUTHORS   Scofield,R.H., Kaufman,K.M., Baber,U., James,J.A., Harley,J.B. and
            Kurien,B.T.
  TITLE     Immunization of mice with human 60-kd Ro peptides results in
            epitope spreading if the peptides are highly homologous between
            human and mouse
  JOURNAL   Arthritis Rheum 42 (5), 1017-1024 (1999)
   PUBMED   10323459
REFERENCE   9  (bases 1 to 8736)
  AUTHORS   Keech,C.L., Gordon,T.P. and McCluskey,J.
  TITLE     Structural differences between the human and mouse 52-kD Ro
            autoantigens associated with poorly conserved autoantibody activity
            across species
  JOURNAL   Clin Exp Immunol 104 (2), 255-263 (1996)
   PUBMED   8625517
REFERENCE   10 (bases 1 to 8736)
  AUTHORS   Wang,D., Buyon,J.P. and Chan,E.K.
  TITLE     Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro
  JOURNAL   Mol Biol Rep 23 (3-4), 205-210 (1996)
   PUBMED   9112230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY121097.1, U66843.1, AL592403.6 and BQ032951.1.
            
            On Mar 27, 2007 this sequence version replaced NM_013835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.17721.1,
                                           SRR1660813.224200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN02415127
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BY121097.1         18-90
            74-3939             U66843.1           1-3866
            3940-8501           AL592403.6         59806-64367         c
            8502-8736           BQ032951.1         1-235               c
FEATURES             Location/Qualifiers
     source          1..8736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.54 cM"
     gene            1..8736
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /note="Ro60, Y RNA binding protein"
                     /db_xref="GeneID:20822"
                     /db_xref="MGI:MGI:106652"
     exon            1..131
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..732
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1769
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /note="Sjogren syndrome antigen A2; 60 kDa SS-A/Ro
                     ribonucleoprotein; roRNP; 60 kDa Ro protein; 60 kDa
                     ribonucleoprotein Ro; TROVE domain family, member 2"
                     /codon_start=1
                     /product="RNA-binding protein Ro60"
                     /protein_id="NP_038863.1"
                     /db_xref="CCDS:CCDS15345.1"
                     /db_xref="GeneID:20822"
                     /db_xref="MGI:MGI:106652"
                     /translation="MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGG
                     TYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQC
                     ADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKG
                     GMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKAL
                     SVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEM
                     PLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAG
                     HGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNA
                     STVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLP
                     MIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTI
                     ADPDDRGMLDMCGFDTAALDVIRNFTLDVI"
     exon            733..953
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1100
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1238
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1355
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1469
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1616
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..8721
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8700..8705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /note="hexamer: AATAAA"
     polyA_site      8721
                     /gene="Ro60"
                     /gene_synonym="1810007I17Rik; A530054J02Rik; SS-A/Ro; Ssa;
                     Ssa2; Trove2"
                     /note="major polyA site"
ORIGIN      
        1 tcgagacggg gcggggcggg gctcgctccg acccgaacct ggagctgtcc tcgccctttc
       61 gggccgcctc ctattcctgg tgcgacgcag gctttctgta ggcgccgcgg gtcctgagca
      121 tcaccttcca ggttccccaa gaaacaagga acatggaagg atctgcaaac cagttgcagc
      181 cactgagtga gactcaagta gttaactcag agggcggctg tgtatggcag gtcaccgaca
      241 tgaaccggct gcgccgcttc ttgtgttttg gctctgaagg tggcacgtac tatatcaaag
      301 aacagaagct gggccttgag aatgctgaag ccttaattag actgattgaa gacggcagag
      361 gatgtgaagt gatccaggaa atcaagtcct ttagtcagga aggcaggact gccaaacaag
      421 agccactgct gtttgcactg gccgtttgtt cccagtgtgc ggacataaac acaaagcaag
      481 cagcctttaa agctgtccct gaagtgtgtc gcattccgac ccacctcttc acttttatcc
      541 agtttaagaa agacctgaag gagagcatga agtgtggcat gtggggtcgc gccctccgga
      601 aggcagtggc agactggtac aatgaaaaag gcggcatggc cgtggcgctg gtggttacaa
      661 agtataaaca acgaaacggc tggtctcaca aagatctcct ccgactgtcc caccttaagc
      721 cttccagtga aggacttgct attgtgacca agtatatcac aaagggctgg aaagaagtcc
      781 atgaagagta taaagaaaag gcgctttctg tggaggctga gaagctgctc aagtacctgg
      841 aggctgtgga gaaagtgaag cgcacgaaag acgacctgga agtcattcat ctgattgaag
      901 agcatcagtt agttagggaa cacctgctga caaatcactt gaagtctaaa gaggtatgga
      961 aggctttgtt acaggaaatg ccccttactg cgctcctgag gaacctggga aagatgactg
     1021 ctaattcagt gcttgaacca ggaaactctg aagtatcttt aatatgtgaa aaactgagca
     1081 atgaaaagct gctcaaaaag gctcgtatac atccatttca tgttttaatt gcattagaga
     1141 cctacagagc aggccacggg ctcagaggga aactgaagtg gattccagat aaagacatct
     1201 tgcaagcctt agatgctgct ttttatacaa catttaagac tgttgaacca actgggaagc
     1261 gcttcttgct cgctgttgac gtcagtgcct ctatgaacca gagagccttg ggtagtgtac
     1321 tcaatgctag tactgttgcc gcagcaatgt gcatggtggt tacacggaca gaaaaagagt
     1381 cttcggtggt tgcttttgcc tgtgatatgg ttccgtttcc agtgactaca gacatgacat
     1441 tacagcaggt tttaacggct atgaataaag ttccagcagg caacacggat tgctctctcc
     1501 caatgatctg ggcccagaaa acagacacag ccgcagatgt cttcgttgtg tttactgata
     1561 atgagacctt tgcagggcag gtgcatcctg ctgttgccct gagagagtac cgaaagaaaa
     1621 tggatattcc tgctaaattg attgtttgtg ggatgacatc aaatggcttt accattgcag
     1681 acccagacga tagaggcatg ttggatatgt gcggctttga tactgcagct ctggatgtaa
     1741 ttcggaattt cacattggat gtcatttaac cctgagtacc agaatgatct gagaggggca
     1801 ctgctgtagt ggttttcatt gaaaatacac agccacttcc ctgctagaca cagtagtgag
     1861 aaatgtcatc agtatgtgca tgatagaaat gcactttggc aagaacagga gaagacagaa
     1921 ggaaggagac aaaagttgag cccaaaggtg catgtactca gctagctctt gagaagtctt
     1981 caggatactg tagcttcctc tgtagagaac ttcgttttaa tagacactgt acaatagtgg
     2041 tgttttactt cactgaatca cacctttgtt ctgaaagtgt gatacagagt ataagtagcc
     2101 tcacatcatg tcacttgtat gagaagtgtt tcttttctta aatgtcttca ttggaaaacg
     2161 acagttttaa taatgtccaa atactctgag gtgcactaga ccatgtgact gtgatggaaa
     2221 tgaacctcac caggtaaatt tttatacaaa ggggtttaaa aaaaaagaca tttggttaaa
     2281 ctaaattatg aatgaatttt acaaattcag agttttctaa gatcatatga acaacagctt
     2341 tcttattcaa tgaaaaagat gttttccttc agatgtttca tttgtacttg ttaggatttg
     2401 ttactatttg ggcaaaacag ggtggaaatc cctaagggac ttgttgagtt tatataggct
     2461 gaggaatttg ctttgtagcc ttgtgttggc tgaacaacaa cagtgtatca tgtacttccg
     2521 ctttcctggg tgtttcatgt atgtaactcc cctgtccata atcctgacag tgtaacaatt
     2581 aaaactctac tgtaaagaca tagattttct gtacccctaa aataccttta actaattttc
     2641 atatttttct aatatttagt ctgaagtctt tcatattttt gccccctatg cattttgtgt
     2701 ctagtttctt ttttgataga gtagagaaat aatacagcaa gctagatcct tctagttcaa
     2761 aggcaatttt agagtagcca tatcaaccaa tcagtgtatg tagaaaatct aagaactgat
     2821 tttgtacaaa ttaaacttcc ttttcaccat attaaaatac attcttttct tgagcaatta
     2881 catgttttca ctgggaagct tagcatgaga atggcctatt gaaacaccag tagtttttct
     2941 cttgattcag taatggtatc taaggtagtt tatactaaaa cgctaatttt tatgtattac
     3001 tctttaaata ttaaaggttt actgggggct tataaaccct ttcaaaacta gtatgtgtag
     3061 gttacataac cttttaagtg tttaggggag tgaagttctt ttatttggga gagaaagggg
     3121 ctttgctagt gtgaggattt atgtacatat tttctttcct aagaaattta gtctcagaga
     3181 ataagaaaat gttcccttca gatgatttga gttaatgaag tttcatatgt agccattcct
     3241 cctgacagta acaaattttc agtgttatta gcaaagatag tatcagctcc agttctaaac
     3301 accattgctt ctgatgctgt tctggcttga ccactgtcac atcttaacta attctgatac
     3361 attaaagttt catgttcaag ttgaatttaa agctttaaac cctagtaatt acatgagatc
     3421 tattgaattc tttaaaccca ggatctaagt tttaatatga tctaacttat tatgaaattt
     3481 acatgccata ttatataaaa gcttttttct tatttttaat gctacttaga taatgctttt
     3541 aggcaagcag agtatatcta ggagctagta tttaacccat aagggaaata agggtcacct
     3601 cccggcagcc ctcctacagt ataggtaaac ctaattaaag agattaaaat tgaatacaga
     3661 ggccaagtgt ggtgatgcat gcctttattc ctgggaaaca gaggcaggta gatctcttaa
     3721 gttagaggcc agcctgctct acatagtgaa ttccagacca gccagggcta catagtgaga
     3781 ccctgtctcc aaaaagaaaa aaaggtttaa gaggcagagg caggcatttt tctgagttca
     3841 aggccagcct ggtctacaaa gtgagttcca ggacagccag agctatacag agaaaccctg
     3901 cctcaaaaaa ccattaaaaa aaaaaaaaaa aaaaaaaaag tcccaacaga tagaaatctt
     3961 atcttcaaat tgcaaaactt cagagtagaa agaaaattta gaaaaaaatg tatttgattg
     4021 ataaccagaa accagtctgg atcttctgga tgtgtgtgtg atggttattt tgttttgttt
     4081 tgttttgttt tgtgacaggg tctctctcca tagacatagt cctggctatt ctagagctca
     4141 ctgtgtagac caggctggcc ttgaacagag agcctcctgc ctctgcctcc caagtgctag
     4201 ggctaaaggt gtgcaacact atgcccaggg taaggctgga tggttttgga gaggggtctg
     4261 cctctctact cagcattctg gcttttagtc tctcatccat gggacatgtt gactttgtaa
     4321 gagaaacagt agaattatga agccttttac ctaatttaga cgttaggaat tgattaggaa
     4381 ttgatgatat gcatgattac tttaggaacc tgtgaatgtg tgtgatttgt ttgtttgttt
     4441 tgatttggag taattctcaa acacaattat gtctctgcag cctatgttgc tatggaatct
     4501 agccacatag caaggcatta ttacctcatt aagcatagga taccctcaag tggtaaacaa
     4561 gttttctttt ccaaattacc actagggtga ctcttaagta aatagtacgg aaaatactgc
     4621 tttaaaaagc aatcttaaga aaagtaaatg ttatttccta gatactatgt aaatatttct
     4681 aggatttagt tgttactaat aacacaaaac actaatcttt tcatctcact gtttttgatt
     4741 agtggatagt ccacgtatta aaactgttac ttagtaactg ttttcagggt gtgttaggaa
     4801 gggatatgct agtaagtaga actactccat cctttggagc ttcttggttt ttttttcatg
     4861 tgctgtgtca ttatgaacaa ccagttcaac atatgtggta aaattctgct ctcctacaaa
     4921 ttcatgtatc ttagtctcag atcatagaag aacaagctgt ttaatattta ccgaatattg
     4981 agaatggaaa agaggccttt cattacaagt ccaaacttca tttttaatta taaacactaa
     5041 gatgtcctta tccctgataa aaaggatata taaaaaaata tatttaaaaa aaaagaaagc
     5101 aaagctcata gtcaaactag gaccatgcta ttactcttac tattactagc ttatctatta
     5161 cttccttaca tattacttta tttgaataac aataagtcta cagcagacaa actgacaggt
     5221 tgcttctcac tttcctagac ttcgacaaga aaaattatac caatgtaaat gtaagaatct
     5281 aatgatcttt agaagcacag gaagtgtaca tctaagcagg aaatgaaagc taaatcattg
     5341 taaattcttt gagttatttt cctgtgacct aaacattttg tcccaaggca agcaagatag
     5401 tcatcgtggg taaagacact caccaccaag tttgatgaat ggttcccagt ccctggaccc
     5461 cacaaggtag gaggagaaac cagttcctgc cggttgtcct ctgtgccatg gcgtgcatgg
     5521 gcgtgcatgg gcgtgtaaaa gtgaaaagaa gtgctgctac agatttggtc tgtgttgttg
     5581 tgtggtgtgc ttgtagtcaa agtaactcaa gatgcaaaat cgtcttggat tccattggtt
     5641 ttgttagggt acaagttgtc atcttagaga aatgtcacac agccagaagg aaggatcagc
     5701 aaagatgaca ggttctttgt gagacaagcc ggtgtttaac tcagaagtta ttgtgttctc
     5761 ttgatacctg ctccatcatc tcttcttcca tggaagatta cttctcgccc atttttctct
     5821 tttgcaaagt cttctcccat ttttgccttt tattcctgtt tgatccagtt gggtaataaa
     5881 ttgcaggacc agaaaatcat ccacagtcag gtttggggcg aatctactgc aggttgtttt
     5941 tttgttttat ataaatttaa gagtatattt ttcagagttg gagagatggc tcactggtta
     6001 aaagccctga gggcccaggt tcaattccca gcacccacat ggcagctcac aactctctgt
     6061 aactccagtt ctgggaatcc tacaccatca cagagacata catgcaagca aaacaccaat
     6121 gtacataaaa aaaaataata ataaataatt catttttaaa aatgttttcc aaattactga
     6181 agtaatatcc ggattgatat gttctttgcc caaatcaagt catgttgtag atattccaga
     6241 aatgttatag ccattcaata agaccagaat ctgtataatc actgataaac actgaaaaga
     6301 gaactgttat actatatatg caatctaatt gaccgcaatt tcagaaagtg acacatatat
     6361 cctctcagtt ctataattac actcctagtt tacaaagtct ttcaactgag tgtctgtcca
     6421 tgcatgcaca catacatgta cactgaactt acaaaaagcc ttataatgac ttacgttgac
     6481 attcactatc ttactggtaa ctatttactc ttttgaaaaa aatcactatg aaatttaaag
     6541 ttgatttgaa aatattttca tatagaaaac taataatgta actaagaatg ctatttgaat
     6601 aacataacag atgacacagt tttcctaaac cctaaaagta acaagatata ttagaaaaaa
     6661 agggaaaatc aatgagattc tattcctaga attgtgatta tttccactca gcatttgtaa
     6721 atataatgaa gatatacaaa agctgtttca tatccttcag ggatatgttt gcctttctac
     6781 tttatccctg cctttaatca tcagaacttt gtgaacacag gtgaactttc attttaaaat
     6841 gtttgaactt ctgtaccttg tataagttag cagaatctgg attaaaaaaa aaaagaaact
     6901 aaattaattt catttctgct ggtttcactt tactgtatat ttgtattatt aaaagtaggg
     6961 ttaatattgt tgactatgcg taactgctaa attatatcag tgaaatcatt acattgaaac
     7021 tgtatccaaa tgatttctca ggctttgttt gaagtgtaaa ctccagcccc attatgacca
     7081 aattagactt aaagatagtg aatgaatact aatgaagaaa gctgctcttg ttgcactgtt
     7141 ctaaataata gaatatatat ttggtatggt tggtgaaata gcttttgtta ttatttaagt
     7201 tacaatttct tattgcaaat ttaataatga attctccaaa ggaatgggat gaatggagtt
     7261 atatttgaaa gaattggaag aaaagtatta caatctgctt ctaaactatt tgttttatta
     7321 caatgacatt tatttctata attggccaat tgatggatct ttcaggtatc cagaattatg
     7381 tctgcgtaaa ataaattata gttatattaa gagccttaaa gtggggaaaa aggactcttt
     7441 tgactgcctt aacatatgac aagctctctt ttccagacat actaatttct ttagggtctg
     7501 ttaaataagt aatgccttaa gagtgtgcta atgatctgaa gagtagagct tacagggtct
     7561 tctagagctt ttaattctac ataatgaatt taagtgttag gtattatacc tgattgcaca
     7621 ttaataattt gaaataagaa aagaataatc tggctatgct gatgtgtaat aagtacatgg
     7681 ctgcaacatc agtatatttt atggttgctt aagattttgt attgttttgt ataaccagtt
     7741 acccagaagc tggacttcct ggccataata tgacctccaa ggaccatgtt gcatatttaa
     7801 cactggatga aaagttcagt tgtatagctc caaaaagaac tgctttttaa gggaaatttt
     7861 tgaggcaaaa ggcaaatgtt ttggttcaaa cctatgagca aagtcattta gagaattgaa
     7921 gatagtatta aaaccttgag actcttgcaa taaaaatatc agaccagtga cttgtttcat
     7981 tgcattctca ttttgcattt gctttgccgt tcaaagcaga aaaatcttac aaaaccgaaa
     8041 gaatgcttta aaattgtcac gctggtgctt aaagatctat tatgcttgat gtataactaa
     8101 cttgtttcca agaacggagc ctggggaagg cttataggcc tttcctagta cttgtgatta
     8161 ttgattgtca agtcttccaa gtttgcaatg taaataatgt gtaacaatgt gacattggtg
     8221 ttttctaatg aggagtggat gaatgcttca gttattactt ctacttcatg ataaaagttt
     8281 tcaccaatac tgagaaatct tgatttttgt aaccttgcaa aataacctat tacatacaag
     8341 ttgattgtct cttacctgaa atgcttggag cctcaagtat tttaagattc ttttttccaa
     8401 ttttggaatc atctgcagat gtataatgga atacctggga tttgctgtat gagccttgta
     8461 tgtgtcatgt gacagaaaat catgttttaa tggacttgct ttggctgtga ctttgcaatt
     8521 ggtctatgga actttccacg ggcattatgt taacactctc aagtttccag ttctggagct
     8581 ttctaaaatt ttatatttcc aaattgggga tgcttaactt gtaagtcatt ccagatgtgg
     8641 agtgggcact acacaaactg tttgtcacca gtttattgta gaaatcgata ggtgtaccaa
     8701 ataaattgta tgcatatcaa aaaaaaaaaa aaaaaa
//
