LOCUS       NM_009070               1934 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus RNA binding protein with serine rich domain 1 (Rnps1),
            transcript variant 1, mRNA.
ACCESSION   NM_009070
VERSION     NM_009070.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Zhong,X., Choi,J.H., Hildebrand,S., Ludwig,S., Wang,J.,
            Nair-Gill,E., Liao,T.C., Moresco,J.J., Liu,A., Quan,J., Sun,Q.,
            Zhang,D., Zhan,X., Choi,M., Li,X., Wang,J., Gallagher,T.,
            Moresco,E.M.Y. and Beutler,B.
  TITLE     RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis
            factor receptor signaling to support hematopoiesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (18), e2200128119 (2022)
   PUBMED   35482923
  REMARK    GeneRIF: RNPS1 inhibits excessive tumor necrosis factor/tumor
            necrosis factor receptor signaling to support hematopoiesis in
            mice.
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Zhang,Z., Guo,M., Liu,Y., Liu,P., Cao,X., Xu,Y. and Zhu,X.
  TITLE     RNPS1 inhibition aggravates ischemic brain injury and promotes
            neuronal death
  JOURNAL   Biochem Biophys Res Commun 523 (1), 39-45 (2020)
   PUBMED   31831174
  REMARK    GeneRIF: RNPS1 inhibition aggravates ischemic brain injury and
            promotes neuronal death.
REFERENCE   3  (bases 1 to 1934)
  AUTHORS   Blazquez,L., Emmett,W., Faraway,R., Pineda,J.M.B., Bajew,S.,
            Gohr,A., Haberman,N., Sibley,C.R., Bradley,R.K., Irimia,M. and
            Ule,J.
  TITLE     Exon Junction Complex Shapes the Transcriptome by Repressing
            Recursive Splicing
  JOURNAL   Mol Cell 72 (3), 496-509 (2018)
   PUBMED   30388411
REFERENCE   4  (bases 1 to 1934)
  AUTHORS   Wei,N., Cheng,Y., Wang,Z., Liu,Y., Luo,C., Liu,L., Chen,L., Xie,Z.,
            Lu,Y. and Feng,Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   5  (bases 1 to 1934)
  AUTHORS   Zhang,X.N. and Mount,S.M.
  TITLE     Two alternatively spliced isoforms of the Arabidopsis SR45 protein
            have distinct roles during normal plant development
  JOURNAL   Plant Physiol 150 (3), 1450-1458 (2009)
   PUBMED   19403727
REFERENCE   6  (bases 1 to 1934)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1934)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1934)
  AUTHORS   Kamma,H., Portman,D.S. and Dreyfuss,G.
  TITLE     Cell type-specific expression of hnRNP proteins
  JOURNAL   Exp Cell Res 221 (1), 187-196 (1995)
   PUBMED   7589244
REFERENCE   9  (bases 1 to 1934)
  AUTHORS   Schmidt,G. and Werner,D.
  TITLE     Sequence of a complete murine cDNA reflecting an S phase-prevalent
            transcript encoding a protein with two types of nucleic acid
            binding motifs
  JOURNAL   Biochim Biophys Acta 1216 (2), 317-320 (1993)
   PUBMED   8241277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868062.1, AK151150.1 and BX526195.1.
            
            On Jan 11, 2007 this sequence version replaced NM_009070.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 2 and 4 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.728195.1,
                                           SRR7652917.1104721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               BB868062.1         3-184
            183-1920            AK151150.1         51-1788
            1921-1934           BX526195.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.39 cM"
     gene            1..1934
                     /gene="Rnps1"
                     /note="RNA binding protein with serine rich domain 1"
                     /db_xref="GeneID:19826"
                     /db_xref="MGI:MGI:97960"
     exon            1..60
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..182
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..363
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1210
                     /gene="Rnps1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribonucleic acid binding protein S1"
                     /codon_start=1
                     /product="RNA-binding protein with serine-rich domain 1
                     isoform 1"
                     /protein_id="NP_033096.2"
                     /db_xref="CCDS:CCDS37488.1"
                     /db_xref="GeneID:19826"
                     /db_xref="MGI:MGI:97960"
                     /translation="MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSK
                     DKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSA
                     SSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKP
                     TKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEK
                     ALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRS
                     PRRRSPVRRRSRSPGRRRHRSRSSSNSSR"
     exon            364..519
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..711
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..814
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..968
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1110
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1923
                     /gene="Rnps1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1898..1903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnps1"
                     /note="putative"
     polyA_site      1920
                     /gene="Rnps1"
                     /note="putative"
ORIGIN      
        1 aaagttgcgc cggcgtcctg gtctgagaag agcgggagga ggtggcggcc ttgggaagat
       61 gctggagacc taggctcgcc acaccgggcc cgacctgagt agtgagtgga gaaagagggt
      121 gggaggcgag gtcgatgtct gtggccggag cggacggtgc agattgcgag ccggcctaaa
      181 aggctgctct ttggcgtaaa ttgcaatcga ttagggatcg tttctcagac tcaagttaga
      241 agtgagagtt cagataagtg aggccgacat tgctgccttg aagaagggga gaatggattt
      301 atcaggagtg aaaaagaaga gcttgctagg agtcaaagag aataataaaa agtccagcac
      361 tagggctcct tctcctacca aacgcaagga ccgatctgat gagaagtcca aggatcgatc
      421 taaagataaa ggggccacta aagagtcaag tgagaaggat cgtggcagag ataagactcg
      481 gaagagacgc agtgcttcaa gcggaagcag cagtaccagg tctaggtcca gctccacctc
      541 cagctcgggc tccagcacca gcacaggctc aagcagtggc tccagctcgt cctctgcatc
      601 cagccgctca ggaagctcca gcacgtcccg gagctccagt tctagcagct cctccggctc
      661 cccaagccct tctcggcgca ggcatgacaa caggcggcgc tcccgctcca aatccaaacc
      721 acctaaaaga gatgaaaaag agaggaaaag gcggagccct tcacctaaac caaccaaagt
      781 gcacattggg aggctcacca ggaatgtgac caaggatcat atcatggaaa tattttctac
      841 ttacgggaaa attaaaatga ttgacatgcc tgttgagagg atgcatcctc acctctccaa
      901 aggctatgca tatgtggagt ttgagaatcc cgatgaagca gagaaggctc tgaaacacat
      961 ggatggagga caaattgatg gccaagagat cactgctact gctgtgttgg caccctggcc
     1021 tcggccacca cctcggcgat tcagcccccc taggaggatg cttccaccac ctcccatgtg
     1081 gcgtaggtca cccccacgga tgaggagaag gtctcgatcc ccaagacgca ggtcccctgt
     1141 gcgtaggagg tctcgctctc ctggccgccg ccgccacagg agccgatcca gctccaactc
     1201 ctcccgataa gcagggacat tgattcgtac ctctgtaact tatgttcccc agactctgtt
     1261 ttgtcctttt ctctagccaa gtgagggtct gtagagaagg atcccttact gggtacagca
     1321 gttgagatat ctcctctaca gaagggttct ggcttgtaga gctactgttg gttcacggct
     1381 gctcccatag aggtgccctg tagttttctg gctagaaagt tcatcccttc agttcttgat
     1441 aggctggtag cagagccagc tggaacctat ggcagcacac ggatttccac agatgaccca
     1501 gaaccagaca gcctggtcta gcccccgctg tgccacacct gtgcaaagga ccacactgct
     1561 cttctgttcg gccgaccatg ccctgctgag tacgcttcaa cttagagggc taaaaccttt
     1621 gaaggattcc tccacaaatg gttacctttc tgtccccgtg tctctgttac tttctagaat
     1681 ttgtgagcca gttctacagg gtcctcatga aacctacccc accccgttgt cacctgccat
     1741 tcatggtgat gttgcaggtt aaccttggca gtgtgtacat tgcccctttt tgcttttatt
     1801 gtacagtcag tactataaaa tttgttttga gttttataac tttgtagcat tttagataag
     1861 gttgtgtttg tacttgtgta gagtgaaagg actgttgaat aaaacctagg attagaatgc
     1921 aaaaaaaaaa aaaa
//
