LOCUS       NM_145417               2301 bp    mRNA    linear   ROD 16-DEC-2022
DEFINITION  Mus musculus arginyl aminopeptidase (aminopeptidase B) (Rnpep),
            transcript variant 1, mRNA.
ACCESSION   NM_145417
VERSION     NM_145417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Fontes G, Lajoix AD, Bergeron F, Cadel S, Prat A, Foulon T, Gross
            R, Dalle S, Le-Nguyen D, Tribillac F and Bataille D.
  TITLE     Miniglucagon (MG)-generating endopeptidase, which processes
            glucagon into MG, is composed of N-arginine dibasic convertase and
            aminopeptidase B
  JOURNAL   Endocrinology 146 (2), 702-712 (2005)
   PUBMED   15539558
  REMARK    GeneRIF: miniglucagon-generating endopeptidase is composed of NRDc
            and aminopeptidase B acting sequentially
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY735801.1, AK159625.1 and AA271633.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_145417.4.
            
            On Apr 25, 2009 this sequence version replaced NM_145417.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145466.1, BC010520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BY735801.1         1-57
            58-2284             AK159625.1         1-2227
            2285-2301           AA271633.1         284-300
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2301
                     /gene="Rnpep"
                     /note="arginyl aminopeptidase (aminopeptidase B)"
                     /db_xref="GeneID:215615"
                     /db_xref="MGI:MGI:2384902"
     exon            1..523
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2029
                     /gene="Rnpep"
                     /EC_number="3.4.11.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aminopeptidase B; AP-B; arginine aminopeptidase; cytosol
                     aminopeptidase IV"
                     /codon_start=1
                     /product="aminopeptidase B isoform 1"
                     /protein_id="NP_663392.2"
                     /db_xref="CCDS:CCDS15317.1"
                     /db_xref="GeneID:215615"
                     /db_xref="MGI:MGI:2384902"
                     /translation="MESGGPGNYSAAARRPLHSAQAVDVASASSFRAFEILHLHLDLR
                     AEFGPPGPGPGSRGLSGTATLELRCLLPEGASELRLDSHSCLEVTAATLRRGQPGDQQ
                     APAEPVPFHTQPFSHYGQALCVAFRQPCGAADRFELELTYRVGEGPGVCWLAPEQTAG
                     KKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFTAVMSADTWEKRGPNKF
                     FFQMSHPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYSGVIEEFLATGEK
                     LFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGN
                     LVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMNVSGEENPL
                     NKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKFQSI
                     LAEDFLEFYLEYFPELKKKGVDSIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEEL
                     AELWVTSEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNA
                     QNAELRLRWGQIILKNDYQEEFQKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKD
                     TFAATASQLHSNVVNYVQQILAPKDS"
     exon            524..664
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            665..813
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            814..930
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1166
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1280
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1393
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1502
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1727
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1870
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2301
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcctcga ggcggagcct gccaagaccc gaggagcgac cgaccttcct ggcgggtgag
       61 caaccgctca ggagccatgg agagcggcgg accaggcaac tacagcgcgg ccgcccggcg
      121 gccactgcac tcggcccaag ccgtggacgt ggcctcggcc tccagcttcc gcgccttcga
      181 gatcctgcac ctgcacctgg acctgcgggc cgagttcggg cctccgggcc cgggtccggg
      241 aagccgcgga ttgagcggca cggcgacgct ggagctgcgt tgtttgcttc ccgagggcgc
      301 ctcggagctg cggctcgact cgcacagctg cttggaggtg acggcggcga cgctgcgacg
      361 gggacagccg ggagaccagc aggcgccggc agagcccgtg cctttccaca cacagccctt
      421 ctcgcactat ggccaggccc tgtgcgtggc cttccggcag ccctgcggtg ccgccgatcg
      481 cttcgagctg gagctcacct accgcgtcgg ggagggaccc ggggtttgct ggttggctcc
      541 tgagcagaca gcaggaaaga agaaaccctt tgtctatacc cagggtcagg cggtcttaaa
      601 ccgagccttt ttcccttgct ttgacactcc agcagtgaaa tgcacgtatt cggctcttat
      661 tgaggttcca gatggcttca cagctgtgat gagtgcagac acctgggaga agagaggacc
      721 aaataagttc ttcttccaga tgagccatcc catcccctcc tatctgatag ctttggccat
      781 tggagatctg gcttcagctg aggttggacc caggagccgg gtgtgggcgg agccctgcct
      841 gattgaagct gccaaggagg aatacagtgg ggtcatagaa gaatttctgg caacaggaga
      901 gaagcttttc ggaccctatg tttggggaag gtatgacttg ctctttatgc caccgtcctt
      961 tccatttgga ggaatggaaa atccttgcct gacctttgtc actccgtgcc tgctagcagg
     1021 ggaccgctcg ttagccgacg ttatcatcca tgagatctcc cacagttggt ttgggaacct
     1081 ggtcaccaat gccaactggg gggagttctg gctcaatgaa ggcttcacca tgtatgccca
     1141 gaggaggatc tccaccatcc tgtttggagc tgcttacact tgcttggagg ctgccacagg
     1201 gagggctctg ctgcgtcagc acatgaatgt ctccggagag gaaaacccac tcaacaagct
     1261 ccgggtgaag attgaaccag gtgtggaccc cgatgacacc tacaatgaga ccccctacga
     1321 gaaaggttac tgctttgtct catacctggc ccacctggtg ggtgatcagg atcagtttga
     1381 caagtttctc aaggcctatg tagatgagtt taaattccaa agtatcttgg ctgaagactt
     1441 tctggaattc tacctggagt atttccctga gttgaagaag aagggagtag attccattcc
     1501 aggttttgag tttgatcgat ggctgaacac ccctggatgg cccccctacc tccccgacct
     1561 ctcccctggg gactcactca tgaagccagc tgaagagctg gcagaactgt gggtgacctc
     1621 agagccagac atgcaagcca ttgaagccgt ggccatctct acctggaaga cctaccagct
     1681 tgtctacttc ctagataaga tcttgcagaa gtctcctctc cctcctggga atgtgaaaaa
     1741 acttggggag acatacccaa agatttccaa tgctcagaat gctgagttac ggctaagatg
     1801 gggccaaatc atccttaaga atgactacca agaggaattc cagaaagtga aggacttcct
     1861 gcagagccag ggaaagcaga agtacactct gcctctgtac cacgccatga tgggtggcag
     1921 tgagatggcc cggaccctgg ccaaggacac ctttgccgcc actgcttccc agctccacag
     1981 caacgtcgtc aactatgtcc agcagatcct ggcgcccaag gacagttaga ggcttcgcct
     2041 gggtggtccc tgcctcagaa aggcttcaca ggcttcctga agaactgctc cttcccaaat
     2101 tcatgttctc actccagtgc cccggagctt ctgttctttg ggtttgggtc tctgccctgg
     2161 tggcggcttc tggtctagag agtcctgaga gtcctaggag gcctcccatg ctccccctag
     2221 cccaggctgc agagagtaaa atgtcattct ttttcacttt aaataaatgt ttttaagcaa
     2281 gaagtagata agttggagtt a
//
