LOCUS       NM_001038696            3888 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA-binding region (RNP1, RRM) containing 3 (Rnpc3),
            transcript variant 1, mRNA.
ACCESSION   NM_001038696
VERSION     NM_001038696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3888)
  AUTHORS   Meinke,S., Goldammer,G., Weber,A.I., Tarabykin,V., Neumann,A.,
            Preussner,M. and Heyd,F.
  TITLE     Srsf10 and the minor spliceosome control tissue-specific and
            dynamic SR protein expression
  JOURNAL   Elife 9, e56075 (2020)
   PUBMED   32338600
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3888)
  AUTHORS   Doggett,K., Williams,B.B., Markmiller,S., Geng,F.S., Coates,J.,
            Mieruszynski,S., Ernst,M., Thomas,T. and Heath,J.K.
  TITLE     Early developmental arrest and impaired gastrointestinal
            homeostasis in U12-dependent splicing-defective Rnpc3-deficient
            mice
  JOURNAL   RNA 24 (12), 1856-1870 (2018)
   PUBMED   30254136
  REMARK    GeneRIF: Our study, using a novel conditional mouse model of Rnpc3
            deficiency, establishes that U12-dependent splicing is not only
            important during development but is indispensable throughout life.
REFERENCE   4  (bases 1 to 3888)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3888)
  AUTHORS   Pessa,H.K., Will,C.L., Meng,X., Schneider,C., Watkins,N.J.,
            Perala,N., Nymark,M., Turunen,J.J., Luhrmann,R. and Frilander,M.J.
  TITLE     Minor spliceosome components are predominantly localized in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8655-8660 (2008)
   PUBMED   18559850
REFERENCE   6  (bases 1 to 3888)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 3888)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY004661.1, AK161063.1 and AK134241.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            encode the same protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134241.1, AK161974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY004661.1         2-19
            19-1583             AK161063.1         2-1566
            1584-3888           AK134241.1         1549-3853
FEATURES             Location/Qualifiers
     source          1..3888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 49.35 cM"
     gene            1..3888
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="RNA-binding region (RNP1, RRM) containing 3"
                     /db_xref="GeneID:67225"
                     /db_xref="MGI:MGI:1914475"
     exon            1..287
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1640
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein 40; RNA-binding motif protein 40;
                     RNA-binding region-containing protein 3"
                     /codon_start=1
                     /product="RNA-binding region-containing protein 3 isoform
                     a"
                     /protein_id="NP_001033785.1"
                     /db_xref="CCDS:CCDS17777.1"
                     /db_xref="GeneID:67225"
                     /db_xref="MGI:MGI:1914475"
                     /translation="MAGPEPPMPLSRGGPGSASLSPPRGDRTLLVRHLPAELTAEEKE
                     DLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAIKALTRLHQLKLLGHTLVVEFAKE
                     QDRVHSPCSTSNTEKKKRLDDTVENDKEKKEPDILTVENGIAPNHGLTFPLNSCLKYM
                     YPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITARPPMYEDYMPLHAP
                     LPPTSPQPPEEPPLPDEDEDLSSKESEYESSDEEDRQRMNRLMELANLQPKRPKTEKP
                     RHVRKKRKIKDMLNIPSSASHSLHPVLLPSDVFDQPQSVGNKKIEFNISTNMPAAFNK
                     DLETQPNNEEENSDSPDTGLDSNTGFGKIFPKPNLNITEEITEDSDEIPSQFISRKEL
                     EKGRISREEMETLSVFRSYEPGEPNCRIYVKNLARHVQEKDLKFIFGRYVDFSSETQR
                     IMFDIRLMKEGRMKGQAFVGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDS
                     KEGKRK"
     exon            288..335
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            336..454
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..538
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            539..650
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            651..719
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..862
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..988
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1137
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1296
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1391
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1450
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1583
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1655
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..3888
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3471..3476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3491
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="major polyA site"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3570
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
     regulatory      3645..3650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3665
                     /gene="Rnpc3"
                     /gene_synonym="2810441O16Rik; C030014B17Rik"
ORIGIN      
        1 ggaaactatc ttccgctcag cctcggtgac tgcgggagtt cggccggaag cttgcgcgga
       61 ggttccgtct ctggccgctt ctgcagggaa gctagatggc ggggcctgag ccgccgatgc
      121 cgctgtcccg aggcggccca ggctccgctt cgctttctcc gccccgggga gaccgcaccc
      181 tcctcgtcag gcacctgccg gccgagctga cggctgagga gaaggaggac ttactgaagt
      241 acttcggggc gcagtcggtg cgcgtcctgt cagataaggg gcgcctgaaa cacacagcat
      301 ttgctacttt ccctaatgaa aaagcagcaa taaaggcact gacgagactc catcagctga
      361 aacttctagg tcatacttta gttgttgaat ttgcaaaaga gcaagatcga gttcactccc
      421 catgttccac ctcaaataca gagaaaaaga aaaggttgga tgacactgtg gaaaatgata
      481 aagagaagaa agaacctgac attttaacag tagaaaatgg aattgcacca aatcatgggc
      541 tgacttttcc tctgaattca tgccttaaat atatgtatcc tccaccatca agcacaatcc
      601 tcgcaaatat agtaaatgct ctggcaagtg tcccaaaatt ctatgtacag gtgcttcatc
      661 ttatgaataa aatgaatttg cccacaccat ttggaccgat tactgcacga cctcctatgt
      721 atgaggacta tatgccattg catgcacccc ttccacctac atcccctcaa ccgcctgagg
      781 agcctccctt accagatgag gatgaggatt tatctagcaa agaatcagaa tatgaaagca
      841 gtgatgagga ggaccgacag agaatgaaca gattaatgga actagcaaat cttcagccca
      901 aaagacccaa aacagaaaag ccacgccacg tgagaaaaaa gcgaaaaata aaggatatgt
      961 tgaatatacc ttcatcagct tcacatagtt tgcatcctgt gctgttacct tcggatgtat
     1021 ttgaccagcc acaatctgta ggtaataaaa aaattgagtt caatatatca accaacatgc
     1081 ctgcagcatt taacaaagat ttggagacac aaccaaataa tgaagaagaa aattctgatt
     1141 caccagacac tggacttgat tcaaatacag gatttggcaa aatcttccct aaacctaatt
     1201 tgaacatcac agaagagatt acagaagact ctgatgaaat accttcacaa tttatttcta
     1261 gaaaagagtt ggaaaagggt cgtatttcta gagaagaaat ggaaacactt tcagttttta
     1321 gaagttatga acctggtgaa ccaaactgca gaatttatgt aaagaattta gctagacatg
     1381 ttcaggaaaa ggaccttaaa tttatatttg gaagatacgt tgacttttct tcagaaacac
     1441 agcggatcat gtttgatatt cgcttaatga aagaaggacg catgaaagga caagcttttg
     1501 ttggacttcc aaatgaaaaa gcagccgcta aagcgttgaa agaagctaat ggctatgttc
     1561 tttttggaaa acccatggtg gttcagtttg ctcgatctgc tagaccaaaa caggattcta
     1621 aagaaggaaa acggaagtga tacaaacaaa taaagaagca ttcctgcgta aatactgctg
     1681 taatactgtc atacaagtgt atcctttctt gtatcctttt cgggcagtgg ttttgtttat
     1741 ttcattttgt ttcctagaag tgcgttgtct actttctatc atttttccag attaagtact
     1801 ttttatactt tattcaaatg aaacatttct caaattagtt ttgtttcctg gacaaatgtt
     1861 ttacacatat tttagattcc ctggttaatt ttctatgcta tcatttaagt caatgagttt
     1921 ttatcaggga aagttagtga atcaggtcac ttggaatata caattgcttg accacggagt
     1981 gtggtaatat ttcttgtata tgtggatttc ttcaacctaa ttcaggaaca tgcttcctac
     2041 tttgtgttat atccaattta ggtggtgttc tagttgcatt tttgttgctg tgacaaatac
     2101 tctgacaaaa aaagcgtctt agtgaagaag aagggattta tttgtcttag aatttatagt
     2161 tcattgctgt ggggaggtca aggcatgaac ttaaagcata atatccacag tcaagaggag
     2221 agagaaagta gagccatagc ttgcctagtc tgagctagct ttttcctatt gtatgctgtt
     2281 cccatttcct aaggaatggt gctacccaca tttgggctga tctcacatta gtgaacagtc
     2341 aagactaaca ttgtctaaat attctagata ttgctttaag acttttccca ggtaattcaa
     2401 cattgtgtca agttgataat taaaaattca gcacagttgt tctatataag atgttgtaaa
     2461 atttgactgg gaaatgatct ttttctttta atagtaaata tattgaaaat gaacaagatt
     2521 tttataaaaa atccttaaga tacaataaga ttgattgagt gcctttgaca agtagaagga
     2581 tttgctttac tctttgtttt ttcaaaacaa gaaaactcca aaaacaaaat ttaaatacac
     2641 acacacacac gaaaagaata acaaataaga caagtttatc tagttatata gttagtaaat
     2701 tatcttctag aaataagaac aattattcca tcctgtatga ttactaaaat ttcccagaac
     2761 agccagcttc aaattctaca catttaaatt ctgagaattt taaaatacat actaatgtat
     2821 tacccgttga tatttgtttt ctgtcttaga ggttgattct agtgtattaa tacagagaga
     2881 accaccaagg aagatgtcaa tgtacaaata tttctagagt ctagattcta tctcagtgct
     2941 aatcagaacc agtggaataa tgtcttataa gataattgag tttcccttag taatagaaag
     3001 gaacattgac aatttttttt tagaaaaata gaaatccaag attttgtggg aattgttgct
     3061 attataagtg ctttaaaact actcataatt ctgttattgt cactgcaaga gtagaaactt
     3121 accaaaattg aaattgcagt ctcttcatat tcacaattga aatattttag tttttagtat
     3181 tataagtagc ctttctttac atatatcttg tactgacatg attcactaat tttctgcaaa
     3241 tatttcggct tttaaaattt aactgaatta ttatgattat ttttaatggg cctttgtggt
     3301 gttttaggtt ccttctgaat tctgtatctt tcaagtactg tggaactttg agagaagaaa
     3361 ttgaccctct ggactttgga actgtgcgta acaactttga aagcattaaa aaattaacat
     3421 atcttcaaat tagtgtttgg agatacattg tagtagctta tcacatatat aataaattat
     3481 ttttttctca acagtgtcta atttttcatt acttggttta tatatctaag gaagtgtaac
     3541 ttaataaatg aattttcatt aataatttta tacatttttt acattcgtat atttttatga
     3601 tactctttta ttttccgttc ttacctatgt acatatgtag gtccattaaa ctttttttac
     3661 aagaatttat ctagttaatt attttatgaa tacttttaat ttttattgac tacttcctac
     3721 tctcttgata gtggtagatt tgtctgttat aaagtattaa tatttgtgac catttctatc
     3781 ttagaatgtg aattttatgt ctctaatctt actttgtgta gaatcactgc tcaaaggtaa
     3841 aggcctatct catagtatat cattctctta gtaaaattta tttttggc
//
