LOCUS       NM_026440               5018 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus RNA (guanine-7-) methyltransferase (Rnmt), transcript
            variant 1, mRNA.
ACCESSION   NM_026440
VERSION     NM_026440.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5018)
  AUTHORS   Young,K., Tscherner,A.K., Zhang,B., Meredith,M., McClatchie,T.,
            Trasler,J.M. and Baltz,J.M.
  TITLE     5,10-Methylenetetrahydrofolate reductase becomes phosphorylated
            during meiotic maturation in mouse oocytes
  JOURNAL   Zygote 30 (5), 674-688 (2022)
   PUBMED   35652653
REFERENCE   3  (bases 1 to 5018)
  AUTHORS   Galloway,A., Kaskar,A., Ditsova,D., Atrih,A., Yoshikawa,H.,
            Gomez-Moreira,C., Suska,O., Warminski,M., Grzela,R., Lamond,A.I.,
            Darzynkiewicz,E., Jemielity,J. and Cowling,V.H.
  TITLE     Upregulation of RNA cap methyltransferase RNMT drives ribosome
            biogenesis during T cell activation
  JOURNAL   Nucleic Acids Res 49 (12), 6722-6738 (2021)
   PUBMED   34125914
  REMARK    GeneRIF: Upregulation of RNA cap methyltransferase RNMT drives
            ribosome biogenesis during T cell activation.
REFERENCE   4  (bases 1 to 5018)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 5018)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   6  (bases 1 to 5018)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   7  (bases 1 to 5018)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 5018)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111069.9, AK129130.1 and CO039099.1.
            
            On Jan 15, 2010 this sequence version replaced NM_026440.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 3 and 4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129130.1, AK082331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC111069.9         77909-77971
            64-5004             AK129130.1         1-4941
            5005-5018           CO039099.1         9-22                c
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 41.22 cM"
     gene            1..5018
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /note="RNA (guanine-7-) methyltransferase"
                     /db_xref="GeneID:67897"
                     /db_xref="MGI:MGI:1915147"
     exon            1..71
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..491
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1511
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /EC_number="2.1.1.56"
                     /note="isoform 1 is encoded by transcript variant 1; mRNA
                     cap guanine-N7 methyltransferase; mRNA cap
                     methyltransferase; mRNA (guanine-N(7)-)-methyltransferase;
                     mRNA cap guanine-N(7) methyltransferase"
                     /codon_start=1
                     /product="mRNA cap guanine-N(7) methyltransferase isoform
                     1"
                     /protein_id="NP_080716.1"
                     /db_xref="CCDS:CCDS37852.1"
                     /db_xref="GeneID:67897"
                     /db_xref="MGI:MGI:1915147"
                     /translation="MEGSAKASVASDPESPPGGNEPAAASGQRLPENTPPCQQVDQPK
                     MQKEFGEDLVEQNSSYVQDSPSKKRKLDVEIILEEKHSEDDGGSAKRSKLERGDVSED
                     EPSLGRLNQTKRKLQPQDDEVPQKLQKLEEGHSSAVAAHYNELQEVGLAKRSQSRIFY
                     LRNFNNWIKSILIGEILEKVRQRKTRDITVLDLGCGKGGDLLKWRKGRISRLVCADIA
                     DISMKQCQQRYEDMRCRRDNEHIFSAEFITADCSKELLVEKFRDPEMYFDVCSCQFAC
                     HYSFESQVQADTMLRNACGRLNPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKF
                     QKKGNYPLFGCKYDFNLEGVVDVPEFLVYFPLLTEMAKKYNMKLIYKKTFLEFYEEKI
                     KNNENKMLLKRMQALEQYPAHENSKLASEKVGDYTHAAEYLKKSQVRLPLGTLSKSEW
                     EATSIYLVFAFEKQQ"
     exon            492..633
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..759
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..872
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1054
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1219
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1337
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1439
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1473
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..5008
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2041..2046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /note="hexamer: AATAAA"
     polyA_site      2063
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /note="major polyA site"
     regulatory      4988..4993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
                     /note="hexamer: AATAAA"
     polyA_site      5008
                     /gene="Rnmt"
                     /gene_synonym="2610002P10Rik; mKIAA0398; Rg7mt1"
ORIGIN      
        1 gaagtgacgt aacaaggcac gcgtggctcc ggccggcgtt tccgcaaaca gaatcgtgga
       61 tgactgtgtg gtgtcgattg atgaggtttt gctgtcagtt caagtaacga gaaatggaag
      121 gttccgcgaa agcgtcagtc gcttctgacc cagagtcccc tccaggtggt aatgagcccg
      181 ctgctgcctc tgggcagagg cttccagaaa atactcctcc atgccagcaa gtagatcagc
      241 caaaaatgca gaaggagttt ggggaggatc ttgtagagca aaattcgagt tatgtgcaag
      301 attctccatc caagaaaagg aaacttgatg ttgaaatcat cttagaggaa aagcactctg
      361 aggatgatgg aggttcggca aagagaagca aactggaaag aggtgatgtg tcggaagatg
      421 agccttccct tggtaggctt aaccagacca agagaaaact gcagcctcag gacgatgagg
      481 taccgcagaa gttgcagaag ctggaggaag gacacagctc agccgtggct gcccactata
      541 atgagcttca ggaagttggc ctggcgaagc gtagtcaaag tcgcattttt tacctaagaa
      601 acttcaataa ttggattaaa agtattctga ttggggaaat tttagaaaag gtacgacaaa
      661 gaaaaacccg tgacatcact gttttggacc tgggatgtgg aaaaggtgga gatttgctca
      721 agtggaggaa ggggagaatt agcaggctag tgtgtgctga tatcgctgat atttctatga
      781 aacaatgtca acagcgttac gaagacatga gatgtcgtcg cgataatgag catattttta
      841 gtgcagaatt tataactgct gactgttcaa aggaactttt ggttgaaaaa ttccgtgacc
      901 cagaaatgta ctttgatgtc tgcagctgcc agtttgcttg ccattactcc tttgagtccc
      961 aggtgcaggc ggatacgatg cttagaaatg cctgcgggag gcttaaccct ggcggctatt
     1021 ttattggcac cactcccaat agctttgaac tgataagacg ccttgaagct tcagaaacag
     1081 aatcatttgg aaatgaaata tacactgtga aattccagaa gaaaggaaat tatcctttat
     1141 ttggctgcaa atatgacttt aacttggaag gtgttgtgga tgtccctgaa ttcttggtct
     1201 attttccatt gctaactgaa atggcaaaga agtataatat gaaactaatc tacaaaaaaa
     1261 catttttgga attctatgaa gaaaagatta aaaacaatga aaacaaaatg ctcttaaaac
     1321 gaatgcaggc cctggagcaa taccctgcac atgagaactc taaacttgcc tctgaaaagg
     1381 tgggtgacta cacgcatgca gcagagtacc tgaagaagag ccaagtgagg ttacctctgg
     1441 gaaccttaag taagtcagaa tgggaagcta caagtatcta cttggtcttt gcctttgaga
     1501 agcagcagtg agcacgttgc tttagagcag cactccatcc tcccaggtgg agcagaccat
     1561 ctcagaaaca tttgacagct gtttgtttat tttaatagta agttctcaat gtgtaggatg
     1621 ctgccacaaa cttcagtgta tgaatttgac acttactgtc tgtgacaggt tagcataatg
     1681 tgtgtacata gggatgagtt gtcttgaaga tctattttta agtactgttg taattgttcc
     1741 cctctactgt caaaactcta gcaaggcatg tcagagcagc tgacctcccc agtgctgtga
     1801 tgtgtgagca gctgacctcc ccagtgctgg gatgtgtgaa tgtgtttaca gagctgattt
     1861 gacagtcgct agaattggca gaggaacgtt cacgtttcct tacagtgttt ttcaagattt
     1921 aatggattgt gttctgtata cttgaatgta agtgttcaat atatattgct aaagttataa
     1981 gattaaattt tgattttaga ttgtcctaag agctacctgg ctagattttg accgtgtttc
     2041 aataaaataa ctatttgcta atacactgca attctgagac tctatagacg aacttagatg
     2101 gcagcacaga gttagtgtgg actggttgga tgttctcttt agaatttctt accgtagcaa
     2161 ttagcatatc taattactga ggttgtgatt aaggtacgag taacttcact ggacagtgat
     2221 tccatggcta gatttcctta aggttttgtg aaaatgccac gtcctaattg tgttccataa
     2281 tgttttccga tggatgtgtg cacgtgcagt aggaacagca cagtgagatg catttcagat
     2341 gaatcctcac caataagaca actcactcac caatgctgta tccttccagg tcccaacatg
     2401 cagctcctgc ccgtctcaca acactgggac tccctcccta aggcagaccc cgctgtctaa
     2461 ttgtctttca gacattaact gttgagacgt taatggtgta gtagtcggcg tggctgcctt
     2521 ccaagggttt acttgctgtc ccacagccat catgattgtc attgtcagtt agagagccgt
     2581 cttctagaac tgaggccaca ctgaagaaac ttgtcagcct ttacatcaag aaacttaaga
     2641 gcaaatataa ttagacattt gtttaaaaat cacttactta aaggacaatt tacaaagatg
     2701 ctactttctg taaaaatcta tagtacttgc ttttaaaata ggctcagggc cagagaggtg
     2761 gctcagtagt tcagagtgct ggctgcgcgt ggagaagacc caggttcagt tcccagcacc
     2821 tacatgacag cttacaacca tcagtaactc tagttccagg ggatctgaca tcatcttttg
     2881 gcctccctgg gcaccaggca tgtgcatagt acatacatat aatgtgcagg cagaatacac
     2941 atataaagta aaaataatta cttaaaaaaa ttaaagttat aatctagttt atatagtcac
     3001 tgttcttagt atttagaggg tagatttggt tctggtgcgg gggttgtggg ttgtgggtgg
     3061 atggggagga atgttcttgc tcttagaaat tcaggctcat tttattcctg gggaagttcc
     3121 agaaagtatt ttgatgatgt ggcgtagtag agaaagcttc gtcacaattc atgatcttag
     3181 ttaacagttg gtacgtcatt tttagtcttt ttctgccctt tccattccat cccatgggtc
     3241 atttttagga gagaagaatt cttcaaaggg tggaataatt gatggttatc ccaagcagca
     3301 agaagagaaa tgtggaggtc ttgggccctt ccctgaggac tcagagaaaa ctggcctggg
     3361 tctgagatgg gctctagtca ttatacctac tgtcaaagac ataggagagt ttccatgatg
     3421 tcaccctaca gaaacagttc aagcagctgc ctttttcctt ttgtgttcct ctctgttgaa
     3481 cgtccatccc tccacccctc cttgcagaag ttcagtgact caggatggat tcttgaggac
     3541 aagaatggga aggtggtctt ttccattgtt tcaacaaata agactttgcc cagcattctt
     3601 ggaacctaaa tgtttaattt tgtcatgact tgtagtacct gatgagaaag gtgtggcttt
     3661 tcattgcagt atccagaaag agtcccttct cttgggttca gtgatgaaaa tggttcagat
     3721 gggctgttca gatacgtcta ggcctgtcac acagtgtatg ctcaggttgt ttccaaatga
     3781 agatcagggg ctggagacag agatctcagg ttaagagtgc ttgcaacttt cagaggactt
     3841 tagtttggtt cccaacacac atatcaagtg gcttagaact acctgtacct ccaattaaag
     3901 gtacttcagc actctccttt agtctttgct ggcacccgca catacatgca gatacctaca
     3961 cgtaaataaa aaatcaaaag aagagcatgt gggccatttt tgggaatgac acaacttgaa
     4021 ctagaggtag ttggcttggg gacaaagctg cacagcagta ggacctagaa catggacttg
     4081 tttgggtcta gaatttactc gggaacagtc cagtgtatag tgttgatgga gagaagctga
     4141 ggagttgtct gtccctcccc atccttctgg taacctaacc tgtacagaga gctgcaagcc
     4201 tgtcagagct ggctcacaca ccacttcagt gcccctgagc acattaggga ctcttaacag
     4261 caagcaaaga ctaagtagag tcactcataa gtagtggacc ctgtctgata actgagtggc
     4321 agagagaaga tagagatttc tcaaaaacag agccctgttg aaacttctac tctgtagtgg
     4381 gcttaaagtc gtatgttcac acacttctca gggtgtaaca ggtggttcct gcagctttga
     4441 gtgatactta ctgaggcccc ttaacttaga tgtattaatt cctgagtaag gcgctttagt
     4501 acataaggta ccctggcagg aatagagata gattattctt cacggtgtgg agacctggtc
     4561 ctctaaccgg acttgtgaaa tgtatgcact agaggtgatg gtgttccccc aaccttattg
     4621 tgtggatcta tcagtgcaaa agagcctctt aagagaagat gctgtctcag tgtgaattaa
     4681 gtaggcaggc ctcattatgt gaatttgctt gcttaaactc tgttgaagtg ttgtatctat
     4741 acaggcgatc agggattctt cacagacaga acatacatga atgcagaagc cagaggttcc
     4801 cttttgccta ctatttcttc cacagccacc atccactttt aagcaaaatc catttcatct
     4861 ggcttgaaat atgtgaaata aaataaaaaa tacgttcctt ggctttcact cggcagtgtt
     4921 catgagactc ttattctcaa tagctgtaca ttgttcattc tcatgattgt acagtattcc
     4981 gtgtatgaat aaacaacatt atacagtgaa aaaaaaaa
//
