LOCUS       NM_145135               1807 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus ribonuclease/angiogenin inhibitor 1 (Rnh1), transcript
            variant 1, mRNA.
ACCESSION   NM_145135
VERSION     NM_145135.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Zhao,W., Liu,Y., Yang,Y. and Wang,L.
  TITLE     New link between RNH1 and E2F1: regulates the development of lung
            adenocarcinoma
  JOURNAL   BMC Cancer 24 (1), 635 (2024)
   PUBMED   38783241
  REMARK    GeneRIF: New link between RNH1 and E2F1: regulates the development
            of lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Bombaci,G., Sarangdhar,M.A., Andina,N., Tardivel,A., Yu,E.C.,
            Mackie,G.M., Pugh,M., Ozan,V.B., Banz,Y., Spinetti,T., Hirzel,C.,
            Youd,E., Schefold,J.C., Taylor,G., Gazdhar,A., Bonadies,N.,
            Angelillo-Scherrer,A., Schneider,P., Maslowski,K.M. and Allam,R.
  TITLE     LRR-protein RNH1 dampens the inflammasome activation and is
            associated with COVID-19 severity
  JOURNAL   Life Sci Alliance 5 (6), e202101226 (2022)
   PUBMED   35256513
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Chennupati,V., Veiga,D.F., Maslowski,K.M., Andina,N., Tardivel,A.,
            Yu,E.C., Stilinovic,M., Simillion,C., Duchosal,M.A., Quadroni,M.,
            Roberts,I., Sankaran,V.G., MacDonald,H.R., Fasel,N.,
            Angelillo-Scherrer,A., Schneider,P., Hoang,T. and Allam,R.
  TITLE     Ribonuclease inhibitor 1 regulates erythropoiesis by controlling
            GATA1 translation
  JOURNAL   J Clin Invest 128 (4), 1597-1614 (2018)
   PUBMED   29408805
  REMARK    GeneRIF: RNH1 binds to the 40S subunit of ribosomes and facilitates
            polysome formation on Gata1 mRNA to confer transcript-specific
            translation.
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Lomax,J.E., Bianchetti,C.M., Chang,A., Phillips,G.N. Jr., Fox,B.G.
            and Raines,R.T.
  TITLE     Functional evolution of ribonuclease inhibitor: insights from birds
            and reptiles
  JOURNAL   J Mol Biol 426 (17), 3041-3056 (2014)
   PUBMED   24941155
  REMARK    GeneRIF: X-ray crystallographic analysis of RNH1 from mouse, bovine
            and chicken binding to RNase reveals two residues that appear to
            contribute to the differential binding affinity.
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Wu,T., Yuan,F., Chang,H., Zhang,L., Chen,G., Tan,C., Chen,H. and
            Bei,W.
  TITLE     Identification of a novel angiogenin inhibitor 1 and its
            association with hyaluronidase of Streptococcus suis serotype 2
  JOURNAL   Microb Pathog 49 (1-2), 32-37 (2010)
   PUBMED   20307645
  REMARK    GeneRIF: Mouse angiogenin inhibitor 1 interacts with hylA of
            Streptococcus suis.
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Yamasaki,S., Ivanov,P., Hu,G.F. and Anderson,P.
  TITLE     Angiogenin cleaves tRNA and promotes stress-induced translational
            repression
  JOURNAL   J Cell Biol 185 (1), 35-42 (2009)
   PUBMED   19332886
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Haigis,M.C., Haag,E.S. and Raines,R.T.
  TITLE     Evolution of ribonuclease inhibitor by exon duplication
  JOURNAL   Mol Biol Evol 19 (6), 959-963 (2002)
   PUBMED   12032252
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Semsei,I. and Goto,S.
  TITLE     Expression of mRNAs of pancreatic and L type RNase inhibitors as a
            function of age in different tissues of SAMP8 and BDF1 mice
  JOURNAL   Mech Ageing Dev 97 (3), 249-261 (1997)
   PUBMED   9234238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM946973.1, AK141351.1 and BY574079.1.
            
            On Feb 3, 2010 this sequence version replaced NM_145135.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (a),
            which is shorter than isoform b.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.162195.1,
                                           SRR1660815.83645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               BM946973.1         1-176
            177-1801            AK141351.1         2-1626
            1802-1807           BY574079.1         403-408
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.44 cM"
     gene            1..1807
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /note="ribonuclease/angiogenin inhibitor 1"
                     /db_xref="GeneID:107702"
                     /db_xref="MGI:MGI:1195456"
     exon            1..261
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            262..366
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1651
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /note="isoform a is encoded by transcript variant 1;
                     ribonuclease inhibitor"
                     /codon_start=1
                     /product="ribonuclease inhibitor isoform a"
                     /protein_id="NP_660117.2"
                     /db_xref="CCDS:CCDS22002.1"
                     /db_xref="GeneID:107702"
                     /db_xref="MGI:MGI:1195456"
                     /translation="MSLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIS
                     SAVQANPALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGCGILPG
                     MLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLASV
                     LRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVV
                     ASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLR
                     AKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTAASCPYFCSVLTK
                     SRSLLELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNSGCSSLANVLLAN
                     RSLRELDLSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIYWTNEVEEQLRALEEERP
                     SLRIIS"
     exon            367..537
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            538..708
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            709..879
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1050
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1221
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1392
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1563
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1803
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /note="hexamer: ATTAAA"
     polyA_site      1803
                     /gene="Rnh1"
                     /gene_synonym="RNH"
                     /note="major polyA site"
ORIGIN      
        1 ctcatcacag tcacacccat ttcgtggcag ctgtggatca ttttacgtat ttttagtcag
       61 gctcaaagaa gtgactcagg tttgtcaagt tctgttccca aagtgcagcc tgcatgtggg
      121 agggacagac ctagtgggcg gtctccagta ggcaaagtga aaggctagtt ggggccagag
      181 aaagagaagc ggcgaaagtc tctacgcccc gccctgggcg gaagaaaacg gatcgtctgg
      241 gacctcttgc agcggcacca gactgcactg tgcacccacc atgagtcttg acatccagtg
      301 tgagcagctg agtgatgccc ggtggacaga gctccttcct ctgatccagc aatacgaagt
      361 ggtcaggctg gatgactgtg gcctcactga agtgcggtgc aaagacatca gctcagcagt
      421 ccaagccaac cctgccctga cagagctcag ccttcgcacc aatgaactgg gtgatggcgg
      481 tgtgggtctg gtgctccagg gcctgcagaa tcccacttgt aagatccaga agctgagcct
      541 tcagaactgc ggcttgacgg aggctggctg tgggatcctg cctggcatgc tgcgctcttt
      601 gtctaccctg cgtgagctac atctcaatga taaccctatg ggggacgcag gcctgaagct
      661 gctctgtgaa ggacttcagg acccccagtg ccgtcttgag aagcttcagt tggaatactg
      721 taacctcaca gctaccagct gcgagcccct ggcttcagtg ctcagggtga aagctgactt
      781 taaggagcta gtattgagca acaacgacct ccatgaacct ggtgtccgta ttctgtgcca
      841 gggcctgaag gactctgcct gtcaactgga gtcactcaag ctggagaact gtggtatcac
      901 agcagccaac tgcaaggatc tgtgcgatgt tgtggcctcc aaagcttcgc tacaggaact
      961 ggacttgagc agcaacaagc taggtaatgc aggcattgca gcactgtgcc caggactgct
     1021 gcttcccagc tgtaagctca ggactctgtg gctctgggaa tgtgatatca ctgcagaggg
     1081 ctgcaaggac ctgtgccgtg tcctcagagc caagcagagc ctgaaggaac tcagccttgc
     1141 ttccaatgag ctgaaggatg agggtgcccg gctgctgtgt gagagcctat tagagcctgg
     1201 ctgtcagctg gagtcactgt ggataaagac ctgtagcctc acagctgcct cctgtcccta
     1261 cttctgctcc gtgttgacca aaagccgttc tctgttggag ctgcaaatga gcagcaaccc
     1321 actgggagac gagggagtcc aggagctttg caaggccctg agccagccag atacagtgct
     1381 gcgtgagctt tggttgggag actgtgatgt gacaaatagt ggttgcagca gccttgccaa
     1441 tgtcctgctg gccaaccgca gcctgaggga actggacctc agtaacaact gcatgggggg
     1501 cccaggtgtc ctgcaactgc tggagagcct caaacagccc agctgcaccc ttcagcagct
     1561 cgtcctgtat gacatttact ggacaaatga ggtggaagaa cagcttcggg ccctggagga
     1621 ggaaaggcct tccctgagga tcatttcctg atgttcctct ggacacatca atccagcccc
     1681 aggggcagcc agcaggatct ctggctctgg gtgtccttgt gttgaccggc aataagcact
     1741 gtggtcttac ttcagtagaa aactttaaga cactttataa ctattaaaac actttgatgg
     1801 caaaaaa
//
