LOCUS       NM_011884               4157 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus RNA guanylyltransferase and 5'-phosphatase (Rngtt),
            transcript variant 1, mRNA.
ACCESSION   NM_011884
VERSION     NM_011884.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4157)
  AUTHORS   Dhandapani L, Salzer MC, Duran JM, Zaffagnini G, De Guirior C,
            Martinez-Zamora MA and Boke E.
  TITLE     Comparative analysis of vertebrates reveals that mouse primordial
            oocytes do not contain a Balbiani body
  JOURNAL   J Cell Sci 135 (1) (2022)
   PUBMED   34897463
REFERENCE   2  (bases 1 to 4157)
  AUTHORS   Mukherjee C, Bakthavachalu B and Schoenberg DR.
  TITLE     The cytoplasmic capping complex assembles on adapter protein nck1
            bound to the proline-rich C-terminus of Mammalian capping enzyme
  JOURNAL   PLoS Biol 12 (8), e1001933 (2014)
   PUBMED   25137142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4157)
  AUTHORS   Liu L.
  TITLE     Functional characterization of the C-terminal domain of mouse
            capping enzyme
  JOURNAL   Cell Biochem Funct 24 (2), 95-102 (2006)
   PUBMED   16342145
  REMARK    GeneRIF: Overall, both in vivo and in vitro studies indicate that
            the functional domain of Mce1 is between a.a. 211 and 567, and the
            heptapeptide sequence between 561 and 567 may play an important
            role in the enzyme activity.
REFERENCE   4  (bases 1 to 4157)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4157)
  AUTHORS   Changela A, Ho CK, Martins A, Shuman S and Mondragon A.
  TITLE     Structure and mechanism of the RNA triphosphatase component of
            mammalian mRNA capping enzyme
  JOURNAL   EMBO J 20 (10), 2575-2586 (2001)
   PUBMED   11350947
REFERENCE   6  (bases 1 to 4157)
  AUTHORS   Wen Y, Yue Z and Shatkin AJ.
  TITLE     Mammalian capping enzyme binds RNA and uses protein tyrosine
            phosphatase mechanism
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12226-12231 (1998)
   PUBMED   9770468
REFERENCE   7  (bases 1 to 4157)
  AUTHORS   McCracken S, Fong N, Rosonina E, Yankulov K, Brothers G, Siderovski
            D, Hessel A, Foster S, Shuman S and Bentley DL.
  TITLE     5'-Capping enzymes are targeted to pre-mRNA by binding to the
            phosphorylated carboxy-terminal domain of RNA polymerase II
  JOURNAL   Genes Dev 11 (24), 3306-3318 (1997)
   PUBMED   9407024
REFERENCE   8  (bases 1 to 4157)
  AUTHORS   Yue Z, Maldonado E, Pillutla R, Cho H, Reinberg D and Shatkin AJ.
  TITLE     Mammalian capping enzyme complements mutant Saccharomyces
            cerevisiae lacking mRNA guanylyltransferase and selectively binds
            the elongating form of RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12898-12903 (1997)
   PUBMED   9371772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151463.1, AK002922.1, AK142016.1, AC093925.5, CO042079.1 and
            BU756706.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by NM_011884.4.
            
            On Mar 7, 2015 this sequence version replaced NM_011884.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoforom (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151463.1, BC043657.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849380,
                                           SAMN00849381 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2452              AK151463.1         3-2454
            2453-2457           AK002922.1         2376-2380
            2458-3278           AK142016.1         2436-3256
            3279-3516           AC093925.5         125772-126009       c
            3517-4152           CO042079.1         21-656              c
            4153-4157           BU756706.1         19-23               c
FEATURES             Location/Qualifiers
     source          1..4157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 14.78 cM"
     gene            1..4157
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /note="RNA guanylyltransferase and 5'-phosphatase"
                     /db_xref="GeneID:24018"
                     /db_xref="MGI:MGI:1329041"
     exon            1..214
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1944
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /EC_number="2.7.7.50"
                     /EC_number="3.6.1.74"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mRNA-capping enzyme"
                     /codon_start=1
                     /product="mRNA-capping enzyme isoform 1"
                     /protein_id="NP_036014.1"
                     /db_xref="CCDS:CCDS38705.1"
                     /db_xref="GeneID:24018"
                     /db_xref="MGI:MGI:1329041"
                     /translation="MAYNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENR
                     FHPSMLSNYLKSLKVKMSLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTEN
                     TETFIRLCERFNERSPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQAR
                     PPGIYKGDYLKELFRRYGDIEEAPPPPVLPDWCFEDEDEEDEDEDGKKDSEPGSSASF
                     SKRRKERLKLGAIFLEGITVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSM
                     DKQNIRLLEQKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLR
                     MHLSNTLLDGEMIIDKVNGQAVPRYLIYDIIKFNAQPVGDCDFNIRLQCIEREIISPR
                     HEKMKTGLIDKTQEPFSVRPKQFFDINISRKLLEGNFAKEVSHEMDGLIFQPIGKYKP
                     GRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELK
                     QYDNKIIECKFENNSWVFMRQRIDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCA
                     AAAQGQKRKYPLDPDTELMPPPPPKRLHRPT"
     exon            215..324
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..428
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..517
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..593
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..834
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..944
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1046
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1182
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1254
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1419
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1488
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1589
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1656
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1780
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..4157
                     /gene="Rngtt"
                     /gene_synonym="HCE; MCE1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggaag tcgcagtgca ttgtgggttc gccgggagcc gcggagtcga acctgaatga
       61 aagtggcgcg ccgctgagga cccgggtaga gctgctgccg ttggggtccg ggctggtttg
      121 ctgtggagct atcggcgagg cggcacagac atggcttaca acaagatccc gccgcggtgg
      181 ctgaactgtc cgcggcgcgg tcagccggtg gcaggaagat tcttacctct gaagacgatg
      241 ctggggccaa gatatgatag tcaagttgct gaagaaaacc ggttccatcc cagtatgctc
      301 tcaaattatc taaagagcct gaaggttaaa atgagcttgt tggtggatct gacaaatact
      361 tcaaggttct atgacagaaa tgacatagaa aaagaaggaa tcaagtatat caaacttcag
      421 tgtaaaggac atggcgaatg ccccaccact gagaatactg agacattcat tcgcctgtgt
      481 gagaggttta atgaaagaag cccacctgaa cttataggtg ttcactgcac ccatggcttc
      541 aaccgtactg gtttccttat atgtgccttt ttggtggaaa aaatggattg gagtattgaa
      601 gcagcagttg ctacatttgc ccaagccaga ccaccaggaa tctacaaggg tgattatttg
      661 aaggaacttt ttcgtcgcta tggagatata gaagaagcac caccaccacc tgtattgcca
      721 gattggtgtt ttgaagatga ggatgaagaa gatgaggatg aagatggaaa aaaggactca
      781 gaaccagggt caagtgcatc ctttagtaaa aggagaaaag agcggttaaa actgggagct
      841 attttcttgg aaggcataac tgttaaaggt gtaactcaag taacaactca acccaagtta
      901 ggagaggtgc agcagaaatg tcatcagttc tgtggctggg aagggtctgg gttccctgga
      961 gcacagcctg tctccatgga caagcaaaat attagacttt tagagcagaa gccttataaa
     1021 gtaagctgga aagcagacgg cactcgttac atgatgttga ttgatggcac aaatgaagtt
     1081 tttatgattg acagagataa ttccgttttt catgtttcaa atctggaatt tccatttcgt
     1141 aaagatcttc gcatgcattt atcaaatact cttttggatg gggaaatgat cattgacaaa
     1201 gtaaatggac aggccgtccc aagatatttg atctatgaca taattaagtt caatgcacaa
     1261 ccagttggag actgtgattt taatattcgt ctacagtgta ttgaacgtga aattataagt
     1321 ccacgacatg aaaaaatgaa gactggactc attgacaaaa cacaggaacc atttagtgtc
     1381 agacctaaac aattttttga catcaatatt tcaagaaagc ttctggaagg aaattttgcc
     1441 aaagaagtca gccatgaaat ggatggactt atttttcagc ctattggaaa atacaagcct
     1501 ggtcgatgtg atgacatttt gaaatggaaa cctcccagtc taaactctgt ggattttcga
     1561 cttaagataa caagaatggg aggagaaggg ttgcttccac agaatgttgg ccttctctat
     1621 gttggaggtt atgaaagacc ctttgcacaa atcaaggtga caaaagaact aaaacagtat
     1681 gacaacaaaa ttatagaatg caaatttgag aacaatagct gggtcttcat gagacagagg
     1741 atagacaaaa gtttcccaaa tgcctacaac acagccatgg ctgtgtgcaa tagcatctcg
     1801 aaccctgtca ccaaggagat gctgtttgaa ttcattgaca gatgtgcagc agccgcccag
     1861 ggacagaagc ggaagtatcc cctggaccct gacacggagc tcatgccgcc cccaccgccc
     1921 aaaagactgc atcggccaac ctagtccgtg cctctgagag gaagaaaaat gctgttgtct
     1981 cattttctca accagagaaa ttaaagagac gagcggcttc gtactggtac acgtgtttta
     2041 agggaagaca tagtcagcct gtatatattt ggtacatttg tttccttgga actacagtac
     2101 atcatggacc taaatatttt atttatacct gataaattca gccttaccct gtggagtcta
     2161 cagattgaaa tacccaaagg tttaaatcag attgaagtta atgaaataga ggccttgttt
     2221 gtatgtgaat agataccttt acatttgatt cataactagc aatctgaagc tgtaagcata
     2281 ttgagttttt taaatgttgg attttaagtt tacctcttta aaatgtgggt actggcatta
     2341 gaaattttct cactaactta tcatggattt cttatatttc tcaatttttt atattctgag
     2401 caatgacaag gtcaagtatt atgtacatta aacagtttgg tctggctata ccattttaag
     2461 aagttcttct ggttttgttt tctgtgagag tggggtgtaa aaacagtaat gaagctccat
     2521 tttcttgtga attgtatcct ttctttagaa actattttga gcattttact atgtctcgtg
     2581 tttgaaccat gacgtcagat gtctggggtt cccatcctgg cagtggtttt gagttccttt
     2641 gtggcactta ccttcatgtg ctgctgtctg ggagcgttgc tgctttcaga cagcagggct
     2701 cctcctgctt tacccactca ctgtgatccc tgggaacagc agcaagcaca accgcgttgt
     2761 gttatttccc tcaaacagtg cttcagacac agtggcagct ttgcctagaa ggtcatgtca
     2821 gctgaacaaa gtgttgtcta ggagatgctg gcctcccatg gacagatgca gaggcgttgc
     2881 tgagactggt catggaggac gtgaagatgt tgctcccact gctcctgctg cacctgcgct
     2941 tggaggtggt ttccgatcct gagctgcacc tcagcgttga ctctggacag taggtccctg
     3001 ccgttgtaaa acttgttctg attggcttgt gaaggaattc agaatagcaa ctagcaagca
     3061 gcttacttaa tgtatttatt ttagagacac aggttttaag tatatgtatt taaaacaaat
     3121 gttcacgatc tgtattttat atatgtataa gcatatctga aagtatatgc aacagtgtat
     3181 attcttatat tgatacagcc agaaatgaaa atccaaatgc tttacctagc aggctaagga
     3241 tctgatggaa tttttatttg gcaaagtaca gattaaccaa aactgtattt atatgaacct
     3301 gagttttaat gtttttaaac gaactttaca tctgcagtgc ttttctgtat ggaatactag
     3361 ggctgtgcct agacttatgc cgctattgtt cccaagttat gtaatatgtt agcaagttta
     3421 ttcaaaatgc cataataatt ttgtcttagg ttgcttttgt acatttgggc actgaaggaa
     3481 tttaaacacc tgactgttac aggattgttg aggggagatt gtcaaggttc cttctgtcgt
     3541 ttacatggtg gatccagaac tgcctgtgga ctccaggcag cctagtgcct gctccccagg
     3601 gtcactgaat cttttctcca tagatggtct gctcccaagc cggtgcaaaa gcggggtcct
     3661 tttgaagata cagtaacgtg ctttgtcagt gatctctgat agaattaaaa tgttatggta
     3721 acattaacct ttcaaatgaa atggaaagag cattatatag gacttacttt ttcagcttat
     3781 cctttccttt caattgtggt gacgtaatca ttggccttaa aagcagaccc catgtagtcc
     3841 ccaaccgcat cacctcctgg agtatcctta cagccattta ggctgttgga cgaaaggtag
     3901 gatttggaca tcttgaagga aaacttccct tctcggctta tgttacaaca gctgttttct
     3961 ttagctgata ttttccagac aggactaaga agactgtttc cctgagttat cgcatgggaa
     4021 ggcttgcttt ttgtttgggg aaaaaaaaat atggatgact actgcctaga tggttccttt
     4081 gctttccatg aaatgccagg acattccttc tctgattgtg tcagtgtgtg ttgtaataaa
     4141 gctactgatg taacaca
//
