LOCUS       NM_001109902            4363 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein, transmembrane 2 (Rnft2),
            transcript variant 2, mRNA.
ACCESSION   NM_001109902
VERSION     NM_001109902.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4363)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY721494.1, BC057302.1 and AW049082.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and at a
            single splice boundary, compared to variant 1, resulting in a
            shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057302.1, AK148930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY721494.1         2-39
            39-4337             BC057302.1         1-4299
            4338-4363           AW049082.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 58.2 cM"
     gene            1..4363
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /note="ring finger protein, transmembrane 2"
                     /db_xref="GeneID:269695"
                     /db_xref="MGI:MGI:2442859"
     exon            1..54
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            55..236
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1550
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /note="isoform 2 is encoded by transcript variant 2; ring
                     finger and transmembrane domain-containing protein 2;
                     transmembrane protein 118"
                     /codon_start=1
                     /product="RING finger and transmembrane domain-containing
                     protein 2 isoform 2"
                     /protein_id="NP_001103372.1"
                     /db_xref="CCDS:CCDS51632.1"
                     /db_xref="GeneID:269695"
                     /db_xref="MGI:MGI:2442859"
                     /translation="MWLLAAHQVLRKMQRRHSSNTDNIPPERSRSQALSPEASVDEGG
                     VFESLKAETASPPALFSGLAGGLPASPFPAGLVLGSTAGGGDVFIPMPATRDEAGGRS
                     AEGSTYHHRQAHHHFHHGAHRGGSLLQHVGGDHRGHSEEGVDEQPGTPAPALSELKAV
                     ISWLQKGLPFILILLAKLCFQHKLGIAVCIGMASTFAYANSTLREQVSLKEKRSVLVI
                     LWILAFLAGNTMYVLYTFSSQQLYSSLIFLKPNLETLDFFDLLWIVGIADFVLKYITI
                     ALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSNSYFLG
                     GVLIVLYSLCKSFDICGRVGGLRKALKLLCTSQNYGVRATGQQCTEAGAVCAICQAEF
                     RDPMILLCQHVFCEECLCLWLDRERTCPLCRSVAVDTLRCWKDGATSAHLQVY"
     exon            237..295
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            296..765
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            766..842
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            843..943
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1097
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1247
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1313
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1415
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..4346
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4319..4324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /note="hexamer: AATAAA"
     polyA_site      4342
                     /gene="Rnft2"
                     /gene_synonym="B830028P19Rik; Tmem118"
                     /note="major polyA site"
ORIGIN      
        1 agggattggc taggctggat tagcagaggc cgtgattgct gcagtgtctg gcaggtctgc
       61 tgtctccaat gagtctcctg tcctgtgctt ccctctgaag aggaggaaga ggaggaggag
      121 gaggcctgct ctctctggga cccagtggcc acatcccatc aggaaccctg agtgtccacg
      181 gcacatttcg tcagcatgga gttctgaggt ccatgtggct ccttgctgcg caccaggtgc
      241 taaggaaaat gcagagacgc cacagtagca acacggacaa cattccacct gaaagaagtc
      301 gcagccaggc gctcagcccc gaggccagcg tggatgaggg tggtgtattt gagagtctga
      361 aggcagagac ggcctcccct cctgcgctct tctcaggcct ggcaggtggc ctgcctgcca
      421 gccccttccc agcaggcctg gtgctgggct ccacggcggg tggcggggat gtcttcatcc
      481 ccatgccagc caccagggat gaggccggtg gccgcagcgc cgaaggaagc acctaccacc
      541 accgccaggc ccaccaccac ttccaccatg gtgcccaccg cgggggctcc ctgctgcagc
      601 acgtgggtgg ggaccaccgt ggacactcag aggaaggggt cgacgagcag cccggaactc
      661 cagcacccgc actgtctgag ctcaaggctg tgatctcctg gcttcagaaa ggactgccct
      721 ttatcctcat cctgctggcc aaactgtgct tccagcacaa gctgggcatt gctgtgtgca
      781 tcgggatggc cagcaccttt gcctatgcca actccaccct ccgggagcag gtgtccttga
      841 aggagaagag gtcggttctg gtcatcttgt ggattctggc cttcctggca gggaatacca
      901 tgtacgtcct ttataccttc agctcccagc agctctacag cagcctcata ttcctgaagc
      961 ccaacctgga gacactggac ttctttgacc tgctgtggat cgtggggatc gccgactttg
     1021 tactgaagta catcaccatc gccctcaagt gcctcatcgt ggccctgccc aagatcatcc
     1081 tggctgtcaa atccaaggga aagttttatc tggtcattga ggagctgagc cagctgttca
     1141 ggtctcttgt ccccatccag ctgtggtaca agtacatcat gggggacgac tcctccaaca
     1201 gctacttcct gggaggagtc ctgatcgtcc tctacagtct ctgcaagtcg ttcgacatct
     1261 gtggtcgcgt gggcggactc aggaaagcat tgaagctcct ttgcacctca cagaattacg
     1321 gggtccgagc cacagggcag cagtgcacgg aggctggcgc cgtctgcgcc atctgccaag
     1381 ctgagttccg agatcccatg attctcctgt gccagcacgt gttctgtgaa gagtgcctct
     1441 gcctgtggct ggacagggaa cgcacctgcc cgctctgccg ctcggttgct gtggataccc
     1501 tgcgatgctg gaaggacggg gccacgtctg cacacttgca ggtgtattga gctaaacatg
     1561 agtgtctggg gagcccagcc ccaaggatgc ctgggaaaca gcctccagga ctttctcctg
     1621 cctcccacca cctctatctg atgaccccag ggcctccaca ccaacacttc ctcagcgccc
     1681 cagtacagtg tgtgtgtcct acctcaccag aaaggggagc cctcctcact cagacttggc
     1741 tcccccacag gtaggtgatc cgtcccctct aagtggagga gttacccata catacacagt
     1801 ctcccttcat ttaacctgct tccagccgct ggtgctcaat gctacgaact agtatgagct
     1861 cagagagtac agtctgaccc aggtctgcac acaggagccg atgggagaac gtccaacatg
     1921 tgagcaccag gcttcaccca cctagctgac cttcaaaaca gcaggatgca ccaagcatcc
     1981 cgctcatgcc gcctcctggc atctccacat cagccctagg gtggggctac ttgctctctc
     2041 tcacacacac accattggca ggtgagaagc ttggggtggc cgcccagcta gtaaggggcc
     2101 aatgtgtctc cagcgctgcc tggtgctgtt gctgcaagtg cccctcgctg gctgagcatc
     2161 cgtggcctgg gcatacagca catcagagac agactgctct gagcaggcag gcagcgaggt
     2221 caaatggcag gagccatgga cagactgcac ctttgtgatt ccttttctcc cgggatccac
     2281 ctgggacagt cagtctcaga agggtcagct ctggtccaga gtgtatgcca cctgccttct
     2341 gtcattcttc tgtccttatt ctcatctaca ttgtccctca ctgacagctc aggcctgtgc
     2401 agagctgtgg acatggctac ctcccccccc caccccccgg aggcttcaat ccatgtcata
     2461 agtggcacac ggcttcggag tgatccatgt gtcgtccccc ctcccccccc ccctctctag
     2521 tgaggtaatt agctcggaga aacaacagtc cttccagagt ctctgaaaag actgctttat
     2581 atctttaact aaccgcccga gcgagcggga acgctgggag cagatggcag gtgtgctttc
     2641 acatccttcg gtctctagga cacagcttct tctccccgcg ggaaactctc tgattggaaa
     2701 cctgggacga aatagcacag gtgaccgcac agaagcctct ggaattctgc ctgcctccac
     2761 tggctcctga ctcggttctc tcacagccgg catccgcaca acaggctggc ccaagccacg
     2821 tttgagatta gcaccaaggg ggttggggga gggagaaagg agcctctgta gattcagggt
     2881 gctctctcct cccctttgta aatttaggac ccatgccttg ggcacccctg ctgggacttc
     2941 ttcctctgct tggtctccag ggcactttcc tggtaccagt aacacaccca ccctttccag
     3001 gagaccaggg catccttcaa gctttgttac tatggcaatg gccatgatgc taagcaatcc
     3061 cactgcctgg atgtcctaag agggaaggga ggatgggccc ttctgtcctc tctggtttga
     3121 gggggtaccc aggagagtgg tgggactgcc tgcaactggt ttttatcaga gagattgctt
     3181 tgcctgagat gctgtcagca ttgtggaggg gtgggagctg caggaggtgc acggaagtgt
     3241 agggtgggat ggatcagatg cagccactgg gagtcgggct tggaaacctg actccaaact
     3301 ttgtgatgtc cctataccct gtatcccccc accctccatg gagctacaaa acctagcatg
     3361 tttcttgcta ggactgagaa aactaacagc aggactgaag atgtagctca gtcggtagag
     3421 cacttgccta gtgtgcagga agccctgagt tccgtggcca gcaccacatg aactaggcat
     3481 ggcagtgcac aactgaattg gcagcgctgg gtgggagagg caggaggatt agaaggacaa
     3541 gatcattcct tggccacata gcgagtccca gggtagcctg ggctctgtga gactccatct
     3601 taaaagggag aacaggtgaa ctaacagtgt gggttactgg agagtgtgcc aagggtttta
     3661 cacaccccct ccattacttc tctgacatct tgtaaatata attatatccc taccacacat
     3721 ggagcatccc ctgggacagt gagatgctct tcagttccca tccttccagg gaacacctca
     3781 gatggccagt ggggttcatc cagtttagag ggctcaggca gtttcccaga cagcaggctg
     3841 tgggaaagtg tcccctgcag tggcgtatca gtcctttgct ttgagcaggt cagtggagca
     3901 tcaggggccg gatatggctc ccggtatatt gtgggtcaca gactcaaatc cctctgagtc
     3961 ctccaagtct tgtgtgtgtg aggacctgag attaacaagg taggggaggc tggtgagagg
     4021 gcagaggttg agagtgcttg gcttgcatct ttaagaggac ccaggactca caccaaaggg
     4081 ctcacaactc cagctccagg gacacacaca tcatttaaaa caaatcttca agaaccatgt
     4141 gggaagaaga acggcctgct ttggacccga gcctaacagg cccagccttc caaagggaac
     4201 ggcacaggta cggagccttg ggaccatccc ccactgctga agcggaagtg ggcagcgacc
     4261 tgaggtcctc tgcttttgct ttgggacatg tctttggtgt ctttgagaac cttctgccaa
     4321 taaacctccc ccatggatgt aacttgaaaa aaaaaaaaaa aaa
//
