LOCUS       NM_029788               4434 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein, transmembrane 1 (Rnft1), mRNA.
ACCESSION   NM_029788
VERSION     NM_029788.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL604063.4.
            
            On Oct 19, 2007 this sequence version replaced NM_029788.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036401.1, BC050796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL604063.4         4217-4359
            144-588             AL604063.4         5621-6065
            589-665             AL604063.4         6216-6292
            666-766             AL604063.4         8627-8727
            767-920             AL604063.4         9918-10071
            921-1079            AL604063.4         11239-11397
            1080-1145           AL604063.4         12721-12786
            1146-1247           AL604063.4         14788-14889
            1248-4434           AL604063.4         15381-18567
FEATURES             Location/Qualifiers
     source          1..4434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.82 cM"
     gene            1..4434
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /note="ring finger protein, transmembrane 1"
                     /db_xref="GeneID:76892"
                     /db_xref="MGI:MGI:1924142"
     exon            1..143
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            144..588
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1382
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /EC_number="2.3.2.27"
                     /note="RING finger and transmembrane domain-containing
                     protein 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNFT1"
                     /protein_id="NP_084064.1"
                     /db_xref="CCDS:CCDS25200.1"
                     /db_xref="GeneID:76892"
                     /db_xref="MGI:MGI:1924142"
                     /translation="MQASCNQLHDPPGTAHEDAAASPCGHSRSTEGSLHPGDVHIQIN
                     SGPKEYSENPSSRNPRSGVCTCAHGCVHGRFRSYSHSEARPPDDFATESGEHGSGSFS
                     EFRYLFKWLQKSLPYILILGIKLVMQHITGISLGIGLLTTFMYANKSIVNQVFLRERS
                     SKLRCAWLLVFLAGSSVLLYYTFHSQSLHYSLIFLNPTLEQLSFWEVLWIVGITDFIL
                     KFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEELCQYYRIFVPIPVWFRYLISYGEFG
                     NVTTWSLGILLALLYLILKLLDFFGHLRTFRQVLRVFFTRPSYGVPASKRQCSDMDGI
                     CTICQAEFQKPVLLFCQHIFCEECITLWFNREKTCPLCRTVISECINKWKDGATSSHL
                     QMY"
     exon            589..665
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            666..766
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..920
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1079
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1145
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1247
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..4434
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1592
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1975
                     /gene="Rnft1"
                     /gene_synonym="0610013E23Rik"
                     /note="major polyA site"
ORIGIN      
        1 agggagcgcg cgcgccgccg cggggccagg ccgagcgctg ctggtggcgt ccgaggctga
       61 aggcttggcg agaagggctt gcggccgcgt gtcgggctgt tggtattgtg gctgccgagg
      121 ccgcccgctc ctggtcatga gaggagaaag agtcctgaag caaagacatt ttagagagaa
      181 aatactcaag ggccatgcaa gccagctgta accaactgca tgatcctccg ggcactgcac
      241 atgaagatgc tgcagcctcc ccgtgtggtc attcaagatc aacagaaggt tcccttcacc
      301 ctggggatgt acatatccaa ataaactccg gaccaaaaga atattctgaa aatccaagct
      361 ctagaaatcc caggtcaggc gtctgtactt gtgcccatgg atgtgtgcat ggtcgtttcc
      421 ggagttactc ccacagtgaa gcaagaccac ctgatgactt tgctacagag tctggggaac
      481 atggaagtgg ctccttctca gaattccgct atctcttcaa gtggttgcaa aaaagtcttc
      541 cttatatttt aattctgggt attaaacttg ttatgcagca tataacagga atttctcttg
      601 gaattgggct gctaacaact tttatgtatg caaacaaaag cattgtaaat caggtttttc
      661 taagagaacg gtcatcaaag ctccgctgtg cttggttact ggtgttcctg gcaggttcct
      721 ccgtcctctt atattacact tttcattctc agtcacttca ttacagctta attttcttaa
      781 atcctacact cgaacagttg agcttctggg aagttctttg gattgttgga attacagact
      841 tcattctgaa attctttttc atgggtttaa aatgcctgat tttattggtg ccttctttca
      901 tcatgccttt taaatcaaag ggatattggt acatgctttt agaagaattg tgtcagtatt
      961 accgaatttt tgttcctata ccagtttggt ttcggtacct tataagctac ggggagtttg
     1021 gtaatgtaac tacatggagt cttgggatat tgctggcttt actctacctc atactaaaac
     1081 ttttggactt ttttggacac ttgagaactt tcagacaggt cttacgagta ttttttacac
     1141 gaccgagtta tggagtgcct gccagcaaga gacagtgttc agatatggat ggtatttgta
     1201 caatatgtca agcggaattt cagaagccag ttcttctctt ttgtcagcat atattctgtg
     1261 aagaatgtat caccttatgg tttaacagag agaaaacatg tccactgtgc agaactgtga
     1321 tttcagaatg tataaacaaa tggaaagatg gggccacttc atctcacctc cagatgtact
     1381 aagttgttcc aactattaag gcctcaagac actaatttta tctggtttgg taactattga
     1441 taaaggtata attgatctcc agcagtagaa aaaggcttta gggtatcacg agacatgttt
     1501 atagttcagt ttctcagaag tttaagtgca agagccctgc atttttaaac tatatattca
     1561 ttcaccttaa taaatatgca acatttattc cacttatttg acaaataatt gcagtgttaa
     1621 attggaaatg tgatttctta tcaataatac caaaatagca attagaaata gaactagcca
     1681 ttttaaaggg gttcaggtac tgtttcctga caggttttca gaataaagat tttgcatagt
     1741 attttaagat atatagtatc tgaaacaatt tacagatttt tataattccc attctaaaaa
     1801 tgcttaaatt tttcataaga ttgtattttt aaatgaaagt tctaaatgct atattttacc
     1861 tataacaatc acattttcta agtgaagatt tactgaggat gatatatttt aatactgtat
     1921 tatgctctat aatatgacta gtaatcagtg agaataaatg atttagattc attcacctgg
     1981 tggacctgtt atgtactcct tgccactagc tgtcttgtgt tttgtgtagt accatgtaat
     2041 agcttgaaat aacaatgaaa gtgatttgaa tgtgggctgg ggatgtagct cacaagtttt
     2101 acaatcacca cctgttgaga tatgaaagct tgcacccaag gctgtggtgg agtgcctgct
     2161 tagtgcgcac tgtgtcctgg ctgaattcca catcgaggag aaagggagaa aacagcaact
     2221 ttcactcagg ggaagccaga acattagtca tctccagctg atttctgcaa gaagaaaagg
     2281 taatggcgca ctttaccttt ccttgtgttt cctctgaaga atctgaaatc tttaccatga
     2341 ctaaagggct gctactgcga aggcttcttc gcatttatca tcagtaacaa ggagaagttg
     2401 agacaaaaac aaattagccg tgtaagacag actaagctgg gttctagaga tggctttagc
     2461 agattagaac atgtgctgca gttccaggac cagagtttat gctgaatgct gggattaaag
     2521 tcgtgtgcta ccaccaccac caccaccacc tgactaaagt taaactttaa agacagacta
     2581 aaccagtaca tggcttaata aggatagtga ccaagtgtca tgggtgaaat catgtctgta
     2641 cagctgctac ctagattgac agaggtacag gaagactgtg ataccctcaa ccagataaac
     2701 accacatcac tttttgtttt aaatgagtat tcactctata tttgtgtata ttgtatgtgt
     2761 ccacacacac atagagtcta ttatacacac acacacacct tgcctaatga gaatcactgc
     2821 taagtatatt aaatcacctt cctggctttg tggtgaagct tagttgttag atatacaagg
     2881 gatgaaggag agaaagtgat ttgtgattaa aatttcactg tgaaagtcag ctgaaatgac
     2941 ttcctgttta aaactattac attcatccct cttaacactt atcacagttt ctccaggcaa
     3001 cttgtttttt taatatgatt aaataacaaa gggagtttgt agaagactga ggtgggtgga
     3061 ttttttcaca aggctatcac ttaaaattag gaaaagggaa gtaactcata gcaaatattt
     3121 taaccccagc aattaaaggc agaagcgggt gaatctgagt ttgatgccca tctagtctcc
     3181 agagcaagtt ccaggacagg cagggctata gagagaaacc ctgtcttgtt ccagaccacc
     3241 tagggctata taaagagatc ttgtctctaa acaaaaacca gaaaatgtag taaggttgtg
     3301 gtactcatta tcagtaataa actgaaacat ttctcttgct tttgcccttt gctttcacct
     3361 caaaggaaga ggattgattt tgtggattta gatcatcctc tctaaacagt tgctgtccca
     3421 gcactgagaa atgctgctag ggcatagagc aatggctcag cagtgaagag cactgttgct
     3481 ccagaggcct gtgggtgttc ccacaccgca gcgaacaacc atctccagtt ccaggggagt
     3541 ctgatgccct cttctggctt tcttgagcaa tgcacacatg atgcagacac atacaggcaa
     3601 aacacctata tacataaaaa taaatgtcca aagagagagg ggaggtaagg ggattggggc
     3661 cggggggaga tgctaccaac caccaggatt gagactataa ctccttgcta gagatacttt
     3721 tgtttttcat ttttttcgag attgggtttc tgtgcagcct acgctgtcct ggaacttgct
     3781 ttataggcca ggctagctac aaacacagag atctgcttgc ctctgtctcc tgaggactgg
     3841 gaagggactg aaggcaggca ccaccgcatg tggcaagatg ggtgatttct ttgtttttca
     3901 gatttatttt gtgatagtta tgatgaacca ctattatgtg agtactagaa accaaaacca
     3961 tgccctcgaa aggcacagca ttgctcctgt gaagctatct gacatatttg ctaatttttt
     4021 gtacaattat tttgaacatg aacattacat tatcaaagct agctatgagg tgtacttagg
     4081 caaattgttg attattaata taagaaatta ttcccactat ttttatgtga aactagattc
     4141 cacatagctt gtttcatgaa tatttttaaa agcaaacaat tcaagtatat taaaaataac
     4201 aagaatctgt aacacttaat acataaaatg accactaaga tttgttatat atttaaatag
     4261 ctccaatgtc tcgggagaaa gttttataac tgttatcttt tatacaaaag tagtttatta
     4321 aatatggtaa catgaacata tctaacacgt taatgaaaaa attgtacatc tgttatgtat
     4381 gctatagtaa atatactaaa atttttttct ctcaagtaat aaaaaatcac ttct
//
