LOCUS       NM_011279               1232 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus ring finger protein 7 (Rnf7), transcript variant 1,
            mRNA.
ACCESSION   NM_011279 XM_905787 XM_988710 XM_991223
VERSION     NM_011279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Wang,W., Li,E., Zou,J., Qu,C., Ayala,J., Wen,Y., Islam,M.S.,
            Weintraub,N.L., Fulton,D.J.R., Liang,Q., Zhou,J., Liu,J., Li,J.,
            Sun,Y. and Su,H.
  TITLE     Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination
            and Mitophagy
  JOURNAL   Circ Res 135 (3), e39-e56 (2024)
   PUBMED   38873758
  REMARK    GeneRIF: Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial
            Ubiquitination and Mitophagy.
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Sun,Y., Li,H., Tan,M. and Sun,Y.
  TITLE     Sag/Rbx2 Partial Inactivation Sensitizes Mice to Radiation and
            Radiation-Induced Tumorigenesis1
  JOURNAL   Radiat Res 199 (3), 273-282 (2023)
   PUBMED   36745565
  REMARK    GeneRIF: Sag/Rbx2 Partial Inactivation Sensitizes Mice to Radiation
            and Radiation-Induced Tumorigenesis1.
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Tan,M., Chang,Y., Liu,X., Li,H., Tang,Z., Nyati,M.K. and Sun,Y.
  TITLE     The Sag-Shoc2 axis regulates conversion of mPanINs to cystic
            lesions in Kras pancreatic tumor model
  JOURNAL   Cell Rep 41 (12), 111837 (2022)
   PUBMED   36543126
  REMARK    GeneRIF: The Sag-Shoc2 axis regulates conversion of mPanINs to
            cystic lesions in Kras pancreatic tumor model.
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Han,J.S., Hino,K., Li,W., Reyes,R.V., Canales,C.P., Miltner,A.M.,
            Haddadi,Y., Sun,J., Chen,C.Y., La Torre,A. and Simo,S.
  TITLE     CRL5-dependent regulation of the small GTPases ARL4C and ARF6
            controls hippocampal morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (37), 23073-23084 (2020)
   PUBMED   32873638
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Duan,H., Tsvetkov,L.M., Liu,Y., Song,Y., Swaroop,M., Wen,R.,
            Kung,H.F., Zhang,H. and Sun,Y.
  TITLE     Promotion of S-phase entry and cell growth under serum starvation
            by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component:
            association with inhibition of p27 accumulation
  JOURNAL   Mol Carcinog 30 (1), 37-46 (2001)
   PUBMED   11255262
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Swaroop,M., Wang,Y., Miller,P., Duan,H., Jatkoe,T., Madore,S.J. and
            Sun,Y.
  TITLE     Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell
            growth, but not for germination: chip profiling implicates its role
            in cell cycle regulation
  JOURNAL   Oncogene 19 (24), 2855-2866 (2000)
   PUBMED   10851089
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Sun,Y.
  TITLE     Alterations of SAG mRNA in human cancer cell lines: requirement for
            the RING finger domain for apoptosis protection
  JOURNAL   Carcinogenesis 20 (10), 1899-1903 (1999)
   PUBMED   10506102
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Duan,H., Wang,Y., Aviram,M., Swaroop,M., Loo,J.A., Bian,J.,
            Tian,Y., Mueller,T., Bisgaier,C.L. and Sun,Y.
  TITLE     SAG, a novel zinc RING finger protein that protects cells from
            apoptosis induced by redox agents
  JOURNAL   Mol Cell Biol 19 (4), 3145-3155 (1999)
   PUBMED   10082581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006703.1, AK003248.1, AK011328.1, BF018220.1 and AC161257.2.
            
            On Jul 24, 2015 this sequence version replaced NM_011279.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011127.1, AK146030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AK006703.1         2-81
            81-1161             AK003248.1         2-1082
            1162-1194           AK011328.1         1081-1113
            1195-1231           BF018220.1         1-37                c
            1232-1232           AC161257.2         113635-113635       c
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.63 cM"
     gene            1..1232
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="ring finger protein 7"
                     /db_xref="GeneID:19823"
                     /db_xref="MGI:MGI:1337096"
     exon            1..268
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..435
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /EC_number="2.3.2.27"
                     /EC_number="2.3.2.32"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RING-box protein 2; sensitive to apoptosis gene protein"
                     /codon_start=1
                     /product="RING-box protein 2 isoform 1"
                     /protein_id="NP_035409.1"
                     /db_xref="CCDS:CCDS40730.1"
                     /db_xref="GeneID:19823"
                     /db_xref="MGI:MGI:1337096"
                     /translation="MADVEDGEEPCVLSSHSGSAGSKSGGDKMFSLKKWNAVAMWSWD
                     VECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLC
                     QQDWVVQRIGK"
     exon            269..316
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /inference="alignment:Splign:2.1.0"
     exon            317..1232
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      795..800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="hexamer: AATAAA"
     polyA_site      817
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="major polyA site"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="hexamer: ATTAAA"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="hexamer: AATAAT"
     polyA_site      1228
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
                     /note="major polyA site"
     polyA_site      1232
                     /gene="Rnf7"
                     /gene_synonym="Rbx2; SAG"
ORIGIN      
        1 gggaggctcc gtggcgtgtg ttgtggcccc gctgagccac cgtacctccc gcctccgcgc
       61 ccaacgtccg cgtcgccgtt ctgcgccgcc gccatggccg acgtggagga cggcgaggaa
      121 ccctgcgtcc tttcttcgca ctccgggagc gcaggctcca agtcgggagg cgacaagatg
      181 ttctctctca agaagtggaa cgcggtagcc atgtggagct gggacgttga gtgcgatacc
      241 tgtgccatct gcagggtcca ggtgatggat gcctgccttc gatgtcaagc tgaaaacaag
      301 caagaggact gtgttgtggt ctggggagag tgtaaccatt ccttccacaa ctgctgcatg
      361 tccctgtggg tgaaacagaa caatcgctgc cctctgtgcc agcaggactg ggtagtccaa
      421 agaatcggca aatgagaggt ggcccaggcg ctcctggtgt ggttgctgac cctggacaaa
      481 gactaaacac tgcaggggat tcatccttga gagagagagg atgctgtgcg cctttgagac
      541 tcaccaaagg cttgctttat taatttgtct gtttagtttt gggaaattct ctacaattaa
      601 gataatttgt taaaaatggc ctttcctacc tctggtgtgt gtgtgtgata cgaatgcata
      661 gaagagcgag aacaccagaa aatgatcttt gtttatctgt acccacgact gtgggaacat
      721 tgtgttcaca gaagaacatt gtttgtgttt atgcttgagg gttaaaaaat agataaacga
      781 atgttacagt aacaaataaa atgcattgaa aagccgactc ctcctaatcc tttttgtgtt
      841 gggagagagg caagcgaggc caccctgctg tcttcatttg ctgtgaatga ggattttaac
      901 ctgcactcag tgaagaggcg taactgtcgg gtaaactgta atatggcgta actgtcgggt
      961 aaacggcttt gtctcctgac ttctccatct ttgacttggc caggaagcct ggattgttca
     1021 accacttagt tctaaagaac tgttttctgt ttttgcgaag gttgtattgt atgttttagt
     1081 caaaatatta gtaggaaaat gcttactagt ataacactga agttcattat gcaatgtttt
     1141 aataaaatat tgtgctttga gttattaaag tttgatatat actcttaaaa tcattaaact
     1201 aattcatcaa ttaaataatt tgaaaaaatt aa
//
