LOCUS       NM_028774               3360 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ring finger protein (C3H2C3 type) 6 (Rnf6), transcript
            variant 1, mRNA.
ACCESSION   NM_028774
VERSION     NM_028774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Zhai,D., Wang,W., Ye,Z., Xue,K., Chen,G., Hu,S., Yan,Z., Guo,Y.,
            Wang,F., Li,X., Xiang,A., Li,X., Lu,Z. and Wang,L.
  TITLE     QKI degradation in macrophage by RNF6 protects mice from MRSA
            infection via enhancing PI3K p110beta dependent autophagy
  JOURNAL   Cell Biosci 12 (1), 154 (2022)
   PUBMED   36088389
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Hunter,C.S., Dixit,S., Cohen,T., Ediger,B., Wilcox,C., Ferreira,M.,
            Westphal,H., Stein,R. and May,C.L.
  TITLE     Islet alpha-, beta-, and delta-cell development is controlled by
            the Ldb1 coregulator, acting primarily with the islet-1
            transcription factor
  JOURNAL   Diabetes 62 (3), 875-886 (2013)
   PUBMED   23193182
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Nedelko,T., Kollmus,H., Klawonn,F., Spijker,S., Lu,L., Hessman,M.,
            Alberts,R., Williams,R.W. and Schughart,K.
  TITLE     Distinct gene loci control the host response to influenza H1N1
            virus infection in a time-dependent manner
  JOURNAL   BMC Genomics 13, 411 (2012)
   PUBMED   22905720
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Tursun,B., Schluter,A., Peters,M.A., Viehweger,B., Ostendorff,H.P.,
            Soosairajah,J., Drung,A., Bossenz,M., Johnsen,S.A., Schweizer,M.,
            Bernard,O. and Bach,I.
  TITLE     The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in
            axonal growth cones
  JOURNAL   Genes Dev 19 (19), 2307-2319 (2005)
   PUBMED   16204183
  REMARK    GeneRIF: Rnf6 controls cellular LIMK1 concentrations and indicate a
            new function for the ubiquitin/proteasome system in regulating
            local growth cone actin dynamics
            Erratum:[Genes Dev. 2005 Nov 1;19(21):2643]
REFERENCE   5  (bases 1 to 3360)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3360)
  AUTHORS   Lopez,P., Vidal,F., Martin,L., Lopez-Fernandez,L.A., Rual,J.F.,
            Rosen,B.S., Cuzin,F. and Rassoulzadegan,M.
  TITLE     Gene control in germinal differentiation: RNF6, a transcription
            regulatory protein in the mouse sertoli cell
  JOURNAL   Mol Cell Biol 22 (10), 3488-3496 (2002)
   PUBMED   11971979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY323318.1, AK004745.1 and AV586321.1.
            
            On Jan 4, 2012 this sequence version replaced NM_028774.2.
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004745.1, AY039004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY323318.1         2-21
            21-3342             AK004745.1         1-3322
            3343-3360           AV586321.1         406-423
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.18 cM"
     gene            1..3360
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /note="ring finger protein (C3H2C3 type) 6"
                     /db_xref="GeneID:74132"
                     /db_xref="MGI:MGI:1921382"
     exon            1..238
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            239..321
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            322..517
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2343
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF6; RLIM-like protein;
                     RING-type E3 ubiquitin transferase RNF6"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF6 isoform 1"
                     /protein_id="NP_083050.1"
                     /db_xref="CCDS:CCDS19868.1"
                     /db_xref="GeneID:74132"
                     /db_xref="MGI:MGI:1921382"
                     /translation="MDPSRSRSGGSGEESSFQENERRWQQERLHREEAYYQFINELSD
                     EDYRLMRDHNLLGTPGEITSEELQQRLERAKEQLASQPGSDSAASDGDSESLRAHSDE
                     DSLLRWLNTFRRTGNVTRSGQNGNQSWRAVSRTNPNSGEFGFSLEIHINPDNRGSEMH
                     GEDSTDIPLSGVNREHRQQRPSSPVARRTRSQTSMSSSGPRGRRGARRQGSVQGSFAT
                     LGRLRNGIGVALGVPRVSAPRTNVINSHTNQSDGSTLRQGGRQRFGAAHIWENGARSN
                     VTVRNTNQRLEPIRLRPAFSSRSRSPIQRQNGTVHHNSQRQGRPVQQTGRNRSVRHRG
                     VTRVFLEQGREHRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQVRRI
                     RPGETRDRDSIANRTRSRAGLAESTVESTSGGFHRTISHLERSGVRTYVSTITVPLRR
                     ISENDVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNGQRLPEVYLELSNGD
                     AADDSGQHGRASSQASQAQDGAEMLAVREPAPPQARPSGSRSRRQLGRADSVVEAGTL
                     PILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQDGVDSELGKVCSVCISDYVAG
                     NKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLEFGATSSG"
     exon            518..613
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..3353
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3322..3327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3346
                     /gene="Rnf6"
                     /gene_synonym="1200013I08Rik; 5730419H05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttccggggag cgccgtttcc agacgcaccg gcagggtcgc tgcagacggt ggccagtctt
       61 agttctccga ggcggtgcga gaaggccgga gatcggacgc tcctctctta gctttctctc
      121 cgccaggtcg actccgagca gcaacacaga ctctgagctt cgcgcctcag gggaagatta
      181 gagggcgtag cggccttcga aggctcggcc aagaaccttc cgccccctcg ccgcctcgat
      241 gagcagctct caaaagaggc acaaacatca gaagcatgga tacagtctca tctgttagaa
      301 gaatgttcaa aggaaaataa ggaaactaga agtctcagga tggatccgtc tagatctaga
      361 tcaggtggga gtggagaaga gagctcattt caagaaaatg agagaagatg gcagcaagaa
      421 cgtctccaca gagaagaagc ctattatcag tttattaatg agctcagtga tgaagattat
      481 cggctaatga gagaccataa tcttttaggc acccctggag aaataacatc agaggagctg
      541 cagcagcgct tagagagagc aaaggaacag ctggcatctc agcctggctc tgacagcgcg
      601 gcaagtgatg gagactcaga aagccttaga gcacattcag atgaggactc tctgctgcga
      661 tggctgaata cctttcggcg cactgggaat gtgactcgaa gcggacagaa tgggaaccaa
      721 agctggaggg ccgtgagtcg aacaaacccg aacagtggcg agttcgggtt tagcctggaa
      781 atccacataa accctgacaa cagaggttct gaaatgcatg gagaggactc gacggacatc
      841 cctctgtcag gtgttaacag agagcatagg cagcaaagac catcgagtcc tgtggctagg
      901 cgaaccagaa gccagacctc catgagctcc agtggtccta ggggcaggcg tggtgcgagg
      961 aggcagggtt ctgtgcaagg gtcatttgca actctgggaa ggttaaggaa tggaattgga
     1021 gtagcccttg gtgttcccag agttagtgcc cctcgcacta atgttattaa ttcccacacc
     1081 aaccagtcag atggtagtac tctcaggcaa ggtggacggc agcggtttgg agcagcacat
     1141 atttgggaaa acggggctag aagtaatgtt acagtgagga acacaaacca aagattagag
     1201 ccaataagat tacgtcctgc tttcagtagt cgaagccggt cccccattca gagacagaat
     1261 ggtactgttc atcataattc ccaaaggcag ggtagaccag tacagcaaac gggtagaaac
     1321 aggtctgtta ggcacagagg tgtaacgcgg gtctttttag aacaaggtag agaacacaga
     1381 ggcactgatt acaccccgct gtccaactca agacttgtgt caagaataac agtagaagag
     1441 ggagagtcta gcaggtcctc agctgccacc cagcgtcatc cagcaatcac actggacctg
     1501 caagtcagga ggattcggcc tggagaaact agagataggg atagcattgc aaatagaacc
     1561 cgatctaggg cggggctggc agaaagtacg gttgagagca ccagtggggg cttccacaga
     1621 actatctctc acttagagcg ctcaggtgtc cgaacctacg tgagcaccat cacagttcct
     1681 cttcgcagga tttctgagaa tgacgtggtc gagccatcct ccgtggctct tcggtcaatt
     1741 ttaaggcaga tcatgactgg gtttggagag ctgagttctc taatggaggt ggagcctgcg
     1801 tcagagaatc aaagcaatgg ccaacgttta ccagaggtgt acctagaact gagtaatgga
     1861 gatgcagccg atgacagtgg tcagcatgga agagcgtcct cacaggccag tcaggcccag
     1921 gacggtgctg aaatgctagc tgtgagggag cccgccccgc cccaggctcg ccccagtggc
     1981 agtagaagta gaaggcagtt aggaagggcg gacagcgtag ttgaggctgg aacattaccc
     2041 attctgcgcc ttgctcactt cttcttactg aatgaaggcg atgatgatcc aattcgtggt
     2101 ttaaccaaag agcagattga caatctttct accaggagtt atgaacaaga cggggttgac
     2161 agtgagttag gtaaggtgtg tagcgtgtgc atcagtgact acgtggctgg gaacaagctc
     2221 cggcagctgc cttgtctgca cgagtttcac attcactgta ttgatcgctg gctgtcggag
     2281 aactgcacct gccccgtctg tcggcggcct gtcttagaat tcggagccac aagcagtggg
     2341 tgagaggtgg ggtctgctca gcgctgtgtt gctggagctt catagtcaaa cgcttttctt
     2401 gagttacttg tgatcaggta accaaggcaa aaaaaaaaca aaaaacaaaa aaacctatca
     2461 gattatagtt tgcactattt tttgtgtgct tttttttaaa acttgttaca gagtttgttt
     2521 atataaaaaa atttaaaatg cagatgttaa attatccaaa agtaaagaat agttaatatt
     2581 gctagaacca aataaccttt aaaatgtttt tattttggta attttgtcat gctaagcact
     2641 tttgtatgtt agggatcttg agtctttctc ctaatactgc agtagggatg gctgggattt
     2701 tccagtttga gctcagtgct ttgtttagac actactgtct ggtctttgta gactgttagg
     2761 gtgaatgtct gctagataga cttaagttac ttgaaatgat aatttaactt gtggcacact
     2821 ctatgtgtgt atgcaggtat gtaactgtgg gaacatatcc aggctaaaaa ctctaagctt
     2881 gagacttaag cttcggggct tagactgcat atggtacagt gtaaacagtg acaagatcat
     2941 ctccacgagg aagtgaatta agatacagtt ttaagataga gattgtttac tgaagcgtgt
     3001 ctgacaatct gacttaatag agagcgagcg acatacaata atgaacctag tatttcttta
     3061 ttcatggaat gtggaaattt tatgacaggt agttttaagt tcgtcttttt tgtgattttt
     3121 tttttttaga agtacaaata cttcttgggg ttaggtaggg tttacagcat gcttgatttt
     3181 tcaaagttag ttttaaaatc taaaatactt taaagtctat aaagtagtga aatgcataga
     3241 aaatatgtaa atttggatgc ccaaaagctc caaataaaag cctttaaaag aacatagagt
     3301 ttatataaac acaaagtatg cattaaagtc tatttctacc agtaaacact aaaaaaaaaa
//
