LOCUS       NM_019403               1101 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 5 (Rnf5), mRNA.
ACCESSION   NM_019403
VERSION     NM_019403.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Yang,L.L., Xiao,W.C., Li,H., Hao,Z.Y., Liu,G.Z., Zhang,D.H.,
            Wu,L.M., Wang,Z., Zhang,Y.Q., Huang,Z. and Zhang,Y.Z.
  TITLE     E3 ubiquitin ligase RNF5 attenuates pathological cardiac
            hypertrophy through STING
  JOURNAL   Cell Death Dis 13 (10), 889 (2022)
   PUBMED   36270989
  REMARK    GeneRIF: E3 ubiquitin ligase RNF5 attenuates pathological cardiac
            hypertrophy through STING.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Ding,M.J., Fang,H.R., Zhang,J.K., Shi,J.H., Yu,X., Wen,P.H.,
            Wang,Z.H., Cao,S.L., Zhang,Y., Shi,X.Y., Zhang,H.P., He,Y.T.,
            Yan,B., Tang,H.W., Guo,D.F., Gao,J., Liu,Z., Zhang,L., Zhang,S.J.,
            Zhang,X.J. and Guo,W.Z.
  TITLE     E3 ubiquitin ligase ring finger protein 5 protects against hepatic
            ischemia reperfusion injury by mediating phosphoglycerate mutase
            family member 5 ubiquitination
  JOURNAL   Hepatology 76 (1), 94-111 (2022)
   PUBMED   34735734
  REMARK    GeneRIF: E3 ubiquitin ligase ring finger protein 5 protects against
            hepatic ischemia reperfusion injury by mediating phosphoglycerate
            mutase family member 5 ubiquitination.
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Kong,Z., Yin,H., Wang,F., Liu,Z., Luan,X., Sun,L., Liu,W. and
            Shang,Y.
  TITLE     Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit
            STING-mediated antiviral immunity
  JOURNAL   PLoS Pathog 18 (5), e1010544 (2022)
   PUBMED   35584187
  REMARK    GeneRIF: Pseudorabies virus tegument protein UL13 recruits RNF5 to
            inhibit STING-mediated antiviral immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Khateb,A., Deshpande,A., Feng,Y., Finlay,D., Lee,J.S., Lazar,I.,
            Fabre,B., Li,Y., Fujita,Y., Zhang,T., Yin,J., Pass,I., Livneh,I.,
            Jeremias,I., Burian,C., Mason,J.R., Almog,R., Horesh,N., Ofran,Y.,
            Brown,K., Vuori,K., Jackson,M., Ruppin,E., Deshpande,A.J. and
            Ronai,Z.A.
  TITLE     The ubiquitin ligase RNF5 determines acute myeloid leukemia growth
            and susceptibility to histone deacetylase inhibitors
  JOURNAL   Nat Commun 12 (1), 5397 (2021)
   PUBMED   34518534
  REMARK    GeneRIF: The ubiquitin ligase RNF5 determines acute myeloid
            leukemia growth and susceptibility to histone deacetylase
            inhibitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Morito,D., Hirao,K., Oda,Y., Hosokawa,N., Tokunaga,F., Cyr,D.M.,
            Tanaka,K., Iwai,K. and Nagata,K.
  TITLE     Gp78 cooperates with RMA1 in endoplasmic reticulum-associated
            degradation of CFTRDeltaF508
  JOURNAL   Mol Biol Cell 19 (4), 1328-1336 (2008)
   PUBMED   18216283
  REMARK    GeneRIF: revealed by small interfering RNA methods that the
            ubiquitin ligase RMA1 functioned as an E3 enzyme upstream of gp78
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Delaunay,A., Bromberg,K.D., Hayashi,Y., Mirabella,M., Burch,D.,
            Kirkwood,B., Serra,C., Malicdan,M.C., Mizisin,A.P., Morosetti,R.,
            Broccolini,A., Guo,L.T., Jones,S.N., Lira,S.A., Puri,P.L.,
            Shelton,G.D. and Ronai,Z.
  TITLE     The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative
            myopathy in transgenic mice and is deregulated in inclusion body
            myositis
  JOURNAL   PLoS One 3 (2), e1609 (2008)
   PUBMED   18270596
  REMARK    GeneRIF: importance of RNF5 in muscle physiology and its
            deregulation in ER stress associated muscular disorders
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Didier,C., Broday,L., Bhoumik,A., Israeli,S., Takahashi,S.,
            Nakayama,K., Thomas,S.M., Turner,C.E., Henderson,S., Sabe,H. and
            Ronai,Z.
  TITLE     RNF5, a RING finger protein that regulates cell motility by
            targeting paxillin ubiquitination and altered localization
  JOURNAL   Mol Cell Biol 23 (15), 5331-5345 (2003)
   PUBMED   12861019
  REMARK    GeneRIF: RNF5 regulates cell motility by targeting paxillin
            ubiquitination and altered localization
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Trachtulec,Z. and Forejt,J.
  TITLE     Synteny of orthologous genes conserved in mammals, snake, fly,
            nematode, and fission yeast
  JOURNAL   Mamm Genome 12 (3), 227-231 (2001)
   PUBMED   11252172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT009767.6.
            
            On Nov 17, 2006 this sequence version replaced NM_019403.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016449.1, AK020514.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               CT009767.6         160761-160988       c
            229-247             CT009767.6         159718-159736       c
            248-360             CT009767.6         159512-159624       c
            361-415             CT009767.6         159361-159415       c
            416-533             CT009767.6         159168-159285       c
            534-1101            CT009767.6         158526-159093       c
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.18 cM"
     gene            1..1101
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /note="ring finger protein 5"
                     /db_xref="GeneID:54197"
                     /db_xref="MGI:MGI:1860076"
     exon            1..228
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..247
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..360
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..415
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..533
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..1101
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /note="hexamer: AATAAA"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
     polyA_site      1097
                     /gene="Rnf5"
                     /gene_synonym="2410131O05Rik; NG2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgcctgt gtgtgtgccc tgtgttagtg tatatgtgtg tgtgcctggg ggtactgagg
       61 gctacgtggg ggcgaagcag aacttgccat ggcagcagcg gaggaagaag acgggggccc
      121 cgaagggcca aatcgcgagc ggggcggggc gagcgcgacc ttcgaatgta atatatgtct
      181 ggagacagct cgcgaagctg tggtcagcgt gtgtggccac ctgtattgtt ggccctgtct
      241 tcaccagtgg ctggagaccc ggccagaccg gcaagaatgc ccggtgtgta aagctggcat
      301 cagcagggag aaggtcgtcc ctctttatgg gcgagggagc cagaagccac aggatcccag
      361 attgaaaact ccaccccgcc ctcagggcca gcgaccagct ccagagagca gaggggggtt
      421 ccagccattt ggtgatgccg ggggattcca cttctccttt ggtgtcggtg ccttcccctt
      481 tggctttttc accaccgtgt tcaatgccca tgaacctttc agaagaggcg caggtgtgga
      541 tctgggacag ggtcacccag cctccagctg gcaagattcc ctattcctgt tcctcgccat
      601 ctttttcttt ttctggctgc tcagtatttg agctctgtct cctccctgcc cacctccagc
      661 tagaggagaa tcagtattgg gagtcctgtg ctggcctttc cttgcttttg gaccaccccc
      721 ttacttccat gacccatctc tgtctgctga ggcctctctc ttgggagggc atggcgagga
      781 gtgaccagtc tgcttaagat gggagtgcct gctgctgtgt actgctggcc cagtagcaca
      841 gacactgtca gcctggagga cggacagaca gacaggtgtc cagttctacc aatcctttgc
      901 tttcccccag atttcttgat ttggtgttta aaggtgggct ctccccaact cctctacttg
      961 acttaattta atttttctct acccactgtc taatatgaat tttgactctt gaagtgtctc
     1021 tttccatccc tcactacctc ctttaattac aaattcaaat aataataata ataataaaaa
     1081 taaaaataaa ggtgaaacac g
//
