LOCUS       NM_172448               4311 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus ring finger protein 43 (Rnf43), transcript variant 1,
            mRNA.
ACCESSION   NM_172448
VERSION     NM_172448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4311)
  AUTHORS   Araki,T. and Miwa,N.
  TITLE     Selective epigenetic alterations in RNF43 in pancreatic exocrine
            cells from high-fat-diet-induced obese mice; implications for
            pancreatic cancer
  JOURNAL   BMC Res Notes 17 (1), 106 (2024)
   PUBMED   38622664
  REMARK    GeneRIF: Selective epigenetic alterations in RNF43 in pancreatic
            exocrine cells from high-fat-diet-induced obese mice; implications
            for pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4311)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4311)
  AUTHORS   Nag,J.K., Appasamy,P., Sedley,S., Malka,H., Rudina,T. and
            Bar-Shavit,R.
  TITLE     RNF43 induces the turnover of protease-activated receptor 2 in
            colon cancer
  JOURNAL   FASEB J 37 (1), e22675 (2023)
   PUBMED   36468684
  REMARK    GeneRIF: RNF43 induces the turnover of protease-activated receptor
            2 in colon cancer.
REFERENCE   4  (bases 1 to 4311)
  AUTHORS   Li,X., Pan,K., Vieth,M., Gerhard,M., Li,W. and Mejias-Luque,R.
  TITLE     JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter
            pylori Infection and Contributes to Immune Escape and Gastric
            Carcinogenesis
  JOURNAL   Int J Mol Sci 23 (8), 4147 (2022)
   PUBMED   35456965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4311)
  AUTHORS   Zhou,X., Sun,Z., Zhang,M., Qu,X., Yang,S., Wang,L., Jing,Y., Li,L.,
            Deng,W., Liu,F., Di,J., Chen,J., Wu,J. and Zhang,H.
  TITLE     Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic
            preneoplasia initiation and malignant transformation
  JOURNAL   Animal Model Exp Med 5 (1), 61-71 (2022)
   PUBMED   35229994
  REMARK    GeneRIF: Deficient Rnf43 potentiates hyperactive Kras-mediated
            pancreatic preneoplasia initiation and malignant transformation.
REFERENCE   6  (bases 1 to 4311)
  AUTHORS   Koo,B.K., van Es,J.H., van den Born,M. and Clevers,H.
  TITLE     Porcupine inhibitor suppresses paracrine Wnt-driven growth of
            Rnf43;Znrf3-mutant neoplasia
  JOURNAL   Proc Natl Acad Sci U S A 112 (24), 7548-7550 (2015)
   PUBMED   26023187
REFERENCE   7  (bases 1 to 4311)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4311)
  AUTHORS   Koo,B.K., Spit,M., Jordens,I., Low,T.Y., Stange,D.E., van de
            Wetering,M., van Es,J.H., Mohammed,S., Heck,A.J., Maurice,M.M. and
            Clevers,H.
  TITLE     Tumour suppressor RNF43 is a stem-cell E3 ligase that induces
            endocytosis of Wnt receptors
  JOURNAL   Nature 488 (7413), 665-669 (2012)
   PUBMED   22895187
  REMARK    GeneRIF: RNF43 and ZNRF3 reduce Wnt signals by selectively
            ubiquitinating frizzled receptors, thereby targeting these Wnt
            receptors for degradation
REFERENCE   9  (bases 1 to 4311)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 4311)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032782.1, BC131957.1 and CF747567.1.
            
            On May 18, 2018 this sequence version replaced NM_172448.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-881               AK032782.1         2-882
            882-4154            BC131957.1         1-3273
            4155-4311           CF747567.1         331-487
FEATURES             Location/Qualifiers
     source          1..4311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.17 cM"
     gene            1..4311
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /note="ring finger protein 43"
                     /db_xref="GeneID:207742"
                     /db_xref="MGI:MGI:2442609"
     exon            1..136
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            137..868
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..2971
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase RNF43; RING-type E3
                     ubiquitin transferase RNF43"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF43 isoform 1
                     precursor"
                     /protein_id="NP_766036.2"
                     /db_xref="CCDS:CCDS25215.2"
                     /db_xref="GeneID:207742"
                     /db_xref="MGI:MGI:2442609"
                     /translation="MSGGHQLQLAVLWPWLLMATLHAGFGHTGRVLAAAVESERSAEQ
                     KAVIRVIPLKMDPTGKLNLTLEGVFAGVAEVTPAEGKLMQSHPLYLCNASDDDNLEPG
                     FISIVKLESPRRAPRPCLSLASKARMAGERGANAVLFDITEDRSAAEQLQQPLGLTKP
                     VVLIWGSDAAKLMEFVYKNRKAYVWIELKEPPAGANYDVWILLTVVGTVFVIILASVL
                     RIRCRPHHSRPDPLQQRTARAISQLATRRYQAGCRRARAEWPDSGSSCSSTPVCAICL
                     EEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGDSFSQAPAASPSYQE
                     PGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPFLPSQEPSMGSRHQRLPR
                     TSHLRAPEEQQHLAVSPHPYAQGWGLNRLRCTSQHPAACPVALRRARPHESSGSGESY
                     CTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDVSLQGIHGSSSTFRSSLSSDFDPL
                     VYCSPEGDLQGKGIQPSVTSRPRSLDSVVPRGETQVSSHIHYHRHRHHHYKRQFQWHG
                     RKPGPETGIPQSMPAASHTQLEPSLPDQQLITPNPTASSMLPNPQRPRALTEPAPGLA
                     EASSPSPSPKPNPSGLLNLQKSSLTVRHPHRKRRGGPSEPLPTSLPPDLTVHTACPVF
                     PHYSPRLAYPWPPEVHPLMFRPPGPDRRLLHEVPGPCYSSSQPVWLYLNPCQPLGPCL
                     PGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGSEEELEELCEQAV"
     exon            869..991
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1066
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1198
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1303
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1465
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1568
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..2927
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..4311
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4289..4294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /note="hexamer: AATATA"
     polyA_site      4311
                     /gene="Rnf43"
                     /gene_synonym="4732452J19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagtgagaa ggtggaagcc ggagccgtac tgggttaagc agctcaggtc tttttttaaa
       61 gcaggattta taaatgcaca attgaatttg tttcatcccc gtgccgtgga ctccagtggg
      121 cccgacagcg caacagggca gcatgtcttc gtgttctgag ctgaagttcc tccctcacct
      181 ccgatgcgct gctttagccg tttactgacc ttgttttctt catcggcctc gggtttagtg
      241 cctcaggaat ctgatacata tggaagacca gcagcaagtg atctgacata ataccaatcc
      301 atgtttgtat ctaaagcaca tttggaaatt ccaaagagaa gaggtggcat ttctgtattc
      361 gcagtgacga tgggagaaaa ggacatacct gccccagagg tgggctgaaa aggccatctt
      421 ctgctcccaa tcaggaatac cccctgtgct tgggaatcta cgttagaaaa aggaaggacc
      481 agaatctgac ttggctctct gaaacggagg gctagcactt ctccccattc gttttctgca
      541 ttgaggacct gcctttggga tgagctggta gtagaagcgg tatgcatggc cgaagagcat
      601 tgatgcagct ggtagcatga gtggtggcca ccagctgcag ctggctgtcc tctggccctg
      661 gctgctgatg gcaaccctgc acgcaggctt cggacacaca ggacgggtgc tggcggcggc
      721 agtggagtcc gaaagatcag cagaacagaa agctgttatc agagtgatcc ccttgaaaat
      781 ggaccccaca ggaaaactga acctcacttt ggaaggcgtg tttgctggtg ttgcagaagt
      841 gactccagca gaagggaagc taatgcagtc ccaccccctg tacctgtgca acgccagtga
      901 tgacgacaac cttgagcctg ggttcatcag catcgtcaag ctggagagcc ctcgacgagc
      961 tcctcgcccc tgcctgtcac tggccagtaa ggcccgaatg gctggtgagc gaggagccaa
     1021 cgcagtactc tttgacatca ccgaggatcg atcagctgct gagcagctgc agcagcccct
     1081 ggggctgact aagccagtgg tgctgatctg gggtagtgat gctgcgaagc tgatggagtt
     1141 tgtgtacaag aatcggaagg cctatgtgtg gattgagctg aaggagcccc ccgccggggc
     1201 aaactatgac gtgtggatcc tcctgaccgt ggtgggtacc gtctttgtga tcatcctggc
     1261 ctcagtgctg cgcatcaggt gccgccccca ccatagcaga ccggatcctc ttcagcagcg
     1321 gacagcccgg gccatcagcc agctggccac caggaggtac caagccggct gtagacgagc
     1381 ccgagccgag tggccagact cggggagtag ctgcagctcg acccccgtgt gtgccatctg
     1441 tctagaagag ttctcagagg ggcaggagct ccgggtcatt tcgtgcctcc acgagtttca
     1501 tcgaacgtgt gtggacccct ggctatacca gcatcggact tgccccctct gcatgttcaa
     1561 catcgtagag ggagattcat tttcccaggc cccggcagcc tctccatctt accaggaacc
     1621 aggcagaaga ctccacctca ttcgccagca tcctggccac gcccactatc atcttccttc
     1681 tgcctatctg ttggggcctt ccaggacttc agtcgcccgg accccaagac ctagaccctt
     1741 tctgccctcc caggagccaa gcatgggctc tcggcatcag cgccttccca ggacttcaca
     1801 tctccgggcc ccagaagaac agcagcactt ggcggtatct ccacacccct atgcacaggg
     1861 ctgggggctg aatcgcctcc gatgtacctc tcagcatcct gcagcttgcc cagtggccct
     1921 acgacgggcc aggcctcatg agagcagcgg gtctggagaa agctactgta cagaacgcag
     1981 cggttacttg gcagatgggc cagccagtga ctccagctca gggccctgtc acggctcatc
     2041 cagtgactcg gtggtcaact gcacggacgt cagcctgcag ggcatccacg gcagcagctc
     2101 caccttccga agctccctga gcagtgactt tgaccccttg gtatactgta gtcctgaagg
     2161 ggatctccaa gggaaaggga tacaacctag tgtgacctct cgaccccgct cgctggactc
     2221 agtggtaccc aggggagaga cccaggtttc cagccacata cactatcacc ggcaccgcca
     2281 ccaccactac aaaaggcagt tccagtggca tggcaggaag cctggcccag aaactgggat
     2341 cccacagtcc atgcctgctg cttctcacac tcagctggag ccatctctcc ctgaccagca
     2401 gctcatcaca cccaacccaa cagcttcttc aatgcttccc aacccacaac ggcccagggc
     2461 tcttacagag ccagcccctg gcctagcaga agcttccagc cctagcccca gtcccaaacc
     2521 taaccccagc ggtcttttga acttgcagaa atccagcctc actgtcagac acccacacag
     2581 aaaacggcgg ggtggtccct cagaacccct gccaacctct ctgcccccgg acttgactgt
     2641 gcacactgct tgcccggttt tcccccacta cagtccccgt ctggcatacc cttggccccc
     2701 agaggttcat ccattgatgt tcagacctcc aggtccggat aggaggctgc tacatgaagt
     2761 cccaggcccc tgttactcaa gttcacagcc agtgtggttg tatctgaatc cctgccagcc
     2821 tctgggacca tgcttacctg gagagggaca ttccaagtgg acttttgaca gcccagaggg
     2881 caggagatgt ccttactcac attgccaggt gctgccagcc caacctggct cggaagagga
     2941 gctggaggag ctgtgcgagc aggctgtgtg acgtgagctg gtcagatgaa gcttcgatgg
     3001 cgagtgtgct ccagatggct cagggttcga cctggccccg gggtcccgct cctgggagga
     3061 gcaggaccac agcaagcatc tcctttcgcc atgcttcctg ggaccactgg aaggagagtg
     3121 ctgatggcga gtgcaggcgg gaggtgctat ttcctgcccc agctcccaag cttgtctgca
     3181 gaacacacct acagtgcaga aagtcttgtg tccagccagc cagccagcca gccagtatcc
     3241 agtatgcatt tgtggggtag actcctcaag gctgagtttt tgacaggaag ctataagtga
     3301 atatctagat gtaaaggtgc tgctctttcc tcaagccccg ctgggtctcc ccctgctggg
     3361 tctcctctgc cccagcttca agctcacaca agccagtggg ttcactgaag gcgagatcac
     3421 gtctcacctc ctttcaaggc ttcactgggg gcaacttcag ctatatcatt tcctgtcttc
     3481 tacaaaagaa gaaggagttt aggtgagccc cagtcccaag agaggtctct ctgtaccttc
     3541 tccctggctg gtgctcaggg aggagcggtt cttccttcct gttcttacac caatcttagc
     3601 ctgcaggctt ggggagccaa ggaatagagg tctgtcccag aggtggggac tgttacagac
     3661 ctgcctggga tgaatctttt gattatcaaa ctccttgtca ctcgggtaac tccagttcct
     3721 ctgaggtaga gaccaggaat ggaggggaat caatactcca agctttcctc cctccaagtc
     3781 caaggcaggc agaaaggaag tctactaaac tgcacctggg aagaggggga atgggatgaa
     3841 ggcagaggag gcacaactac aggagtcctc tctgagaggt tcttggagca gagatggaga
     3901 atggcgacat gtaacctcgt gggtctgcag ggcccggagg cccaccttcc cagtgtaagc
     3961 catacaaaac cagcaaccca actgaaggtg tgcaagtggg agtggagcag aaagttggcc
     4021 cgggcagctt gtaccacgtg ggtaagggct gatggtgcct cctgtggctt tgtcccagca
     4081 tcctgaccac tgtcagcccc tcaggcagta tccttgcctg caatgtgaag gtgggggcaa
     4141 aatggacatg ggatcctcct tgggaacctt ctctcctcag agtcaatggg gagactggca
     4201 tccaggcacc cacatgggta tttatatctg aaccagacag aaagatgctt gaatcaggca
     4261 ctatgttgaa aaaatgtatt tatttgctaa tatatttatc cataaatatg a
//
