LOCUS       NM_001164237            4394 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus ring finger protein 41 (Rnf41), transcript variant 1,
            mRNA.
ACCESSION   NM_001164237
VERSION     NM_001164237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4394)
  AUTHORS   Li,Q.Q., Guo,M., He,G.H., Xi,K.H., Zhou,M.Y., Shi,R.Y. and
            Chen,G.Q.
  TITLE     VEGF-induced Nrdp1 deficiency in vascular endothelial cells
            promotes cancer metastasis by degrading vascular basement membrane
  JOURNAL   Oncogene 43 (24), 1836-1851 (2024)
   PUBMED   38654108
  REMARK    GeneRIF: VEGF-induced Nrdp1 deficiency in vascular endothelial
            cells promotes cancer metastasis by degrading vascular basement
            membrane.
REFERENCE   2  (bases 1 to 4394)
  AUTHORS   Wu,X., Chen,Z., Chen,Q., Lin,C., Zheng,X. and Yuan,B.
  TITLE     Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional
            Recovery in Mice with Mild Neurological Impairment after
            Intracerebral Hemorrhage
  JOURNAL   Neuroscience 545, 16-30 (2024)
   PUBMED   38431041
  REMARK    GeneRIF: Nrdp1-mediated Macrophage Phenotypic Regulation Promotes
            Functional Recovery in Mice with Mild Neurological Impairment after
            Intracerebral Hemorrhage.
REFERENCE   3  (bases 1 to 4394)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4394)
  AUTHORS   Zong,C.Y., Ji,Q.Q., Chen,F.F., Yang,J.J., Zhou,H., Zhu,B.F. and
            Zhou,G.X.
  TITLE     Correlation between neuregulin receptor degradation protein-1 and
            Crohn's disease
  JOURNAL   J Physiol Pharmacol 75 (1) (2024)
   PUBMED   38583443
  REMARK    GeneRIF: Correlation between neuregulin receptor degradation
            protein-1 and Crohn's disease.
REFERENCE   5  (bases 1 to 4394)
  AUTHORS   Luo,Z.Y., Jiang,T.X., Zhang,T., Xu,P. and Qiu,X.B.
  TITLE     Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome
            Biogenesis and Mitochondrial Arrangement during Spermiogenesis
  JOURNAL   Cells 12 (18), 2211 (2023)
   PUBMED   37759433
  REMARK    GeneRIF: Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated
            Acrosome Biogenesis and Mitochondrial Arrangement during
            Spermiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4394)
  AUTHORS   Wu,X., Yen,L., Irwin,L., Sweeney,C. and Carraway,K.L. 3rd.
  TITLE     Stabilization of the E3 ubiquitin ligase Nrdp1 by the
            deubiquitinating enzyme USP8
  JOURNAL   Mol Cell Biol 24 (17), 7748-7757 (2004)
   PUBMED   15314180
REFERENCE   7  (bases 1 to 4394)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4394)
  AUTHORS   Qiu,X.B. and Goldberg,A.L.
  TITLE     Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and
            degradation of the epidermal growth factor receptor family member,
            ErbB3
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14843-14848 (2002)
   PUBMED   12411582
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17220.]
REFERENCE   9  (bases 1 to 4394)
  AUTHORS   Ogino,Y., Suzuki,K., Haraguchi,R., Satoh,Y., Dolle,P. and Yamada,G.
  TITLE     External genitalia formation: role of fibroblast growth factor,
            retinoic acid signaling, and distal urethral epithelium
  JOURNAL   Ann N Y Acad Sci 948, 13-31 (2001)
   PUBMED   11795391
REFERENCE   10 (bases 1 to 4394)
  AUTHORS   Abdullah,J.M., Li,X., Nachtman,R.G. and Jurecic,R.
  TITLE     FLRF, a novel evolutionarily conserved RING finger gene, is
            differentially expressed in mouse fetal and adult hematopoietic
            stem cells and progenitors
  JOURNAL   Blood Cells Mol Dis 27 (1), 320-333 (2001)
   PUBMED   11358394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045760.1, AK028551.1 and BC049078.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript which encodes a functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.105364.1,
                                           SRR1660821.132955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AK045760.1         1-130
            131-3270            AK028551.1         2-3141
            3271-4394           BC049078.1         2177-3300
FEATURES             Location/Qualifiers
     source          1..4394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.55 cM"
     gene            1..4394
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="ring finger protein 41"
                     /db_xref="GeneID:67588"
                     /db_xref="MGI:MGI:1914838"
     exon            1..210
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..393
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..506
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1370
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase NRDP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NRDP1"
                     /protein_id="NP_001157709.1"
                     /db_xref="CCDS:CCDS24277.1"
                     /db_xref="GeneID:67588"
                     /db_xref="MGI:MGI:1914838"
                     /translation="MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACIT
                     QWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSH
                     LSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHK
                     HQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMI
                     STPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYV
                     AKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
     exon            507..778
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..914
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1018
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..4377
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="hexamer: AAGAAA"
     polyA_site      1692
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="major polyA site"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="hexamer: AAGAAA"
     polyA_site      2358
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="major polyA site"
     regulatory      3253..3258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="hexamer: AATAAA"
     polyA_site      3277
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
     regulatory      4334..4339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /note="hexamer: AATATA"
     polyA_site      4375
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
ORIGIN      
        1 gagcttccgc cccgttgcgt agcagcagtg ggcgtggcta agggctaacc cgagacagcg
       61 aggagtggtc ggaaccttct tccccatcct taccttcccc ttcccctacg gggaaaggct
      121 gagaccgggc acacagtgtg ctacgcggcc gccgtgtcct cagctgcagc caggccccgc
      181 gtccggagaa accaggctgc gttccgggtg agcgttcctg attgtgacat cacacccacc
      241 tctgggccat gagacttgtc actaggaaga aagactcagt tggagaatag ccaacaagat
      301 gggatactca gagcatctcc tgagcggcac tgagcggagg caccaggggg ttggaacctt
      361 gtgaacaggg aacctgcccc caccacttaa aaggacctgg gtttcagtga tgagacatgg
      421 ggtatgatgt gacccgtttc cagggggacg ttgacgagga ccttatctgc cctatttgca
      481 gtggagtctt ggaggagcca gtgcaggcgc ctcattgtga gcatgccttc tgcaacgcct
      541 gcatcaccca atggttctct cagcagcaga cgtgtccggt agaccgtagc gttgtcacgg
      601 ttgcccacct gcgcccagta cctcggatca tgcggaacat gttgtcaaag ctacagattg
      661 cctgtgacaa cgctgtgttt ggctgcagtg ctgttgtcag gcttgacaac ctcatgtccc
      721 acctcagtga ctgtgagcac aacccgaagc ggcctgtgac ctgtgagcag ggctgtggcc
      781 tggagatgcc caaagatgaa ctgccaaacc acaattgcat taagcacctg cgctccgtgg
      841 tccagcagca gcagtcgcgc attgcagagc tggagaagac ctcggctgaa cacaagcacc
      901 agctggcaga gcagaagcga gacattcagc tgctgaaggc gtatatgcga gccatccgca
      961 gtgtcaaccc caaccttcag aacctggagg agacaatcga atacaatgag atcctcgagt
     1021 gggtgaactc cctgcagccg gcaagggtga cccgctgggg gggcatgatc tccactcctg
     1081 atgctgtgct ccaggctgtc atcaagcgct ccctcgtgga aagtggctgc ccggcctcca
     1141 tcgtcaacga gctgattgaa aatgcccatg aacgcagctg gccccagggt ctggccacac
     1201 tagagacaag acagatgaac cggcgctact atgagaacta cgtggccaag cgcatccctg
     1261 gcaagcaggc tgtagtggtg atggcctgtg agaaccagca catgggggac gacatggtgc
     1321 aggagccagg gctcgtcatg atatttgcgc atggtgtgga ggagatataa gagcgtaact
     1381 ggctgtcagg aagaggtaga gttggaaaac ccattgctcc agcagctgag ccctgacttc
     1441 tcccacagcc cttatgccgc ggcttgtacc tgagccacgt actccctgct tctggcatga
     1501 aggactttgg ggcacttagc tcagcctttc agcggagaac ccagattcct gccttttgct
     1561 atattctttc ccccacaatg tctgtaaatt ttcagtcagg gtggagaaat ccccacttct
     1621 gtattttcct gactaagatc ccctggttcc caaatatttt cagaaagcac aaagaaattt
     1681 gttttcccta gaggatcagg gtagagtgag gcatttctaa ttgtctatct cttccaaaac
     1741 cagggagtcc cagcaggcag gagtcccagc aggcaggctt gctgaagtca cgcagcattg
     1801 agagctgctc tgaggagcca gcacctggca gaagggctga gggtgtggcc caaaccctct
     1861 aaccagtgag gccaaagcct ggtcctcacg cgcatccctg tccaggccgc tgtgaaggtg
     1921 caggccttga tgggtgcgca gggtggcccc tgtgagggtg cacagggtgg gttgttgaaa
     1981 tgttgctgaa ctctttccta cacgtttcat aattaggaag ggaaggaagg ggtgggcgtg
     2041 agagcactgg tgttcgtaca ctcagcagga agctgctgtc tggctctgct gatccagaac
     2101 ggcactgcct caagagggtg tctgtgttgc ctcggtggcc cctcttcagc cctgtgattg
     2161 cagttagctt gatttccttt ggtgttgttt gtttatattt ccaagtcaca aaccccatct
     2221 gttacccagt cttgttttca taggatggac tggctgtgtc tctctgatct agcccagcca
     2281 cattgttggc aatttaattt atttactttt ttttttttta agaaaggaga aaagaaaaaa
     2341 catcaagaaa acttaaaacc tttcttatgc cctttctttg gctgttccta ttgtgggatt
     2401 tgggtagggt ggggctggta aggtctgttt catgtgtttc cttttcagca tgagctctgg
     2461 tctgatacct gctctgaccc tcccctccat caccctgcag gagctttggc tgtggcagtc
     2521 cagcgttgat gcctgtgacc catgaagaaa tttgttccct gcccctttag gtctccttgt
     2581 gaaaccctag aattaactgg ctggcacatg tgttttgaag gtgactcttc catgtttcct
     2641 gaggaaactt cctgtttatc tgggttctaa ccttcaccag ccaagtggga tataaatcag
     2701 atgtctccaa agccaggctg actacactgg ctcagtcaag tccacccaag gacttggggt
     2761 ccattcaagg ctctctgggt ggctgctggg tcccccatgg tggctagtag agtgagcaag
     2821 gagaaagagt ggtgtgatta ttttaaaagc gtaggtggga gtgtgattgg agaggtcaga
     2881 gggcccccct tcaccatact ctagcttctc tctgggagtt ccacttcagg ctagcctgct
     2941 gttggtctca ctggttgagt cgtgtgcctc ctgtggggtt gggatagaag gatatagctt
     3001 gaggaccgta agaaaaagtt gggtgttcca gctccaggac attgtgctca ggagtttgaa
     3061 aaaggctgct atactcagtc gggttactgg gtttcttgtt cctctttgtg cctgcctgcc
     3121 ttgcccaagc tcactctgtc tattccttac tctgagatga atgatggagg aggctgaagt
     3181 ttgcttgccc tttgcaccag tatctgcagc tcttccattg tgctgtgtgc tgtacatggt
     3241 gttcactgca ctaataaatc tctcactcaa ctctaaattc ttagtcaccc cccttatgaa
     3301 ggattcttcc tagcttggta atgcaccttc cactgacctc tgccttgaga gaccgtctgt
     3361 ctggaaactg catacacttc acacgcttca cgttctgtgc tctactgctc tcgtaagcct
     3421 aactgcattc tcttcagagt gtccctttag ccggaattct gttttcctaa atgtcctgca
     3481 ttcggaggat gctaccgaag actttagcac ctctttccag cgagtgggga gcttctgccc
     3541 tctaggggct cctgatatta atgtagggag gaaacctgaa acagctctcc tgctgttcag
     3601 accttgacaa ggactttcct ggctagggag atggctaggg agaggtaaga gctctaactg
     3661 cacgtgagga tgtgagttca aattcccagc acctgcataa aaagctgagc atggtcaaga
     3721 gataactccc tcgttgtgtg gggcagaggt agagggctta ctggagcttg ctggtcccta
     3781 tttgagctcc aagttcagtg actgacagtg tctcaaagaa tgaagccagg tatggtggaa
     3841 catgccttta atcccagtac tttggagcca gcagacagat ctcagtgagg ggcctgcaag
     3901 tttaaaggaa tatggcatag taataaaaca ggacacccaa catcctcttc caaacacctt
     3961 gaaagcatga gtatgcacaa tgcacataca tgtccaccat gctcacacat ttttgctgaa
     4021 cactttttgt tactatctta ttcctcctat gagaaaccat gtgtgtgtgt gtgtgtgtgt
     4081 gtgcatgtgt gacttaagat atttatgtat attaatgttt tgcctgtatt tctgtctgtg
     4141 tgccacatgt atgtctgttg cccacagagt ctagaaaaga gcactgggtc tcctagaact
     4201 ggagtcacag aaggttgtga gccaccatgt cgagtttgaa actaggtgct atagagcagc
     4261 cagtgctctt aaccactgag ccagctccca actgtatgtt gaatttgttg acctttatcg
     4321 tgcaccgaat gtaaatataa tggaactctc ctgacactta agttgaggga aaggacaaaa
     4381 aaaaaaaaaa aaaa
//
