LOCUS       NM_172281               4172 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus ring finger protein 40 (Rnf40), transcript variant 1,
            mRNA.
ACCESSION   NM_172281
VERSION     NM_172281.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4172)
  AUTHORS   Kosinsky RL, Zerche M, Kutschat AP, Nair A, Ye Z, Saul D, von
            Heesen M, Friton JJ, Schwarzer AC, Paglilla N, Sheikh SZ, Wegwitz
            F, Sun Z, Ghadimi M, Newberry RD, Sartor RB, Faubion WA and Johnsen
            SA.
  TITLE     RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in
            inflammatory bowel disease
  JOURNAL   Cell Death Differ 28 (11), 3161-3175 (2021)
   PUBMED   34088983
REFERENCE   2  (bases 1 to 4172)
  AUTHORS   VanDusen NJ, Lee JY, Gu W, Butler CE, Sethi I, Zheng Y, King JS,
            Zhou P, Suo S, Guo Y, Ma Q, Yuan GC and Pu WT.
  TITLE     Massively parallel in vivo CRISPR screening identifies RNF20/40 as
            epigenetic regulators of cardiomyocyte maturation
  JOURNAL   Nat Commun 12 (1), 4442 (2021)
   PUBMED   34290256
  REMARK    GeneRIF: Massively parallel in vivo CRISPR screening identifies
            RNF20/40 as epigenetic regulators of cardiomyocyte maturation.
            Erratum:[Nat Commun. 2021 Aug 19;12(1):5105. PMID: 34413306]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4172)
  AUTHORS   Prokakis E, Dyas A, Grun R, Fritzsche S, Bedi U, Kazerouni ZB,
            Kosinsky RL, Johnsen SA and Wegwitz F.
  TITLE     USP22 promotes HER2-driven mammary carcinoma aggressiveness by
            suppressing the unfolded protein response
  JOURNAL   Oncogene 40 (23), 4004-4018 (2021)
   PUBMED   34007022
REFERENCE   4  (bases 1 to 4172)
  AUTHORS   Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W,
            Johnsen SA and Tuckermann J.
  TITLE     RNF40 exerts stage-dependent functions in differentiating
            osteoblasts and is essential for bone cell crosstalk
  JOURNAL   Cell Death Differ 28 (2), 700-714 (2021)
   PUBMED   32901120
  REMARK    GeneRIF: RNF40 exerts stage-dependent functions in differentiating
            osteoblasts and is essential for bone cell crosstalk.
REFERENCE   5  (bases 1 to 4172)
  AUTHORS   Wust HM, Wegener A, Frob F, Hartwig AC, Wegwitz F, Kari V, Schimmel
            M, Tamm ER, Johnsen SA, Wegner M and Sock E.
  TITLE     Egr2-guided histone H2B monoubiquitination is required for
            peripheral nervous system myelination
  JOURNAL   Nucleic Acids Res 48 (16), 8959-8976 (2020)
   PUBMED   32672815
REFERENCE   6  (bases 1 to 4172)
  AUTHORS   Xie W, Nagarajan S, Baumgart SJ, Kosinsky RL, Najafova Z, Kari V,
            Hennion M, Indenbirken D, Bonn S, Grundhoff A, Wegwitz F, Mansouri
            A and Johnsen SA.
  TITLE     RNF40 regulates gene expression in an epigenetic context-dependent
            manner
  JOURNAL   Genome Biol 18 (1), 32 (2017)
   PUBMED   28209164
  REMARK    GeneRIF: Our results support a model in which the direct function
            of RNF40-mediated H2B monoubiquitination increases transcriptional
            elongation by promoting the spreading of H3K4me3 into the 5'
            transcribed region of a select subgroup of genes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4172)
  AUTHORS   Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M,
            Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC and
            Brown JM.
  TITLE     Deficiency in mammalian histone H2B ubiquitin ligase Bre1
            (Rnf20/Rnf40) leads to replication stress and chromosomal
            instability
  JOURNAL   Cancer Res 72 (8), 2111-2119 (2012)
   PUBMED   22354749
  REMARK    GeneRIF: We show that Bre1 (human BRE1A/B (RNF20/40) and mouse
            Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal
            instability
REFERENCE   8  (bases 1 to 4172)
  AUTHORS   Vethantham V, Yang Y, Bowman C, Asp P, Lee JH, Skalnik DG and
            Dynlacht BD.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   9  (bases 1 to 4172)
  AUTHORS   Chernikova SB, Dorth JA, Razorenova OV, Game JC and Brown JM.
  TITLE     Deficiency in Bre1 impairs homologous recombination repair and cell
            cycle checkpoint response to radiation damage in mammalian cells
  JOURNAL   Radiat Res 174 (5), 558-565 (2010)
   PUBMED   20738173
  REMARK    GeneRIF: the observed defects in the radiation response of
            Bre1a/b-deficient cells
REFERENCE   10 (bases 1 to 4172)
  AUTHORS   Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman
            RD, Eick D, Aylon Y, Oren M and Johnsen SA.
  TITLE     CDK9 directs H2B monoubiquitination and controls
            replication-dependent histone mRNA 3'-end processing
  JOURNAL   EMBO Rep 10 (8), 894-900 (2009)
   PUBMED   19575011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122417.4, AK171462.1 and BM899169.1.
            
            [WARNING] On May 25, 2023 this sequence was replaced by
            NM_172281.3.
            
            On May 1, 2009 this sequence version replaced NM_172281.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129184.1, BC038348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC122417.4         139239-139310
            73-3755             AK171462.1         2-3684
            3756-3937           AK171462.1         3686-3867
            3938-4172           BM899169.1         1-235               c
FEATURES             Location/Qualifiers
     source          1..4172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..4172
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /note="ring finger protein 40"
                     /db_xref="GeneID:233900"
                     /db_xref="MGI:MGI:2142048"
     exon            1..114
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            115..318
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..3192
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase BRE1B; RING-type E3 ubiquitin
                     transferase BRE1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1B isoform 1"
                     /protein_id="NP_758485.2"
                     /db_xref="CCDS:CCDS21871.1"
                     /db_xref="GeneID:233900"
                     /db_xref="MGI:MGI:2142048"
                     /translation="MSGLSNKRAAGDGGSGPPEKKMNREEKTTTTLIEPIRLGGISST
                     EEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLD
                     ETVEALLQCYENQRELSSGTEVPGCQEGLTRDVIPRPDPGTSDLREPLPVQFRAPLSE
                     PALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGD
                     SEAPGEVARVRTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEME
                     TTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFEM
                     LNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQ
                     AQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLED
                     TLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL
                     REVQAEIGKLRAQASGSSHCIPTLSHPDDPGLNALAPGKEDSGPGPGGTPDCKKEMAL
                     LAGATSATSSIKKEELVSSEDDAQALTPVTQGLPSRGREPEARPKRELREREGPSLGP
                     PPAASTLSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKE
                     QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHL
                     QRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQ
                     IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQAL
                     ELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISR
                     LRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECV
                     RGRYEARQRKCPKCNAAFGAHDFHRVYIS"
     exon            319..486
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            487..628
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            629..835
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            836..957
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1104
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1179
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1299
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1479
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1615
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1737
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2165
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2283
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2433
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2646
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2772
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2913
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3015
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..4154
                     /gene="Rnf40"
                     /gene_synonym="BRE1-B; mKIAA0661"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaacaggaa ataagtttcg ccacatccgg agcggctctg acgcctgcgc tgtgcgtctg
       61 gcggccggtg acgtccggtg aaatccaaga tggtggcgct tggctgaccc tacggtgacg
      121 gaagtgccgc ctccacccgc ctgccagccc cggagagccc tgagttgccc ctccgccacc
      181 gccgctatgt ctggcctcag caacaagcgc gccgccggcg acgggggctc aggaccccca
      241 gagaagaaga tgaaccgcga ggagaagacc acgaccactc taatcgaacc cattcgtctc
      301 ggcggcattt cttccacgga ggagatggat tccaaggtac tgcagttcaa gaacaagaag
      361 ctggcggagc ggttggagca gcggcaagcc tgcgaggatg agctccggga gagaattgag
      421 aaattggaga agaggcaggc cactgatgat gccacactcc tcatcgtcaa ccgctactgg
      481 gcccagctgg atgaaactgt agaagccctc ctccagtgct acgagaacca gagggaactg
      541 tcttcaggga cagaggtgcc tgggtgccaa gagggcctga cccgtgatgt gatccctcga
      601 ccagacccag ggacatcaga tctgagggaa ccgctgccag tgcagtttcg agcccctctc
      661 agtgagccgg ccttggcttt tgtggtggca ctgggcgcca gcagctgtga ggaagtggag
      721 ctgcagctgc agggtcggat ggaattctcc aaggctgccg tgtctcgggt ggtcgaggcc
      781 tcggaccgcc tgcaacggca ggtggaagaa ctctgtcagc gagtatacag ccggggggac
      841 agtgaggccc ctggggaggt ggcacgggtg cgcacccggg agctaggcag agagaaccgt
      901 aggctacagg acttggccac tcagctgcaa gagaaacacc accgcatctc gttggagtac
      961 tctgagctcc aagataaagt gacatcgaca gagaccaagg tcctagagat ggagaccaca
     1021 gtggaggacc tgcagtggga cattgagaag ctgcgcaagc gagaacagaa gctcaataag
     1081 cacttggcag aggccttgga gcagctcaac tccggctact atgtgtctgg gagctccaca
     1141 ggctttcagg gaggccagat tacactcagc atgcagaagt ttgagatgtt gaatgcagag
     1201 ctggaagaaa atcaggaatt ggccaatagc cgaatggcag agctggagaa gctgcaggcg
     1261 gagcttcagg gagccgttcg gaccaatgag cgtctcaagg tggccctgcg tagccttcct
     1321 gaggaggtcg ttcgtgagac aggggagtac cgcatgctgc aggcacagtt ctccctgctc
     1381 tacaatgagt ctttgcaagt gaagacccag ctcgatgagg cccgggggtt gctgctggcc
     1441 tccaagaact cccacttgag acacattgaa catatggaga gtgatgaatt ggggctgcag
     1501 aagaagctgc gcacagaagt tatccagctg gaagacaccc tggcccaggt acgcaaggag
     1561 tacgagatgc tgcgcatcga gtttgaacag aaccttgcgg ccaacgagca ggctgggcct
     1621 atcaaccggg aaatgcgcca cctgattagc agcctccaga accacaatca ccagctaaaa
     1681 ggagatgccc agcgatacaa gcggaaactt cgagaagtac aggctgagat tggtaaactc
     1741 cgggcacagg ccagcggctc ttcccactgc attcccaccc tgagccaccc agatgaccct
     1801 ggcctcaatg cccttgcccc agggaaggaa gatagtgggc caggccctgg aggtacccct
     1861 gactgcaaga aggagatggc tttattggct ggagccacct ctgctacttc ttccataaag
     1921 aaagaggagc tggtctcctc tgaagatgac gcccaggccc taacccctgt aacccagggc
     1981 ttgccctcca ggggtcgaga acctgaggcc agacccaagc gagaacttcg ggaacgggaa
     2041 gggcctagcc taggaccccc acctgcagcc tcaactctgt caagggctga tcgagaaaag
     2101 gccaaggtgg aagaagccaa aaggaaggaa tcggaactgc tcaaaggtct ccgagcagag
     2161 ctcaagaagg ctcaggaaag ccagaaggag atgaagctgc tcctggacat gtacaagtca
     2221 gcacccaagg agcagcggga caaggtgcag ctcatggcag ctgagcgcaa ggccaaggct
     2281 gaggtggatg agcttcggag ccgcatccga gagctggaag aacgagaccg aagagaaagc
     2341 aagaagattg cggatgaaga tgccctgcgg cggatccggc aggcagaaga gcagattgaa
     2401 cacttgcaac gcaaattggg tgccaccaag caggaggagg aggcgttgct gtcggagatg
     2461 gatgtaacag gtcaggcttt tgaagacatg caggagcaaa acgggcggct acttcagcag
     2521 ttacgggaaa aggatgacgc caacttcaag ctcatgtcgg agcggatcaa ggccaaccag
     2581 attcacaagc tgctccgaga ggagaaggat gagttgggcg agcaggttct tggccttaag
     2641 tcccaggtgg atgcccagct gctgaccgta cagaagcttg aggagaagga gcgggctctg
     2701 cagggcagcc tcgggggtgt ggaaaaggag ttgactctgc gcagccaggc tctggagctt
     2761 aataagagaa aggctgtaga agcagcccag ttggctgagg acctgaaggt gcagttggag
     2821 catgtgcaga ctcgacttcg agagatccag ccctgcctgg cagagagccg ggctgcccgg
     2881 gagaaggaga gcttcaacct caagagggct caggaggaca tttcccggct tcggcgaaaa
     2941 ctagagaaac agcggaaagt ggaggtttat gcagatgctg acgagatcct gcaggaggag
     3001 atcaaggagt acaaggcccg gttgacctgc ccctgctgta acacccgcaa gaaggatgcc
     3061 gtgcttacca agtgcttcca cgttttctgc tttgaatgtg tgcggggccg ctatgaggcc
     3121 cgccagagga aatgtcccaa gtgcaacgca gcctttggtg cccacgactt ccaccgtgtg
     3181 tacatcagct gaacctgaaa ctcaggggac tttgaacacc cgaggggctg tgccccagct
     3241 ccccactccc ccaggggcaa tggccccaac ctccctttca gactccatga gcccagcccc
     3301 tatgtgccta gatggtttgg ggctactggt gcgtgcagga gaggtggggt cacccaagct
     3361 gagtgccatc ttttcctgaa tgtcagatct gcagcctcgg ggactcccag gtacacagca
     3421 tcctactgta accttggaag ctgaccaaaa cctgtttcta ctgagaagac agatacatcc
     3481 ttacccctag aagggaattc ctccaccagg aaagggctca ccacccatct gcacaagctc
     3541 agtgctgacc agggacctgg gcttcacatt gggtcctggc ccgaggagcc ttgcttcact
     3601 tacttagccc caggcctggg cagggatttg gccttccagt ggagtttcct gtaccctggt
     3661 gtagcttttg tgttgaagac actcttgggt gtgcacccta ttcaggtcag ggacactgcc
     3721 acctcatggt ctgattcagg ggcatttttt tttttagcca gactctttcc aatctcctcc
     3781 tttcctccca agtccacttt accctttctc acgcatcctg gtggtccctt gggtacctgg
     3841 ccctagccct gctttctttc atcctggtga tcttaattgt ggaggtgcaa cttgccagga
     3901 gggaagaaac aatctagcac ttgcaggcat tccaggtaga agagctttgc ccgtgctcca
     3961 gctagcctac actgatcctg cctaagcagg gtcctgaacg ccggagacag ggtctgctgg
     4021 agctgggaga cggcgctgca gatagatggc tacaggagct tttggactca cagcctctgc
     4081 tctagaggtg ttgtgtatgg gctgctaatt gttatgaata aaatacccaa ccctaggctg
     4141 cagagaagcc cgtcaaaaaa aaaaaaaaaa aa
//
