LOCUS       NM_011278               3091 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ring finger protein 4 (Rnf4), transcript variant 1,
            mRNA.
ACCESSION   NM_011278
VERSION     NM_011278.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Her,J., Zheng,H. and Bunting,S.F.
  TITLE     RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication
  JOURNAL   J Clin Invest 134 (10), e167419 (2024)
   PUBMED   38530355
  REMARK    GeneRIF: RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3091)
  AUTHORS   Shimada,T., Kudoh,Y., Noguchi,T., Kagi,T., Suzuki,M., Tsuchida,M.,
            Komatsu,H., Takahashi,M., Hirata,Y. and Matsuzawa,A.
  TITLE     The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-alpha-Induced
            Cell Death Triggered by RIPK1
  JOURNAL   Int J Mol Sci 22 (11), 5796 (2021)
   PUBMED   34071450
  REMARK    GeneRIF: The E3 Ubiquitin-Protein Ligase RNF4 Promotes
            TNF-alpha-Induced Cell Death Triggered by RIPK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3091)
  AUTHORS   Liu,Y., Zhao,D., Qiu,F., Zhang,L.L., Liu,S.K., Li,Y.Y., Liu,M.T.,
            Wu,D., Wang,J.X., Ding,X.Q., Liu,Y.X., Dong,C.J., Shao,X.Q.,
            Yang,B.F. and Chu,W.F.
  TITLE     Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates
            Cardiac Fibrosis
  JOURNAL   Mol Ther 25 (3), 666-678 (2017)
   PUBMED   28143738
  REMARK    GeneRIF: These findings suggest that the UBC9/PML/RNF4 axis plays a
            critical role as an important SUMO pathway in cardiac fibrosis.
            Modulating the protein levels of the pathway provides an attractive
            therapeutic target for the treatment of cardiac fibrosis and heart
            failure.
REFERENCE   5  (bases 1 to 3091)
  AUTHORS   Sun,H., Liu,Y. and Hunter,T.
  TITLE     Multiple Arkadia/RNF111 structures coordinate its Polycomb body
            association and transcriptional control
  JOURNAL   Mol Cell Biol 34 (16), 2981-2995 (2014)
   PUBMED   24912682
REFERENCE   6  (bases 1 to 3091)
  AUTHORS   Hirvonen,S.J., Santti,H., Janne,O.A. and Palvimo,J.J.
  TITLE     GC-rich elements flanking the transcription start site govern
            strong activation on the SNURF gene
  JOURNAL   Biochem Biophys Res Commun 291 (4), 897-902 (2002)
   PUBMED   11866449
  REMARK    GeneRIF: GC-rich elements flanking the transcription start site
            govern activation
REFERENCE   7  (bases 1 to 3091)
  AUTHORS   Lyngso,C., Bouteiller,G., Damgaard,C.K., Ryom,D., Sanchez-Munoz,S.,
            Norby,P.L., Bonven,B.J. and Jorgensen,P.
  TITLE     Interaction between the transcription factor SPBP and the positive
            cofactor RNF4. An interplay between protein binding zinc fingers
  JOURNAL   J Biol Chem 275 (34), 26144-26149 (2000)
   PUBMED   10849425
REFERENCE   8  (bases 1 to 3091)
  AUTHORS   Galili,N., Nayak,S., Epstein,J.A. and Buck,C.A.
  TITLE     Rnf4, a RING protein expressed in the developing nervous and
            reproductive systems, interacts with Gscl, a gene within the
            DiGeorge critical region
  JOURNAL   Dev Dyn 218 (1), 102-111 (2000)
   PUBMED   10822263
REFERENCE   9  (bases 1 to 3091)
  AUTHORS   Moilanen,A.M., Poukka,H., Karvonen,U., Hakli,M., Janne,O.A. and
            Palvimo,J.J.
  TITLE     Identification of a novel RING finger protein as a coregulator in
            steroid receptor-mediated gene transcription
  JOURNAL   Mol Cell Biol 18 (9), 5128-5139 (1998)
   PUBMED   9710597
REFERENCE   10 (bases 1 to 3091)
  AUTHORS   Chiariotti,L., Benvenuto,G., Fedele,M., Santoro,M., Simeone,A.,
            Fusco,A. and Bruni,C.B.
  TITLE     Identification and characterization of a novel RING-finger gene
            (RNF4) mapping at 4p16.3
  JOURNAL   Genomics 47 (2), 258-265 (1998)
   PUBMED   9479498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104889.10.
            
            On Jan 15, 2015 this sequence version replaced NM_011278.4.
            
            Summary: This gene encodes a small nuclear RING finger protein that
            mediates ubiquitylation of polysumoylated proteins. Deficiency of
            the encoded protein in mice leads to embryonic lethality and global
            DNA hypermethylation. A similar protein in humans is required for
            arsenic-induced degradation of promyelocytic leukemia protein in
            acute promyelocytic leukemia. Alternative splicing of this gene
            results in multiple transcript variants. A pseudogene for this gene
            has been identified on chromosome 10. [provided by RefSeq, Jan
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003282.1, AK158987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC104889.10        17227-17518         c
            293-450             AC104889.10        11089-11246         c
            451-577             AC104889.10        6867-6993           c
            578-657             AC104889.10        5025-5104           c
            658-667             AC104889.10        4209-4218           c
            668-827             AC104889.10        3697-3856           c
            828-876             AC104889.10        2930-2978           c
            877-3091            AC104889.10        323-2537            c
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.87 cM"
     gene            1..3091
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /note="ring finger protein 4"
                     /db_xref="GeneID:19822"
                     /db_xref="MGI:MGI:1201691"
     exon            1..292
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            293..450
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1026
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin ligase RNF4; RING-type E3 ubiquitin
                     transferase RNF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF4"
                     /protein_id="NP_035408.1"
                     /db_xref="CCDS:CCDS57336.1"
                     /db_xref="GeneID:19822"
                     /db_xref="MGI:MGI:1201691"
                     /translation="MSTRNPQRKRRGGTVNSRQTQKRTRETTSTPEVSLETEPIELVE
                     TVGDEIVDLTCESLEPVVVDLTHNDSVVIVEERRRPRRNGRRLRQDHADSCVVSSDDE
                     ELSRDKDVYVTTHTPRSTKDDGATGPRPSGTVSCPICMDGYSEIVQNGRLIVSTECGH
                     VFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI"
     exon            451..577
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            578..657
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            658..667
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            668..827
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            828..876
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            877..3091
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /note="hexamer: AATAAA"
     polyA_site      3082
                     /gene="Rnf4"
                     /gene_synonym="Gtrgeo8; SNURF"
                     /note="major polyA site"
ORIGIN      
        1 cgcaagcagg cggggggcgt gaccggaaga aggtgtattt caaagtggta atagatggtt
       61 ttctcaccca ataaaattgc aatttatcct cctaaaccgg tagagcacgg gagaaaaggc
      121 gggagaggcc aataagggct gagaagggcg ggccggtgcc ggacgagcgg aagtgggtct
      181 tcgtgaggcg gtggaggctt gcttgaacgg gtctcctcag cggcggctgg agtcggtacg
      241 tccttgcccg agctcatcag ccgaggcgtc tggcagcaaa ccccagctcc aaaatttgga
      301 aatactgcac atctagttgg ctccaaattg taaaccacag gatgagtatt cagtgggcat
      361 gagagattga gaacatccta ccacaccata aaccttggtg tagatcactt ccttttctgt
      421 ggattgaagc cagagagcac aatgagtaca agaaatcctc aaagaaagcg gcgtggtgga
      481 actgtgaatt ctagacaaac ccagaagcga actcgggaaa caacttcgac ccctgaggtt
      541 tccttggaaa cagaacccat agaacttgtg gaaactgttg gagatgaaat tgtggacctc
      601 acctgtgaat ctttagagcc cgtggttgtg gacctgactc acaatgactc tgttgtgatt
      661 gttgaagaaa ggagaaggcc aaggagaaat gggaggaggt tgcgccaaga ccatgctgac
      721 agctgtgtgg tgagcagtga tgatgaggag ctgtctaggg acaaagatgt gtacgtgact
      781 acccatactc ctcgaagcac caaggatgat ggagctactg gacccaggcc ctcaggtacc
      841 gtcagttgtc ctatctgtat ggatggatac tctgagattg tgcagaatgg gcgtctcatt
      901 gtttctacag aatgtggcca cgtcttctgt agccagtgcc tccgtgattc ccttaagaat
      961 gctaacactt gcccaacttg taggaaaaag atcaaccata agcggtacca ccccatttat
     1021 atatgaaatg ttcacaactg ctcaggatag accaatggac agacagccag gctggccttt
     1081 tctgcatggt atctgcctcc agtttcctga gctcaaaaag actttcaaaa atcaatgtct
     1141 gatgtaaact ggtcttttgt tttccaaccc cttagatcct tttgttatct cgtttgatgc
     1201 tatggagcac ggtccaggga tcctcctaga tcagctcagc atcactgccc ctttgggtgg
     1261 tctgagccca gagtagggaa aaaaggagtc gggcatattg gggttgagca tcatggctcc
     1321 agcctcttta tggagcttac atgttggcca agtagtttcc ctgttgggaa agtttgcccc
     1381 agctcttgtg tgtgcagaac cttcccaagg cacctgtcag ttagctgttc tgcctgccag
     1441 acagtgacct ggccagacag cccaaatagc ccaaggatac cagtgcatga gctgcccacg
     1501 aaaagccacg aaaaggtgga cttttagttt ccttcccacg agagcagagg tgacctatga
     1561 ttccgcctga aactcatcat tggtgtgcag tgttttctgc aaatccagtg actctgcagg
     1621 acgatcctgt tccctaagaa tgagaaagtg caataaaacc cgttcttcac ctgctcttca
     1681 gcaatctgga agctgtagca ctgctggtat cctcagccca gtgtcgccta tgggagcagt
     1741 gctcatccca ccccatgtct gttcaccagc tgttctcagg aaccctaccc atgctccaaa
     1801 gttcttttac tggcacagaa cattgaaggc taataggaca agtgtttgag tgtcctctct
     1861 ttaatgctaa gatgggtcct gtgttgtcta cagtgccctc caaccctcag tttttcagtt
     1921 cccactgcct aatgtctgct caagcatagt ataataggag gtggtagcag tagcaatggc
     1981 cttatcagct gttcacttac atgcttttgc ccaagtcacc gttgcccatt tgtcagaggt
     2041 gttgccctac tcaacctcca ctgccctagc ttttcccaca ccccttgaat agataggtat
     2101 ttccaaagct gcttgctctt ctagccagtt gagctttgat cctctggact tttgactgct
     2161 cagtgggttt tggtcagcaa agcatggtgc ctcttccagt gggaccacat aacaatgtct
     2221 gctccaccgt atatgtgtgg gagactctgg tgctcacgga gacaggtgga aaattgcccc
     2281 tggggacacc aggcacaggg cggcttgtag aggataggcc ttgaatgcca gcctgcctcc
     2341 acctccacac tacttcctca gagggcttca agccaaacca atagcctttt tgtgtgaaac
     2401 atctttgagg tgggaaaggg accactggag ctttgctagc aataactgac tttcagtgta
     2461 atgttctgaa ggagcaggga ctcagcacag aattcacttt aaatggagct gaaggagtgg
     2521 ccctcctcta tgtgaaaaga aaatagtttt attcttcatt ctgactttct agctgtttga
     2581 cttcagttag tttgaatgag agtaataggt tttttttttc tacatggact cagagggtaa
     2641 gagcattagc tctcatcatt gtgatgtgtg tgctctcctc tcccccttgg atgtcacagc
     2701 cattgatttc tttgtgggcc tcatggactt ggtcttgtta gtctaatgaa agccagactt
     2761 caaagagaca aggcaaccat gcagccagtt caccagtaaa tgtggtaaca cccacttaaa
     2821 aatttgtttt ctcctcaagg acggtgtatg aagttgatca taaaagttct attactttat
     2881 cctaaattaa attgagaaaa agatgtgttc ttctaatcag acactgcatt aatagggaaa
     2941 gattggtata gaaaagattt tctttccttt ttacttaatg tatatagttt aactcttttc
     3001 tttgttacat ttaaactatg ctcatgggta tcagtctgtt ttggactagt attaaagatg
     3061 gaaataaaac aatttgaact aagtatcttt c
//
