LOCUS       NM_030564               1935 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ring finger protein 34 (Rnf34), transcript variant 1,
            mRNA.
ACCESSION   NM_030564
VERSION     NM_030564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Fang,S., Cheng,Y., Deng,F. and Zhang,B.
  TITLE     RNF34 ablation promotes cerebrovascular remodeling and hypertension
            by increasing NADPH-derived ROS generation
  JOURNAL   Neurobiol Dis 156, 105396 (2021)
   PUBMED   34015492
  REMARK    GeneRIF: RNF34 ablation promotes cerebrovascular remodeling and
            hypertension by increasing NADPH-derived ROS generation.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Qu,X., Wang,N., Chen,W., Qi,M., Xue,Y. and Cheng,W.
  TITLE     RNF34 overexpression exacerbates neurological deficits and brain
            injury in a mouse model of intracerebral hemorrhage by potentiating
            mitochondrial dysfunction-mediated oxidative stress
  JOURNAL   Sci Rep 9 (1), 16296 (2019)
   PUBMED   31704983
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Wei,P., Pan,D., Mao,C. and Wang,Y.X.
  TITLE     RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and
            modulates brown fat cell metabolism
  JOURNAL   Mol Cell Biol 32 (2), 266-275 (2012)
   PUBMED   22064484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115728.11 and AC121564.4.
            
            On Mar 13, 2023 this sequence version replaced NM_030564.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159753.1, AK046274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC115728.11        13961-14052         c
            93-311              AC115728.11        2352-2570           c
            312-583             AC115728.11        1-272               c
            584-719             AC121564.4         175102-175237       c
            720-824             AC121564.4         172590-172694       c
            825-1026            AC121564.4         172175-172376       c
            1027-1935           AC121564.4         170551-171459       c
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.62 cM"
     gene            1..1935
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /note="ring finger protein 34"
                     /db_xref="GeneID:80751"
                     /db_xref="MGI:MGI:2153340"
     exon            1..92
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1217
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF34; phafin 1; RING finger
                     protein RIFF; RING-type E3 ubiquitin transferase RNF34"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF34 isoform 1"
                     /protein_id="NP_085041.1"
                     /db_xref="CCDS:CCDS19656.1"
                     /db_xref="GeneID:80751"
                     /db_xref="MGI:MGI:2153340"
                     /translation="MKAGATSMWASCCGLLNEVMGTGAVRGQQAGFPGSTGPFRFTPS
                     SDFPTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSLCSVSQENLRRCSTC
                     HLLQETAFQRPQLMRLKVKDLRQYLLLRNIPTDTCREKEDLVDLVLCHRGLGSGDDLD
                     SSSLNSSRSQTSSFFTQSLFSNYTPPSATVSSFQGELMDRDGAFRSEVLAQVQSEIAS
                     ANTDDDDDDDDDDDDDEDDDDEQEEEEQNPGLSKKKARASLSDLSSLEEVEGMSVRQL
                     KEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERMQLQDEEDDSLCRICMD
                     AVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS"
     exon            93..311
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            312..719
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            720..824
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1026
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1935
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /note="hexamer: AATAAA"
     polyA_site      1935
                     /gene="Rnf34"
                     /gene_synonym="RIFF"
                     /note="major polyA site"
ORIGIN      
        1 agaaggaagg aagatccgtt gtgtgaggag gctgctatgg tgctgagttc cccggtagag
       61 ccgaccgagc cgaggcggtc gcggccatga aggcgggtgc tacttctatg tgggcttcat
      121 gctgtgggct gctgaatgaa gtcatgggaa ctggagctgt ccgaggccag caggcgggat
      181 ttccgggaag cactggccca ttcagattta caccgagctc tgacttcccc acctacccac
      241 cagcagctac tgaaggaccc aatatagttt gcaaagcctg tgggctttcg ttttcagtct
      301 ttagaaagaa gcatgtctgc tgtgactgca agaaggattt ctgctccctc tgctcagtct
      361 cccaagaaaa cctccgcaga tgttctactt gtcacctact acaagagacg gccttccagc
      421 gccctcagtt gatgcgacta aaagtgaagg acctgcggca gtatctcctc ctcagaaaca
      481 taccaaccga cacttgtcgt gagaaggaag acttggtgga tctagtactg tgccaccgtg
      541 gactaggctc aggggatgac ctggactcaa gtagcctgaa ttcctcaagg tcccagactt
      601 ctagtttttt tacacagtcc ctcttttcaa attacactcc tccctctgct actgtgtcct
      661 ccttccaggg agagctcatg gacagagatg gcgccttcag atcagaagtc ctggcacagg
      721 tacaaagtga aatagcttca gcaaacacag atgatgatga cgacgacgat gatgatgacg
      781 acgatgatga agatgacgac gacgaacaag aggaggagga acagaacccg gggctctcta
      841 aaaagaaagc aagagcttcc ctgtctgacc tctcaagcct tgaagaggta gaagggatga
      901 gtgtgcgcca gctgaaggag atcctggctc ggaattttgt caactattct ggctgttgtg
      961 aaaaatggga gctggtagag aaagtcaacc ggctgtacaa agagaatgaa gaaaaccaaa
     1021 agtcatatgg tgagcggatg caacttcagg atgaggaaga tgacagcctg tgccgaatct
     1081 gcatggatgc ggtcattgac tgtgtcctgc tggagtgcgg gcacatggtc acctgcacca
     1141 agtgtggcaa gcgaatgagt gagtgtccca tctgcaggca gtatgtggtt cgagctgtgc
     1201 atgtttttaa gtcatgaaat tgagggccct gcagtaggac actcacatga cattacccca
     1261 aacatttcag tgcactagag ggactggaaa cttcttgttc taaggcaaaa gctattttca
     1321 aaaattattt tcattactaa ctggggacag aaagttcacc ctaagttgca gaaacctggc
     1381 cagtgccatg acccatctcc ctgtggacac acggctttcc caggttctgc tgggttttgt
     1441 ctcccctgag cactagctga agccaaactg ttcagtgtgg gtgtggaagc cactcactcg
     1501 cctgtcttcc cttactttac cttcatcctg tgtttgttct ctttgaagtg aactcactgt
     1561 catgactggg tagtgtggac tatcctgagc cgtaactgct ctgaatgttc actcgattag
     1621 ccatgtatat tttaaatgct aatatttaat gaatgtaagt ttcaacattg ttgctatttc
     1681 tgcatttaaa cataattggg agacaactga cattctacag tcaactgcca gggccttaga
     1741 ctaagtatgt ccatttttgt tcaggtacag cttttaaaag caagggctgc atctagcttc
     1801 ttatcttaga agtatatgtg tgctaaattc tttattaaca tgtaatcaat ttacaatgtt
     1861 ttgtatagtg aaggtgtatt tttagttcta cctgctagta atttcaactt taggaataaa
     1921 attaaatgaa aaggc
//
