LOCUS       NM_194346               3432 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus ring finger protein 31 (Rnf31), mRNA.
ACCESSION   NM_194346 XM_193760
VERSION     NM_194346.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3432)
  AUTHORS   Chen,Y., Yang,F., Shi,Y., Sheng,J., Wang,Y., Zhang,L., Zhou,J.,
            Jin,Y. and Yan,Y.
  TITLE     RNF31 alleviates liver steatosis by promoting p53/BNIP3-related
            mitophagy in hepatocytes
  JOURNAL   Free Radic Biol Med 219, 163-179 (2024)
   PUBMED   38615890
  REMARK    GeneRIF: RNF31 alleviates liver steatosis by promoting
            p53/BNIP3-related mitophagy in hepatocytes.
REFERENCE   2  (bases 1 to 3432)
  AUTHORS   Fu,Y., Li,L., Zhang,X., Deng,Z., Wu,Y., Chen,W., Liu,Y., He,S.,
            Wang,J., Xie,Y., Tu,Z., Lyu,Y., Wei,Y., Wang,S., Cui,C.P., Liu,C.H.
            and Zhang,L.
  TITLE     Systematic HOIP interactome profiling reveals critical roles of
            linear ubiquitination in tissue homeostasis
  JOURNAL   Nat Commun 15 (1), 2974 (2024)
   PUBMED   38582895
  REMARK    GeneRIF: Systematic HOIP interactome profiling reveals critical
            roles of linear ubiquitination in tissue homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3432)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3432)
  AUTHORS   Wang,P., Tang,C.T., Li,J., Huang,X., Jin,R., Yin,F., Liu,Z.,
            Chen,Y. and Zeng,C.
  TITLE     The E3 ubiquitin ligase RNF31 mediates the development of
            ulcerative colitis by regulating NLRP3 inflammasome activation
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111194 (2023)
   PUBMED   37951199
  REMARK    GeneRIF: The E3 ubiquitin ligase RNF31 mediates the development of
            ulcerative colitis by regulating NLRP3 inflammasome activation.
REFERENCE   5  (bases 1 to 3432)
  AUTHORS   Griewahn,L., Muller-Foxworth,M., Peintner,L., Wissler,M., Weiss,M.,
            Brauns-Schubert,P., Massoumi,R., Borner,C., Gross,O., Yabal,M.,
            Charvet,C. and Maurer,U.
  TITLE     SPATA2 restricts OTULIN-dependent LUBAC activity independently of
            CYLD
  JOURNAL   Cell Rep 42 (1), 111961 (2023)
   PUBMED   36640323
REFERENCE   6  (bases 1 to 3432)
  AUTHORS   Tokunaga,F., Sakata,S., Saeki,Y., Satomi,Y., Kirisako,T., Kamei,K.,
            Nakagawa,T., Kato,M., Murata,S., Yamaoka,S., Yamamoto,M., Akira,S.,
            Takao,T., Tanaka,K. and Iwai,K.
  TITLE     Involvement of linear polyubiquitylation of NEMO in NF-kappaB
            activation
  JOURNAL   Nat Cell Biol 11 (2), 123-132 (2009)
   PUBMED   19136968
REFERENCE   7  (bases 1 to 3432)
  AUTHORS   Nakamura,M., Tokunaga,F., Sakata,S. and Iwai,K.
  TITLE     Mutual regulation of conventional protein kinase C and a ubiquitin
            ligase complex
  JOURNAL   Biochem Biophys Res Commun 351 (2), 340-347 (2006)
   PUBMED   17069764
REFERENCE   8  (bases 1 to 3432)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   9  (bases 1 to 3432)
  AUTHORS   Bromann,P.A., Weiner,J.A., Apel,E.D., Lewis,R.M. and Sanes,J.R.
  TITLE     A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts
            with the muscle-specific kinase (MuSK)
  JOURNAL   Gene Expr Patterns 4 (1), 77-84 (2004)
   PUBMED   14678832
REFERENCE   10 (bases 1 to 3432)
  AUTHORS   Yawata,M., Murata,S., Tanaka,K., Ishigatsubo,Y. and Kasahara,M.
  TITLE     Nucleotide sequence analysis of the approximately 35-kb segment
            containing interferon-gamma-inducible mouse proteasome activator
            genes
  JOURNAL   Immunogenetics 53 (2), 119-129 (2001)
   PUBMED   11345588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC174678.2, BC057595.1 and BY426496.1.
            
            On Apr 17, 2018 this sequence version replaced NM_194346.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057595.1, AK156320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC174678.2         69376-69423         c
            49-3429             BC057595.1         1-3381
            3430-3432           BY426496.1         295-297
FEATURES             Location/Qualifiers
     source          1..3432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..3432
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /note="ring finger protein 31"
                     /db_xref="GeneID:268749"
                     /db_xref="MGI:MGI:1934704"
     exon            1..331
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3343
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /EC_number="2.3.2.31"
                     /note="putative Ariadne-like ubiquitin ligase;
                     HOIL-1-interacting protein; RING-type E3 ubiquitin
                     transferase RNF31"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF31"
                     /protein_id="NP_919327.2"
                     /db_xref="CCDS:CCDS27118.1"
                     /db_xref="GeneID:268749"
                     /db_xref="MGI:MGI:1934704"
                     /translation="MPGDEERGFLAAREELASALRWDSAQVFPLEQLMPLLATSLPPA
                     ARYLQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNP
                     VFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPEGQEEPDEYQVAVVTLEVLLLRTELS
                     LLLQNTHPRQNALDQLLRESVEDGMLQLSEFHPLLREIVPGPRPSAQGSTPGPCFLCG
                     SAPGTLHCPACNQVSCPACDILFHGHPSRAHHLRQALPGSHQTASLSSSLPASSQPRP
                     PSSSLALGDSSLSSPDPANACLPWHCLTCATLNEPWAVFCAVCSQPKGCKVPGIEGSH
                     GTGGLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVCQQSL
                     KQEDPLLTAAQPQVWYCDHCTFCNSGPVWVCAMCNRTRDPIPTQPALQSYPSSLEKGR
                     PKPGSSQHLGSSLPASCGDPEKQRQDKMRKEGLQLVSMIQEGETAGASPEEVFSALQY
                     SGTEVPLQWLRSELSYVLEMVAELAGQQDPELGAFSCQEARKAWLDRHGNLDEAVEEC
                     VRARRRKVHELQSLGFGPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWDRDPE
                     PTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDR
                     AFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPA
                     CGRPDLTDDAQLLSYFSTLDIQLRESLDPDAYALFHKKLTEAVLMRDPKFLWCAQCSF
                     GFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAM
                     YLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKK
                     SLHGHHPRDCLFYLRDWTAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVH
                     SGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATIRYLHL
                     APQPADGEDLPAYQARLLQKLREEVPLGQSIARRRK"
     exon            332..478
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            479..634
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            635..694
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            695..764
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            765..942
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1321
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1612
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1861
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2047
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2254
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2428
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2527
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2617
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2732
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2851
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2965
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3023
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3120
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3289
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3432
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3406..3411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /note="hexamer: AATAAA"
     polyA_site      3429
                     /gene="Rnf31"
                     /gene_synonym="Flj10111; HOIP; mFLJ00217; Paul"
                     /note="major polyA site"
ORIGIN      
        1 aggacttcct gttcccggta accctggccg tggatggggc tgagcggggc ggtggcttaa
       61 gtgacccggg ctgctgtggc gccgcgcgca cctgcgccag cccctggagg gcagagaagc
      121 tgagcctgtc tccagtctca ggatgccggg agacgaggag cgaggcttcc tggcggcccg
      181 cgaggagctg gcgagcgccc tgaggtggga ttctgcgcag gtttttcccc tggagcagct
      241 catgccgctt ctggccacct ctctgccacc agccgcccgc tacctgcagc tggacgccgg
      301 acgcttggtc cgctgcaacg ctcatgggga gcctcgaaac tacctcaaca ccctatccac
      361 ggccctgaac atcctggaaa aatatggtcg caacctcctc agcccgcagc ggccccggta
      421 ttggcgctca gtgaagttta ataaccccgt ctttcgcagc acggtggatg ctgtgcaggg
      481 tggccgggat gtactacggt tgtatggcta tactgaggag cgcccagatg gattgagttt
      541 ccccgaaggg caggaggaac cagatgaata ccaggttgct gttgtcacac tagaagtact
      601 gctgcttcgc accgagctca gtttgctgtt gcagaatact catcccagac agaatgcact
      661 ggaccagctg ctaagagaga gcgttgaaga tggtatgctg cagctttcag agtttcaccc
      721 ccttctgagg gagattgttc ctggcccccg cccctctgcc caaggctcca ctcctggtcc
      781 ctgtttcctc tgtggttctg ccccaggcac actgcactgt ccagcctgta accaagtctc
      841 gtgcccagct tgtgacattt tgttccatgg gcatccgtcc cgtgcacatc accttcgcca
      901 agccctgcct gggtcccacc agactgccag cctgagctct agtttacctg cctcgtccca
      961 accacggccc ccctcctcct ccttggccct gggagatagc tctctttctt cccctgaccc
     1021 tgcaaatgcc tgtctgccct ggcattgtct tacctgtgcc acactaaatg agccttgggc
     1081 agtgttctgt gcagtctgta gtcagcccaa aggctgcaag gtgccgggaa tagagggttc
     1141 ccatggaacc gggggcctag aacctgagcc tgcacgggat caatgggcct gccagagctg
     1201 tacctttgag aatgaggcag cagctgtgct atgcgccata tgtgagcgac ctcggctggc
     1261 ccagcctccc agcttggtgg tggattccca tgatgctggt gtttgccaac agtcccttaa
     1321 gcaggaggat cctttgctca ccgctgccca gcctcaggtg tggtactgtg accattgtac
     1381 cttctgcaat tcaggccctg tctgggtgtg tgccatgtgc aaccgaaccc gagaccccat
     1441 ccctacacag cctgccctcc agtcctatcc cagctctttg gaaaagggac gcccaaagcc
     1501 agggtcctca caacaccttg gttcctccct gcctgcttcc tgtggagacc cagagaaaca
     1561 acgccaagat aagatgcgga aggaaggtct ccagctcgtg agcatgatcc aggaaggaga
     1621 aactgcgggt gccagtccag aagaggtctt ctcagctctc caatactcag gcacagaggt
     1681 gcccctccag tggttgcgtt cagagctgtc ctacgtcctg gagatggtgg ctgagcttgc
     1741 tggacaacag gatccagagc tgggggcctt ttcctgtcag gaagcccgga aagcctggct
     1801 tgatcgccat ggcaacctgg atgaagctgt agaggagtgt gtgagggcca ggaggaggaa
     1861 ggtgcacgag ctgcagtccc tgggctttgg gcctaaggaa gggtcactac aggcattgtt
     1921 ccagcatggg ggtgacgtgg ctcgggccct gactgagtta cagcgccagc gcctggagcc
     1981 cttccatcag cgcctatggg acagagaccc tgaacccact ccctgctggg atgggctgga
     2041 cagacagagc ttggtcagac gccttctggc cgtctacaca ctccccagct ggggccgagc
     2101 agagctggcg ctggcgctgc tgcaggagac acccaggaac tatgagttgt tggacgtggt
     2161 ggaggctgtg aggcacagcc aggaccgggc ctttctgcgt cgactgcttg cccaggaatg
     2221 tgctgtgtgc gggtgggccc ttccccgcaa ccggatgcag gccctgatct cctgtgagtg
     2281 caccatatgt cccgaatgct tccgccaaca cttcaccatt gccctgaagg agaagcacat
     2341 cacagacatg gtgtgccctg cctgtggccg ccctgacctc actgatgacg ctcagttact
     2401 cagctacttc tccacccttg acatccagct cagagagagc ctagaccccg atgcatatgc
     2461 cctgtttcac aagaagctga ccgaggctgt gcttatgcga gaccccaagt tcttgtggtg
     2521 cgcccagtgt tcctttggct tcatctatga acgcgaacag ctggaggcga cgtgtcccca
     2581 gtgtcaccag accttctgtg tgcgctgcaa gcgccagtgg gaggagcagc acagaggacg
     2641 gagttgtgag gatttccaga actggaaacg caccaatgac ccagagtacc aggctcaagg
     2701 cttggccatg taccttcagg aaaacggcat tgactgtccg aaatgcaagt tctcgtacgc
     2761 actggcccgg ggaggctgca tgcacttcca ctgcacgcag tgtcgacacc agttctgcag
     2821 tggctgctac aacgcctttt acgccaagaa taaatgtcca gaccctaact gcaaggtgaa
     2881 aaagtccctg catggccacc accctcgaga ctgcctcttc tacctacggg actggactgc
     2941 tgcccgcctc cagaaactgt tgcaggacaa taatgtcatg tttaatacag agcctccagc
     3001 tgggacacgg gcagtccctg gagggggctg cagagtgatg gagcagaagg aggtccatag
     3061 tgggttcagg gatgaagctt gcggcaagga aactccacct ggctatgccg gcctatgtca
     3121 ggcacactac aaagagtatc tcgtgagcct catcaatgcc cattcactgg acccagctac
     3181 cttgtatgaa gtggaggagc tggagacagc cactattcgc tacctacatt tagctcctca
     3241 gcccgcggat ggagaggatc tgcctgctta ccaggcccgg ctattacaga agctgagaga
     3301 agaggtaccc ttgggacaga gtattgcccg cagaagaaag tagtagcaga gagccgggtc
     3361 ctgatgggac ttcctgaccc aggcctcagc agcagttcca gcaccaataa agaggcatct
     3421 tatggcctag gc
//
