LOCUS       NM_021313               1498 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ring finger protein 25 (Rnf25), transcript variant 1,
            mRNA.
ACCESSION   NM_021313
VERSION     NM_021313.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Ding,W., Li,C., Hu,T., Graves-Deal,R., Fotia,A.B., Weissman,A.M.
            and Coffey,R.J.
  TITLE     EGF receptor-independent action of TGF-alpha protects Naked2 from
            AO7-mediated ubiquitylation and proteasomal degradation
  JOURNAL   Proc Natl Acad Sci U S A 105 (36), 13433-13438 (2008)
   PUBMED   18757723
  REMARK    GeneRIF: identify an EGFR-independent action of TGF-alpha, in which
            it protects Naked2 from proteasomal degradation, thus ensuring its
            delivery to the basolateral surface of polarized epithelial cells
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Asamitsu,K., Tetsuka,T., Kanazawa,S. and Okamoto,T.
  TITLE     RING finger protein AO7 supports NF-kappaB-mediated transcription
            by interacting with the transactivation domain of the p65 subunit
  JOURNAL   J Biol Chem 278 (29), 26879-26887 (2003)
   PUBMED   12748188
  REMARK    GeneRIF: RING finger protein AO7 supports NF-kappaB-mediated
            transcription by interacting with the transactivation domain of the
            p65 subunit.
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002399.1, BE853767.1, AC117610.7 and BP774070.1.
            
            On Mar 5, 2015 this sequence version replaced NM_021313.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002399.1, BC048821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               AK002399.1         2-762
            762-1088            BE853767.1         235-561
            1089-1364           AK002399.1         1090-1365
            1365-1365           AC117610.7         146879-146879       c
            1366-1471           AK002399.1         1367-1472
            1472-1498           BP774070.1         534-560
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..1498
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /note="ring finger protein 25"
                     /db_xref="GeneID:57751"
                     /db_xref="MGI:MGI:1890215"
     exon            1..73
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1403
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; RING
                     finger protein AO7; RING-type E3 ubiquitin transferase
                     RNF25; E3 ubiquitin-protein ligase RNF25"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF25 isoform 1"
                     /protein_id="NP_067288.2"
                     /db_xref="CCDS:CCDS15052.1"
                     /db_xref="GeneID:57751"
                     /db_xref="MGI:MGI:1890215"
                     /translation="MAASASTAAGEEDWVLPSEVEVLESIYLDELQVMKGNGRSPWEI
                     FITLHPATAEVQDSQFVCFTLVLRIPVQYPHEVPQISIRNPRGLSDEQIHKISQALGH
                     VAKEGLGTAMLYELIEKGKEILTDNNIPHGQCVICLYGFQEKEAFTKTPCYHYFHCHC
                     LARYIQHMEQELTTQEQEQERQHVVTKQKAVGVQCPVCREPLVYDLASLKAAPEPQQP
                     MELYQPSAESLRQQEELKLLYQRQQEKGGIIDLEAERNRYFISLQQPPAALEPESAVD
                     VSREPQPPNALSAEQSTSLADQSTLPTSLPMTTQYTYEKTSGAGPNQQRPGETQKSVL
                     DPPRHGRGSWRQYDRRHPKGGECCTPKGTSEIHELPPPEKPLKETVDLKAEPRNKGLT
                     GHPQEKGPGSWQGPSARRTRDCARWERSKNRTPGSCYPHLPRGQGAYRSGTRREPLGL
                     ESEEGS"
     exon            74..148
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            149..248
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            249..316
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            317..386
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            387..458
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            459..596
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            597..689
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            690..824
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1479
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Rnf25"
                     /gene_synonym="0610009H16Rik; AO7"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggtt ccggccaaga gccggagaag acatggcggc gtctgcgtcg acagctgctg
       61 gggaagagga ctgggtcctt ccctctgaag ttgaagtatt agagtctatc tatctggatg
      121 agctacaggt gatgaaaggg aatggcagat caccatggga gatctttatc actctgcacc
      181 ctgccaccgc agaggtccaa gattcgcagt ttgtctgctt tactctggtt cttcggatcc
      241 cagtccagta tccccacgag gttccacaga tctccatccg taaccctcga ggactttcag
      301 atgagcagat ccacaagatc tcacaggccc tgggccatgt ggccaaggaa ggactaggca
      361 ctgccatgct ctatgaactc attgagaaag ggaaggagat tctcacggat aacaacattc
      421 cccatggcca gtgtgtcatc tgcctctatg gtttccagga gaaggaggcc tttaccaaaa
      481 caccctgtta ccactacttc cactgccatt gccttgccag gtacatccag cacatggaac
      541 aagagctgac tacacaggaa caggaacagg agcgacagca cgttgtcacc aagcagaagg
      601 cagtcggtgt gcagtgtcct gtgtgcaggg agccccttgt gtatgatctt gcctcgctga
      661 aagcagcccc tgaaccccaa caacccatgg agctgtacca acccagtgca gagagcttgc
      721 gccaacagga agagctcaaa ctgctgtatc agaggcagca ggaaaagggt ggtatcattg
      781 accttgaggc tgaacggaac cgatacttca ttagccttca gcagcctcct gctgctcttg
      841 agccggagtc agctgtagat gtctccagag aaccccagcc acctaatgcc ctttctgcag
      901 aacaatctac ttccctagct gaccaatcaa ctctgccaac ttctctaccc atgacaaccc
      961 agtatacgta tgagaagact tcgggggctg ggccaaatca acagaggccg ggtgagaccc
     1021 agaaatccgt gctagatcct ccacgacatg gtcgtggctc ctggcgacag tatgatcgga
     1081 ggcacccaaa aggaggggag tgctgcaccc caaaaggtac cagtgaaatc catgaactgc
     1141 cacctcctga gaagcctctc aaggagactg tagacttaaa ggcagaaccc cgtaacaaag
     1201 ggctcacagg tcatcctcag gagaaggggc ctggtagctg gcagggcccc tcagctcgca
     1261 ggactcggga ctgtgctcgc tgggaacgct ccaaaaaccg tacaccgggt tcttgctatc
     1321 cccacctacc tcggggccag ggagcatacc ggtctggtac tcgcagggag cccctgggct
     1381 tggaatctga ggaaggttcc tagcagtact gttgggggac agggaattgg ggtgggaggg
     1441 aggcaataaa gagaattgac ctttgcttaa cagcatctaa aaaaaaaaaa aaaaaaaa
//
