LOCUS       NM_025739               3043 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 220 (Rnf220), transcript variant
            1, mRNA.
ACCESSION   NM_025739
VERSION     NM_025739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Li,Y., Wan,L.P., Song,N.N., Ding,Y.Q., Zhao,S., Niu,J., Mao,B.,
            Sheng,N. and Ma,P.
  TITLE     RNF220-mediated K63-linked polyubiquitination stabilizes Olig
            proteins during oligodendroglial development and myelination
  JOURNAL   Sci Adv 10 (6), eadk3931 (2024)
   PUBMED   38324685
  REMARK    GeneRIF: RNF220-mediated K63-linked polyubiquitination stabilizes
            Olig proteins during oligodendroglial development and myelination.
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Deng,T., Zhong,P., Lou,R. and Yang,X.
  TITLE     RNF220 promotes gastric cancer growth and stemness via modulating
            the USP22/wnt/beta-catenin pathway
  JOURNAL   Tissue Cell 83, 102123 (2023)
   PUBMED   37295272
  REMARK    GeneRIF: RNF220 promotes gastric cancer growth and stemness via
            modulating the USP22/wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Ma,P., Wan,L.P., Li,Y., He,C.H., Song,N.N., Zhao,S., Wang,H.,
            Ding,Y.Q., Mao,B. and Sheng,N.
  TITLE     RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate
            synaptic transmission
  JOURNAL   Sci Adv 8 (39), eabq4736 (2022)
   PUBMED   36179027
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Wang,Y.B., Song,N.N., Zhang,L., Ma,P., Chen,J.Y., Huang,Y., Hu,L.,
            Mao,B. and Ding,Y.Q.
  TITLE     Rnf220 is Implicated in the Dorsoventral Patterning of the
            Hindbrain Neural Tube in Mice
  JOURNAL   Front Cell Dev Biol 10, 831365 (2022)
   PUBMED   35399523
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Roma,G., Cobellis,G., Claudiani,P., Maione,F., Cruz,P., Tripoli,G.,
            Sardiello,M., Peluso,I. and Stupka,E.
  TITLE     A novel view of the transcriptome revealed from gene trapping in
            mouse embryonic stem cells
  JOURNAL   Genome Res 17 (7), 1051-1060 (2007)
   PUBMED   17540781
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041785.1, BC056359.1 and AI837557.1.
            
            On Jul 18, 2015 this sequence version replaced NM_025739.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058415.1, SRR7974084.26155.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK041785.1         2-138
            138-3028            BC056359.1         1-2891
            3029-3043           AI837557.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.44 cM"
     gene            1..3043
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:66743"
                     /db_xref="MGI:MGI:1913993"
     exon            1..370
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1112
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..2188
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase Rnf220; RING-type E3 ubiquitin
                     transferase Rnf220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Rnf220 isoform 1"
                     /protein_id="NP_080015.3"
                     /db_xref="CCDS:CCDS18534.1"
                     /db_xref="GeneID:66743"
                     /db_xref="MGI:MGI:1913993"
                     /translation="MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQ
                     PRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPP
                     NLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADG
                     KEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFD
                     SQAPLCPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASI
                     KREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREG
                     SCMAEDDAVDIEHADSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDA
                     DLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFS
                     KWASDEMPSTSNGEGSKQEAMQKTCKNSDIEKITEESAVTTFEALKARVRELERQLSR
                     GDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL
                     "
     exon            1113..1245
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1291
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1393
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1436
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1480
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1613
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1710
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1797
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1853
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1932
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2041
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2116
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..3029
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3028
                     /gene="Rnf220"
                     /gene_synonym="4732477A13; 4931406I20Rik; 5730503K05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgtgagt gtgagagaat gtgtgcgtgc atgtgtgtgt gagtgtgtgt gtgcgcgcgc
       61 gcgtgtgtgt gcgcctccga gtccctggga gagtggaggc tcattcactg attagagcca
      121 gcgctgagag gcagcactgc tcttctctca caccaacaga gtctcttgat ctgtacatgc
      181 aatcccaggc agctcgcgag cacaaacccg gggccagccg cctgctgctg ctgctgctgc
      241 cgctgccgcc accaccgccg ccgctgcccc cgccggctct gcgcacccgg gacttttcat
      301 gcaccacact ctccgtcttc ttaccttggt gtcctgaaaa gtgcgatcgt tctccccagg
      361 aatttccacg gtcttcgaag ggcatgattc cccagtaata atcctcgccc tgatccaagg
      421 tgcaggtcgc cctcccttcc agggaagact gcttcttgtg tgacaccggc catcgaaaga
      481 gactccgatg gacttacacc gggcagcctt caagatggag aactcatcct atcttcccaa
      541 ccctctggcg tccccagcac tgatggtctt ggcgtccact gccgaggcca gcagggatgc
      601 ctccatccct tgtcagcagc cacgaccctt tggtgtacct gtctcagtag acaaggacgt
      661 tcacattccc ttcaccaatg gctcctacac ctttgcctct atgtaccacc ggcaaggtgg
      721 ggtgccgggc acttttgcca atcgtgattt ccccccttcc ttactacacc tccaccccca
      781 gtttgctccc ccaaacctag attgcacccc aatcagtatg ctaaatcaca gtggtgtggg
      841 ggcattccgt cccttcgctt ccacggagga cagggagagc tatcagtctg cctttactcc
      901 agccaagaga ctcaagaact gccatgacac agagtctccc cacctgcgct tctccgatgc
      961 agatggcaag gaatatgact ttgggaccca gctgccatcc agctcccctg gctcacttaa
     1021 ggttgatgat actgggaaga agatctttgc tgtgtctggc ctcatctctg accgggaaac
     1081 ctcctcgagt ccagaggatc ggaatgacag atgtaagaag aaagcagtag cgttgtttga
     1141 cagccaagcc ccgctctgcc ccatctgcca agtcctgctg aggcccagcg agttgcagga
     1201 acatatggag caggaactgg aacagctggc ccagctgcct gccagcaaaa attcccttct
     1261 gaaggatgcc atggctccgg gcacccccaa gtccctcctg ttgtctgctt ccatcaagag
     1321 ggaaggagac tctccaacgg cttccccaca ctcttctgcc acggaggacc tgcaccactc
     1381 agacagatac cagaccttcc tgcgagtgcg agccaaccgg caaacccgac tgaatgctcg
     1441 gattgggaaa atgaaacgga ggaagcaaga tgaagggcag agggaaggct cctgcatggc
     1501 tgaagatgat gctgtggaca tcgagcatgc ggacagcaac cgctttgagg aatatgagtg
     1561 gtgtgggcag aagcggatac gggccaccac actcctggaa ggtggcttcc gaggctccgg
     1621 cttcgtcatg tgcagtggca aagagaaccc agacagtgac gctgacctgg atgtggatgg
     1681 agatgacaca ctggagtatg ggaaaccaca atacacggag gctgatgtca tcccgtgcac
     1741 aggagaagag cctggtgaag ccaaggagag agaggcactc cggggcgcag tcctaaatgg
     1801 tggccctccg agcacccgca tcacacctga gttctctaaa tgggccagtg atgagatgcc
     1861 atccaccagc aatggtgaag gcagcaagca ggaggccatg cagaagacct gcaagaacag
     1921 cgacattgag aaaatcaccg aagagtcagc tgtaactaca tttgaggctc tgaaggctcg
     1981 ggtccgggag cttgaacggc agctatctcg gggggaccga tacaaatgcc tcatctgcat
     2041 ggactcttac tcgatgcctc tgacgtcgat ccagtgttgg catgtgcact gtgaagagtg
     2101 ttggctgcgg actctgggtg ccaagaagct ctgccctcag tgcaacacca tcacagcccc
     2161 cggagacctg cggaggatct acttatgagc tagctgtcta ggcaggcctt gcctcgagca
     2221 acgcccctgc ccagcctctg tgacagtgac tccctctccc cttgtacata ctctcacaca
     2281 ggttcccctt gtacatacat gcacatacac acccaaacac acatagagga ctctggagcc
     2341 gcagtgggac agccctgcct gcttgttctt ctgaacttgg ggaccatgcc tctttgggct
     2401 ctgcttccag gatggtttgg gaagcatagc agggcacggc tcggctcctg agatccatcc
     2461 cctagactga ctgaccgaca gacacacaaa caccagactg aagcacatgt aatatagact
     2521 gtgtatgttt acaatgttgt gtataaatgg gacactttgc cctctaccac ctcccctttg
     2581 gttgtatgat tttcttcttt tttaatgact cctggaagca gtgccccttc agagctggct
     2641 gggagcttgg ctcagccacc tcttagggtg cctgcctctg ccatggcatc ctgtcccttt
     2701 cccatgtgct cggtgttcag tggtgtatat ttcttctccc agacatgggg cgtgtgcccc
     2761 aaggggtctg atcccctcct tagtcttagc tcatggggcg gctcatgagg agctgggggc
     2821 agggtagaat gggaccgagc aggaacagag gctgcagttg ggctggctga ctgagggtgc
     2881 ctggctgccc agcctgcggt agccgtgctc cctgccctcc tgtggcccta tggtgtgatg
     2941 ctgtgtctgt atctatgtgt ctatacaaag gtacttgccc tttccctttg taaactacat
     3001 ttgacatgga ttaaaacagt ataaacaaga aaaaaaaaaa aaa
//
