LOCUS       NM_001146349            2873 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 217 (Rnf217), mRNA.
ACCESSION   NM_001146349 XM_193558 XM_985771
VERSION     NM_001146349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2873)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2873)
  AUTHORS   Jiang,L., Wang,J., Wang,K., Wang,H., Wu,Q., Yang,C., Yu,Y., Ni,P.,
            Zhong,Y., Song,Z., Xie,E., Hu,R., Min,J. and Wang,F.
  TITLE     RNF217 regulates iron homeostasis through its E3 ubiquitin ligase
            activity by modulating ferroportin degradation
  JOURNAL   Blood 138 (8), 689-705 (2021)
   PUBMED   33895792
  REMARK    GeneRIF: RNF217 regulates iron homeostasis through its E3 ubiquitin
            ligase activity by modulating ferroportin degradation.
REFERENCE   3  (bases 1 to 2873)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116557.30, BF467827.1, CN459606.1, BG070699.2 and AI853829.1.
            
            On or before Apr 9, 2009 this sequence version replaced
            XM_985771.1, XM_193558.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2091179.1,
                                           SRR7345562.2461408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1342              AC116557.30        157274-158615       c
            1343-1816           BF467827.1         128-601
            1817-2126           CN459606.1         359-668
            2127-2848           BG070699.2         12-733              c
            2849-2873           AI853829.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2873
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 17.45 cM"
     gene            1..2873
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /note="ring finger protein 217"
                     /db_xref="GeneID:268291"
                     /db_xref="MGI:MGI:3610311"
     exon            1..1342
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..2089
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /EC_number="2.3.2.31"
                     /note="IBR domain containing 1; IBR domain-containing
                     protein 1; probable E3 ubiquitin-protein ligase RNF217"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF217"
                     /protein_id="NP_001139821.1"
                     /db_xref="CCDS:CCDS48531.1"
                     /db_xref="GeneID:268291"
                     /db_xref="MGI:MGI:3610311"
                     /translation="MGEEQSTVSGSGGARASGGGSAGQPESPRPRGDRVRTAGPRAAA
                     SSSRPNGGGGGRDPGCVDASVQEPASNRAPAGQPARLPLSGPLDPQSLELQLEREAEG
                     AGPREAPPGQQPPDGLLLDVLAQRHPPPAKPQVLCSVYCVESDLPEAPSAESPSPSES
                     PPQAPLGPIPASPPPSFPSSPLSLPADPLSPDGGSIELEFYLAPEPFSVPGLLGAPPY
                     SGLGGVGDPYAPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKIYLSSQVQLGQVEIK
                     CPVTECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHI
                     PTPSRSESRYKIQCPTCQLIWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRN
                     AQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYR
                     YLPERPHLRRLVRGSVCAGKLFIAPLILVLGLALGAIAVVIGLFVFPIYCLCKKQRKR
                     SRTGMHW"
     exon            1343..1576
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1741
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1943
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2015
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2860
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2860
                     /gene="Rnf217"
                     /gene_synonym="Ibrdc1"
                     /note="major polyA site"
ORIGIN      
        1 agggccctag gtgctgcacg aggagaggga ggtctcccgc ttctcctcca gggacaccag
       61 ccactgcttg cggactcggc cacctctcgg tgacgccaca ggcccggcga ccctcgggat
      121 cgccggctgc gcgccccgcc gcggaggcag ggatggcgcg gggctgaccg tctcctcccg
      181 cctcccggga actcttccgc cccacccggg actcgcgggt ccgcggcagc gccgcgacgt
      241 gcatgcgggc cgggccccct cagcctgagg ccctcggagt cctcgaggcg gtgcccggcc
      301 gcgccggacg aggaggaaga cgacgactac gaggtggagg aggaggagcc ggctgcccgc
      361 acgctgcggc ccgggagccc gggctccccg gagggcgctt ggggcgtccc ggccccggag
      421 gagggatccg gaagcagaag ggccgccgcg agtggagcgg agccgcttgc ccgcgctgcc
      481 cggcgccggc tgggggtccg ggcggctgga tgggcggcgg cggcgcaggc cgcgggcggc
      541 gatgggcgag gagcagagca cggtgagcgg cagcggcggg gcgcgggcct ctggcggagg
      601 ctcggcgggc cagcccgagt cccccaggcc gcgaggggac cgcgtccgga cagccgggcc
      661 gcgcgctgca gcctcctctt cacggccgaa cggcggcggc ggcggcagag acccgggctg
      721 cgtggacgcg agtgtccagg agcctgcgag caaccgggcc ccggcagggc agcccgcgcg
      781 actgccactc agcgggcccc tggaccccca gagtctggaa ctgcagctgg agcgcgaggc
      841 ggagggagcg gggccacggg aggcgccccc cggccagcag ccccccgacg ggctgctcct
      901 ggacgtgctg gcccagcgac acccgccccc cgccaagccg caagtcctct gctccgtgta
      961 ctgcgtggag agcgacttgc ccgaggcccc ctccgccgag tccccgtcgc cgtcggagtc
     1021 cccacctcaa gcaccgctgg ggccgattcc cgccagcccg ccgccctcct tccccagctc
     1081 cccgctgtcg ctcccggctg accccctttc ccccgacggc ggcagcatcg agctggagtt
     1141 ctacctggct ccggagccct tctccgtgcc tggcctatta ggggctccac cctactctgg
     1201 cctgggggga gtaggggacc cctatgcgcc cctcatggtg ctgatgtgcc gggtgtgcct
     1261 ggaagacaaa cccatcaagc ccctgccctg ctgcaagaag gcggtgtgcg aggagtgcct
     1321 caaaatctac ctgagctctc aggtacaact tggccaagta gaaatcaaat gcccagtcac
     1381 agagtgtttc gaattcctgg aggaaacaac tgttgtctac aatttaaccc atgaggactc
     1441 tatcaagtat aagtacttct tggaacttgg ccgaattgac tccagcacca agccatgtcc
     1501 tcaatgcaaa cacttcacaa cctttaagaa aaaaggacat atccccactc cttccagatc
     1561 agaaagcaga tacaaaatcc agtgtcccac ttgccaattg atctggtgtt ttaagtgcca
     1621 ctctccttgg catgaaggtg ttaactgcaa ggagtacaaa aaaggagaca agttactgcg
     1681 tcactgggcc agtgagattg agcacgggca gagaaatgcc cagaagtgtc caaagtgcaa
     1741 gatccatatc cagagaacag aagggtgtga ccatatgact tgttcacagt gtaacactaa
     1801 tttttgctat cgatgtggag agagataccg ccagctccgg tttttcggag accacacatc
     1861 aaacctcagt atatttggat gcaaatatcg ctacctccca gagagacctc atttaagaag
     1921 attagttcga gggtcagtct gtgctggaaa gctcttcatt gcgcctctca tcctggtttt
     1981 gggattggca ctaggggcca tagcagttgt aatcggttta tttgtatttc ctatatattg
     2041 cctttgtaaa aaacagagaa agcgatcacg gacaggtatg cactggtaat ccacagagga
     2101 tttcacatga tgtcagccgg taccgggagg agccatgcag gatggtgcac ttgtctgtga
     2161 gttggatcct taaaactacc tagaggaact tctgccatct tgtctcctgt ggttctctgc
     2221 agaccacagt gcctctagct acggtgcact cccaacatgg catcctgtcc tttccttaag
     2281 cagattgctg ctttttaaaa aaatggtcac tttcgttaac tatatacatt tatatagtaa
     2341 ctctcacctt tgtggttctt ggaagaaaat attttgagaa caggatatcc tcagatgtct
     2401 tttgaggata cctcacctgg agtgttattt ggattgtctg aaccttgtgc ttcccccggg
     2461 ctgtctctga gacatggtat gcatagctga atccggcctg tctcaacaaa caaagccact
     2521 tttcagaaga taaatcaaag ttcaccaaat gtacctaatt gtcctctgta acccaaatgg
     2581 tatcatcgtt ttgttttttg gatactgtaa ttgctttaaa aaaaaaagtg tcagcaccca
     2641 gagggaatta atgaaactaa attaatgaaa agaaccatga gttactggtc cgtctatgta
     2701 aggatgtgaa tgtgtgtata taaacaccgt attaaaccag gctccataac catgtgcttg
     2761 cctatttcca tgtctatttt catagaacct ttcagccttg atggttattt ttgtgggcct
     2821 aacttggtaa tgtactgaat taaagccaat gtcaacaaca aaaaaaaaaa aaa
//
