LOCUS       NM_178709               4085 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 214 (Rnf214), transcript variant
            1, mRNA.
ACCESSION   NM_178709
VERSION     NM_178709.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4085)
  AUTHORS   Faghihi,M.A., Modarresi,F., Khalil,A.M., Wood,D.E., Sahagan,B.G.,
            Morgan,T.E., Finch,C.E., St Laurent,G. 3rd, Kenny,P.J. and
            Wahlestedt,C.
  TITLE     Expression of a noncoding RNA is elevated in Alzheimer's disease
            and drives rapid feed-forward regulation of beta-secretase
  JOURNAL   Nat Med 14 (7), 723-730 (2008)
   PUBMED   18587408
REFERENCE   3  (bases 1 to 4085)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126804.3.
            
            On Mar 1, 2018 this sequence version replaced NM_178709.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051527.1, BC094247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AC126804.3         214507-215066       c
            561-674             AC126804.3         212961-213074       c
            675-1185            AC126804.3         207901-208411       c
            1186-1245           AC126804.3         206587-206646       c
            1246-1386           AC126804.3         204240-204380       c
            1387-1526           AC126804.3         198959-199098       c
            1527-1623           AC126804.3         180026-180122       c
            1624-1712           AC126804.3         179701-179789       c
            1713-1803           AC126804.3         177609-177699       c
            1804-1902           AC126804.3         177334-177432       c
            1903-2279           AC126804.3         175894-176270       c
            2280-2412           AC126804.3         175655-175787       c
            2413-2508           AC126804.3         174721-174816       c
            2509-4085           AC126804.3         171577-173153       c
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.26 cM"
     gene            1..4085
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="ring finger protein 214"
                     /db_xref="GeneID:235315"
                     /db_xref="MGI:MGI:2444451"
     exon            1..560
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..674
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..2574
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RING finger protein 214 isoform 1"
                     /protein_id="NP_848824.1"
                     /db_xref="CCDS:CCDS23136.1"
                     /db_xref="GeneID:235315"
                     /db_xref="MGI:MGI:2444451"
                     /translation="MAASEVAGLGAGTPSPSESSALCASKSDESLPDGLSPKDSAQKQ
                     KNLSPPSVSSQMITKESNRNAHLEHPEQNPGSSVGDTSAAHEEVVGENLVATALCLSG
                     NGSQSDLKDLTNPAGEEGDTSLRESLHPVTRSLKAGCHSKQLASGNCSEEKCPAASVL
                     KEGSRDAGLDLLPVVPPANGVEGVRVDQDDDQDSSSLKLSQNIAVQTDFKTADSEVNT
                     DQDIEKNLDKMMTERTLLKERYQEVLDKQRQVESQLQVQLKQLQQRREEEMKNHQEIL
                     KAIQDVTIKREETKKKIEKEKKEFLQKEQDLKAEIEKLCEKGRREVWEMELDRLKNQD
                     GEINRNIMEETERAWKAEILSLESRKELLVLKLEEAEKEAELHLTYLKSTPPTLETVR
                     SKQEWETRLNGVRIMKKNVRDQFNSHIQLVRNGAKLSSLPQIPTPTLPPPPSEADFML
                     QVFQPSPSLTPRMPFSIGQVTMPMVMPSADPRSLSFPILNPALSQSSQPSPPLPGSHG
                     RNSPGLGSLVSPHGPHMPPAASIPPPPGLGGIKASSETPRPQPVDKLEKILEKLLTRF
                     PQCNKAQMTNILQQIKTARTTMAGLTMEELIQLVAARLAEHERVASSTQAPPTCKLCL
                     MCQKLVQPSELHPMACTHALHKECIKFWAQTNTNDTCPFCPTLK"
     exon            675..1185
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1245
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1386
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1526
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1623
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1712
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1803
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1902
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2279
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2412
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2508
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..4085
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="hexamer: AGTAAA"
     regulatory      3209..3214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="hexamer: AACAAA"
     polyA_site      3215
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="major polyA site"
     polyA_site      3237
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      3982
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
     polyA_site      4085
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
ORIGIN      
        1 aatcagcggc tgggcctgcg gcctcttgac cagcgggccg agctccgggc gctccgccga
       61 cagcttctgt cacaggcccg tgagggctgt gggagttccg gcgcctcgaa tcctcgtgtc
      121 ctccgccaca ggaccccctc cgccacaggg ccctcgtcct tcatggcgtc ctctgtaagg
      181 accatcccgg ttccgacctc taaacacccc tcgcggctct tctccgtcgg actgccatag
      241 ccttgactct tccccataaa ctcctcagag aggctctcgc ctccatccgg ccgccgtctc
      301 tctggcccgc gtgtccctcg ggctccgctt gggtctcagg gctggtcccc tcagcggctc
      361 cgttgtccgg tcgctgtccg cgcctgccgc cagagggcgc cgtcggtggc ggccgctcac
      421 cccgcgggtt ccgctcctct cgccgccccg gcctcgcccc cttgcgctcg cgccgccgga
      481 agtgggaggt gccgcgcgcg ggccagcgct cgacccctcc cccaggcttg gccgccccct
      541 cccccgctcc gcccgctcag agtgcagatg gcggcctctg aggtagctgg ccttggggcc
      601 ggtaccccga gtccttcgga atcttctgct ttgtgtgcat ccaagtccga tgaatctctc
      661 ccagatggcc taagccccaa agactctgcc cagaaacaga agaacttgtc tccgccgagt
      721 gtaagtagcc aaatgataac caaggagagt aacagaaatg cccatttgga acatccagaa
      781 cagaatcctg gttcatcagt gggtgatact tcagcagcgc acgaggaagt tgtaggagaa
      841 aacttggtag ccacagccct ttgtctttct ggcaatgggt ctcagtctga tttgaaggac
      901 ttgaccaacc cagcaggaga ggagggggac acgagcctcc gggagagcct ccatccagtc
      961 actcggtctc ttaaggcagg gtgccactca aaacaacttg cctccgggaa ttgctctgaa
     1021 gagaaatgcc cagcagcctc cgtcctaaag gaaggtagca gggatgcagg cttggacttg
     1081 ctacctgtag taccgcctgc aaatggggtt gaaggagtga gagtggatca ggatgatgat
     1141 caggatagct cttccttgaa gctttctcag aacattgctg tgcagactga ctttaaaaca
     1201 gcagattcgg aagtaaacac agaccaagat attgaaaaga atctggacaa aatgatgaca
     1261 gagagaactc tgttgaagga gcgttaccaa gaagtcctgg acaagcagag gcaggtggag
     1321 agtcagctcc aggtgcagtt aaagcagctt cagcaaaggc gagaagaaga aatgaagaat
     1381 caccaggaga tactaaaggc cattcaggat gtgaccataa agcgagaaga aaccaagaag
     1441 aagatagaga aagaaaagaa ggagttcttg cagaaggagc aggacctgaa agctgaaatc
     1501 gagaagctct gtgagaaggg cagaagagaa gtgtgggaaa tggaactgga tagactcaag
     1561 aaccaggatg gtgaaatcaa ccggaatatt atggaagaga cagagcgggc ctggaaagca
     1621 gagatactgt cactagagag ccggaaggag ttgctggtgt tgaaactgga agaagcagaa
     1681 aaagaagcag aacttcatct gacttacctc aagtcaactc ctccaacact agagacagtt
     1741 cgttccaaac aagagtggga gacaagactg aatggagttc ggataatgaa aaagaatgtt
     1801 cgggaccagt ttaatagtca tatccagcta gtgaggaatg gagccaagct gagcagcctt
     1861 cctcagatcc ctaccccaac tttgcctcca ccaccctcag aggcagattt catgcttcaa
     1921 gtatttcagc ccagtccctc tctgacccct cggatgccct tctctatcgg gcaggtcact
     1981 atgcctatgg ttatgcccag tgcggatcct cgctctttgt cttttccgat cttgaaccct
     2041 gccctttccc agtccagcca accttcccca cctcttcctg gctcacatgg gagaaatagc
     2101 cctggcttgg gttccctggt cagccctcat ggtccacaca tgcctcctgc tgcctccatc
     2161 ccgcctcccc caggcttggg cggtattaag gcttcttctg aaactccccg gccccaacca
     2221 gtagacaaac tggagaagat cctggagaag ctgctgactc ggttcccaca gtgcaataag
     2281 gcccagatga ccaacattct tcagcaaatc aagacagcac gtaccaccat ggcgggcctg
     2341 accatggagg aactaatcca actggtagcc gcacgactgg cagagcatga acgggtggca
     2401 tcaagcactc aggctccacc cacttgtaaa ctgtgtctga tgtgtcagaa acttgtccag
     2461 cccagtgagc tgcacccgat ggcctgcacc cacgcactgc acaaggagtg tatcaaattc
     2521 tgggcccaga ccaacacaaa tgacacttgt cccttttgcc caactcttaa atgatggacc
     2581 cgactgggga ggaagaagag gagaaacaga tgcgaacagg aagcgcgggt tcaagatttc
     2641 taaaactcta tatatttata cagtgacata tactcatgcc gtgtacattt ttattatata
     2701 ggtaatgtgt gtatagaaag tctgtattca aatgttcgta atgaaagtat gtatataatg
     2761 cagaaacacc ccttttcccc tcatcttgca gtttttgggg ggatgcagac tgtagggata
     2821 tatgatgttt aatttggcct tgaaatcatg atccctgcat aggactgttg tctaacccat
     2881 ctaggaagct gctgttgctg taaggccatc ctgctttggt ttgtcccagc ctctagtcca
     2941 tttttataag gcttgtgtat gcagatgtga tgtctggtgc tcacctgctg tgcatccaga
     3001 tgctggcctt gcaggggcct ccaagccttg gtgttagttt agccactcta ctccaataga
     3061 caaaatgata ctgactgagg ggaacaaatg taactctgat agtttgattc attgaacatt
     3121 ttactgtgtt aatcctcatt atttatacat tgatatcagg tatacaggat attctgtttt
     3181 atgtcagtaa aatccacagt ccaagaacaa caaaatcagg ttccatttct cccaccatct
     3241 tctgtctact ctgctttcta gatagaaaag cacaattcac agatttttcc cctgggccaa
     3301 gccaccatcc cttgttgcta ctggtttagc ctccactaag cactgaccag ccaggcttgc
     3361 aaagtgctca cccttccatt cctctggttt cctaatctag ctatcccctc cccccaaagg
     3421 ttaaggcaat tggttcacca ccaagtgatt tggtgacctt aggtgagctc cagacaggca
     3481 ctggggtgag atgtctgtgc aaaattactt gcagaataat cgtgggatgt tggacttcat
     3541 ttatcaatca agaacgctat gaaggataca ttccctgtct agaatacagt ggagacagtg
     3601 agatgaagga aggtggtaca gttgtaagct atgctttgtg gattcccatc tggaggaaga
     3661 taggtttgcc accgccactt actgagttct tctggttttt atgtctgaga cagctgtggc
     3721 tctgagaacc ttgagtcttt cccaatcttt atctttactc ctacaggaaa tggttttaat
     3781 taccttcttt tttcagaatt aaacaagtgt taattgagaa aaaatgcatc tgggggaagg
     3841 gtaacatgct actgacaatt gatgttttcc catcctggga ctgggggtgc ttattgagtc
     3901 tagcagtttc tgttaggata gcaaagactt tgtcctttct gagctaacta aattctcttg
     3961 tttttctctg ccttgcctat gagctcatgg atgaattctt ttctcttgcc ttattgtcca
     4021 ggttgattga taagcatgat taggggtgga cttcccaggg ttaccttaaa atctttaagg
     4081 gggaa
//
