LOCUS       NP_848824                668 aa            linear   ROD 02-MAY-2024
DEFINITION  RING finger protein 214 isoform 1 [Mus musculus].
ACCESSION   NP_848824
VERSION     NP_848824.1
DBSOURCE    REFSEQ: accession NM_178709.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 668)
  AUTHORS   Faghihi,M.A., Modarresi,F., Khalil,A.M., Wood,D.E., Sahagan,B.G.,
            Morgan,T.E., Finch,C.E., St Laurent,G. 3rd, Kenny,P.J. and
            Wahlestedt,C.
  TITLE     Expression of a noncoding RNA is elevated in Alzheimer's disease
            and drives rapid feed-forward regulation of beta-secretase
  JOURNAL   Nat Med 14 (7), 723-730 (2008)
   PUBMED   18587408
REFERENCE   3  (residues 1 to 668)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126804.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051527.1, BC094247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.26 cM"
     Protein         1..668
                     /product="RING finger protein 214 isoform 1"
                     /calculated_mol_wt=73494
     Region          1..87
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Region          103..125
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Region          486..552
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            497
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            511
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Site            516
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8ND24; propagated from
                     UniProtKB/Swiss-Prot (Q8BFU3.1)"
     Region          621..665
                     /region_name="RING-H2_RNF214"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 214 (RNF214) and similar proteins; cd16477"
                     /db_xref="CDD:438140"
     CDS             1..668
                     /gene="Rnf214"
                     /gene_synonym="D130054N24Rik"
                     /coded_by="NM_178709.5:568..2574"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23136.1"
                     /db_xref="GeneID:235315"
                     /db_xref="MGI:MGI:2444451"
ORIGIN      
        1 maasevaglg agtpspsess alcasksdes lpdglspkds aqkqknlspp svssqmitke
       61 snrnahlehp eqnpgssvgd tsaaheevvg enlvatalcl sgngsqsdlk dltnpageeg
      121 dtslreslhp vtrslkagch skqlasgncs eekcpaasvl kegsrdagld llpvvppang
      181 vegvrvdqdd dqdssslkls qniavqtdfk tadsevntdq dieknldkmm tertllkery
      241 qevldkqrqv esqlqvqlkq lqqrreeemk nhqeilkaiq dvtikreetk kkiekekkef
      301 lqkeqdlkae ieklcekgrr evwemeldrl knqdgeinrn imeeterawk aeilslesrk
      361 ellvlkleea ekeaelhlty lkstpptlet vrskqewetr lngvrimkkn vrdqfnshiq
      421 lvrngaklss lpqiptptlp pppseadfml qvfqpspslt prmpfsigqv tmpmvmpsad
      481 prslsfpiln palsqssqps pplpgshgrn spglgslvsp hgphmppaas ippppglggi
      541 kassetprpq pvdklekile klltrfpqcn kaqmtnilqq iktarttmag ltmeeliqlv
      601 aarlaeherv asstqapptc klclmcqklv qpselhpmac thalhkecik fwaqtntndt
      661 cpfcptlk
//
