LOCUS       NM_001040005           16751 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ring finger protein 213 (Rnf213), mRNA.
ACCESSION   NM_001040005 XM_895037 XM_911952
VERSION     NM_001040005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 16751)
  AUTHORS   Yang,X., Zhu,X., Sheng,J., Fu,Y., Nie,D., You,X., Chen,Y., Yang,X.,
            Ling,Q., Zhang,H., Li,X. and Hu,S.
  TITLE     RNF213 promotes Treg cell differentiation by facilitating
            K63-linked ubiquitination and nuclear translocation of FOXO1
  JOURNAL   Nat Commun 15 (1), 5961 (2024)
   PUBMED   39013878
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16751)
  AUTHORS   Li,S., Li,Y., Huang,P., Mao,X., Jiang,K., Chen,R., Li,Q., Wang,L.,
            Jin,Z., Wan,C., Xiong,Y., Yu,Y., Sheng,W., Hong,D. and Lin,J.
  TITLE     Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury
            by Inhibiting Neuronal Apoptosis Through the
            Akt/GSK-3beta/beta-catenin/Bcl-2 Pathway
  JOURNAL   Neuroscience 533, 10-21 (2023)
   PUBMED   37778692
  REMARK    GeneRIF: Knockout of Rnf213 Ameliorates Cerebral
            Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis
            Through the Akt/GSK-3beta/beta-catenin/Bcl-2 Pathway.
REFERENCE   3  (bases 1 to 16751)
  AUTHORS   Ye,F., Niu,X., Liang,F., Dai,Y., Liang,J., Li,J., Wu,X., Zheng,H.,
            Qi,T. and Sheng,W.
  TITLE     RNF213 loss-of-function promotes pathological angiogenesis in
            moyamoya disease via the Hippo pathway
  JOURNAL   Brain 146 (11), 4674-4689 (2023)
   PUBMED   37399508
  REMARK    GeneRIF: RNF213 loss-of-function promotes pathological angiogenesis
            in moyamoya disease via the Hippo pathway.
REFERENCE   4  (bases 1 to 16751)
  AUTHORS   Li,W., Niu,X., Dai,Y., Wu,X., Li,J. and Sheng,W.
  TITLE     Rnf-213 Knockout Induces Pericyte Reduction and Blood-Brain Barrier
            Impairment in Mouse
  JOURNAL   Mol Neurobiol 60 (11), 6188-6200 (2023)
   PUBMED   37438553
  REMARK    GeneRIF: Rnf-213 Knockout Induces Pericyte Reduction and
            Blood-Brain Barrier Impairment in Mouse.
REFERENCE   5  (bases 1 to 16751)
  AUTHORS   Ahmed,S., Habu,T., Kim,J., Okuda,H., Oikawa,S., Murata,M.,
            Koizumi,A. and Kobayashi,H.
  TITLE     Suppression of RNF213, a susceptibility gene for moyamoya disease,
            inhibits endoplasmic reticulum stress through SEL1L upregulation
  JOURNAL   Biochem Biophys Res Commun 609, 62-68 (2022)
   PUBMED   35413541
  REMARK    GeneRIF: Suppression of RNF213, a susceptibility gene for moyamoya
            disease, inhibits endoplasmic reticulum stress through SEL1L
            upregulation.
REFERENCE   6  (bases 1 to 16751)
  AUTHORS   Ito,A., Fujimura,M., Niizuma,K., Kanoke,A., Sakata,H.,
            Morita-Fujimura,Y., Kikuchi,A., Kure,S. and Tominaga,T.
  TITLE     Enhanced post-ischemic angiogenesis in mice lacking RNF213; a
            susceptibility gene for moyamoya disease
  JOURNAL   Brain Res 1594, 310-320 (2015)
   PUBMED   25446450
  REMARK    GeneRIF: Angiogenesis was enhanced in mice lacking RNF213 after
            chronic hind-limb ischemia, which suggested the potential role of
            the RNF213 abnormality in the development of pathological vascular
            networks in chronic ischemia.
REFERENCE   7  (bases 1 to 16751)
  AUTHORS   Sonobe,S., Fujimura,M., Niizuma,K., Fujimura,T., Furudate,S.,
            Nishijima,Y., Kure,S. and Tominaga,T.
  TITLE     Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease
            susceptibility gene
  JOURNAL   Neuroreport 25 (18), 1442-1446 (2014)
   PUBMED   25383461
REFERENCE   8  (bases 1 to 16751)
  AUTHORS   Sonobe,S., Fujimura,M., Niizuma,K., Nishijima,Y., Ito,A.,
            Shimizu,H., Kikuchi,A., Arai-Ichinoi,N., Kure,S. and Tominaga,T.
  TITLE     Temporal profile of the vascular anatomy evaluated by 9.4-T
            magnetic resonance angiography and histopathological analysis in
            mice lacking RNF213: a susceptibility gene for moyamoya disease
  JOURNAL   Brain Res 1552, 64-71 (2014)
   PUBMED   24440776
  REMARK    GeneRIF: Functional loss of RNF213 did not sufficiently induce
            moyamoya disese. Suppression of vascular remodeling in RNF213-/-
            requires further examination to clarify the role of RNF213.
REFERENCE   9  (bases 1 to 16751)
  AUTHORS   Kobayashi,H., Yamazaki,S., Takashima,S., Liu,W., Okuda,H., Yan,J.,
            Fujii,Y., Hitomi,T., Harada,K.H., Habu,T. and Koizumi,A.
  TITLE     Ablation of Rnf213 retards progression of diabetes in the Akita
            mouse
  JOURNAL   Biochem Biophys Res Commun 432 (3), 519-525 (2013)
   PUBMED   23410753
  REMARK    GeneRIF: These findings indicated that the disruption of Rnf213
            improved glucose tolerance by protecting islet beta cells.
REFERENCE   10 (bases 1 to 16751)
  AUTHORS   Silva,A.M., Bottrel,R.L. and Reis,L.F.
  TITLE     Identification and partial characterization of FRAG-6, a novel
            interferon-stimulated gene that is expressed in an
            IRF-1-INDEPENDENT manner
  JOURNAL   Cytokine 11 (11), 813-821 (1999)
   PUBMED   10547268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645911.14.
            
            On Jul 8, 2018 this sequence version replaced NM_001040005.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL645911.14        97034-97061
            29-141              AL645911.14        100019-100131
            142-311             AL645911.14        109457-109626
            312-779             AL645911.14        115649-116116
            780-893             AL645911.14        116348-116461
            894-1063            AL645911.14        117040-117209
            1064-1219           AL645911.14        117657-117812
            1220-1431           AL645911.14        118362-118573
            1432-1715           AL645911.14        121267-121550
            1716-1975           AL645911.14        121974-122233
            1976-2173           AL645911.14        123382-123579
            2174-2399           AL645911.14        125009-125234
            2400-2455           AL645911.14        126108-126163
            2456-2609           AL645911.14        127001-127154
            2610-2774           AL645911.14        128249-128413
            2775-2864           AL645911.14        129940-130029
            2865-2987           AL645911.14        131091-131213
            2988-3168           AL645911.14        132928-133108
            3169-3342           AL645911.14        134431-134604
            3343-3492           AL645911.14        134948-135097
            3493-4076           AL645911.14        137101-137684
            4077-4242           AL645911.14        138523-138688
            4243-4460           AL645911.14        140346-140563
            4461-4601           AL645911.14        141623-141763
            4602-4769           AL645911.14        141871-142038
            4770-5919           AL645911.14        142846-143995
            5920-6113           AL645911.14        144553-144746
            6114-6269           AL645911.14        144908-145063
            6270-9872           AL645911.14        147124-150726
            9873-10009          AL645911.14        152565-152701
            10010-10105         AL645911.14        153045-153140
            10106-10224         AL645911.14        154170-154288
            10225-10344         AL645911.14        155689-155808
            10345-10454         AL645911.14        156180-156289
            10455-10605         AL645911.14        156659-156809
            10606-10744         AL645911.14        157028-157166
            10745-10936         AL645911.14        159446-159637
            10937-11082         AL645911.14        161375-161520
            11083-11237         AL645911.14        163088-163242
            11238-11462         AL645911.14        165203-165427
            11463-11644         AL645911.14        165668-165849
            11645-11765         AL645911.14        166876-166996
            11766-11866         AL645911.14        168826-168926
            11867-12049         AL645911.14        169036-169218
            12050-12219         AL645911.14        170239-170408
            12220-12319         AL645911.14        170503-170602
            12320-12431         AL645911.14        171940-172051
            12432-12642         AL645911.14        172821-173031
            12643-12833         AL645911.14        173159-173349
            12834-12956         AL645911.14        174162-174284
            12957-13067         AL645911.14        174905-175015
            13068-13310         AL645911.14        175753-175995
            13311-13392         AL645911.14        177067-177148
            13393-13427         AL645911.14        177790-177824
            13428-13522         AL645911.14        178650-178744
            13523-13682         AL645911.14        180299-180458
            13683-13851         AL645911.14        181101-181269
            13852-13943         AL645911.14        183398-183489
            13944-14195         AL645911.14        183984-184235
            14196-14328         AL645911.14        186472-186604
            14329-14412         AL645911.14        186799-186882
            14413-14593         AL645911.14        187686-187866
            14594-14795         AL645911.14        188081-188282
            14796-14873         AL645911.14        189332-189409
            14874-15068         AL645911.14        189866-190060
            15069-15158         AL645911.14        190590-190679
            15159-15337         AL645911.14        190772-190950
            15338-16751         AL645911.14        192940-194353
FEATURES             Location/Qualifiers
     source          1..16751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.48 cM"
     gene            1..16751
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /note="ring finger protein 213"
                     /db_xref="GeneID:672511"
                     /db_xref="MGI:MGI:1289196"
     exon            1..28
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            29..141
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..15491
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF213; E3
                     ubiquitin-lipopolysaccharide ligase RNF213"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF213"
                     /protein_id="NP_001035094.2"
                     /db_xref="GeneID:672511"
                     /db_xref="MGI:MGI:1289196"
                     /translation="MECPQCGHVSSEKAPKFCSECGQKLPSAATVQGDLKNDNTLVVS
                     STPEGKTEQGAVLREEEVLLSSTDPGKELEKPEESDSNASWTTQMSKKEKRRRKRQGT
                     ISSSEAPSSGLWSLDMPPSPGSHNSALPQNQAQQGGAASQPGHPLDTENMPMEDGFVH
                     TEGSGSPLQGQAAERTDAQSNLAPSDLAEVKDLNTSKPSVDKGLPLDGGPALSAFKGH
                     PKMTDASQKAPLPESKGETSGQEKKVPPIDAAASPVKTAGKETGEDVRKPKPSPVSPV
                     ASKHGDQEAELKGKLATPVRKSNEGGNTQPEDQRKPGEGRNFAAAVKTQQAAAPQQAA
                     APEPTSAFNPRDTVTVYFHAIVSRHFGFNPEEHKVYVRGGEGLGQKGWTDACEMYCTQ
                     DLHDLGSLVEGKMDIPRQSLDKPIPYKYVIHRGGSSKDTVEYEFIYEQAQKKGEHVNR
                     CLRVVSTSLGNGDWHQYDDIICMRSTGFFQQAKNRILDSTRKELLKGKKQAAVVMLDR
                     IFSVLQPWSDINLQSFMTQFLQFYSVVREPMIHDGRARKWTSLQYEEKEVWTNLWEHV
                     KKQMAPFLEGKSGESLPADCPVRSKLTLGLSILFMVEAAEFTVPKKDLDSLCYLLIPS
                     AGSPEALHSDLSPVLRIRQRWRIYLTNLCLRCIDERCDRWLGILPLLHTCMQKSPPKK
                     NSKSQPEDTWAGLEGISFSEFRDKAPTRSQPLQFMQSKMALLRVDEYLFRSWLSVVPL
                     ESLSSYLENSIDYLSDVPVRVLDCLQGISYRLPGLRKISNQNMKKDVENVFKMLMHLV
                     DIYQHRIFGENLLQIYLTECLTLHETVCNITANHQFFEIPALSAELICKLLELSPPGH
                     TDEGLPEKSYEDLVTSTLQEALATTRNWLRSLFKSRMLSISSAYVRLTYSEEMAVWRR
                     LVEIGFPEKHGWKGSLLGDMEGRLKQEPPRLQISFFCSSQCRDGGLHDSVSRSFEKCV
                     IEAVSSACQSQTSVLEGLSCQDLQKFGTLLSAVITKSWPVHNGEPVFDVDEIFKYLLK
                     WPDVRQLFELCGTNEKIIDNITEEGRQLMATAESVFQKVAGELENGTIVVGQLELILE
                     HQSQFLDIWNLNRRRLPSQEKACDVRSLLKRRRDDLLFLKQEKRYVESLLRQLGRVKH
                     LVQVDFGNIEIIHSQDLSNKKLNEAVIKLPNSSSYKRETHYCLSPDIREMASKLDSLK
                     DSHIFQDFWQETAESLNTLDKDPRELKVSLPEVLEYLYNPCYDNFYTLYENLKSGKIT
                     FAEVDAIFKDFVDKYDELKNDLKFMCTMNPQDQKGWISERVGQIKEYHTLHQAVSSAK
                     VILQVRRALGVTGDFSVLNPLLNFADSFEDFGNEKLDQISPQFIKAKQLLQDISEPRQ
                     RCLEELARQTELVAWLHKALEDINELKVFVDLASISAGENDIDVDRVACFHDAVQGYA
                     SLLYKMDERTNFSDFMNHLQELWRALDNDQHLPDKLKDSARNLEWLKTVKESHGSVEL
                     SSLSLATAINSRGVYVIEAPKDGQKISPDTVLRLLLPDGHGYPEALRTYSTEELKELL
                     NKLMLMSGKKDHNSNTEVEKFSEVFSNMQRLVHVFIKLHCAGNMLFRTWTAKVYCCPD
                     GGIFMNFGLELLSQLTEKGDVIQLLGALCRQMEDFLDNWKTVVAQKRAEHFYLNFYTA
                     EQLVYLSSELRKPRPSEAALMMLSFIKGKCTVQDLVQATSACESKADRYCLREVMKKL
                     PQQLLSEPSLMGKLQVIMMQSLVYMSAFLPHCLDLDALGRCLAHLATMGGTPVERPLP
                     KGLQAGQPNLILCGHSEVLPAALAIYMQAPRQPLPTFDEVLLCTPATTIEEVELLLRR
                     CLTSGSQGHKVYSLLFADQLSYEVGCQAEEFFQSLCTRAHREDYQLVILCDAAREHCY
                     IPSTFSQYKVPLVPQAPLPNIQAYLQSHYQVPKRLLSAATVFRDGLCVGIVTSERAGV
                     GKSLYVNTLHTKLKAKLRDETVPLKIIRLTEPHLDENQVLSALLPFLKEKYQKMPVIF
                     HIDISTSVQTGIPIFLFKLLILQYLMDINGKIWRRSPGHLYLVEIPQGLSVQPKRSSK
                     LNARAPLFKFLDLFPKVTCRPPKEVIDMELTPERSHTDPAMDPVEFCSEAFQRPYQYL
                     KRFHQQQNLDTFQYEKGSVEGSPEECLQHFLIYCGLINPSWSELRNFAWFLNCQLKDC
                     EASIFCKSAFTGDTLRGFKNFVVTFMILMARDFATPTLHTSDQSPGRQSVTIGEVVEE
                     DLAPFSLRKRWESEPHPYVFFNGDHMTMTFIGFHLETNNNGYVDAINPSNGKVIKKDV
                     MTKELFDGLRLQRVPFNIDFDNLPRYEKLERLCLALGIEWPIDPDETYELTTDNMLKI
                     LAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLKRGSVEAETMKLVKVHGGTTPSMIY
                     SKVKEAERTAFSNKAQHKLDTILFFDEANTTEAVSCIKEILCDRTVDGEHLHEDSGLH
                     IIAACNPYRKHSQEMILRLESAGLGYRVSAEETADRLGSIPLRQLVYRVHALPPSLIP
                     LVWDFGQLNDSAEKLYIQQIVQRLVDSVSVNPSETCVIADVLSASQMFMRKRENECGF
                     VSLRDVERCVKVFRWFHDHSDMLLKELDKFLHESSDSTHTFERDPVLWSLVMAIGVCY
                     HASLEEKASYRTAIARCFPKPYNSSRAILDEVTHVQDLFLRGAPIRTNIARNLALKEN
                     VFMMVICIELKIPLFLVGKPGSSKSLAKIIVADAMQGQAAFSELFRCLKQVHLVSFQC
                     SPHSTPQGIISTFKQCARFQQGKDLGQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDG
                     CIEDDPAPYKKVGFVGISNWALDPAKMNRGIFVSRGSPNEKELIESAEGICSSDRLVQ
                     DKIRGYFAPFAKAYETVCQKQDKEFFGLRDYYSLIKMVFAKAKASKRGLSPQDITHAV
                     LRNFSGKDNIQALSIFTASLPEARYKEEVSTVELIKQNIYPGPQASSRGLDGAESRYL
                     LVLTRNYVALQILQQTFFEGQQPEIIFGSSFPQDQEYTQICRNINRVKICMETGKMVV
                     LLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHTAFRLIVIEEKDVVYK
                     QFPVPLINRLEKHYLDMNTVLQPWQKSIVQELQQWAHEFADVKADQFIARHKYSPADV
                     FIGYHSDACASVVLQAVERQGCRDLTEELYRKVSEEARSILLDCATPDAVVRLSGSSL
                     GSFTAKQLSQEYYYAQQHNSFVDFLQAHLRMTHHECRAVFTEITTFSRLLTGNDCDVL
                     ASELRGLASKPVVLSLQQYDTEYSFLKDVRSWLTNPGKRKVLVIQADFDDGTRSAQLV
                     ASAKYTAINEINKTQGTKDFVFVYFVTKLSRMGSGTSYVGFHGGLWRSVHIDDLRRST
                     IMASDVTKLQNVTISQLFKPEDKPEQEEMEIETSQSKELAEEQMEVEDSEEMKKASDP
                     RSCDCSQFLDTTRLVQSCVQGAVGMLRDQNESCARNMRRVTILLDLLNEDNTRNASFL
                     RESKMRLHVLLNKQEENQVRSLKEWVTREAANQDALQEAGTFRHTLWKRVQDVVTPIL
                     ASMIAHIDRDGNLELLAQPDSPAWVQDLWMFIYSDIKFLNISLVLNNTRSNSEMSFIL
                     VQSHMNLLKDAYNAVPFSWRIRDYLEELWVQAQYITDTEGLSKKFVEIFQKTPLGVFL
                     AQFPVAQQQKLLQSYLKDFLLLTMKVSSREELMFLQMALWSCLRELQEASGTPDETYK
                     FPLSLPWVHLAFQHFRTRLQNFSRILTIHPQVLSSLSQAAEKHSLAGCEMTLDAFAAM
                     ACAEMLKGDLLKPSPKAWLQLVKNLSTPLELVCSEGYLCDSGSMTRSVIQEVRALWNR
                     IFSIALFVEHVLLGTESHIPELSPLVTTYVSLLDKCLEEDSNLKTCRPFVAVMTTLCD
                     CKDKASKKFSRFGIQPCFICHGDAQDPVCLPCDHVYCLRCIQTWLIPGQMMCPYCLTD
                     LPDKFSPTVSQDHRKAIEKHAQFRHMCNSFFVDLVSTMCFKDNTPPEKSVIDTLLSLL
                     FVQKELLRDASQKHREHTKSLSPFDDVVDQTPVIRSVLLKLLLKYSFHEVKDYIQNYL
                     TQLEKKAFLTEDKTELYLLFISCLEDSVHQKTSAGCRNLEQVLREEGHFLRTYSPGLQ
                     GQEPVRIASVEYLQEVARVRLCLDLAADFLSELQEGSELAEDKRRFLKHVEEFCTRVN
                     NDWHRVYLVRKLSSQRGMEFVQSFSKQGHPCQWVFPRKVIAQQKDHVSLMDRYLVHGN
                     EYKAVRDATAKAVLECKTLDIGNALMACRSPKPQQTAYLLLALYTEVAALYRSPNGSL
                     HPEAKQLEAVNKFIKESKILSDPNIRCFARSLVDNTLPLLKIRSANSILKGTVTEMAV
                     HVATILLCGHNQILKPLRNLAFYPVNMANAFLPTMPEDLLVHARTWRGLENVTWYTCP
                     RGHPCSVGECGRPMQESTCLDCGLPVGGLNHTPHEGFSAIRNNEDRTQTGHVLGSPQS
                     SGVAEVSDRGQSPVVFILTRLLTHLAMLVGATHNPQALTVIIKPWVQDPQGFLQQHIQ
                     RDLEQLTKMLGRSADETIHVVHLILSSLLRVQSHGVLNFNAELSTKGCRNNWEKHFET
                     LLLRELKHLDKNLPAINALISQDERISSNPVTKIIYGDPATFLPHLPQKSIIHCSKIW
                     SCRRKITVEYLQHIVEQKNGKETVPVLWHFLQKEAELRLVKFLPEILALQRDLVKQFQ
                     NVSRVEYSSIRGFIHSHSSDGLRKLLHDRITIFLSTWNALRRSLETNGEIKLPKDYCC
                     SDLDLDAEFEVILPRRQGLGLCGTALVSYLISLHNNMVYTVQKFSNEDNSYSVDISEV
                     ADLHVISYEVERDLNPLILSNCQYQVQQGGETSQEFDLEKIQRQISSRFLQGKPRLTL
                     KGIPTLVYRRDWNYEHLFMDIKNKMAQSSLPNLAISTISGQLQSYSDACEALSIIEIT
                     LGFLSTAGGDPGMDLNVYIEEVLRMCDQTAQVLKAFSRCQLRHIIALWQFLSAHKSEQ
                     RLRLNKELFREIDVQYKEELSTQHQRLLGTFLNEAGLDAFLLELHEMIVLKLKGPRAA
                     NSFNPNWSLKDTLVSYMETKDSDILSEVESQFPEEILMSSCISVWKIAATRKWDRQSR
                     "
     exon            142..311
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            312..779
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            780..893
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1063
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1219
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1431
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1715
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1975
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2173
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2399
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2455
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2609
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2774
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2864
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2987
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3168
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3342
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3492
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..4076
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4242
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4460
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4601
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4769
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..5919
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6113
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            6114..6269
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            6270..9872
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            9873..10009
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10010..10105
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10106..10224
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10225..10344
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10345..10454
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10455..10605
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10606..10744
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10745..10936
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            10937..11082
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11083..11237
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11238..11462
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11463..11644
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11645..11765
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11766..11866
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            11867..12049
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12050..12219
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12220..12319
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12320..12431
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12432..12642
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12643..12833
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12834..12956
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            12957..13067
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13068..13310
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13311..13392
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13393..13427
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13428..13522
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13523..13682
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13683..13851
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13852..13943
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            13944..14195
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14196..14328
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14329..14412
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14413..14593
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14594..14795
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14796..14873
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            14874..15068
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            15069..15158
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            15159..15337
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     exon            15338..16751
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16733..16738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /note="hexamer: AATAAA"
     polyA_site      16751
                     /gene="Rnf213"
                     /gene_synonym="6030403J01; D11Ertd759e; mysterin"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcgcg ggcgcatggg cactgcaggg ctgcggataa cagcatggag tgtccacagt
       61 gcgggcatgt ctcctcagag aaggcaccca agttctgtag cgagtgcgga cagaaattgc
      121 cttctgcagc tactgtgcaa ggagacctca agaacgacaa taccttggtg gtgtcatcaa
      181 ccccggaagg aaagactgag cagggggcag tgctgagaga ggaggaggtc ctactctcgt
      241 ccacagaccc aggcaaggaa ctggagaaac cagaggagtc cgattccaat gcctcctgga
      301 ccacccaaat gagtaaaaag gagaagagga ggaggaagag acagggcacc atttcttcct
      361 cagaggcacc ttcctctggc ctctggagtc tggacatgcc tccaagtcct ggatctcaca
      421 actcagcctt gccccagaac caagcccagc agggtggtgc ggccagccag cctgggcatc
      481 ccctggacac agagaacatg ccaatggagg atggcttcgt tcacactgag ggcagcggca
      541 gccctctgca gggtcaggct gcagaacgca ccgacgctca gagcaacctt gctcccagtg
      601 accttgcaga agtgaaggac ctcaatacct ctaagccctc agtggacaag ggcctgcccc
      661 tagatggggg cccagccctt tctgcgttca aaggccaccc taagatgact gatgcttccc
      721 agaaggctcc attacctgaa tctaaggggg agacatctgg acaagagaag aaagtgccgc
      781 caattgatgc tgcggccagt ccggtgaaga cagctgggaa agaaacagga gaggatgttc
      841 ggaaaccgaa accctcgcct gtgagccctg tagcctccaa gcacggagac caggaagctg
      901 aactcaaagg caagttggcc acccctgtta ggaaaagtaa tgaaggtggc aacacccagc
      961 cagaagatca gaggaagcca ggagagggca gaaactttgc agcagctgtg aaaacccagc
     1021 aggcggctgc accccagcag gctgctgcac cggagcctac aagtgcgttt aacccacggg
     1081 atacagtcac tgtgtacttc cacgctattg tctcccgtca ctttggattc aatccggagg
     1141 agcacaaagt gtatgtcaga ggcggagaag gacttgggca gaaaggctgg actgatgcat
     1201 gcgagatgta ctgcacccaa gacctgcatg acctgggatc tctcgtcgag ggcaaaatgg
     1261 acattcccag acagagcctg gacaaaccca tcccttataa gtatgtcatt caccgtggtg
     1321 gcagtagcaa ggatactgtg gaatatgagt tcatctatga acaggcacag aagaaaggag
     1381 aacacgtgaa tcgttgtctg cgagttgtct ctacctcctt gggcaatgga gactggcatc
     1441 agtatgatga cataatctgc atgaggtcca ctgggttttt ccagcaagcc aagaaccgca
     1501 tcctcgatag tacaagaaag gaactgttga aagggaagaa gcaggctgct gtggtcatgc
     1561 tggaccgcat cttcagcgtg ctccagccct ggagtgacat caacctgcag agtttcatga
     1621 ctcaattcct gcagttttac tcggtggtcc gagagcccat gattcatgat ggccgtgcaa
     1681 ggaaatggac cagtctgcaa tatgaggaga aagaggtttg gacgaacctg tgggagcacg
     1741 tgaaaaagca gatggcccca ttcctggaag gaaagagtgg ggagtctctg cctgctgact
     1801 gccctgtgag gagtaagctg acgttgggcc tgagcatcct tttcatggtg gaagcagctg
     1861 aatttactgt acccaaaaag gacctggatt cgctgtgcta tctcctcatt ccgagtgctg
     1921 gctcaccaga agccctccac agcgacctga gccctgtcct ccgcattcgt caaagatggc
     1981 gtatatactt gacaaaccta tgcctcaggt gcatagacga gagatgtgac cgttggctgg
     2041 gtatcttacc cctcctgcac acctgcatgc agaagtctcc acccaagaag aactccaaga
     2101 gccagcccga ggacacctgg gcaggccttg aaggaatctc cttctcagag tttcgggaca
     2161 aagcacccac taggagccag cccctccagt tcatgcagag taagatggcc ctgctgcgcg
     2221 tggatgagta cctcttccgc tcctggctca gcgtggtccc tcttgaaagc ttatcttcct
     2281 acttggagaa ctccatagac tacctgagtg atgtgcccgt gagggtcctg gactgtttgc
     2341 aagggatttc ataccgtctt ccagggctaa ggaagatctc aaaccagaac atgaagaagg
     2401 atgtcgagaa cgtctttaaa atgctgatgc accttgtgga catttatcag cacaggatct
     2461 ttggggagaa cctgctacag atctacttga ctgagtgttt gaccctccat gaaactgtct
     2521 gcaacatcac agctaaccac cagttctttg agattcctgc cctgtctgct gagcttatct
     2581 gtaaactgct tgagctcagt cctccagggc atactgacga ggggctgccc gaaaaatctt
     2641 acgaagactt ggtgacaagc acccttcagg aggccctggc caccacgaga aactggctgc
     2701 gcagcttgtt taaaagtcgc atgctctcca ttagctcagc ctatgtccga cttacctatt
     2761 ctgaagagat ggcggtatgg cgacggctgg tggagatcgg cttcccagag aagcatggct
     2821 ggaagggatc attgctggga gacatggaag ggaggctcaa gcaggagcct ccccgtttgc
     2881 agatctcctt cttctgcagc agtcagtgtc gtgacggagg actccatgac agtgtttcga
     2941 ggagctttga gaagtgtgtc atcgaggctg tgagctctgc ctgccagtct cagaccagtg
     3001 tgcttgaggg gctctcctgt caagacttgc agaaatttgg aaccctcttg tctgccgtga
     3061 taaccaagtc atggcctgtg cataacgggg agcctgtgtt tgacgtggat gagatcttca
     3121 aatacctgct caagtggcca gatgtgaggc agctcttcga actgtgtgga accaatgaga
     3181 aaatcataga caacatcacg gaggaaggca ggcagctgat ggccactgct gagtctgtgt
     3241 tccagaaggt cgcaggggaa cttgaaaatg gcaccattgt ggttggacag ctggagctga
     3301 tcctcgagca ccagagtcag tttcttgaca tctggaactt aaatagaagg cggctgccat
     3361 cccaagagaa ggcctgtgat gtgaggagct tgctgaaaag gagaagggat gatctgctgt
     3421 tcctcaagca agagaagaga tacgtggaga gcctcctgag gcagctcgga agagtgaaac
     3481 accttgtgca agtggatttt ggaaacattg aaataatcca ctctcaagac ctcagcaata
     3541 agaaactaaa tgaagccgtg attaagctcc ccaattcctc ctcctacaaa agggagacac
     3601 attactgcct gagccctgac atccgagaaa tggcaagcaa gctagactcc ctgaaagaca
     3661 gccatatctt ccaggacttc tggcaagaga cagcagagtc actgaatact ctggataagg
     3721 accccagaga gttgaaggtt tcgcttccag aggtcttgga atacctgtac aacccttgtt
     3781 atgacaactt ctacacactc tatgagaatc tgaagtcagg aaagatcacc tttgctgaag
     3841 ttgatgccat cttcaaagac tttgtagata aatatgatga actgaaaaac gaccttaaat
     3901 tcatgtgcac tatgaacccc caggaccaaa aaggttggat ctcagagcgt gttgggcaga
     3961 tcaaagaata tcacaccctg caccaggctg tcagctctgc caaggtcatc ttgcaggtcc
     4021 gaagagcttt gggtgtgact ggtgacttca gtgttcttaa cccattgtta aactttgcgg
     4081 attcctttga ggactttggt aatgagaaac tggaccagat cagcccacag ttcatcaagg
     4141 ccaaacagct gcttcaggac atcagtgagc ctcgccagcg ctgcttggag gagcttgccc
     4201 ggcagacgga gcttgttgcc tggctgcaca aggccctgga agacatcaac gaactcaagg
     4261 tgtttgtgga cttggcctcc atctcagcgg gagagaatga cattgatgtg gaccgggtgg
     4321 cctgtttcca cgatgccgtg cagggctatg cttctctgct gtacaagatg gatgaaagaa
     4381 caaatttctc tgacttcatg aatcatctac aggaactctg gagggccctg gacaatgacc
     4441 agcaccttcc cgataagctg aaagattctg ccagaaattt ggagtggctg aagacagtga
     4501 aggaaagcca tggatctgtg gagctctcat ctctgtccct cgccacagca atcaacagca
     4561 ggggcgtcta cgttattgag gcacccaaag atggccagaa gatttcccca gacactgttc
     4621 tccgcctcct cctccctgat ggccatggtt accccgaggc attgcgcacc tactccacag
     4681 aggaactgaa ggaactttta aataagctga tgctcatgtc tggaaagaaa gaccacaaca
     4741 gcaatacaga agtggagaag ttttcagagg tcttcagcaa catgcagcgg cttgtacatg
     4801 tcttcataaa actgcactgc gcgggcaaca tgctgttcag gacttggact gctaaggtct
     4861 actgttgccc tgacgggggc atcttcatga actttggctt ggagctgctg agccagctga
     4921 cagagaaggg agatgtcata cagctcctgg gagccctctg caggcagatg gaggacttcc
     4981 tagataactg gaaaacagtg gtcgcccaga agagagctga acacttttac ctcaacttct
     5041 acacagctga gcagctggtc tacctaagca gtgagctcag gaaacccaga cctagtgaag
     5101 ctgccctcat gatgctatcc ttcattaaag gcaaatgcac tgtccaggac ctcgtacaag
     5161 ctaccagtgc ctgtgaaagc aaggctgaca gatactgcct gcgggaggtt atgaaaaagt
     5221 tgccccagca gctgctttct gagcccagcc taatgggcaa gcttcaggtt attatgatgc
     5281 aatccctcgt gtacatgagt gccttcctgc cacactgtct ggacctggat gccctgggta
     5341 gatgccttgc tcatctggcc acgatgggtg gcactcctgt ggagcggcca ctccccaaag
     5401 gcctgcaggc tggccagcct aacctgatct tgtgtggcca ctcggaggtg ttgccagctg
     5461 cactggccat ctacatgcag gcccccaggc agcccctgcc cacctttgat gaggtgttgc
     5521 tctgcacccc agcgaccaca attgaggaag tggaactact cctgcggcgc tgcctcactt
     5581 cgggctccca ggggcacaag gtctacagct tgctgtttgc agaccagctg agctatgaag
     5641 tgggctgcca ggcagaggag ttcttccaga gcctgtgcac acgagcgcac cgtgaagact
     5701 accagttggt gatactctgt gatgctgccc gggagcactg ctatatcccc tccaccttca
     5761 gccagtacaa agtgcccctg gtgccccagg ccccgctccc gaacatccaa gcttacctgc
     5821 agagccatta tcaggtcccg aagcggctcc tgtcagcagc aactgtattc agagacgggc
     5881 tgtgtgttgg catcgtgacc tctgaaagag ctggcgttgg aaagtctctc tacgtgaaca
     5941 cactgcatac aaaactaaaa gcaaagctac gtgacgagac ggtcccttta aaaattattc
     6001 gattgacaga gcctcatcta gatgagaacc aagtcctaag cgcactgctg ccgttcttga
     6061 aggagaaata tcagaagatg ccggttatat tccacattga tatcagcact tcagttcaga
     6121 ctggaattcc catttttctt ttcaaactcc tcattctgca gtacctgatg gatatcaatg
     6181 ggaaaatatg gcgtcggagc ccgggtcatt tataccttgt tgaaatccca caagggctct
     6241 cggtacagcc aaagaggtct tctaaactga acgcacgtgc acccctgttc aagtttcttg
     6301 atctcttccc caaagtcacc tgccgtcctc ccaaggaagt gatagacatg gagctgactc
     6361 cagagaggag ccacacagac cctgccatgg acccagtgga gttctgcagt gaagctttcc
     6421 aacgacctta ccagtattta aaacggttcc atcagcagca gaacctggac acatttcagt
     6481 atgaaaaagg ctctgtggaa ggctctcctg aggagtgcct gcagcacttc ctcatttact
     6541 gtggcctcat aaacccttcc tggtcagagc ttcggaactt tgcttggttt ctgaactgtc
     6601 agctcaaaga ctgtgaggcg tctatctttt gcaagtcagc ttttactgga gacacacttc
     6661 ggggcttcaa gaactttgtg gtgaccttca tgatcttaat ggccagggat tttgctactc
     6721 cgactcttca cacttcagac caaagcccag gtaggcagtc agtcaccatt ggcgaagttg
     6781 ttgaagaaga cctagctccc ttctctcttc gaaagaggtg ggagtcagag ccccatccat
     6841 atgttttctt caatggtgac cacatgacca tgacattcat aggttttcac ttggagacca
     6901 ataacaatgg ctatgttgat gccatcaatc cctcaaatgg taaggtcatc aaaaaagacg
     6961 tcatgaccaa agaactgttt gatgggctga ggcttcagag agtgcccttc aacattgact
     7021 ttgataactt gcccagatat gagaagcttg aaagactctg cctggcacta ggtattgagt
     7081 ggcctattga tcctgatgaa acatatgaac ttaccacaga caatatgctt aagatcctgg
     7141 ccattgaaat gcggttccga tgtgggatcc ctgttatcat catgggagag acaggctgtg
     7201 ggaaaaccag gctcatcaaa tttcttagtg acctcaagcg tggtagtgtg gaggcagaaa
     7261 cgatgaagtt agtgaaggtc catggaggga caacaccatc catgatctac tccaaggtca
     7321 aggaggctga gagaacagcc ttctccaata aggcccagca caagctggat accatcttgt
     7381 tctttgatga agccaacaca acagaagctg taagctgtat caaagagatc ttgtgtgatc
     7441 ggacagtgga tggtgagcac ctacatgagg actctggcct gcatatcatt gctgcctgca
     7501 acccatatcg gaagcactcc caggagatga tcctccgcct ggagtcagca ggtttgggat
     7561 acagagtgag tgcagaggag actgcagaca ggctgggctc catccctctg cggcagctgg
     7621 tctaccgtgt tcatgctctg cctccaagcc tcattccttt ggtatgggac tttgggcagc
     7681 tgaatgactc tgcagaaaag ctctacatcc agcagatcgt acagagactg gtggactccg
     7741 tctctgtgaa tcccagtgag acttgtgtga ttgcagatgt gctctctgcc tcgcagatgt
     7801 tcatgaggaa gagggagaat gaatgtggtt tcgtcagcct ccgggacgtg gagcgctgtg
     7861 tcaaagtttt ccggtggttt catgaccata gtgatatgct cttaaaggag ctcgacaagt
     7921 ttctccatga atccagtgac agcacacata cttttgagag agatcctgtt ctctggtccc
     7981 tggtgatggc cattggggta tgctaccatg cctctttaga agagaaagca tcctaccgca
     8041 ctgccatcgc caggtgcttt cccaaaccat acaatagcag cagggccatc ctggatgagg
     8101 tcacacatgt ccaggatctt tttttgaggg gggcacccat aaggaccaac atagccagga
     8161 acttggcttt gaaggagaat gtcttcatga tggtaatctg cattgagctt aagattcccc
     8221 ttttcctagt ggggaagccc ggcagctcca aatcccttgc caagatcatt gtggcagatg
     8281 ccatgcaagg gcaggctgcc ttctctgagc tctttcgctg cctgaaacag gtccacttgg
     8341 tgtcattcca gtgcagccca cactccaccc cccaaggtat catcagcacc ttcaagcagt
     8401 gcgctcgatt ccagcagggt aaggacctgg ggcagtatgt ctcagtggtg gtgttggatg
     8461 aagttgggct ggctgaagac tcacccaaaa tgcccctgaa gactctgcac cccctgctgg
     8521 aagacgggtg cattgaagat gaccctgccc catacaaaaa agttggcttt gttggcattt
     8581 ccaactgggc tctagatcct gccaagatga accgaggcat ctttgtgtcc cgcggcagtc
     8641 ccaacgagaa agagctcata gagagtgctg aggggatctg ctcttcagac aggctggtgc
     8701 aggataaaat ccgtgggtat tttgcaccct ttgccaaggc ctatgaaaca gtgtgtcaga
     8761 agcaggataa ggagttcttt gggcttcgtg actattacag cctcatcaag atggtctttg
     8821 ccaaggccaa agcttctaaa agggggcttt ccccacaaga catcacgcat gctgtcctca
     8881 ggaacttcag tggtaaagac aacatccagg ccctgagcat ctttacagcc agtctcccgg
     8941 aggccaggta caaggaggaa gtcagcaccg tggagctgat caagcagaac atttaccctg
     9001 gcccgcaggc gtccagcagg ggcctggacg gcgctgagtc ccgttacttg ctcgtgctga
     9061 ccaggaacta tgtggcgctg caaatcctac agcagacgtt ctttgagggt cagcaaccag
     9121 agatcatttt tggctccagc tttccccagg accaggaata cacccagatc tgcaggaaca
     9181 ttaaccgggt aaagatttgc atggagactg ggaagatggt ggtgctgctg aacctgcaga
     9241 atctctatga gagcctgtat gatgctctca accagtacta tgtctacctt gggggtcaga
     9301 agtacgtgga ccttggacta ggcacccacc gagtcaagtg ccgagtgcac actgccttcc
     9361 gcctcatcgt catcgaggag aaggatgtgg tgtacaagca gttccctgtg cccctcatca
     9421 accgtctgga gaagcactac ctggacatga acactgtgct gcagccgtgg cagaagagca
     9481 tcgtgcagga gctacagcag tgggcacacg agttcgcaga tgtaaaagca gaccagttca
     9541 ttgccagaca caagtacagt cctgcagatg tcttcattgg ctaccattca gatgcctgtg
     9601 cctctgtggt gctgcaggct gtagagaggc agggctgtag ggatctgacg gaggagctgt
     9661 accgaaaggt gtctgaagag gccaggtcca tcctgctgga ttgtgcaaca ccagacgctg
     9721 tggtccggct gagcggttcc tcattaggct cgttcactgc aaagcagctg tcacaggagt
     9781 actactacgc ccagcagcac aactcttttg tagatttcct ccaggcccac ctgcgcatga
     9841 cccatcatga atgccgggct gtcttcacag agatcaccac tttctccaga ctgctgactg
     9901 gaaatgactg tgatgtccta gcatctgagc tgagaggact ggcctcgaaa cctgtggtgc
     9961 tgtcactaca gcaatatgac actgaatatt cgttccttaa ggatgtccgc tcctggttaa
    10021 cgaacccagg caaacgtaaa gtcctagtca tccaggcaga ctttgacgat ggcacccgta
    10081 gcgcgcagct cgtagcctct gccaagtata ctgccatcaa tgaaatcaac aaaacacagg
    10141 gaacaaaaga cttcgtcttt gtttattttg tcacaaaact gtcgagaatg ggaagcggta
    10201 catcatacgt ggggttccat ggagggctat ggcggtctgt gcatattgat gacctccgca
    10261 gatcaacaat tatggcttca gatgtcacca aactgcagaa tgtcaccatc agccagttgt
    10321 tcaagccaga ggacaaacct gagcaggagg agatggagat agagacaagc cagtcaaagg
    10381 aattggcaga ggaacaaatg gaagtggaag attcagagga gatgaaaaag gcctctgacc
    10441 caagaagctg tgactgttca cagttcctag ataccaccag actggtgcag agctgtgtgc
    10501 agggtgctgt ggggatgctc agagaccaga atgagagctg tgcgcgcaac atgagaagag
    10561 tcaccattct tcttgacctc ttaaatgaag ataacacacg caatgcttct tttttgcggg
    10621 aatctaagat gcgtctccat gttcttctaa acaagcaaga agagaaccag gtccgcagtt
    10681 taaaggagtg ggtcaccagg gaggctgcga atcaggatgc cctgcaggag gcaggcacct
    10741 tcaggcatac cctttggaag cgggtccaag atgtggtcac tcccatcctg gcgagcatga
    10801 tagctcacat tgatagagat ggcaacctgg agctactggc ccaaccagat tcaccggcct
    10861 gggttcaaga tctttggatg tttatttaca gtgatattaa gttcctgaac atctctcttg
    10921 tgttgaataa cacaaggtcc aacagtgaga tgtccttcat cctggtgcag agccacatga
    10981 acctgctcaa ggatgcctac aatgctgtcc ctttcagctg gaggatcagg gactacctgg
    11041 aggagctctg ggtgcaggct cagtatatca cagacactga gggattatcg aagaagttcg
    11101 tggaaatttt ccagaaaact cccttgggcg tgtttctcgc tcagttccct gtggcacagc
    11161 agcaaaaact cctgcagagc tacttgaagg acttcctgct cttgaccatg aaagtgtctt
    11221 caagggagga attaatgttt ctgcagatgg ccctgtggtc ctgcctccgt gagctccaag
    11281 aggcttcagg aacacctgat gaaacttata agtttcctct ctccttgccc tgggtgcacc
    11341 ttgcctttca gcacttcagg acccggctac agaacttctc cagaattttg accattcacc
    11401 cccaggttct gagcagcctc agtcaagcag cagagaagca cagcttggct gggtgtgaaa
    11461 tgacactgga tgcatttgca gcaatggcct gcgctgaaat gctcaaggga gacctcctga
    11521 agccaagccc caaggcttgg ttacagcttg tgaagaatct gtccacgcca ctggagctcg
    11581 tctgctccga agggtacttg tgtgacagtg ggagcatgac cagatctgtc atccaggagg
    11641 tcagagccct gtggaaccgc attttctcca ttgccctctt tgtggaacac gttcttctgg
    11701 ggactgagag ccatattcct gagctgagtc cactggtaac cacatatgtc tccttactag
    11761 acaaatgtct tgaagaggac tctaacctca agacctgcag gccatttgtg gctgtaatga
    11821 ccacactctg tgactgcaag gacaaggcca gcaagaagtt cagcaggttt ggtattcagc
    11881 catgtttcat ctgccatgga gatgcgcagg accccgtctg tctgccctgt gatcatgtgt
    11941 attgtctacg ttgcattcag acctggctca tccctgggca aatgatgtgc ccctactgct
    12001 taactgactt gccagacaag ttctcaccaa ctgtttccca ggaccacagg aaagccattg
    12061 agaagcacgc ccagttccgg cacatgtgca acagcttttt tgtggacctt gtttctacca
    12121 tgtgcttcaa ggataacacg ccccctgaga agagtgtcat agatacactg ctgtccttgc
    12181 tcttcgtaca aaaggagctg ctgagagatg cttcccagaa acatcgtgaa cacacaaagt
    12241 ctctgtctcc atttgatgat gttgttgacc agactcctgt catccgctct gtgctgttaa
    12301 aactgcttct caagtacagc ttccatgaag tgaaggatta catccagaac tacctgacac
    12361 agttagagaa gaaggcgttc ctaacggaag acaaaacgga actgtacctg ctcttcatca
    12421 gctgcctgga ggactcagta caccagaaga caagtgctgg ctgcagaaat ctcgagcagg
    12481 ttctcagaga ggaaggtcac ttccttagga catattcccc gggactgcaa ggccaggagc
    12541 ccgtccgcat tgcttcagtg gagtacctgc aggaggtggc cagagtccgc ctatgccttg
    12601 acttggcagc tgacttcctc tcagagctcc aggaaggctc agaactggct gaagacaagc
    12661 ggcgcttcct gaagcatgtt gaggagttct gcacacgcgt caacaatgat tggcacaggg
    12721 tgtacctggt gaggaaactc tcaagccagc gtgggatgga attcgtgcag agcttctcca
    12781 agcagggcca tccatgccaa tgggtgtttc ccaggaaagt cattgcacag cagaaggacc
    12841 acgtaagcct gatggaccga tacctcgtcc acggtaatga atacaaggct gtccgtgatg
    12901 caacggccaa agctgtgctt gagtgcaaga ccctagacat tgggaatgct ctgatggcct
    12961 gcagaagccc caaaccccag cagacagcct acttattgct ggccttgtac acagaggtgg
    13021 ctgctttgta ccgttccccc aatggcagcc tccatccaga agcaaagcaa ttggaggcag
    13081 tgaacaaatt cattaaggaa agcaagatcc tctctgatcc taacatcaga tgctttgcaa
    13141 gatcgctagt ggataatact ctgcccctgc tgaagatcag gtctgctaac agcatcctga
    13201 agggaacggt gactgaaatg gccgtccatg tggcaaccat cctcctctgt ggacacaacc
    13261 aaattttgaa gcccctgagg aacttggcct tctatcctgt caacatggcg aatgcttttc
    13321 ttccaacaat gcctgaagac ctgctagttc acgccaggac ttggaggggc ctggaaaatg
    13381 tcacctggta cacttgtccc agaggccatc catgctctgt gggagagtgt ggcaggccaa
    13441 tgcaagagag cacctgtctg gactgtggtc ttccagtcgg aggtcttaac cacacgccgc
    13501 atgagggctt cagtgctatc agaaacaatg aggacagaac gcagactggc cacgtgttgg
    13561 ggagcccaca gtccagtggt gtagcagaag tatctgaccg agggcagtcc ccagtggtct
    13621 ttattctcac ccggctactc actcacttgg ctatgcttgt gggagccacc cacaatcccc
    13681 aggccctgac agtaatcatt aagccttggg tccaggaccc acaaggcttc ctacagcagc
    13741 acatccagag agacctggag cagctaacca agatgctggg caggagtgcc gacgagacca
    13801 tccatgtggt ccacctcatc ctgagcagcc tgctcagggt gcagagccac ggggtgttaa
    13861 attttaatgc agaattgtca accaaaggat gcaggaacaa ctgggagaag cattttgaaa
    13921 ctcttctgct acgtgaactg aagcatcttg acaaaaactt gccagctata aatgctctta
    13981 tcagccaaga tgagcgcatc agctccaacc ctgtgaccaa aatcatctat ggggacccag
    14041 caaccttctt gccccacttg ccccaaaaaa gtataattca ttgctcaaag atttggagct
    14101 gcaggaggaa aatcacagtg gagtacctgc agcacatcgt ggaacagaag aacggcaagg
    14161 aaacggtgcc tgtcctctgg cacttcctcc agaaggaagc agaactaagg ttggtgaaat
    14221 tcctgcctga gatattggct ctgcaaaggg atctggtcaa acagttccag aatgtctcga
    14281 gagtggaata cagttccatc agaggcttca ttcacagtca cagttcagat gggctgagaa
    14341 agctgttgca tgaccgaatc accatctttc tgtccacgtg gaatgcactg aggcggtcac
    14401 tggagaccaa tggtgagatc aagctaccaa aagattactg ctgttctgac ttggatctgg
    14461 atgctgaatt tgaggtcatc cttccaaggc gtcagggcct aggcctctgt ggaactgctt
    14521 tagtcagcta cttgattagc ctacacaata acatggtcta cacggtgcaa aagttttcca
    14581 atgaagacaa cagctattct gtagatatct ctgaggttgc tgacctgcat gtcatcagtt
    14641 atgaggtgga acgggatctg aatccactga tcctctccaa ctgccagtac caagtgcagc
    14701 aaggtgggga aacctcacaa gagtttgatc tagagaagat ccaacggcag atcagcagcc
    14761 ggttcctaca gggcaagccc aggctgaccc tcaagggaat acccaccctg gtatacagac
    14821 gggactggaa ctatgagcat ctcttcatgg acatcaagaa caaaatggca cagagctcac
    14881 tccctaactt agcaatcagt accatcagcg gacagctaca gtcctatagt gatgcctgtg
    14941 aagccctgtc tatcatagaa atcactctgg gtttcctgag cacagctggt ggggatcctg
    15001 gcatggactt gaatgtgtac atcgaagaag tcctacggat gtgtgatcag acagctcagg
    15061 tcttaaaggc cttcagtaga tgtcagctga gacacatcat tgctctctgg cagttcctat
    15121 ctgcacataa gtcagaacag cggctgcgac tgaacaaaga gctatttcgg gaaattgatg
    15181 tgcaatacaa agaggagctc agcacacagc accaaagact cctgggcaca ttcctgaatg
    15241 aggcaggcct agacgccttc ctcctggagc tccatgagat gattgtgctc aagctcaagg
    15301 gcccccgggc tgcgaacagc ttcaacccca attggagcct caaggatact ctagtaagtt
    15361 acatggagac taaagacagt gacatccttt cagaagtgga gtcccagttc cctgaagaaa
    15421 tactcatgtc cagctgcatc tcagtgtgga aaatagctgc tacacgaaaa tgggaccgac
    15481 aatcaaggta gagcagctca gccttcaaac ccagctggaa aggaaggtct tcctcacctc
    15541 cctccacagc tcccagtatg ggctgtggct tttgtgtgaa ggaaagtgtg ggcacagact
    15601 ggattcaagg cctacactca ccctacaatg tgatagcttt ttcaaagcca agctgtttct
    15661 ggatcatgtg cctattccaa aatttcctta agtctgatga atgattgtca gtcaactgcc
    15721 tcatgaacat tccagaagga acaagagaac tgcactaagg tcacacccaa taccgatcct
    15781 tcttaagact gactgcctct tacctcaaat accatggcca ccactttact gcatagagag
    15841 aaaaaactca gggtagtcaa ttttttaaat ttttttactt atgtatagaa ggacctcaat
    15901 ttattctttc tcccagtccc ttaatttcta agtagtatac tcatatctct tggtttgcaa
    15961 gatgcatgaa aattgccaca ctaacccaag gaaatccaag gtgctgataa aagctgtaaa
    16021 gcctcatgaa caacccacca tgtaaaccca ccatgagcca ctgccaacca ctcactgaga
    16081 tcaccggaca gagagtggag aaggatgagc gcactggtga gctggaacta gagtgcgctg
    16141 tggagtactt gcctaccata gcaaagccct gggttctctc cccagcactg caagtgggaa
    16201 tagggacaga caaacaaagc actttccagt tctcatgtct tgagatttca agtaaagatg
    16261 tgttagtgta agctcagatc cgaggtattt gggtgctggg aacatggcag agcccttgcc
    16321 tagcatctgt ggtgccctaa agtccaattc ctagcactgt tagaaagaaa ggtattagga
    16381 tcacagtggt gagcttttat tctaaactat gagagtacct gtcctccgat gtctgcatcc
    16441 caggtttttg ggggtacagg gcttaatgaa cttgccaact tggccttgga gctcctgtga
    16501 tccatcagag ggcagctcag ccccacacgt cttgctgtaa ggccccttct ggctttgaac
    16561 taggcattat tttttttttc tgtcatgaag aatttttaat tatgatgctt tattttgtat
    16621 gctctgcttt taaagtcata actgtctgtg tagtattacc cactgtgatg tacaaaatgc
    16681 atggatctaa cattggcaaa gtagactgca tcatgtttac catacctatt ttaataaact
    16741 tgaatttcac a
//
