LOCUS       NM_001370899            1205 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus ring finger protein 212B (Rnf212b), mRNA.
ACCESSION   NM_001370899
VERSION     NM_001370899.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Condezo,Y.B., Sainz-Urruela,R., Gomez-H,L., Salas-Lloret,D.,
            Felipe-Medina,N., Bradley,R., Wolff,I.D., Tanis,S., Barbero,J.L.,
            Sanchez-Martin,M., de Rooij,D., Hendriks,I.A., Nielsen,M.L.,
            Gonzalez-Prieto,R., Cohen,P.E., Pendas,A.M. and Llano,E.
  TITLE     RNF212B E3 ligase is essential for crossover designation and
            maturation during male and female meiosis in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 121 (25), e2320995121 (2024)
   PUBMED   38865271
  REMARK    GeneRIF: RNF212B E3 ligase is essential for crossover designation
            and maturation during male and female meiosis in the mouse.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2418611121.
            doi: 10.1073/pnas.2418611121. PMID: 39348550]
REFERENCE   3  (bases 1 to 1205)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   4  (bases 1 to 1205)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116591.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.95289.1,
                                           SRR17784647.449902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC116591.4         88818-88953         c
            137-237             AC116591.4         86517-86617         c
            238-290             AC116591.4         83514-83566         c
            291-365             AC116591.4         82891-82965         c
            366-481             AC116591.4         64875-64990         c
            482-542             AC116591.4         63818-63878         c
            543-571             AC116591.4         62808-62836         c
            572-618             AC116591.4         61174-61220         c
            619-661             AC116591.4         60922-60964         c
            662-722             AC116591.4         60694-60754         c
            723-771             AC116591.4         60268-60316         c
            772-811             AC116591.4         54397-54436         c
            812-906             AC116591.4         53714-53808         c
            907-968             AC116591.4         52506-52567         c
            969-1205            AC116591.4         48995-49231         c
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..1205
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /note="ring finger protein 212B"
                     /db_xref="GeneID:102632837"
                     /db_xref="MGI:MGI:5589964"
     exon            1..136
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            137..237
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1031
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein C14orf164 homolog"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF212B"
                     /protein_id="NP_001357828.1"
                     /db_xref="CCDS:CCDS88665.1"
                     /db_xref="GeneID:102632837"
                     /db_xref="MGI:MGI:5589964"
                     /translation="MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCMTLEKCAVCGNLCK
                     HLALSDNLKPQEKKFFKSPVETALQCFSHISQVWCFQKKQTDLLIAFYKDRITKLEAA
                     VKEAQEMAASQNKELSALRKENGELKKILDILKGSPSCYYGSRLTTPRPVGITSPSQS
                     VAPRPSSHHSSQVVSRSSSMESIPYTVAGMGHVEQGSRGLHVRSTPGDSYTETPSPAS
                     THSLSYRPSSASSGQGVSFRPFFSGDSGHTRVLTPNNSGRRESRTTPESLPGFQLPVL
                     QTFYQQRQMGLARKDGWNISR"
     exon            238..290
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            291..365
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            366..481
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            482..542
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            543..571
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            572..618
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            619..661
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            662..722
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            723..771
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            772..811
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            812..906
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            907..968
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1205
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1183..1188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /note="hexamer: ATTAAA"
     polyA_site      1205
                     /gene="Rnf212b"
                     /gene_synonym="Gm10332; Gm30805"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgtgcg cagcttcgaa cctggtggcc gtgccctggg cggaggctgc ttgttttccc
       61 gccgtttcct gtgcctcgtg agggagagaa ccggatggtc tgagaacaga aacgttggaa
      121 cccggctgcc aagctgaatg gattggtttc attgcaacca gtgtttccga aaagatgggg
      181 cccatttctt tgtcaccagc tgtggccata ttttctgtaa aaagtgtatg actttggaaa
      241 aatgtgctgt ttgtggaaat ctttgcaagc atctggctct ttctgataat ctaaagcctc
      301 aagaaaagaa gttcttcaaa agccctgtag agacagcttt gcaatgcttt agtcacatct
      361 ctcaggtgtg gtgctttcag aagaaacaaa cagatcttct tattgccttt tataaggaca
      421 gaattacaaa gttagaagca gctgtgaagg aggcccagga aatggcggcc agccagaaca
      481 aagagctatc agccttaaga aaggagaatg gagaactgaa gaaaattcta gacatcctaa
      541 agggatctcc aagctgctac tatggaagca ggttaaccac acctcgaccc gtgggtatta
      601 cttccccatc acagtcagtt gctccacgac ccagttccca ccatagcagc caagtagtca
      661 gtcgctcttc ttctatggag tccatccctt acacagtggc tggcatgggt cacgtggaac
      721 agggaagcag aggtctgcac gtaaggagca ctcctggaga ctcttacact gaaacccctt
      781 ctccagcttc aactcatagc ctctcttaca gaccttcgtc tgcctcctcc ggacaggggg
      841 tttcttttag gccattcttc agtggggatt caggccacac aagagtcctc actcccaaca
      901 attctggtcg gagggaaagc agaaccacac cagagagtct tcctggtttc caacttccag
      961 tcctacagac gttctaccaa cagaggcaga tgggactagc caggaaagac ggatggaaca
     1021 tttccagata gacatccctc ttccaggtct gctctgtgca taatgctcaa ggttggcctg
     1081 cagtgtccag ttctctcagg ggctatgggc acttgctggt tcctggtttc agtctgcagc
     1141 ttgttttctt gaacgttatc ttacatgtct ttctctccaa acattaaaaa aatttttaaa
     1201 aactg
//
