LOCUS       NM_001362887            1032 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus ring finger protein 212 (Rnf212), mRNA.
ACCESSION   NM_001362887
VERSION     NM_001362887.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Bondarieva,A., Raveendran,K., Telychko,V., Rao,H.B.D.P.,
            Ravindranathan,R., Zorzompokou,C., Finsterbusch,F., Dereli,I.,
            Papanikos,F., Trankner,D., Schleiffer,A., Fei,J.F., Klimova,A.,
            Ito,M., Kulkarni,D.S., Roeder,I., Hunter,N. and Toth,A.
  TITLE     Proline-rich protein PRR19 functions with cyclin-like CNTD1 to
            promote meiotic crossing over in mouse
  JOURNAL   Nat Commun 11 (1), 3101 (2020)
   PUBMED   32555348
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Qiao,H., Rao,H.B.D.P., Yun,Y., Sandhu,S., Fong,J.H., Sapre,M.,
            Nguyen,M., Tham,A., Van,B.W., Chng,T.Y.H., Lee,A. and Hunter,N.
  TITLE     Impeding DNA Break Repair Enables Oocyte Quality Control
  JOURNAL   Mol Cell 72 (2), 211-221 (2018)
   PUBMED   30270110
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Fujiwara,Y., Matsumoto,H., Akiyama,K., Srivastava,A., Chikushi,M.,
            Ann Handel,M. and Kunieda,T.
  TITLE     An ENU-induced mutation in the mouse Rnf212 gene is associated with
            male meiotic failure and infertility
  JOURNAL   Reproduction 149 (1), 67-74 (2015)
   PUBMED   25342176
  REMARK    GeneRIF: Mutation in the mouse Rnf212 gene is associated with male
            meiotic failure and infertility.
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Qiao,H., Prasada Rao,H.B., Yang,Y., Fong,J.H., Cloutier,J.M.,
            Deacon,D.C., Nagel,K.E., Swartz,R.K., Strong,E., Holloway,J.K.,
            Cohen,P.E., Schimenti,J., Ward,J. and Hunter,N.
  TITLE     Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212
            regulate meiotic recombination
  JOURNAL   Nat Genet 46 (2), 194-199 (2014)
   PUBMED   24390283
  REMARK    GeneRIF: Antagonistic roles of ubiquitin ligase HEI10 and SUMO
            ligase RNF212 regulate meiotic recombination.
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Reynolds,A., Qiao,H., Yang,Y., Chen,J.K., Jackson,N., Biswas,K.,
            Holloway,J.K., Baudat,F., de Massy,B., Wang,J., Hoog,C., Cohen,P.E.
            and Hunter,N.
  TITLE     RNF212 is a dosage-sensitive regulator of crossing-over during
            mammalian meiosis
  JOURNAL   Nat Genet 45 (3), 269-278 (2013)
   PUBMED   23396135
  REMARK    GeneRIF: We show that mouse RNF212 is essential for crossing-over,
            functioning to couple chromosome synapsis to the formation of
            crossover-specific recombination complexes
REFERENCE   10 (bases 1 to 1032)
  AUTHORS   Qiao,H., Chen,J.K., Reynolds,A., Hoog,C., Paddy,M. and Hunter,N.
  TITLE     Interplay between synaptonemal complex, homologous recombination,
            and centromeres during mammalian meiosis
  JOURNAL   PLoS Genet 8 (6), e1002790 (2012)
   PUBMED   22761591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123743.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849376
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC123743.11        23881-24034
            155-216             AC123743.11        28296-28357
            217-291             AC123743.11        38823-38897
            292-348             AC123743.11        41789-41845
            349-407             AC123743.11        43026-43084
            408-460             AC123743.11        49459-49511
            461-512             AC123743.11        49614-49665
            513-555             AC123743.11        51451-51493
            556-619             AC123743.11        53184-53247
            620-692             AC123743.11        67171-67243
            693-856             AC123743.11        68931-69094
            857-1032            AC123743.11        69431-69606
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..1032
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /note="ring finger protein 212"
                     /db_xref="GeneID:671564"
                     /db_xref="MGI:MGI:3645767"
     exon            1..154
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..969
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /note="probable E3 SUMO-protein transferase RNF212"
                     /codon_start=1
                     /product="probable E3 SUMO-protein ligase RNF212"
                     /protein_id="NP_001349816.1"
                     /db_xref="CCDS:CCDS89962.1"
                     /db_xref="GeneID:671564"
                     /db_xref="MGI:MGI:3645767"
                     /translation="MASWVFCNRCFQSPHRKSSFSLTSCGHVYCHSCLLKGTKNECVI
                     CQAPCQTVLLSKHTNSNIQTFFLGIDGLCKKYSQETSQISEFQEKHRRRLVAFYQEKI
                     SQLEESLRKSVLQIKQLQSMRSSQQPAFNKIKNSVSTKPNGYLFLPPNSSLPDRIESM
                     DIDLTPPARKPEMSAGPSRISVISPPQDGRMGSVTCRGPQHLSLTPSHASMTKASRVP
                     PLQMPYKELSPPPASQLSSRATQGPSPSVSSSWTGPPRQPISISGLLQRQCAGSASPR
                     GMDTEKMSPFLPSTPTNLRSVASPWHACVHR"
     exon            155..216
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            217..291
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            292..348
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            349..407
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            408..460
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            461..512
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            513..555
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            556..619
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            620..692
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            693..856
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1032
                     /gene="Rnf212"
                     /gene_synonym="EG330157; F830003B07; repro57"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcctcg ctggcctcgc gcgagtctca cgtgggtcct cggtcatggc cagctgggtg
       61 ttctgtaatc gctgtttcca gtcgccgcac aggaagtcgt ccttcagcct gaccagctgc
      121 gggcacgtgt actgccactc ctgcctcctc aaaggtacaa agaatgaatg cgtaatctgt
      181 caagctcctt gtcagacagt tctactctca aaacatacaa actccaatat ccagacattc
      241 tttctgggca tagatggtct atgtaagaag tattcccagg agacctctca gatttcagaa
      301 tttcaagaaa aacacaggag gaggttagta gctttctatc aagaaaagat ttctcagttg
      361 gaggagtccc tcagaaagtc agtactacaa atcaagcaac tacaaagtat gagatcatca
      421 caacaaccag ctttcaacaa aatcaaaaat tcagtttcaa caaagccaaa tggatatctc
      481 tttctaccac ccaactcttc actccctgac agaatagagt caatggacat tgacctgact
      541 cctccagcaa gaaagcctga gatgtcagca ggcccttcaa gaatctctgt gattagtcca
      601 cctcaggatg gacgcatggg cagcgtcacc tgcaggggac cccagcatct tagcttgaca
      661 cccagccatg caagcatgac aaaggctagc agagtcccac cattgcagat gccctacaag
      721 gagctgtcac cacctccagc atcacagcta tccagcagag caacacaagg gccttccccc
      781 agtgtcagca gttcatggac aggaccacct cggcagccca tcagtatctc aggcctgctg
      841 cagagacagt gtgcaggatc agcatcccct agggggatgg atactgagaa gatgagccca
      901 ttcttgcctt ccacacctac aaatctacgc tctgtagcca gcccctggca tgcatgcgtt
      961 catcggtaaa tatcacggta gagttcactc tagagagatg atgtaactaa ataaagtagc
     1021 tttctgataa ag
//
