LOCUS       NM_001360844            3576 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus ring finger protein 2 (Rnf2), transcript variant 1,
            mRNA.
ACCESSION   NM_001360844
VERSION     NM_001360844.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3576)
  AUTHORS   Rong Y, Zhu YZ, Yu JL, Wu YW, Ji SY, Zhou Y, Jiang Y, Jin J, Fan
            HY, Shen L and Sha QQ.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   2  (bases 1 to 3576)
  AUTHORS   Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang
            Y, Li Q, Zuo G, Miao D and Jin J.
  TITLE     Bmi-1-RING1B prevents GATA4-dependent senescence-associated
            pathological cardiac hypertrophy by promoting autophagic
            degradation of GATA4
  JOURNAL   Clin Transl Med 12 (4), e574 (2022)
   PUBMED   35390228
  REMARK    GeneRIF: Bmi-1-RING1B prevents GATA4-dependent
            senescence-associated pathological cardiac hypertrophy by promoting
            autophagic degradation of GATA4.
REFERENCE   3  (bases 1 to 3576)
  AUTHORS   Sawai A, Pfennig S, Bulajic M, Miller A, Khodadadi-Jamayran A,
            Mazzoni EO and Dasen JS.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3576)
  AUTHORS   Liu S, Aldinger KA, Cheng CV, Kiyama T, Dave M, McNamara HK, Zhao
            W, Stafford JM, Descostes N, Lee P, Caraffi SG, Ivanovski I,
            Errichiello E, Zweier C, Zuffardi O, Schneider M, Papavasiliou AS,
            Perry MS, Humberson J, Cho MT, Weber A, Swale A, Badea TC, Mao CA,
            Garavelli L, Dobyns WB and Reinberg D.
  TITLE     NRF1 association with AUTS2-Polycomb mediates specific gene
            activation in the brain
  JOURNAL   Mol Cell 81 (22), 4663-4676 (2021)
   PUBMED   34637754
  REMARK    Erratum:[Mol Cell. 2021 Nov 18;81(22):4757. PMID: 34798045]
REFERENCE   5  (bases 1 to 3576)
  AUTHORS   Zhang Z, Luo L, Xing C, Chen Y, Xu P, Li M, Zeng L, Li C, Ghosh S,
            Della Manna D, Townes T, Britt WJ, Wajapeyee N, Sleckman BP, Chong
            Z, Leavenworth JW and Yang ES.
  TITLE     RNF2 ablation reprograms the tumor-immune microenvironment and
            stimulates durable NK and CD4+ T-cell-dependent antitumor immunity
  JOURNAL   Nat Cancer 2 (10), 1018-1038 (2021)
   PUBMED   35121884
  REMARK    GeneRIF: RNF2 ablation reprograms the tumor-immune microenvironment
            and stimulates durable NK and CD4(+) T-cell-dependent antitumor
            immunity.
REFERENCE   6  (bases 1 to 3576)
  AUTHORS   del Mar Lorente M, Marcos-Gutierrez C, Perez C, Schoorlemmer J,
            Ramirez A, Magin T and Vidal M.
  TITLE     Loss- and gain-of-function mutations show a polycomb group function
            for Ring1A in mice
  JOURNAL   Development 127 (23), 5093-5100 (2000)
   PUBMED   11060235
REFERENCE   7  (bases 1 to 3576)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 3576)
  AUTHORS   Garcia E, Marcos-Gutierrez C, del Mar Lorente M, Moreno JC and
            Vidal M.
  TITLE     RYBP, a new repressor protein that interacts with components of the
            mammalian Polycomb complex, and with the transcription factor YY1
  JOURNAL   EMBO J 18 (12), 3404-3418 (1999)
   PUBMED   10369680
REFERENCE   9  (bases 1 to 3576)
  AUTHORS   Hemenway CS, Halligan BW and Levy LS.
  TITLE     The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of
            RING finger domains
  JOURNAL   Oncogene 16 (19), 2541-2547 (1998)
   PUBMED   9627119
REFERENCE   10 (bases 1 to 3576)
  AUTHORS   Schoorlemmer J, Marcos-Gutierrez C, Were F, Martinez R, Garcia E,
            Satijn DP, Otte AP and Vidal M.
  TITLE     Ring1A is a transcriptional repressor that interacts with the
            Polycomb-M33 protein and is expressed at rhombomere boundaries in
            the mouse hindbrain
  JOURNAL   EMBO J 16 (19), 5930-5942 (1997)
   PUBMED   9312051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115060.9 and AC165946.4.
            
            [WARNING] On May 9, 2023 this sequence was replaced by
            NM_001360844.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR17253012.5996745.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN01164134
                                    [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC115060.9         13943-14215
            274-510             AC115060.9         15444-15680
            511-645             AC165946.4         153709-153843       c
            646-734             AC165946.4         148515-148603       c
            735-895             AC165946.4         146850-147010       c
            896-1111            AC165946.4         146118-146333       c
            1112-1384           AC165946.4         143050-143322       c
            1385-1556           AC165946.4         141616-141787       c
            1557-3576           AC165946.4         139376-141395       c
FEATURES             Location/Qualifiers
     source          1..3576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3576
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /note="ring finger protein 2"
                     /db_xref="GeneID:19821"
                     /db_xref="MGI:MGI:1101759"
     exon            1..273
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            274..510
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            511..645
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            646..734
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            735..895
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1111
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1384
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1556
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..3576
                     /gene="Rnf2"
                     /gene_synonym="dinG; Ring1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcctcc ccgcgcggtg cgcgtccgcg tcccgcgcct ccgcctcctc gctcgctcgc
       61 tcgctcgctc gctccttccc gccctccccg cagctccggc cgagccggct cccccctccc
      121 cagtctctca tgaatattga gcggcccctg ttgtatttcc cgagctccat tgcggaagcc
      181 gagactcgcc atattgtgcg gcggcgccgg cggttgattc tcgagtctcg ctccggccac
      241 tgccagcgca cccccgggct ggggcaggag ccgcgaccca ttcagtattg tccaggcaag
      301 ctggcctcat actcgatact gagtttaagg caatcctcct gtctcagctt ccctggtgac
      361 aagattatag acattcaaca cagctgtctt acattttgtg tcttaagttg aacttttaac
      421 ctctgattta taaagaactt aaacggcaac aatattactc ctggatatac ctctttgccc
      481 tctaaaatct ctacttgcta caatcaacag agtctcctta tatatccttg actgtcctgg
      541 aacttgctgt gtagacaagg ctgtccttga actcagagat ctgcctaccc acctgtctct
      601 ggagtgctgg gattaaaggg atgtgctgcc accacctggc aagagaaatg tctcaggctg
      661 tgcagacaaa tggaactcaa ccattaagca aaacatggga actcagtttg tatgagttac
      721 aacgaacacc tcaggaggca ataacagatg gcttggaaat tgtggtttca cctagaagtc
      781 tacacagtga attaatgtgc ccaatttgtt tggatatgtt aaagaacacc atgactacaa
      841 aggagtgttt acatcggttt tgcgcggatt gtattatcac agcccttaga agtggcaaca
      901 aagagtgtcc tacctgtcgg aaaaaactgg tttctaaaag atcactaagg ccagacccga
      961 actttgatgc actcatcagc aagatttatc ccagtcgtga tgagtatgaa gcgcatcagg
     1021 aaagggtctt agcaaggatc aacaaacaca acaatcagca ggctctcagc cacagcatcg
     1081 aggaggggct gaagatacag gccatgaaca gattacagcg aggcaaaaag cagcagatag
     1141 aaaatggtag tggagcagaa gataatggtg acagctccca ctgtagtaac gcatccacac
     1201 acagcaacca ggaagcgggc ccgagtaaca aacggaccaa aacctctgat gactctgggc
     1261 ttgaacttga taacaacaat gcagcagtgg cgattgatcc agtcatggac ggtgccagtg
     1321 agattgagtt agtcttcagg ccccatccaa ctcttatgga aaaggacgac agcgcacaga
     1381 caagatacat aaagacttca ggcaatgcca ctgttgatca cttatccaag tatctggctg
     1441 tgaggttagc tttagaagaa cttcgaagca aaggagaatc aaaccagatg aacctggata
     1501 cagccagtga gaagcagtac accatttaca tagccacagc cagtggccag ttcaccgttt
     1561 taaatggctc cttttctttg gaattggtca gtgagaaata ctggaaagtg aacaaaccca
     1621 tggaacttta ttatgcaccc accaaggagc acaaatgagc ttttaaaagt caattctaag
     1681 actgaacttt ttatagtcta ttcctttact attaaagatg taccattgtt actttcatgg
     1741 acagacctgg gatatgttca gttttctttc tgagccagac ttgtttacac tattagatta
     1801 ccgtctcctt aatttaaaga cagtactttg tggaaaggac tctgtgattc agagctccca
     1861 ctccctccat agacgctcta agttgttgct tacagaaaac ggggttcctc tggggaggag
     1921 actttgaact aggagttttt tgtagttctg tattctttat tttttccttc cattttttga
     1981 tattttcaga cagtgtctca ttattataaa gccctggcta gcctggaact tgctgagtag
     2041 aacaggctgg ccttgacttt ggagtaatgc tcctgcccaa gtactgggat tctgcctggc
     2101 ttaagattca gttggccatc agccatcttt tcccctttca aaagtttttt agcttaaaga
     2161 atgttagaca atatgtattc tgatgttttc cccttgaagt cttgtatatt tatagttttc
     2221 tatacaaact gtaatatctt catgaagacc aaggctcaaa ttactgtgct taaaacaatt
     2281 ctcataggat tattattttc atggtatttt cttacataat atctcattta aaggaggttc
     2341 tttatgaact tggtgtccat tgtcatgcaa tgttttgttt ttgtcatgtg tttccactat
     2401 aagtttagaa tttcaggtca cggggaaaag tcgaataaag ttctttgaga acgtggttca
     2461 tttacaggtt tcactgaaga aagagaagtt taagatggtg aaaatatgtg tattcctctg
     2521 tacatttgag agtttactgt ccctttatta tgtatgtttg atgcttttct ctattaaaat
     2581 accagagatt atggagatat tttgcacttt agccttgatg aaaagtacaa gatatgttca
     2641 aagcttcccc tcatttcttt tcttattaat tcaagaataa catgacacag ttaaaaatag
     2701 aaaagaaagg ttttgtttga agagttcttt gcattctgag ttaccatgtg tttataaatt
     2761 tagtgctctg ctaaattaca ctctgtagaa acaggttaat ggagtgtgaa cattgcattg
     2821 acatagaatg ggacagctct gtagaaggat gtcagcaggt tgggcagcca ttcagaagcc
     2881 ttagttttgt attgagaaag tgttggtagt ctgggaacca caagactttc tgctgaccag
     2941 tcagacttaa tgtcttagat ttcatttctg tcccgatgct acatatgtct ctaagtttaa
     3001 attctcacag tatttacaaa gacatgtttg cattgaaaaa tttaacccaa aggggttttg
     3061 atagaaggaa gagacttccg gtaccattgt aactaaagtg tcagtcattt taactattta
     3121 tctgtcagtt tagacagatt ggggccagct tgatgcttta atcttgagcc gactatgaaa
     3181 acttaaaggc ttattcaatt ttttaccatt ttactgaaaa tatttgaaat ctgtttttac
     3241 agtttttttg gtaatctgtg ccataagatt tgaaaaccac caaaaattat acgaactttt
     3301 atatccaatt ccttttctgg ggtaatgtta agttgtatag attattaatg catgttcgct
     3361 gaatataact cttgttttgt gatgtgattg cttagacttt attggtgaca tattagatta
     3421 gtggttgtat taaataatta aattctcctt gtggttattg aaattttatc taagcagaaa
     3481 gttatttgtg actataagct ttgtgcttag agaatgtatg tgtttttatc tgtctatggg
     3541 agcacataaa ctatttgcat catttagtga agttat
//
