LOCUS       NM_029219               2659 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 19B (Rnf19b), transcript variant
            2, mRNA.
ACCESSION   NM_029219 XM_204030 XM_910375
VERSION     NM_029219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2659)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2659)
  AUTHORS   Lawrence,D.W., Shornick,L.P. and Kornbluth,J.
  TITLE     Mice deficient in NKLAM have attenuated inflammatory cytokine
            production in a Sendai virus pneumonia model
  JOURNAL   PLoS One 14 (9), e0222802 (2019)
   PUBMED   31539400
  REMARK    GeneRIF: Results indicate that natural killer lytic-associated
            molecule (NKLAM/RNF19b) plays a role in regulating the production
            of pro-inflammatory cytokines during viral infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2659)
  AUTHORS   Lawrence,D.W. and Kornbluth,J.
  TITLE     Reduced inflammation and cytokine production in NKLAM deficient
            mice during Streptococcus pneumoniae infection
  JOURNAL   PLoS One 13 (3), e0194202 (2018)
   PUBMED   29518136
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2659)
  AUTHORS   Lawrence,D.W., Gullickson,G. and Kornbluth,J.
  TITLE     E3 ubiquitin ligase NKLAM positively regulates macrophage inducible
            nitric oxide synthase expression
  JOURNAL   Immunobiology 220 (1), 83-92 (2015)
   PUBMED   25182373
  REMARK    GeneRIF: E3 ubiquitin ligase NKLAM positively regulates macrophage
            inducible nitric oxide synthase expression.
REFERENCE   6  (bases 1 to 2659)
  AUTHORS   Lawrence,D.W. and Kornbluth,J.
  TITLE     E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and
            plays a role in bacterial killing
  JOURNAL   Cell Immunol 279 (1), 46-52 (2012)
   PUBMED   23085241
  REMARK    GeneRIF: Data show that Natural Killer Lytic-Associated Molecule
            (NKLAM) is a component of macrophage phagosomes and is involved in
            macrophage bactericidal functions.
REFERENCE   7  (bases 1 to 2659)
  AUTHORS   Hoover,R.G., Gullickson,G. and Kornbluth,J.
  TITLE     Impaired NK cytolytic activity and enhanced tumor growth in NK
            lytic-associated molecule-deficient mice
  JOURNAL   J Immunol 183 (11), 6913-6921 (2009)
   PUBMED   19915045
  REMARK    GeneRIF: support the role for NKLAM in NK function both in vitro
            and in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606977.28.
            
            On Feb 25, 2019 this sequence version replaced NM_029219.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.339223.1,
                                           SRR5286962.42080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AL606977.28        4558-5310
            754-959             AL606977.28        18151-18356
            960-1101            AL606977.28        19916-20057
            1102-1264           AL606977.28        21984-22146
            1265-1379           AL606977.28        22576-22690
            1380-1520           AL606977.28        25321-25461
            1521-1728           AL606977.28        26756-26963
            1729-1860           AL606977.28        29161-29292
            1861-2659           AL606977.28        30142-30940
FEATURES             Location/Qualifiers
     source          1..2659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.76 cM"
     gene            1..2659
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /note="ring finger protein 19B"
                     /db_xref="GeneID:75234"
                     /db_xref="MGI:MGI:1922484"
     exon            1..753
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2323
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /EC_number="2.3.2.31"
                     /note="isoform 2 is encoded by transcript variant 2; IBR
                     domain containing 3; E3 ubiquitin-protein ligase RNF19B;
                     IBR domain-containing protein 3; natural killer
                     lytic-associated molecule"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF19B isoform 2"
                     /protein_id="NP_083495.1"
                     /db_xref="CCDS:CCDS51305.1"
                     /db_xref="GeneID:75234"
                     /db_xref="MGI:MGI:1922484"
                     /translation="MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASAR
                     GRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEE
                     DEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISC
                     PECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCA
                     SCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESG
                     PDDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGK
                     KPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKH
                     KRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGK
                     GVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSE
                     TASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMA
                     GSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGA
                     GGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITS
                     DECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE"
     exon            754..959
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1101
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1264
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1379
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1520
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1728
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1860
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2659
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /note="hexamer: AATAAA"
     polyA_site      2659
                     /gene="Rnf19b"
                     /gene_synonym="4930534K13Rik; 4930555L03Rik; Ibrdc3"
                     /note="major polyA site"
ORIGIN      
        1 ctgtctctgg gaggactgcc gaggcggtgg cggcggcggc ggcggccggg gcgccggctg
       61 ggagggggcg ctgaggcggg agctacggcg gcgctgggcg cccctggctc ctcagcctct
      121 gcgggccatg ggctccgaga aggactccga gtcgccgcgc tccacctcgc tccatgcggc
      181 cgcccccgac cctaagtgcc gcagcggcgg ccggcgccgg cgcctcacct tccacagcgt
      241 cttctccgcc tcggcccgcg gccgccgcgc ccggaccaag cctcaggccg aaccgccgcc
      301 cccggctgcg ccgccgccgc cgccgccgcc cgctccggcc ccggttgagg ctcaggcccc
      361 gccggtggaa gctctgccct ccgagcccgc tgccgaggct gaggcggagg ccgtggctgc
      421 cgggccggag gaggacgagg cggcggaggg cggcggcgcg gaggaggtgg agtgcccgct
      481 gtgcctggtg cgcctgccgc ccgagcgggc cccgcgcctc ctcagctgcc cgcatcgctc
      541 gtgccgggac tgcctccgcc actacctgcg cctggagatc agcgagagcc gcgtgcccat
      601 cagctgcccc gagtgcagcg agcggctcaa cccacacgac atccgtctgc tgctggccga
      661 cccgccgctc atgcacaagt acgaagagtt catgctgcgc cggtacctgg cctcggaccc
      721 cgactgccgc tggtgtccgg cccctgactg cggttatgct gttattgcct atggctgtgc
      781 cagttgccca aagctaacct gtgagaggga gggctgccag actgagttct gctaccactg
      841 caagcagata tggcatccaa accagacctg cgatatggcc cgtcagcaga gggctcagac
      901 tttacgagtt cggaccaagc acacttcagg tctcagttac gggcaagaat ctggaccaga
      961 tgacatcaag ccatgcccac gatgcagtgc ttacattatc aagatgaatg atgggagctg
     1021 taaccacatg acctgtgcag tgtgtggctg tgaattctgc tggctttgca tgaaagagat
     1081 ctctgacttg cattacctca gtccctctgg ctgtacattc tggggcaaga agccatggag
     1141 ccgcaaaaag aaaattcttt ggcagttggg cacattgatc ggtgctccgg tggggatctc
     1201 actcattgct ggcattgcaa ttcccgccat ggtcatcggc atccctgtat acgtggggag
     1261 aaagattcac agcaggtacg agggaaggaa aacctccaag cacaagagga atttggctat
     1321 cacaggagga gtgaccttgt cagtcattgc atccccagta atcgctgctg ttagcgttgg
     1381 tattggtgtc cccattatgc tggcatatgt ttatggggtt gtgcccattt ctctttgccg
     1441 tggaggtggc tgtggagtta gcacagccaa tggaaagggg gtaaaaattg agtttgatga
     1501 agatgatggt ccaatcacag tggcagatgc ctggcgagcc ctcaagaacc ccagcatcgg
     1561 agaaagcagc attgagggcc tgactagtgt gctgagtacc agcggaagcc ctacagatgg
     1621 actcagtgtc atgcagggac catacagcga gacagccagc ttcgctgccc tctcaggggg
     1681 cacactgagt ggtggtattc tctccagcgg caagggaaag tacagccggt tagaagttca
     1741 agctgatgtc caaaaggaaa ttttccccaa agacacagcc agtcttggtg caattagcga
     1801 cagcgcaagc actcgtgcta tggccggttc cataatcagt tcctacaacc cacaggacag
     1861 agagtgcaac aatatggaaa tccaagtgga cattgaagcc aaaccaagtc actatcagtt
     1921 ggtgagtggc agcagcacag aggactcgct ccatgtccat gctcaggtgg cagagaagga
     1981 agaagagggt aatggtgctg gtggtggcag cggtggcagt gaagacgatc ccccttacaa
     2041 acaccaaagc tgtgaacaga aagactgcct ggccagcaag gcttgggaca tcagcctggc
     2101 ccagcctgag agcatccgca gtgacctgga gagctctgac acgcagtcag atgacgtgcc
     2161 agacatcacc tcagatgagt gtggctcgcc ccgctcccat gctgcagcct gcccctccac
     2221 cccccaagtc cacggtgcac cgagcccaag tgcccacaag aacctcgctg ctccagctga
     2281 gggccagact gtcttgaagt cagaagagta tgaagtggaa tgaaggcccc tgttctgaga
     2341 agcacacttg ttgtaactgc atcttttgga atctttttcg ggggagggtg gggatttatg
     2401 tattttgttt caaagattct ctggtcaggg ttcccccagg gaagttctga gaaatttaca
     2461 atttcttacc agataaaaaa tgaaatttgc ctctagtatc cctcccccta tcctctcatt
     2521 tttagtttta atttattggc taaactgatg ttggcaatct gtgaggtgtg tcaaagaatg
     2581 tacatatgta tgtgtgtata ttgtatgtat gctaacatta ttgatgacac attttaataa
     2641 agaattctgt cataactga
//
