LOCUS       NM_013923               4276 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus ring finger protein 19A (Rnf19a), transcript variant
            1, mRNA.
ACCESSION   NM_013923
VERSION     NM_013923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Zhu,S., Tao,M., Li,Y., Wang,X., Zhao,Z., Liu,Y., Li,Q., Li,Q.,
            Lu,Y., Si,Y., Cao,S. and Ye,J.
  TITLE     H3K27me3 of Rnf19a promotes neuroinflammatory response during
            Japanese encephalitis virus infection
  JOURNAL   J Neuroinflammation 20 (1), 168 (2023)
   PUBMED   37480121
  REMARK    GeneRIF: H3K27me3 of Rnf19a promotes neuroinflammatory response
            during Japanese encephalitis virus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Yang,Y., Cao,X., Huang,L. and Yang,A.
  TITLE     RNF19a inhibits antiviral immune response to RNA viruses through
            degradation of TBK1
  JOURNAL   Mol Immunol 143, 1-6 (2022)
   PUBMED   34990937
  REMARK    GeneRIF: RNF19a inhibits antiviral immune response to RNA viruses
            through degradation of TBK1.
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Park,H., Yang,J., Kim,R., Li,Y., Lee,Y., Lee,C., Park,J., Lee,D.,
            Kim,H. and Kim,E.
  TITLE     Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a,
            display reduced adult neurogenesis, enhanced long-term
            potentiation, and impaired contextual fear conditioning
  JOURNAL   Sci Rep 5, 16410 (2015)
   PUBMED   26553645
  REMARK    GeneRIF: These results suggest that Dorfin may regulate adult
            neurogenesis, synaptic plasticity, and contextual fear memory.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Sone,J., Niwa,J., Kawai,K., Ishigaki,S., Yamada,S., Adachi,H.,
            Katsuno,M., Tanaka,F., Doyu,M. and Sobue,G.
  TITLE     Dorfin ameliorates phenotypes in a transgenic mouse model of
            amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 88 (1), 123-135 (2010)
   PUBMED   19610091
  REMARK    GeneRIF: In addition to causing a decrease in the amount of mutant
            SOD1 protein in the spinal cord, Dorfin overexpression ameliorated
            neurological phenotypes and motor neuron degeneration in a mouse
            model of amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Niwa,J., Yamada,S., Ishigaki,S., Sone,J., Takahashi,M., Katsuno,M.,
            Tanaka,F., Doyu,M. and Sobue,G.
  TITLE     Disulfide bond mediates aggregation, toxicity, and ubiquitylation
            of familial amyotrophic lateral sclerosis-linked mutant SOD1
  JOURNAL   J Biol Chem 282 (38), 28087-28095 (2007)
   PUBMED   17666395
  REMARK    GeneRIF: Dorfin ubiquitylated mutant SOD1 by recognizing the
            Cys(6)- and Cys(111)-disulfide cross-linked form and targeted it
            for proteasomal degradation
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Paces-Fessy,M., Boucher,D., Petit,E., Paute-Briand,S. and
            Blanchet-Tournier,M.F.
  TITLE     The negative regulator of Gli, Suppressor of fused (Sufu),
            interacts with SAP18, Galectin3 and other nuclear proteins
  JOURNAL   Biochem J 378 (Pt 2), 353-362 (2004)
   PUBMED   14611647
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Parraga,M. and del Mazo,J.
  TITLE     XYbp, a novel RING-finger protein, is a component of the XY body of
            spermatocytes and centrosomes
  JOURNAL   Mech Dev 90 (1), 95-101 (2000)
   PUBMED   10585566
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Lopez-Alanon,D.M. and del Mazo,J.
  TITLE     Cloning and characterization of genes expressed during
            gametogenesis of female and male mice
  JOURNAL   J Reprod Fertil 103 (2), 323-329 (1995)
   PUBMED   7616504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY207861.1, AK147768.1, CO432840.1, DV656092.1 and CN695058.1.
            
            On Mar 24, 2007 this sequence version replaced NM_013923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147768.1, SRR1660813.36883.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY207861.1         2-15
            15-936              AK147768.1         3-924
            937-1345            CO432840.1         286-694
            1346-1713           AK147768.1         1334-1701
            1714-2256           DV656092.1         198-740
            2257-3206           AK147768.1         2245-3194
            3207-3522           CN695058.1         263-578
            3523-4276           AK147768.1         3511-4264
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.46 cM"
     gene            1..4276
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /note="ring finger protein 19A"
                     /db_xref="GeneID:30945"
                     /db_xref="MGI:MGI:1353623"
     exon            1..236
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            237..992
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2841
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /EC_number="2.3.2.31"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF19A; double ring-finger
                     protein; UBCM4-interacting protein 117;
                     gametogenesis-expressed protein GEG-154; ubiquitin
                     conjugating enzyme 7 interacting protein 2; XY body
                     protein; ring finger protein (C3HC4 type) 19"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF19A isoform 1"
                     /protein_id="NP_038951.1"
                     /db_xref="CCDS:CCDS27427.1"
                     /db_xref="GeneID:30945"
                     /db_xref="MGI:MGI:1353623"
                     /translation="MQEQEISFIFKYNEGLCMNIDSDSILMSILDMSLHQQMGSDRDL
                     QSSTSSVSLPSVKKAPKQRRISIGSLFRRKKDSKRKSRELNGGVDGIASIESIHSEMC
                     ADKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLR
                     QYLRIEISESRVNISCPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW
                     CPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLR
                     LRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMK
                     EISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPV
                     YVGRKIHNRYEGKDVSKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVV
                     PISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNAAIDTTSVAEARHNPSIGEGSV
                     GGLTGSLSASGSHMDRIGTIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQA
                     DVQKERCSLSGESGTVSLGTVSDNASTKAMAGSILNSYIPLDREGNSMEVQVDIESKP
                     FKFRHNSGSSSVDDSGATRGHTGGASSGLPEGKSSATKWSKEATGGKKSKSGKLRKKG
                     NMKINETREDMDAQLLEQQSTNSSEFEAPSLSDSMPSVADSHSSHFSEFSCSDLESMR
                     TSCSHGSSDCHARFTAVNTLPEVENDRLENSPHQCSSALLSKAASCSDVPQPSHAADE
                     HGTSRSGGKPMVDLCFGDALRETNNNHSHQTADLKVAVQTEI"
     exon            993..1201
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1346
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1509
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1624
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1786
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2000
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2144
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..4276
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4256..4261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /note="putative"
     polyA_site      4276
                     /gene="Rnf19a"
                     /gene_synonym="Dorfin; Rnf19; Ubce7ip2; UIP117; XYbp"
                     /note="putative"
ORIGIN      
        1 gggggagaat ggcagttgct gtgttggttc ccggctgcga cggtccgact ggagtcacag
       61 aggggagttc gggaaagcgg ccgcccgcaa ccgttccacc ggcagctctc gccctagctg
      121 agaaggttcc gcggcggtgc tgaaaagtcg tcctccgttc tgcctccgct ttctgcctcc
      181 gcgggatggg cctgctcgcc agccgccccg cgccgccgcc gccctgagga gctgaggaca
      241 tctgtgacaa cagtcttctc ttgaactttt taagattctc tgaagaatgg atctttttta
      301 catcatgact taatctgaat gcaagaacaa gaaataagtt ttatttttaa gtataatgaa
      361 gggctgtgta tgaacattga ctctgactca attctgatga gcattttaga catgagttta
      421 catcagcaaa tgggctcaga tagagatctt cagtcttcta cttcctccgt gagcttgcct
      481 tctgtcaaaa aggcacccaa acagagaagg atttcaatag gctctctctt tcggaggaag
      541 aaggacagca aacgaaaatc aagggagctc aatggtggag tggatggaat tgcaagtatt
      601 gagagtatac attctgaaat gtgtgctgat aagaactcca ttttctctac aaatacctct
      661 tctgacaatg gattgacttc catcagcaaa caaattggag actttataga atgtcctttg
      721 tgccttttac ggcattctaa agacagattt cctgatataa tgacatgcca ccatagatct
      781 tgtgtggatt gcttacgaca atacctaagg atagaaatct ctgaaagtag agttaatatc
      841 agttgtccag aatgcactga acggtttaat cctcatgaca ttcgcttgat attaagtgat
      901 gatgtcttaa tggaaaaata tgaagaattt atgcttcgac ggtggcttgt tgcagatcct
      961 gactgtaggt ggtgtccggc tccagactgt ggatacgctg tgatagcatt tggatgtgcc
     1021 agctgtccaa aactaacttg tgggcgagaa ggctgtggaa cagagttttg ctaccactgt
     1081 aaacagatct ggcatccaaa ccagacctgt gatgctgctc gacaggaaag agcccaaagt
     1141 ttacgcttaa gaactatacg ttcttcatct attagttaca gccaggaatc tggagcagca
     1201 gctgatgata taaagccatg tccacgatgt gctgcttata taataaagat gaatgatggg
     1261 agttgcaatc atatgacatg tgctgtctgt ggttgtgagt tttgttggct atgtatgaaa
     1321 gaaatctccg atttacatta tctaagtccc tcaggttgta ctttttgggg gaagaaaccc
     1381 tggagccgaa agaagaaaat cctgtggcag ctgggaaccc ttgttggtgc tcccgtaggg
     1441 attgctctca tagctggcat tgccattccc gccatgatca ttggcattcc tgtgtacgtg
     1501 ggccgcaaga ttcataatcg ctatgaaggc aaagatgttt caaaacataa gcggaatctg
     1561 gccatagcag gcggtgtcac cctgtctgta atcgtgtctc cggtggtagc tgcagtgact
     1621 gtaggcattg gtgttcccat catgctagct tatgtctatg gtgtggtccc aatttctctc
     1681 tgccgaagtg ggggttgtgg tgtctctgcg ggcaatggga aaggagtgag gattgagttt
     1741 gatgatgaga atgacataaa cgtcggtggg actaacgcag ccatagatac aacatcagta
     1801 gcagaagcaa ggcacaaccc tagcatagga gagggaagtg tcggcggcct gactggcagt
     1861 ttgagtgcaa gtggaagcca catggatcga ataggcacca ttagagacaa cctgagtgag
     1921 acagcgagca ccatggcatt agctggagct agtatcacgg gcagtctgtc gggaagtgcc
     1981 atggtaaact gtttcaacag gttggaagta caagcagacg tacagaaaga acggtgtagt
     2041 ctcagtggag agtctggcac agtgagcttg ggaacagtta gtgataacgc cagcaccaaa
     2101 gcaatggcgg gatccattct caactcctac atccctctgg acagagaagg gaacagcatg
     2161 gaagtgcaag tggatattga gtcaaagcca ttcaagttcc gacacaacag tggaagcagc
     2221 agtgtggatg acagtggtgc tacccgaggc cacacaggcg gggcgtccag tggcttgccc
     2281 gaaggtaaat ccagtgctac caagtggtcc aaggaagcaa caggaggaaa aaagtcaaaa
     2341 agtggtaaac tgaggaaaaa gggtaacatg aagatcaatg agaccagaga ggacatggat
     2401 gcacagttgt tagagcaaca aagcacgaac tcaagtgagt ttgaggcgcc atccctcagt
     2461 gacagcatgc cgtctgtagc agattcccac tccagtcatt tttctgaatt tagctgctca
     2521 gacttagaaa gcatgagaac gtcctgtagt cacggctcca gtgattgcca cgcccgcttc
     2581 acagctgtga acacccttcc tgaggtagaa aacgaccgac tggagaactc accacaccag
     2641 tgcagcagcg ctctgctttc caaagctgct tcctgttcag atgtcccaca gcccagccat
     2701 gctgcagacg agcatggcac cagcagaagt ggggggaagc ctatggtgga tttgtgtttt
     2761 ggtgatgcac tgagagagac aaataataac cactcgcacc agacagcaga cctgaaagtt
     2821 gctgtccaga ctgaaattta ggcccgtgaa tgctgcagag taagaaccac tgaacaaccg
     2881 tgttgggagc tggttgaacc atgtgcgact gttaagctta agttaccagc aaaagccagg
     2941 tttcataatc gtaatgcaaa tacattttgt atgtctagca aagcattgtg tttcatgttg
     3001 atattaatta ccaaattatg aattgaaggc tttaaagtgc gttagtacaa gatagtaaca
     3061 taagaaaaag gcatgttttg tgttcttgtc acaaaacact gcttgatgca catacctgtg
     3121 tatttagata gaaatttgac ttaatttata accgtatgat actaacactg ttctacggca
     3181 ttcttaagga agatggaggc ttagggatga gtggttagtg acattttatt gaaaccacta
     3241 agggatggaa cgtggcagat tactcagtac atgatcctct tggtaacatt tctcttcata
     3301 actgagctga aatttcattt cttcatatgc aatgtggata tcaagcttaa tgcagcccat
     3361 tggtaaccat ttggatactt agacacttga gcaagatggt ggcagttttt gcacaactct
     3421 gaagtagaaa tacttggtac tgttacatat ctcaagtgtg gttgttgcca ttttagaaga
     3481 cggtaaaagg taactaaggg actgacagtg gcagaagacg gtcccattag gatggaagta
     3541 ttacagtcac ctgtcactaa ggcaagttag tgccctttga ttcttggtgc ctttgggaga
     3601 gactgggttt tatgagcctc gtcatttgag gatttttctc tatcatttcc cataatgtct
     3661 tctctagtca ccttggatta tatagaaaaa tacaggaaat aggtaaacat gaatgtgatt
     3721 attaactaca ctgaaaaagt attcacctac caaagacaca ctcaggcttt agtaaattta
     3781 acgttacata acctcaattt ttaacatgta tatctttttg aaccatgaaa tcaaaacaat
     3841 gcagagcttg taccaagctt atataaaagg tctacgtgtg gctttgtttc cttttccttt
     3901 tgtttacggg ggatgttcag ctgacacgag cagaagttgg ccaaaatact gcctgcacta
     3961 ttgacttccc acacagctct cccggcagac taacctcata gtggtcaagt actccacctt
     4021 aggtgtttcc tctaagtgtt accattatgg tgctactgag cattttcttt tggtaaacaa
     4081 ggaaaatgtc cgggctgcag ccgtgtgccg tccgtcgttt tcctcgctgc atccattaat
     4141 ctgcttagag aacactagtg ccagctcttt tagctgatac tgctcattat ggtatttgta
     4201 catttgtttg cattccaatt ttgttcagta atgagtgtgt gaacagcaga catgaaataa
     4261 atgtaaatac taatgg
//
