LOCUS       NM_025786               1247 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus ring finger protein 186 (Rnf186), mRNA.
ACCESSION   NM_025786
VERSION     NM_025786.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Du,J., Ji,X., Xu,B., Du,Q., Li,Y., Zhou,B., Liu,X., Xu,Z.,
            Jiang,Y., Kou,B., Li,Z., Cui,C. and Lin,J.
  TITLE     Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic
            lipophagy in non-alcoholic fatty liver disease
  JOURNAL   Metabolism 152, 155769 (2024)
   PUBMED   38158076
  REMARK    GeneRIF: Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates
            hepatic lipophagy in non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Du,J., Jiang,Y., Liu,X., Ji,X., Xu,B., Zhang,Y., Liu,Y., Zhang,T.
            and Lin,J.
  TITLE     HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells
            Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186
  JOURNAL   Stem Cells 41 (2), 153-168 (2023)
   PUBMED   36573461
  REMARK    GeneRIF: HGF Secreted by Menstrual Blood-Derived Endometrial Stem
            Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through
            Downregulation of Hepatic Rnf186.
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Zhang,H., Cui,Z., Pan,T., Hu,H., He,R., Yi,M., Sun,W., Gao,R.,
            Wang,H., Ma,X., Peng,Q., Feng,X., Liang,S., Du,Y. and Wang,C.
  TITLE     RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for
            Colorectal Tumorigenesis in Colorectal Epithelial Cells
  JOURNAL   J Immunol 209 (9), 1796-1805 (2022)
   PUBMED   36130827
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Hu,X., Zhang,Q., Guo,M., Yuan,Q., Tong,X., Zhang,Q., Lin,L.,
            Zhang,L., Lv,S., Liu,X., Gao,C., Chang,Y. and Zhang,H.
  TITLE     Deletion of RNF186 expression suppresses diet-induced hepatic
            steatosis by regulating insulin activity
  JOURNAL   iScience 25 (2), 103859 (2022)
   PUBMED   35198905
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Zhang,H., Cui,Z., Cheng,D., Du,Y., Guo,X., Gao,R., Chen,J., Sun,W.,
            He,R., Ma,X., Peng,Q., Martin,B.N., Yan,W., Rong,Y. and Wang,C.
  TITLE     RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the
            colonic epithelial cells for the maintenance of intestinal
            homeostasis
  JOURNAL   Autophagy 17 (10), 3030-3047 (2021)
   PUBMED   33280498
  REMARK    GeneRIF: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy
            in the colonic epithelial cells for the maintenance of intestinal
            homeostasis.
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Ji,Y., Tu,X., Hu,X., Wang,Z., Gao,S., Zhang,Q., Zhang,W., Zhang,H.
            and Chen,W.
  TITLE     The role and mechanism of action of RNF186 in colorectal cancer
            through negative regulation of NF-kappaB
  JOURNAL   Cell Signal 75, 109764 (2020)
   PUBMED   32882406
  REMARK    GeneRIF: The role and mechanism of action of RNF186 in colorectal
            cancer through negative regulation of NF-kappaB.
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Tong,X., Zhang,Q., Wang,L., Ji,Y., Zhang,L., Xie,L., Chen,W. and
            Zhang,H.
  TITLE     RNF186 impairs insulin sensitivity by inducing ER stress in mouse
            primary hepatocytes
  JOURNAL   Cell Signal 52, 155-162 (2018)
   PUBMED   30223017
  REMARK    GeneRIF: The results of the current study reveal that RNF186
            triggers endoplasmic reticulum stress in mouse primary hepatocytes.
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Fujimoto,K., Kinoshita,M., Tanaka,H., Okuzaki,D., Shimada,Y.,
            Kayama,H., Okumura,R., Furuta,Y., Narazaki,M., Tamura,A.,
            Hatakeyama,S., Ikawa,M., Tsuchiya,K., Watanabe,M., Kumanogoh,A.,
            Tsukita,S. and Takeda,K.
  TITLE     Regulation of intestinal homeostasis by the ulcerative
            colitis-associated gene RNF186
  JOURNAL   Mucosal Immunol 10 (2), 446-459 (2017)
   PUBMED   27381925
  REMARK    GeneRIF: RNF186 maintains gut homeostasis by controlling
            endoplasmic reticulum stress in colonic epithelia
REFERENCE   9  (bases 1 to 1247)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 1247)
  AUTHORS   Yu,J., Valerius,M.T., Duah,M., Staser,K., Hansard,J.K., Guo,J.J.,
            McMahon,J., Vaughan,J., Faria,D., Georgas,K., Rumballe,B., Ren,Q.,
            Krautzberger,A.M., Junker,J.P., Thiagarajan,R.D., Machanick,P.,
            Gray,P.A., van Oudenaarden,A., Rowitch,D.H., Stiles,C.D., Ma,Q.,
            Grimmond,S.M., Bailey,T.L., Little,M.H. and McMahon,A.P.
  TITLE     Identification of molecular compartments and genetic circuitry in
            the developing mammalian kidney
  JOURNAL   Development 139 (10), 1863-1873 (2012)
   PUBMED   22510988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805923.6.
            
            On Mar 15, 2019 this sequence version replaced NM_025786.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK078919.1, BC011492.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1247              AL805923.6         24309-25555
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..1247
                     /gene="Rnf186"
                     /gene_synonym="9130020G10Rik"
                     /note="ring finger protein 186"
                     /db_xref="GeneID:66825"
                     /db_xref="MGI:MGI:1914075"
     exon            1..1247
                     /gene="Rnf186"
                     /gene_synonym="9130020G10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..875
                     /gene="Rnf186"
                     /gene_synonym="9130020G10Rik"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF186"
                     /protein_id="NP_080062.5"
                     /db_xref="CCDS:CCDS51338.1"
                     /db_xref="GeneID:66825"
                     /db_xref="MGI:MGI:1914075"
                     /translation="MSCTEAPQPIPAGTTTTSTIIALGPTGRLSISVEGDLECLVCRE
                     PYNCARSPKLLSCQHTFCAVCLKLLLYVQEDTWSIPCPLCRKVTAVPGGLICSLRDQE
                     AMVGRLALPCPEVRLCPQRLVGSAASATRPANWTGEEEQDTVSVNRVAARRLAVHLLL
                     LALVIVLILPFIYPGVIRWVLAFVIALALLMSTLFCCHPQSQNSNWLCPRTLFCREQK
                     QTQITSIA"
ORIGIN      
        1 ggagaaacaa gcagggcaac caagggagca agatgccaga catcggttgt cagcaggtac
       61 ccgcagagag cagaagggag actggaagcg tccccacagg accggaaccc atgcaagtcc
      121 tggcagctcc ggtggatgtc gcatgcggat gcccgtgcgc ggatcagcct tgtccctcca
      181 cctctgtacc cagaatgtcc tgcactgagg ccccacagcc tatcccagcg ggtaccacca
      241 ccaccagcac catcattgcc ttggggccca ccgggcggct cagcatctct gtggagggtg
      301 acctggaatg cttggtgtgc cgagagccct acaactgtgc tcggtccccc aagctgctta
      361 gctgtcagca caccttctgt gccgtatgcc tgaagcttct gctatatgtg caggaagaca
      421 cctggtccat cccctgtccg ctgtgccgaa aggtcactgc tgtcccggga ggcctcatct
      481 gcagcttgcg agaccaggag gcgatggtgg ggcgtctggc cctgccatgc ccagaggtgc
      541 gcctatgtcc tcagaggcta gtgggttctg ccgcttcagc aactcggcca gccaactgga
      601 caggagaaga agaacaggac actgtaagtg tcaaccgtgt agctgcccgg cgcctggctg
      661 tacacttgct cttgttggct cttgtcattg tccttatcct gcctttcatc tacccgggtg
      721 tcatccggtg ggtgttggcc tttgtcattg ctctggctct cctgatgtcc accctattct
      781 gctgtcaccc ccagagccag aacagcaact ggctttgccc caggactctg ttctgcagag
      841 agcaaaagca aacccagatc acttctattg cctgagaact ctggatccct acaggcccag
      901 tgctgccaag gttccctcct cccccagacc tcacagtctg catgggtaag gggctagggg
      961 ccgcctttca aaatcacatt cgaactggac ttgcgtgtca aagccagact ggccatgttg
     1021 gatcaaggat tctgtgctgg aacagtggga tcgcacctgc ctgttcctgt gtagcatagg
     1081 aaggaaaggg ggaaagagag gagacacccc ctgaatgagt gactcaaggg tggtggggtc
     1141 cctaccccta ttccagagct cctaagtttt gtatatatcc ctttgtacac atattgggac
     1201 attggcctta ctacaaagca aatagaacca ggtctctttt gtaatcc
//
