LOCUS       NM_001290472            3389 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus ring finger protein 185 (Rnf185), transcript variant
            2, mRNA.
ACCESSION   NM_001290472 XM_006514591
VERSION     NM_001290472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Van Espen,B., Oo,H.Z., Collins,C., Fazli,L., Molinolo,A., Yip,K.,
            Murad,R., Gleave,M. and Ronai,Z.A.
  TITLE     RNF185 Control of COL3A1 Expression Limits Prostate Cancer
            Migration and Metastatic Potential
  JOURNAL   Mol Cancer Res 22 (1), 41-54 (2024)
   PUBMED   37831068
  REMARK    GeneRIF: RNF185 Control of COL3A1 Expression Limits Prostate Cancer
            Migration and Metastatic Potential.
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075756.1, AL713875.14, AK034108.1 and AV347010.1.
            
            On Mar 13, 2014 this sequence version replaced XM_006514591.1.
            
            Transcript Variant: This variant (2) lacks part of the 5' coding
            region and uses a downstream start codon, compared to variant 1.
            The encoded isoform (2) has a shorter N-terminus, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075756.1, AK053358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AK075756.1         2-156
            156-156             AL713875.14        106463-106463       c
            157-1708            AK075756.1         158-1709
            1709-3377           AK034108.1         1198-2866
            3378-3389           AV347010.1         218-229
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.4 cM"
     gene            1..3389
                     /gene="Rnf185"
                     /note="ring finger protein 185"
                     /db_xref="GeneID:193670"
                     /db_xref="MGI:MGI:1922078"
     exon            1..748
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     exon            749..969
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..1372
                     /gene="Rnf185"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin
                     transferase RNF185"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF185 isoform 2"
                     /protein_id="NP_001277401.1"
                     /db_xref="CCDS:CCDS70127.1"
                     /db_xref="GeneID:193670"
                     /db_xref="MGI:MGI:1922078"
                     /translation="MASKGPSASASTENSNAGGPSGSSNGTGESGGQDSTFECNICLD
                     TAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDP
                     REKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPP
                     AVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA"
     exon            970..988
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1101
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1156
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1274
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..3389
                     /gene="Rnf185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3362..3367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf185"
                     /note="hexamer: ATTAAA"
     polyA_site      3380
                     /gene="Rnf185"
                     /note="major polyA site"
ORIGIN      
        1 acctggcaac agcgaggtat gcccggctta ctataaaagg ggctgttcgc cccctcctct
       61 cccttactct ttgccccctt ccccctccgc cctctctctt cacgcgttcc tggccggcct
      121 ctctcccttc tcctcattct ctactccctt tcctactcca cttcccatgc ctcctcctcc
      181 tgttcttctt ctttataaaa cagaacaacc actgacctta ctttcttgta caaggcattc
      241 caaactggta tttctagaac tggctttttc atccgcccat tatttttgcg acacggtccc
      301 atgtatccca agcctgcttc gaaaacgaca ttgaagttct gacccatcac ccgaatgaat
      361 gctatgatta gctggcgggt acgcacatat ttattcccac gtcttcacgc gggcgaggcg
      421 agctcgccca tccaccgagc tgccttccct cctcttccag cgctaggaaa ccctacggaa
      481 agaccagacg ccctcccctt cctgtcccgg ggcggaactt accagccggg cgcctgggcc
      541 ggagagcagc gctgcacacc agccttttcc ggctggaacc ggaagttgtt ctactagagg
      601 cggctccgcg tcaggtgacc aagttcccgg taggaggggt cggaggttca atctttctga
      661 ctgacgcgtc tctaagactg gctcggctac tccgggacgg gggaacggac agctggcgtc
      721 gctggcgctc gctctaccgc ggcggcagga ttgtcttgag aatcttccct ggaagctttg
      781 ctggcaagca gccatggcaa gtaaagggcc ttcggcctct gcatccactg agaattccaa
      841 tgcagggggg cccagtggca gcagcaatgg cactggtgag agtggagggc aggacagcac
      901 ctttgagtgc aacatatgcc tggacacagc caaggatgct gtcatcagcc tgtgtggcca
      961 cctcttctgt tggccgtgtt tacatcagtg gttggagact aggcctaaca gacaagtgtg
     1021 tccagtctgc aaagctggca tcagccgaga caaagtcatc cccctctatg gcagaggcag
     1081 cactggacag caggatccca gagagaagac tcctcctcgt cctcaaggcc agaggccaga
     1141 gccagaaaat agagggggat ttcaaggatt tggatttgga gatggtggct ttcagatgtc
     1201 ttttggaatt ggagcatttc catttgggat atttgccaca gcatttaaca taaatgatgg
     1261 acggcctcct ccagctgtcc ctgggacacc ccagtatgtg gatgagcagt tcctgtcacg
     1321 cctcttcctg tttgtcgccc tggtgatcat gttctggctc ctgatcgcct aatacaggac
     1381 cctgttaaca tctacagcag cgcctctgga ctggtgatat gccgcaccca ctcctgtgtt
     1441 tgatttgttt aatcctgacc cagggatcaa gggtcagaga cacaccaagg agttggaact
     1501 caaaaccaaa ggaaccccca atttcaccac tgctgtaaac actcttgtat aacctcaggt
     1561 cttgtgctga atctcctctc atgggtggca gtgtgaagtc ctgctccagc cttctcagca
     1621 ggtcccagct ctacacaggg aagagatggg aagaaagaaa cagtttcttt aacaagaact
     1681 ttaaattaca aaaatgaagg gatgaaccaa atggtattta cagaaactta ctttcatctt
     1741 tttacatact ccttggtaag tggcctccac tccctatcct gagagactcc cttccacatc
     1801 ccagtactgc tcctcccacc tcccgcttcc tcagcaaaga cataagaagg tcggtcggtt
     1861 gcagcagcag aaactgaaaa tgctgatgac cttaccagag actctggttt ttgattggct
     1921 ctgggccttg ttcagtgtct tgaccctaga aagcagctta gatgacctgc tggcttcctg
     1981 gtatagattg tccctgatgt cactgggctc aaatttccca tcagccttct ctagacttct
     2041 gctgaattca agactgactg ttatgcttta gggctgatac aagaataaca ggacaggttg
     2101 ccctgcccta ggctacagaa gcctgagtca ttctctcaca gaacttgccc agagaaactg
     2161 gaggctttct caggtcagcc cagctgcatg tagaacacta ctaccctcag aagccattgt
     2221 cctttttaaa aaaggttacg acgctgactc catctgatgg tgaaaactcc ttgaatgtgt
     2281 gctgagccca gggatacatg aggctcctga gcaagcaacc cctctctggt gacataacac
     2341 aaggacctca gagatacagt gtggtcgaca ttccttagtc ttcctcgtgt tgatttgttc
     2401 ttgaacttat aagctgtttc ctctgaatct gattgtggga ttgtgttgac aggcaggaga
     2461 atagtcacct gctgagacgg ttcttgctct gcccatcagg cctcatctta gaaatgtcac
     2521 ctctccctgg agacctcagc agggcagcaa gataagcgtc tactggaccc ttttgttcac
     2581 ttctccaaca cccactgccc cagcaataac aaactgggag aaagccttgc ctggtgattt
     2641 ttctagatgt gactctatat aatctctgga accctagacc ttgaggatgg tgaaagagcc
     2701 ctcctcctca cagcacaatc cttacctgcc aacgccagtg ttagtgttga aatgaataca
     2761 gtatgagtat tgtgtaggag ggtggtttgg caactctagc tgttaagaat aagccaccaa
     2821 atttatggta tgcctgacag attttaaata ttctttggcg cttggaaatc cctggtcacg
     2881 gggcccctgg agtgtctctg ttctagagag aattggtagg atccctcagt gtagcatagc
     2941 cctaagtagt agagggaaaa cttaagccaa tgaacacaaa ggagatgaga gagggattgt
     3001 gagtagtgga gtaaaccatt tggaatctgg tgaaatggat gacccaggtg tgcagcagca
     3061 gagtcatcgc agggcatgca gtagcacagc tgtggtggca tgtgcccctg tgaacattaa
     3121 cataacaggg ctatacatct gccagcagct gaggctagac agccaacttg gactttatgg
     3181 gccattcctc tacaggctca ccactcatcc catggccaag gcagctttcc cttctgtgtt
     3241 ttctgtgtcc tcagcctcca cctttctgcc acccacatgg acaaggacaa tgggaacatg
     3301 taaggccgca taccctgacc agccactgat tttcactgtt gtgaaagtga tttgacttag
     3361 aattaaatgg ttttacatta ctgtgagtg
//
