LOCUS       NM_001379623            1430 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ring finger protein 183 (Rnf183), transcript variant
            1, mRNA.
ACCESSION   NM_001379623 XM_030253876
VERSION     NM_001379623.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Okamoto,T., Wu,Y., Matsuhisa,K., Saito,A., Sakaue,F., Imaizumi,K.
            and Kaneko,M.
  TITLE     Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na,
            K-ATPase lysosomal degradation through ubiquitination of its beta1
            subunit
  JOURNAL   Biochem Biophys Res Commun 521 (4), 1030-1035 (2020)
   PUBMED   31732153
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Maeoka,Y., Okamoto,T., Wu,Y., Saito,A., Asada,R., Matsuhisa,K.,
            Terao,M., Takada,S., Masaki,T., Imaizumi,K. and Kaneko,M.
  TITLE     Renal medullary tonicity regulates RNF183 expression in the
            collecting ducts via NFAT5
  JOURNAL   Biochem Biophys Res Commun 514 (2), 436-442 (2019)
   PUBMED   31053298
  REMARK    GeneRIF: results indicated that RNF183 is predominantly expressed
            in the renal medullary collecting ducts, and that decreased renal
            medullary tonicity by furosemide treatment decreases RNF183
            expression by NFAT5 downregulation
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Maeoka,Y., Wu,Y., Okamoto,T., Kanemoto,S., Guo,X.P., Saito,A.,
            Asada,R., Matsuhisa,K., Masaki,T., Imaizumi,K. and Kaneko,M.
  TITLE     NFAT5 up-regulates expression of the kidney-specific ubiquitin
            ligase gene Rnf183 under hypertonic conditions in inner-medullary
            collecting duct cells
  JOURNAL   J Biol Chem 294 (1), 101-115 (2019)
   PUBMED   30413537
  REMARK    GeneRIF: These results indicate that (i) RNF183 is predominantly
            expressed in the normal renal medulla, (ii) NFAT5 stimulates
            transcriptional activation of Rnf183 by binding to its cognate
            binding motif in the Rnf183 promoter, and (iii) RNF183 protects
            renal medullary cells from hypertonicity-induced apoptosis.
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Wu,Y., Guo,X.P., Kanemoto,S., Maeoka,Y., Saito,A., Asada,R.,
            Matsuhisa,K., Ohtake,Y., Imaizumi,K. and Kaneko,M.
  TITLE     Sec16A, a key protein in COPII vesicle formation, regulates the
            stability and localization of the novel ubiquitin ligase RNF183
  JOURNAL   PLoS One 13 (1), e0190407 (2018)
   PUBMED   29300766
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1430)
  AUTHORS   Yu,Q., Zhang,S., Chao,K., Feng,R., Wang,H., Li,M., Chen,B., He,Y.,
            Zeng,Z. and Chen,M.
  TITLE     E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory
            Bowel Disease
  JOURNAL   J Crohns Colitis 10 (6), 713-725 (2016)
   PUBMED   26818663
  REMARK    GeneRIF: RNF183, which is negatively regulated by miR-7, is a novel
            regulator promoting intestinal inflammation by increasing the
            ubiquitination and degradation of IkappaBalpha, thereby inducing
            NF-kappaB activation. The interaction between RNF183-mediated
            ubiquitination and miRNA may be an important novel epigenetic
            mechanism in the pathogenesis of inflammatory bowel disease.
REFERENCE   8  (bases 1 to 1430)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732594.5.
            
            On Apr 10, 2020 this sequence version replaced XM_030253876.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX524117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL732594.5         27793-27905         c
            114-283             AL732594.5         27120-27289         c
            284-368             AL732594.5         23133-23217         c
            369-1430            AL732594.5         20195-21256         c
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.13 cM"
     gene            1..1430
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /note="ring finger protein 183"
                     /db_xref="GeneID:76072"
                     /db_xref="MGI:MGI:1923322"
     exon            1..113
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            114..283
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            284..368
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1430
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..983
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /EC_number="2.3.2.27"
                     /note="probable E3 ubiquitin-protein ligase RNF183"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF183"
                     /protein_id="NP_001366552.1"
                     /db_xref="GeneID:76072"
                     /db_xref="MGI:MGI:1923322"
                     /translation="MSEPQGQELRAECPVCWNPFNNTFHTPKVLDCCHSFCVECLAHL
                     SLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLTLLRLEPHHVILEGHQLCLKD
                     QPKSRYFLRQPRVYTLDLGAEPGSQTGLPQDTAPDTRPVPIPSHYSLRECVRNPHFRI
                     FAYLMAVILSVTLLLIFSIFWTKQFFWGMG"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1430
                     /gene="Rnf183"
                     /gene_synonym="5830442J12Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgtttggga tttgaatgca ggttcttgtg ctcgcatagc aagtactctg accactgaac
       61 tgtctcccta gttgcacccc acaaggaagg tggatttctc cgcgcagctg cagagttcca
      121 aagtcatccg aggaaggaag aagaaagcca gccagagagt ggaccaagag ctggggagac
      181 ccatgcaaaa gaggctggct cccagcaacc tggaagccag cgaggaagcc agcgcaacct
      241 gcctcaaggc tgggctgaga gaggaagaag ctggctgaag ctgcagccta tgaatgtcat
      301 gagagaaaag agaaggtcaa ttttattccc ctctatcttt cagtacctgg tacagcacct
      361 ggcatgtggg catcctctgg aggttccggc tccctgtatg tgatcagagg atgagcgaac
      421 cacagggcca ggagctcaga gccgagtgcc ctgtctgctg gaaccctttc aacaacacat
      481 tccacacccc caaagtgcta gactgctgtc actccttctg tgtggaatgc ctggcccacc
      541 tcagcctggt aaccccagcc aggcgccgct tgctctgccc actctgtcgt cagcccaccg
      601 tgctggcttc agggcagcca gtcactgact tgcctacaga cactgccatg ctgaccctgc
      661 tccgcctaga gccccaccat gtcatcctag agggccacca gctctgtctc aaggaccagc
      721 ccaagagccg ctacttcctg cgtcagcctc gggtctacac cctggacctt ggcgctgagc
      781 ctgggagcca gactgggctc cctcaggaca cagcccctga caccaggccg gtgcccatcc
      841 ccagtcacta ctctctcaga gagtgtgtcc gcaaccctca cttccggatc ttcgcctatc
      901 tgatggctgt catcctcagt gtcaccctgc tgctcatctt ctccatcttt tggactaagc
      961 agttcttttg gggcatgggg tgagcactct gtgttccagg acaaggaaca gagcctttct
     1021 cagtggttgc tggaccgagg actattgcga atcctttggt gttaccgttc ttgctcattt
     1081 tacagcccag gggtctgcta ggtctatctt ggagaacaga gacggcccaa caggaagaga
     1141 agagctaaag gaccagggac ctgatcataa actacggggt catggagggt agagaagcag
     1201 ttctatggct acatagcaag ttgtgccaaa agggctggac agcaccaccc agacatccaa
     1261 ctagttgaga gagctcggag cctctttcac tggagcagtg ttgagctgtt tgtgtgttgc
     1321 tgataattct ggaaagtgtt tcaattctgt gggcccacgt gcttgtctcc cctttcagcc
     1381 tttcctgatt cttgccacag tttccagtaa agctagcctg cattctttaa
//
