LOCUS       NM_025607               1436 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ring finger protein 181 (Rnf181), transcript variant
            1, mRNA.
ACCESSION   NM_025607
VERSION     NM_025607.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Li,Y., Xiang,Z.Y., Xiong,J., Hou,Z.W., Zhu,Z. and Bao,W.W.
  TITLE     RN181 regulates the biological behaviors of oral squamous cell
            carcinoma cells via mediating ERK/MAPK signaling pathway
  JOURNAL   Acta Histochem 123 (5), 151733 (2021)
   PUBMED   34052676
  REMARK    GeneRIF: RN181 regulates the biological behaviors of oral squamous
            cell carcinoma cells via mediating ERK/MAPK signaling pathway.
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY772494.1, AK166904.1 and AA154118.1.
            
            On Sep 13, 2016 this sequence version replaced NM_025607.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159788.1, AK166904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY772494.1         1-39
            40-1428             AK166904.1         1-1389
            1429-1436           AA154118.1         446-453
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..1436
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /note="ring finger protein 181"
                     /db_xref="GeneID:66510"
                     /db_xref="MGI:MGI:1913760"
     exon            1..192
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..565
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF181; RING-type E3 ubiquitin
                     transferase RNF181"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF181 isoform 1"
                     /protein_id="NP_079883.3"
                     /db_xref="CCDS:CCDS20240.1"
                     /db_xref="GeneID:66510"
                     /db_xref="MGI:MGI:1913760"
                     /translation="MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGGRSL
                     FNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVI
                     EMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLH
                     GAMYT"
     exon            193..320
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            321..430
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            431..505
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1436
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1434
                     /gene="Rnf181"
                     /gene_synonym="1700047F16Rik; 2500002L14Rik;
                     6230415N01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcgctggat tcggctctcc agcggcaacc taaagctgtg tcagacaagc ccggcagccc
       61 aggagccatg gcgtcttatt ttgatgagca cgactgcgag ccgttgaacc ctgagcgtga
      121 ggcccgcaac aatatgttgc tggaactcgc gagaagagtg cgcggggctt ggagctgggc
      181 cccgggcggc agatcactct ttaataggat ggactttgag gacctgggat tggtagattg
      241 ggaacaccac cttcccccac cagctgccaa ggctgtggtg gagagcctcc ctagaacagt
      301 catcagtagc gccaaggctg atctcaagtg ccccgtgtgc cttttggaat ttgaggcgga
      361 ggagactgtg attgagatgc cctgccatca tctcttccat tccaactgca ttctgccctg
      421 gctaagtaag acaaattcct gccctctgtg ccgccatgag ctgcccactg atgatgacag
      481 ctatgaagag cacaagaaag acaaggctcg caggcagcag cagcagcacc gcctggagaa
      541 cctccacgga gccatgtaca cgtgaggcag ctgccagggc tgagcgctca gcctctctga
      601 taccttccct ctgcactctg aatcattaaa ggtttcttta cccaccctgc agctgcacgg
      661 ctcaccagcc gaagcagggg ctccttccga atcctccacc ctgctgctag ccagaaagat
      721 gtcaaaggtg tcaaatgtcc gaaggtgcca ggctgcaatt ccctctgcca gcctctagac
      781 tctgggtggt ggggccctag aacaaccagg gcttgggtct gagtgttctt ttagaagtca
      841 aactgtgtca gagcctggcg ctttgtagct gtttaaaact gataaattaa cttgcaccac
      901 cccactccgg aaatctctag ttaaccttgg aacctttagt taaccgtgga atcctggggg
      961 tgttctttat ttccacatag aaaactttta acattgtaaa agttgctctc tgtatcccac
     1021 tcctgtaggc gccattatca aggaatcaaa ggtcaagcca gcccaagtag ggcaaggctg
     1081 tttagagact cttcaaaggg ggacagtcct tgtggaagtt ttgaaagtgg gtttcattca
     1141 ctatgtgacc ttggctgtct tggaacccac tatatagacc aggctcgcct tgtacttagg
     1201 acatccttct gctctgtctt cccagtgttg ggattactgg tatgtacaca cccttacgat
     1261 gtatctgaat ggcatctgtc actcttagtt tctggcaacc tcaagaatct ttcctggggg
     1321 aaaggacttc tgtccatccc tgcccactgg atcggaccct ccgtgattct ccagaacaca
     1381 ctgcagacgt gcaaattaga attcttttaa tagatataaa aaagtactaa aatact
//
