LOCUS       NM_001360890            2793 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus ring finger protein 180 (Rnf180), transcript variant
            2, mRNA.
ACCESSION   NM_001360890 XM_006517762
VERSION     NM_001360890.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Wang,K., Liu,F., Muchu,B., Deng,J., Peng,J., Xu,Y., Li,F. and
            Ouyang,M.
  TITLE     E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to
            promote colon inflammation and Th17/Treg imbalance in ulcerative
            colitis mice
  JOURNAL   Arch Pharm Res 47 (7), 645-658 (2024)
   PUBMED   39060657
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5
            axis to promote colon inflammation and Th17/Treg imbalance in
            ulcerative colitis mice.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Zhao,Q., Liu,N., Xu,T. and Song,K.
  TITLE     RING finger gene 180 inhibits osteosarcoma progression through
            regulating chromobox homolog 4 ubiquitination
  JOURNAL   Cell Cycle 22 (10), 1246-1258 (2023)
   PUBMED   37095741
  REMARK    GeneRIF: RING finger gene 180 inhibits osteosarcoma progression
            through regulating chromobox homolog 4 ubiquitination.
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Kabayama,M., Sakoori,K., Yamada,K., Ornthanalai,V.G., Ota,M.,
            Morimura,N., Katayama,K., Murphy,N.P. and Aruga,J.
  TITLE     Rines E3 ubiquitin ligase regulates MAO-A levels and emotional
            responses
  JOURNAL   J Neurosci 33 (32), 12940-12953 (2013)
   PUBMED   23926250
  REMARK    GeneRIF: Rines is a critical regulator of the monoaminergic system
            and emotional behavior and identify a promising candidate drug
            target for treating diseases associated with emotion.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Ogawa,M., Mizugishi,K., Ishiguro,A., Koyabu,Y., Imai,Y.,
            Takahashi,R., Mikoshiba,K. and Aruga,J.
  TITLE     Rines/RNF180, a novel RING finger gene-encoded product, is a
            membrane-bound ubiquitin ligase
  JOURNAL   Genes Cells 13 (4), 397-409 (2008)
   PUBMED   18363970
  REMARK    GeneRIF: The involvement of RNF180 in the ubiquitin-proteasome
            pathway was further supported by its binding to the UbcH6
            ubiquitin-conjugating enzyme and by its trans-ubiquitination
            enhancing activities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC075700.1 and AC154203.2.
            
            On Feb 16, 2018 this sequence version replaced XM_006517762.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046775.1, AK157911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               BC075700.1         1-624
            625-625             AC154203.2         24408-24408
            626-2046            BC075700.1         626-2046
            2047-2047           AC154203.2         143489-143489
            2048-2049           BC075700.1         2048-2049
            2050-2793           AC154203.2         143492-144235
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.92 cM"
     gene            1..2793
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /note="ring finger protein 180"
                     /db_xref="GeneID:71816"
                     /db_xref="MGI:MGI:1919066"
     exon            1..223
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1999
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF180; RING-type E3 ubiquitin
                     transferase RNF180"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF180 isoform 2"
                     /protein_id="NP_001347819.1"
                     /db_xref="CCDS:CCDS88517.1"
                     /db_xref="GeneID:71816"
                     /db_xref="MGI:MGI:1919066"
                     /translation="MKRSEESTSTQSPEEQTGTLHCWRCRKCIASSGCFMTPLETQVV
                     EDRHESVDAQNTCHLWHMNVDALPEWISCLLQKAQWTVGKLNCPFCGARLGGFNFVST
                     PKCSCGQLAAVHLCKSRTDHQAAQGGRLMRPALKHLPHPGVPSGCDKETLLTGGGSKT
                     RNHWLLSMARNSNGLGRLTEALCLEVRATYFEMKNEKLLFKASDPKCQPFVPQPDTGR
                     CPSRASHRKSHSLDLNISEKLILLPTLYEIHRKPTAYPRLNETGPIDLSGLALPCSNS
                     SCSFQSPPSFDPNMLLHRLSVAPHETQAQRGRECQCGLEASSVYSDHANANSLPFLMD
                     LPSAGRSVLEASDQEEHLSQLDFLRSASFPLGTINHRLNNRERSKLRTLRRQQRRERW
                     LQKQGKYSGVGLLDHMTVSNEMSTDEETEFPEEKDSYMCAVCLDVYFNPYMCYPCHHI
                     FCEPCLRTLAKDNPASTPCPLCRTIISRVFLQTELNNATKTFFTKEYLKIKQSFQKSS
                     SAKWPLPSCRKGFHLFGGFHRRAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMVI
                     IYIYSVNWVIGFVVFCFLCYFFFPF"
     exon            224..358
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            359..454
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1411
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1447
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1673
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1799
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2793
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggcggg tctacgcggg gtcaggctcg gcgccgccca cgcgcggctc gtgggagacg
       61 cggagcggga gcgcaggcgg atgttgggcg ccgaatccca ggccaagggg tcgggctgcg
      121 ggagcatctc cagcgctttc cgcggggttt gtctcctgcc gcttcccgtc tctggagccg
      181 gcctcgccgt gagtgctggg agccgggcgg ggcgcggacg cagatgaaaa gaagcgaaga
      241 gtcgacaagt acgcagagcc ccgaggagca aacaggcacc cttcattgtt ggagatgtag
      301 aaaatgcatt gcaagttctg gttgcttcat gactcctctt gagactcaag tggttgagga
      361 cagacatgaa tcagttgatg ctcaaaacac ctgtcacctg tggcacatga atgtagacgc
      421 ccttccggag tggatcagct gcttgctgca gaaggcccag tggacagttg ggaaactgaa
      481 ttgtcctttc tgtggggccc gattaggggg ctttaatttt gtcagcactc caaaatgttc
      541 ctgtggccag cttgcagctg tacatctctg caagagccgg actgatcacc aagcagcaca
      601 gggagggaga ctaatgagac cagcgctgaa acatttgcca catcccggag tcccgtcagg
      661 ttgtgataag gaaactctgc tgacaggtgg tggctccaaa accagaaacc actggctttt
      721 aagcatggcc cgaaacagta acggcctcgg aagacttaca gaagcactct gcctggaggt
      781 gcgagcgacg tattttgaga tgaagaatga aaaactgctc ttcaaagcct cggacccaaa
      841 atgccagcct tttgttcctc agcctgacac cggcaggtgt ccttcaagag cgtctcacag
      901 aaagtcacac agtttggacc tgaacatcag tgagaagctg attttattac ccactttata
      961 tgaaatacat cgtaagccta ctgcctatcc caggctaaat gaaacggggc ccattgacct
     1021 ttcaggcttg gctttaccgt gtagtaacag tagctgctcc tttcaaagcc cacctagttt
     1081 tgatccgaat atgctgctgc acagactttc agtggctccc catgagaccc aggcacaaag
     1141 gggaagagaa tgccagtgcg gcctagaagc ttcttcagtc tactcggatc acgctaacgc
     1201 taacagcctg ccattcctga tggatctgcc ctcagcaggg aggagcgtgc tggaggcctc
     1261 ggaccaagag gagcacctct cccagctgga cttcctgcgc tctgccagct tccccttggg
     1321 caccattaac cacaggctga acaacaggga gagaagcaag ttgaggactc tgcgaaggca
     1381 gcagaggcgc gaacgatggc tacagaagca gggtaaatac tcaggagtgg gcttgctgga
     1441 tcacatgacc gtgagtaatg agatgagtac agatgaggaa acggagttcc cagaggagaa
     1501 ggacagctac atgtgtgcag tgtgcctgga tgtgtacttc aacccctaca tgtgctaccc
     1561 ctgccaccac atcttctgcg agccctgcct acgaactctg gccaaagaca accccgcaag
     1621 cactccctgc ccactgtgcc ggacaattat ttctagagtc tttctccaga cagaactgaa
     1681 caatgccaca aagacattct ttactaaaga atatttgaaa atcaagcaaa gctttcagaa
     1741 atccagctct gcgaagtggc ccttgccgag ctgcaggaaa ggattccatc tcttcggagg
     1801 attccacagg cgcgccgccc cagtgacacg gaggcagttc ccgcacggcg ctcacaggat
     1861 ggactacctg cacttcgagg acgacagccg tggatggtgg tttgacatgg atatggtgat
     1921 catctatatt tattcagtga actgggtcat tggattcgtt gttttctgct ttctttgcta
     1981 ttttttcttt ccgttttagg aatcgttgta ctctgctcta attgaacaat cataaatgta
     2041 aacaacaatg gcttgaacat tttcaaagtg tgcttcgaag tttttataat attgcattat
     2101 aaaaattgtt agtgtttata gaaatcctga gggtaatgga tttatttatt aatttctttc
     2161 atgtaacaac ctaaacttta ttcatgagct ggtctccagc cattagaaac agtgcactac
     2221 taattcatac tttttacttt aggacttggg gctctgattt tacaatgtca tttttatact
     2281 tactatgatt gtaaagactg aggttttacc tccatttaaa aatagtagaa aaaatgaata
     2341 atctggatgg ataccatcat tattactaag atgtttagtc aagcactatg tattcttagg
     2401 caaatgatgt acgttaaaga tagaccatat tctctgggaa ctaatcaagc agggtatata
     2461 ttgcattttg atttctgaat atctctactt ctgtctccta ttaccaaaaa tgtgactatc
     2521 cttttgtaaa gacttcatag ctttggtgca acatttttaa ctattgtaag aacaaaatat
     2581 tacatgcagt aagactaaca cccaagagct atgtttgaga gccatattaa caccttccaa
     2641 cttcacaatg aatcacttga gaaataacaa atctgacttt tagtaacctt actgatcagt
     2701 gcatgtccaa actgtaatta acctggtgat tcatttaact agacagttgt caactatatt
     2761 gtcaatgtgc aataaagagt ggcttttaca ttt
//
