LOCUS       NP_001347819             591 aa            linear   ROD 27-APR-2025
DEFINITION  E3 ubiquitin-protein ligase RNF180 isoform 2 [Mus musculus].
ACCESSION   NP_001347819 XP_006517825
VERSION     NP_001347819.1
DBSOURCE    REFSEQ: accession NM_001360890.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Wang,K., Liu,F., Muchu,B., Deng,J., Peng,J., Xu,Y., Li,F. and
            Ouyang,M.
  TITLE     E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to
            promote colon inflammation and Th17/Treg imbalance in ulcerative
            colitis mice
  JOURNAL   Arch Pharm Res 47 (7), 645-658 (2024)
   PUBMED   39060657
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5
            axis to promote colon inflammation and Th17/Treg imbalance in
            ulcerative colitis mice.
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Zhao,Q., Liu,N., Xu,T. and Song,K.
  TITLE     RING finger gene 180 inhibits osteosarcoma progression through
            regulating chromobox homolog 4 ubiquitination
  JOURNAL   Cell Cycle 22 (10), 1246-1258 (2023)
   PUBMED   37095741
  REMARK    GeneRIF: RING finger gene 180 inhibits osteosarcoma progression
            through regulating chromobox homolog 4 ubiquitination.
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Kabayama,M., Sakoori,K., Yamada,K., Ornthanalai,V.G., Ota,M.,
            Morimura,N., Katayama,K., Murphy,N.P. and Aruga,J.
  TITLE     Rines E3 ubiquitin ligase regulates MAO-A levels and emotional
            responses
  JOURNAL   J Neurosci 33 (32), 12940-12953 (2013)
   PUBMED   23926250
  REMARK    GeneRIF: Rines is a critical regulator of the monoaminergic system
            and emotional behavior and identify a promising candidate drug
            target for treating diseases associated with emotion.
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 591)
  AUTHORS   Ogawa,M., Mizugishi,K., Ishiguro,A., Koyabu,Y., Imai,Y.,
            Takahashi,R., Mikoshiba,K. and Aruga,J.
  TITLE     Rines/RNF180, a novel RING finger gene-encoded product, is a
            membrane-bound ubiquitin ligase
  JOURNAL   Genes Cells 13 (4), 397-409 (2008)
   PUBMED   18363970
  REMARK    GeneRIF: The involvement of RNF180 in the ubiquitin-proteasome
            pathway was further supported by its binding to the UbcH6
            ubiquitin-conjugating enzyme and by its trans-ubiquitination
            enhancing activities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC075700.1 and AC154203.2.
            
            On Feb 16, 2018 this sequence version replaced XP_006517825.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046775.1, AK157911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.92 cM"
     Protein         1..591
                     /product="E3 ubiquitin-protein ligase RNF180 isoform 2"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase RNF180; RING-type E3
                     ubiquitin transferase RNF180"
                     /calculated_mol_wt=67112
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U827.2)"
     Region          281..488
                     /region_name="Interaction with ZIC2.
                     /evidence=ECO:0000269|PubMed:18363970"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U827.2)"
     Region          427..485
                     /region_name="RING-HC_RNF180"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 180 (RNF180) and similar proteins; cd16554"
                     /db_xref="CDD:438216"
     Region          490..590
                     /region_name="RNF180_C"
                     /note="E3 ubiquitin-protein ligase RNF180 C-terminus;
                     pfam19332"
                     /db_xref="CDD:437164"
     Site            564..584
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U827.2)"
     CDS             1..591
                     /gene="Rnf180"
                     /gene_synonym="3110001E11Rik; Rines"
                     /coded_by="NM_001360890.1:224..1999"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS88517.1"
                     /db_xref="GeneID:71816"
                     /db_xref="MGI:MGI:1919066"
ORIGIN      
        1 mkrseestst qspeeqtgtl hcwrcrkcia ssgcfmtple tqvvedrhes vdaqntchlw
       61 hmnvdalpew iscllqkaqw tvgklncpfc garlggfnfv stpkcscgql aavhlcksrt
      121 dhqaaqggrl mrpalkhlph pgvpsgcdke tlltgggskt rnhwllsmar nsnglgrlte
      181 alclevraty femknekllf kasdpkcqpf vpqpdtgrcp srashrkshs ldlnisekli
      241 llptlyeihr kptayprlne tgpidlsgla lpcsnsscsf qsppsfdpnm llhrlsvaph
      301 etqaqrgrec qcgleassvy sdhananslp flmdlpsagr svleasdqee hlsqldflrs
      361 asfplgtinh rlnnrerskl rtlrrqqrre rwlqkqgkys gvglldhmtv snemstdeet
      421 efpeekdsym cavcldvyfn pymcypchhi fcepclrtla kdnpastpcp lcrtiisrvf
      481 lqtelnnatk tfftkeylki kqsfqksssa kwplpscrkg fhlfggfhrr aapvtrrqfp
      541 hgahrmdylh feddsrgwwf dmdmviiyiy svnwvigfvv fcflcyfffp f
//
