LOCUS       NM_029965               3933 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus ring finger protein 170 (Rnf170), transcript variant
            1, mRNA.
ACCESSION   NM_029965
VERSION     NM_029965.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Song,X., Liu,S., Wang,W., Ma,Z., Cao,X. and Jiang,M.
  TITLE     E3 ubiquitin ligase RNF170 inhibits innate immune responses by
            targeting and degrading TLR3 in murine cells
  JOURNAL   Cell Mol Immunol 17 (8), 865-874 (2020)
   PUBMED   31076723
  REMARK    GeneRIF: E3 ubiquitin ligase RNF170 inhibits innate immune
            responses by targeting and degrading TLR3 in murine cells.
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Kim,Y., Kim,S.H., Kim,K.H., Chae,S., Kim,C., Kim,J., Shin,H.S.,
            Lee,M.S. and Kim,D.
  TITLE     Age-dependent gait abnormalities in mice lacking the Rnf170 gene
            linked to human autosomal-dominant sensory ataxia
  JOURNAL   Hum Mol Genet 24 (25), 7196-7206 (2015)
   PUBMED   26433933
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Lu,J.P., Wang,Y., Sliter,D.A., Pearce,M.M. and Wojcikiewicz,R.J.
  TITLE     RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase,
            mediates inositol 1,4,5-trisphosphate receptor ubiquitination and
            degradation
  JOURNAL   J Biol Chem 286 (27), 24426-24433 (2011)
   PUBMED   21610068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093366.9.
            
            On May 14, 2019 this sequence version replaced NM_029965.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162554.1, BC114210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC093366.9         44454-44686         c
            234-357             AC093366.9         43491-43614         c
            358-498             AC093366.9         40067-40207         c
            499-574             AC093366.9         38075-38150         c
            575-683             AC093366.9         34899-35007         c
            684-757             AC093366.9         28352-28425         c
            758-868             AC093366.9         24964-25074         c
            869-3933            AC093366.9         20179-23243         c
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.38 cM"
     gene            1..3933
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /note="ring finger protein 170"
                     /db_xref="GeneID:77733"
                     /db_xref="MGI:MGI:1924983"
     exon            1..233
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            234..357
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            358..498
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1138
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF170; RING-type E3 ubiquitin
                     transferase RNF170"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF170 isoform 1"
                     /protein_id="NP_084241.2"
                     /db_xref="CCDS:CCDS22207.1"
                     /db_xref="GeneID:77733"
                     /db_xref="MGI:MGI:1924983"
                     /translation="MARYYSEGQSLQQDDSFIEGVSDQVLVAVVVSLALTATLLYALL
                     RNVQQNIHPENQELVRVLREQFQTEQDVPAPARQQFYTEMYCPICLHQASFPVETNCG
                     HLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVNDYNR
                     RFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDF
                     VPEALFGILGFLDDFFVIFLLLIYISIMYREVITQRLTR"
     exon            499..574
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..683
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..757
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..868
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            869..3933
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2813
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /note="major polyA site"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3933
                     /gene="Rnf170"
                     /gene_synonym="6720407G21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtccaaggc ccgcgggcgc gcgccccggc cgggccctgc ggtggcggcc ggtctgtgtg
       61 tctctccagt ccgctcaccc tcgccggggc tccgcactgc gcgtgcgctg acgccggcgc
      121 tctggcttaa gaagccgcct gtagtttgca cgggaggagt agctaggtag tccccggaaa
      181 tgagctctat gccgacccgc cgactggccc ggtagttcct cggccgcgac gagcttaggg
      241 cgtctaagaa taatgctata ataaacagtc gaccttaatg caaagatatt ggcgtttcca
      301 agacaacaag atacaagata tatgctttgg agtcctagga gaatcttgga ttcaaagacc
      361 tgtaatggcc aggtactaca gtgaaggtca gagtttgcag caggatgact catttataga
      421 aggagtgagc gaccaagtcc ttgtggctgt ggtggtcagc ttggcgttga ccgctactct
      481 cctgtatgca cttctcagaa atgtacagca gaacatccat ccagaaaacc aggagctagt
      541 cagagtgctt cgagaacaat tccaaacaga acaggatgtc cctgctcctg cccgacagca
      601 gttctacact gaaatgtact gtccaatctg cttacatcaa gcctcctttc ctgttgaaac
      661 aaactgtgga catctctttt gtggttcctg cataattgca tactggcgat acgggtcctg
      721 gcttggtgca atcagttgtc ctatctgtag acaaacggta actctcctcc taacagtatt
      781 tggtgaagat gatcaatctc aggatgttat aagattgcgt caagatgtta atgattataa
      841 ccggagattc tcagggcagc ctagatctat tatggaaagg atcatggacc tccccacctt
      901 gctgagacat gcgttcaggg aagtgttctc agttgggggc ctcttctgga tgttccgcat
      961 taggataatg ctttgtttga tgggagcttt tttctattta atatcacctc tagattttgt
     1021 acctgaagcc ttgtttggaa ttctgggctt tctagatgat ttctttgtta tctttttgtt
     1081 gcttatttac atctccatta tgtatcgaga agtgataacc caaagactaa ctaggtgaaa
     1141 aaaaattagt ttactagaat atccgagctt atatataaaa ttaaacaaaa ggatccatgg
     1201 cagtatcatt cacccaaata ttattttaca cgcttaaaac atttggttat catttgacaa
     1261 atgcctaaga atatacaact ggaacattta catactacag cttctaatgt taacatcaga
     1321 tgtatagtga tctacaggtt tatctcaatt ctgtgttgtc tgtaaaaaag tatgaagcca
     1381 attgaaaagg gatactttgt tgttttcttc tgcagattat ttacttagat atgcagttca
     1441 atattggacg cattacaatt catcatcctc agtgggtact catacaagaa tagagaactt
     1501 tgaaacttgc ctaaatattt ttgttaaagt aaaatatttt atgatagtag ggaaaggtca
     1561 gagtctcggt gtgtgctaag ctctatggac ttggagcaac tctgcttttt catttttgta
     1621 taattctttg tgatcaactg aaaatgaaag aaacttgaac ttcctgattt gacctcattt
     1681 tcagtctcta gaccacttta atcaatagga ggattaacaa gtgaaaacta cgcatctcct
     1741 ggaggcactt ttgatattca gttatgacat tcaactaaga gtttggactt tttatagaaa
     1801 cacatacaaa agtaacttgt agccagctgt ggcagcttta cacttgtact ttctgcattc
     1861 aagaagctga ggtagaagat tgctgcaagt tcagggtctg cctagactat gtaatgagtt
     1921 cccagaagct tgagctaaag agtgagatcc tacccaaacc aaaagcaggg cagtggggaa
     1981 aggtgcttgc tcccaagcct gacaacctgg gtctcacatc atggaagtac agaacggatt
     2041 ctgtgagctg tcctctgacc ttcacatgag tgtacacaca cacacacaca cacaccccac
     2101 aatcacacac cacaaacaca aagtaaataa aatgcaatgg aaaggaaaat agagtagctt
     2161 gtaaagggaa atgattttgt cccaggaaca taagtaacct tgggaacaag tagtaatggg
     2221 tacgattttg aggaaacagg ctgttcattt ctattggcat gggtcagggc ctttaggaag
     2281 gtactaagga cagtatttag attttacaaa taatgagtta acccttgcag caaaatgaag
     2341 atatttgatt agttgtctat tgtcctgaaa atgtaaaact attatcttgt agatggcatt
     2401 atttggctca gattcatcgt gccttgggca gaatgaggaa atgtgtatta gacgcctaac
     2461 tactgaggtt catactgatt tggttgtctt tgatggctgt gacatgggga tgtgaggtct
     2521 gtagttctgt ttgaatggac tgagtactgt aactgagccg ctaactggag agcagctgga
     2581 tggggtgtga ggtgatgccc aggccctgcc ttctcattgc tagtaccatt gacttcttag
     2641 cctcagtgtg tgtgtttagg gacagaaagc taaaatctgt cacattccaa aaaaaaaaag
     2701 aaacaatcag attagctgcc aagtaatgag attctgaacg aaacgtcaat ttctttccta
     2761 atctaggctt aaaatgaagg tgttgtctgc cattaaaaac aacataaaac ccagtcctta
     2821 tatagagaac acgatcaatg caatctctca taatttttct tttatcctta gaaaatgttg
     2881 taaggaagga agagcagcat cagcttcctg ttgcagaggt gaaaccttca tcctatggat
     2941 gaaagacttt tgttttccta acataatgga actagtgata tttaggtagg catgaaagct
     3001 agtctgagga gaagcgggag gagtggaatt ctctggagtc aggttttcat aacacagttt
     3061 tccttccctg gaacagtttc ggtgcttcta agctaaagct ccaggaagaa cactcgtcac
     3121 agcctttatc aatctcgagg gtatacttgc aaatgaagtt aagagtggca tgcatcatag
     3181 aaaactgtgg ccactcatca ccaacttggg aagctattga gtaggggagc tcgttgccag
     3241 cctgggaaaa cattttccac cttttaaaaa tgcaatgtgg actatagcta tggtttactg
     3301 aaatgatttt attttctgtg catgtgttct gctgcaaatg tcatccttct gtaatatttg
     3361 gacttactct aatatctgag aagaggtgta ctgtacaaaa ttttgtaaca tacaaaacca
     3421 ctgtatggct aaagtcttac tgagccaaaa agggaacaca gcggtatctc cgaattttac
     3481 acctactgtt ccctcatctt tacggatcat tagtgatgaa tgcagcagca atttgagaaa
     3541 gtcttcaaag caagtagagt ctatcagtgc tttaaacatc atagaaagac tttgtattcc
     3601 gaggtcatat aaatcaaagc aacaagcttt ttaaacaaaa cagagtaact gtcacaaaag
     3661 caatggtaca agcccaggaa caaacaatac tttgagtggc tctgtgggga atgagaaggg
     3721 aactgttcca ttaaccactc actagagtag ggtttctcca gctccattct cagttgtgaa
     3781 gggcagcaga gttcctgggc cccatggctg tacagacgcc tacctcacag agtctgtgca
     3841 caggagagag cggaggcgtc tcacaagctt tgtgatctgg agagtttgtt cagcatttat
     3901 tctttggaat aaaaatagtt tatctaaaag ttt
//
