LOCUS       NM_175388               7157 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus ring finger protein 169 (Rnf169), mRNA.
ACCESSION   NM_175388
VERSION     NM_175388.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7157)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7157)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7157)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 7157)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 7157)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC113298.14.
            
            On Aug 1, 2009 this sequence version replaced NM_175388.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.3458110.1,
                                           SRR11927938.4051104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               AC113298.14        41992-42478
            488-561             AC113298.14        66910-66983
            562-708             AC113298.14        79345-79491
            709-827             AC113298.14        87170-87288
            828-927             AC113298.14        95258-95357
            928-7157            AC113298.14        95967-102196
FEATURES             Location/Qualifiers
     source          1..7157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.22 cM"
     gene            1..7157
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /note="ring finger protein 169"
                     /db_xref="GeneID:108937"
                     /db_xref="MGI:MGI:1920257"
     exon            1..487
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2109
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF169"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF169"
                     /protein_id="NP_780597.2"
                     /db_xref="CCDS:CCDS52322.1"
                     /db_xref="GeneID:108937"
                     /db_xref="MGI:MGI:1920257"
                     /translation="MAAAGPSTRASSAAAAAALSRRGRRGRCDEMAAAKAGAPGPASS
                     PALLVLRSAPRPEESGCTGCLETPGEVAALPCSHSRCRGCASRAAGPGCRRCRPRGSG
                     WARRRARDDGQAAAELMGERARRGQPEPCRPRRDGGAAASGPRPEPEPLAEPEFIFRT
                     PIKLSKPGELSEEYGCLRKLRGEKLQEEKDCDDQIHKLLQEDSEMGKRKADEQKKRDE
                     AVVLKTSLEQCPARLSDSENEEPSRGQMMQTHRSAFVSKNSSCSLAFLAGKLNTKVQR
                     SQSCSDTVQDRVRSRLRTAPPNRAKITTITPGSTPIIGVLLSTQNNRCLSAPDLTIEK
                     RLPFGSLSSLASLHKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPL
                     IIKSTPRNLTRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEAGEEF
                     PGSDTIHSSKERPSLAFNTRLSRVQVLSECAGPTSTALECFPSVNQTKVEQDCVRKRS
                     REFSLETCHSSEHGGASSGPSLEREQCEESGSTVDATLVKTCISTVMKTAAVNSLLPK
                     NDVLGGVLKTKQQLKTLNHFDLGNGILVNSLGEEPIPSLRRGRKRRCKTKHLEQNGVK
                     KLRPPSSDMDLAPKDPGLLEVGRKLQQEEEDQQLALQSHRMFDSERRTMSRRKGSVDQ
                     YLLRSSSLAGAK"
     exon            488..561
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..708
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..827
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..927
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..7157
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7133..7138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      7157
                     /gene="Rnf169"
                     /gene_synonym="2900057K09Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctctcccttc aaacgggaaa caagatggcg gcggcaggtc cgagcactcg ggcttcttcc
       61 gctgcggccg cggcagctct gagtcggcgg ggccggaggg gccgctgtga cgagatggcg
      121 gcagcgaaag ccggggctcc gggcccggcc tccagccccg cgttgttagt gttgcggtca
      181 gcgccacggc cggaggagtc gggctgcacc gggtgcctgg agaccccggg ggaagtggcg
      241 gccctgccgt gcagccactc gcggtgccga ggctgcgcct cgcgcgcggc gggcccgggc
      301 tgccgtcgct gccgtccccg cggttcgggc tgggcccgcc gtcgggcgcg cgacgacggc
      361 caggccgccg cggagctgat gggcgagcgc gcccgtcgtg gacagccaga accctgccgc
      421 ccgcgccggg acgggggcgc ggctgcctcg gggcccaggc cggagccgga gccgctcgcg
      481 gagccagagt ttatattcag aacgccaatc aagttaagca agccgggaga actcagtgag
      541 gagtatggat gcctgagaaa gctgagaggg gagaagttac aggaagaaaa agattgtgat
      601 gatcagatac acaagctact gcaggaggat tccgaaatgg ggaagaggaa agctgatgag
      661 cagaaaaaaa gggatgaagc agtggtgctg aaaacaagtc tggagcagtg tcctgcgcgt
      721 ctctcggatt cagagaatga agagccttct cggggccaga tgatgcagac ccatcgctcc
      781 gcctttgttt ctaagaacag ctcctgctcc ttagcgttcc tggcagggaa gttaaacacc
      841 aaggtgcaga gaagtcagag ctgcagcgac acagttcagg acagagtgag gagcaggctc
      901 agaacagctc cgcccaacag agccaagatc acaactataa ctccaggctc cacccccatt
      961 attggtgttc tcttgtctac tcaaaacaac cgctgcctct ctgcccctga cttaaccatc
     1021 gaaaagcgcc tgcccttcgg ctccctttca tccttggctt ccttgcataa gccagagcgc
     1081 tccatcagcc ctgaaagcaa tgacagcatc tctgaagagc taaaccactt caagcccatc
     1141 gtctgctcgc catgcacccc tcccaagaga ctccctgatg gccgggtgct cagtcctctc
     1201 atcatcaagt caacccctcg caacctgacc agaagcctgc agaagcagac ttcatatgag
     1261 gccagccctc gcatcctcaa gaagtgggag cagatcttcc aggagcggca gatcaagaag
     1321 accctttcca aagccactct cacctccctg gctcctgaag caggggaaga gtttccaggt
     1381 tctgacacaa tccattccag caaggagagg ccgtctctgg cctttaatac aaggctgtcc
     1441 agggtccagg tgctctccga gtgtgctggg cccacctcca ctgcccttga gtgcttcccc
     1501 tctgttaacc agaccaaagt agaacaggac tgtgttagaa aacggagccg tgagttctca
     1561 ctggaaacct gccattcctc ggagcacgga ggagcctcca gtgggccttc tctggaacgg
     1621 gagcagtgtg aggagtcagg gtccaccgtg gacgccacat tagtcaaaac ttgcataagc
     1681 acagtcatga agactgcagc ggttaattca ctgctaccca aaaatgatgt tttgggtggg
     1741 gtcctcaaaa caaaacaaca actgaagaca ctcaatcatt ttgatctggg taatggcatt
     1801 ctggtcaaca gcctaggaga ggagccgatt ccttccctgc gcagaggccg gaaaaggcgc
     1861 tgtaagacca agcacttgga acaaaacggt gttaaaaaac tgcgaccacc gagcagtgac
     1921 atggatctgg cccccaagga cccagggctg cttgaggtgg ggcggaaatt gcagcaggag
     1981 gaagaggacc agcagctggc tctgcagtca catcgcatgt ttgacagtga gaggcggact
     2041 atgagccggc gaaaaggaag cgtagatcag tatctcttga ggtccagcag cttggctggg
     2101 gccaagtagc acttgatgta tagaataatg ttacctgctt cagaggtcct tgacctgtca
     2161 tttatccaaa agagctagct gaatgttctc attttgagtt tctctcaatg gcaaaccact
     2221 gtctgctatg gttctgagag gatccagagc cttggtattc aaaagccaag tgtcggcatc
     2281 tttggctttc taggaccagg gccagtactc ctcactcttt gagtgagcca actctgaagg
     2341 cttctgggcc caaatctggc agtacccact tggagtgagc ttgggagtgg ccctcattca
     2401 tgaatgtgag ggccagtgtt agagatggta gggagatggg atggatacct tctcacactc
     2461 ataaagcccc tggcttcttc ccacagagtg gtgtttaagt tagccttgca gataaacatg
     2521 gattcttttc agagacaagc agtgccagta ctttggaaga gccaagataa atagatgctc
     2581 acattcatct tccctcccct tcgctacatg ttatttctac atacccaagt cagttgagct
     2641 cagaactttt acctctacag aaattatttg cattctttgt ctaaactatg acatttgatt
     2701 gaagcagtgt ggctgacgct ggtcttcctg cgacctgatt gctaagtgct gtcagctgga
     2761 tgtccaggtt ctcttagctg ccaggtggcc tagcccagac tgaccactgg ctctcaggcc
     2821 acaagtccca tggattctct acaatcacag ggtgtccaaa ggaagtacag cctagggcac
     2881 gccagggcca tgactgaaca tgacagtgca aagcccacct agaagcactt caccttgccg
     2941 ggatggaaag caggactgga gtgacttccc tgcctgctta ctgctcctct tctcccggga
     3001 gccctcgcct ggggccgaac tgggaggttt ccttactact tcccacatgg caatggcaaa
     3061 acttccctaa agtcaggcaa aggacaaagc tgaaactcca tactgtggaa acaaggtatc
     3121 tagctggatg cagctggtca attcagtccc atggaccttt ggggtttatt tttcttagca
     3181 gcttgacacc gtgtgtcttt tgcatccctg gtggtgcttg gtgcttctgc ccttctgggc
     3241 ttattgagaa taggattatg atacggtttt agggactctc aggtgggctg gcctttcctg
     3301 tgtgtgtgag ctgttacata gtcatgtgac tgtcattttc acaaaccttc cagagctttt
     3361 acacttttgt tccctttaaa aggtcccagc aagatactcc atagtcatct gatcagaatg
     3421 cttctgaaac gttcgaagct agaagtagct ggagcttaga ctcacttttc tgtgccaagg
     3481 gagatgtcag tctctgggaa ttctagaaga gagaacttca gatttggagt tagacagaaa
     3541 ctggttgaag cttctgaagg tgggaagaag gatgtggact cccaagcact atgtcccttg
     3601 aagcagacag aacttaattt ctctgcagct catagttgac tgttcgcagg aatgtttgat
     3661 gtgtaaggtg gccattagca aggtggcttc agaggctgct ctggcaggaa ctgtgtgagt
     3721 ctggagtgtg tgtgtgtttt taaaacatga aatagtctca ttactttata ctcacacggc
     3781 tttactcccc atcctaggca acttagggct tttcagggct gcgggaaggc aggccagcac
     3841 cccagggagg agagctggcc ccggctgcgg acaccggaaa atcccattag agaaaactta
     3901 gaaatgtcta ccaagtcatg tatttccttt atgagcttag taattattat tggaaggcta
     3961 ggcttactgg gtagctttaa agacacttat ttttccactt gccacccttt tatatgtcac
     4021 tagtgcttag aaaaacactt tcagttggaa ttaatttttg gttttggtaa gaagataaaa
     4081 tattttaata gatgaaagat atatatttta aatattcccc tgcccctagt gactaccttg
     4141 agtagagtgc gcagcagtgg caacaagtgt gggctcaggt gctgttgctg ctgagtgagt
     4201 gttgcagaca ctgggctgtc cctctgtacc ccaccccacc ccccagggag accccaagga
     4261 ctgtagacag tgttctttcc cataattcct gctgagagca gtggcccttg aaatagaggc
     4321 aaaacagttt atgttgggaa ggcgtggctt attctttagt ttgcttaccc ttgaaaatgg
     4381 aaaaactact aacgtatctg catacaagat gctctcaaac tcagtgaaac ctgaacactt
     4441 catttctgag aattccccat cttggtgttt gactgaagtc cattgcagct acagttgctg
     4501 atggggatcc cataggagaa aatggaccag ggaagagaac gcttgggagg ctggtgagct
     4561 tgagtggaag acatcctttt acagctagaa ctagctgcag tcactgcagt cctagcgacc
     4621 tgcacactgc ccacattctg ctgtgctcct tagtgtgtgt gcaaagagga aactaggaga
     4681 gacaggaggc taagtctttc tgatggggaa tccaagagat gtgctatgcc tcaagagggc
     4741 ttggtagccc ttctctagag gggaaccctt atacctgttt gaagaagtca tctaaatcat
     4801 ctgggcctga tgtgctggta tcaagtcggg aagtactctg ccagcaccca gcttctggcc
     4861 tcgggccctt agtactctgc cagcacccag cctctggcct cgggccctta gttgcctctt
     4921 taaataaaag aaaagaaaga aagaaaaaag tctgcctgag acttgactag aaatccttcc
     4981 taactgacct catttattta aaaaaaaatt ctttgattat ggaagaagta cttttttttt
     5041 ttaagtcttt ttttttttta aggtaaaatg cccctcaaaa attaaagcta tttagttatt
     5101 gtctgattac aaactggcca ctgactaaaa tgggaggcta gtgagggagg ctgtgttcat
     5161 tcagaaggca cttctgagct cttagacctg ccaccctgtg ctgggccatg tgtagtgcag
     5221 tgtgcatgga tgcgcttgac ccaagagtat atccatgaac tttgaaaggc cgttccatcc
     5281 ctggcaatgc tctacaatgt tcctgttcag gagatctggc tcagcagatc actcacattt
     5341 tctatacctt atcagtattt ctgagtttga ttaactctgc tttttcctaa gtaattttcc
     5401 caaggaagaa tggattttcc ctgcagtgat tatagactag tctcccctgt tcaaaggctg
     5461 catttagctc aaatcccaag aaaggagtca agtctggatc gccctgacaa agcctgtcct
     5521 tcacttgagt gacctcctag tgcatcccaa gctgacagtg gcagtgactg ggctttcttt
     5581 ctagcttgtc attgaagcag agagccagta gggatagcta gctagcccat cattgggtta
     5641 aatttggacc agcatcaacc cctaccttta aatgaagacc cacagctctg gttcccactg
     5701 tagtgctcca gggcccaaat aattgtgaaa gttatgtggt ttgtgaaggg gacatccaaa
     5761 tgacaggttt tatgatgttt gtttcttctg ttttcttcag ttaagaaata cctgtatctc
     5821 ctgaatacac ccacactata taaagtactt agtagggggt accccgtagt gtgatttaag
     5881 tcattggtga gattttggtt ggagtagctg tggttttaat taacagcctt ggcggtttct
     5941 ttcactcaaa ctccataggg tcctaaccct tccttagcca gccctttcct caccagccgt
     6001 acagtcctct ttagactgag cccttaggat ggatggagct ggagttctta gaacgcagca
     6061 ggatttgagg atgaggctgc tgcacagaat tttttttttt tttggtgggg ggtgggcagg
     6121 ggcagagatg acagagatgc acatttccca gattgttatc catggtagca ttctgaggat
     6181 tgttctgtgg aagagacttg gaggtacaca gaggttacca atttttagtc atacaggatg
     6241 gaggaaaaag tgccatgtcc ccatgagtag acagctttgt gtattggcag gattttttct
     6301 gagggggaaa atgcactctt gtgtttccta agtttgttgc caggagtgtg ggaacttaca
     6361 ccacacgaga gctgacccta gactctgagg tccctcactc cctcactctt cggagtcttg
     6421 ggtctaggag gagttagaca aggccatgct aaggccagac ttgctcatgc ccttcccagt
     6481 gctgcgtttg aggcacagac agttcagcct tcggatgtca agctgggccg ggagcagctt
     6541 caacgtggtt ccagatacct gcagctgcag ccagggtctc tctagctgct acctgccctc
     6601 caaaccgagc ctcagtggag cccagcagat cccagtttgc tcaggcataa ccaccagcaa
     6661 agcaagcaga cagactatgc aagacgggaa ataactagct gaaatgccaa ctatgtttgt
     6721 ttttttttct acctgataac actgtttact tataactgta taaatatagt tgtcctaaga
     6781 gccaggaggg aaacctttcc acctagaaat agaatggttg tctgttggct ttaggccacc
     6841 tgttacagct ccttgtggtc tgatgattgt ggtttattca acctgtttac attagaattg
     6901 gagaaggggc cctggatctt ggtgggctgc cactgctgtc tgtatcccct tgactcctaa
     6961 agagcctttt gatagaggga cttgggacaa ggtatgccct gtcagggatg cttttaccac
     7021 aaaggaatgg tatggaatca agtgggatga ttgatggatg attaacacag taccaaagtg
     7081 cattcttcaa tgtgtatgtg cctgttccag gcaaggccca agttgaaaat gcagtaaagc
     7141 agactcatga aagcaaa
//
