LOCUS       NM_027355               4468 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 168 (Rnf168), mRNA.
ACCESSION   NM_027355
VERSION     NM_027355.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4468)
  AUTHORS   Zou,L., Sun,L., Hua,R., Wu,Y., Sun,L. and Chen,T.
  TITLE     Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy
            Activation Promotes RNF168 Nuclear Translocation and NF-kappaB
            Activation in Lupus Nephritis
  JOURNAL   J Innate Immun 15 (1), 428-441 (2023)
   PUBMED   36944318
  REMARK    GeneRIF: Degradation of Ubiquitin-Editing Enzyme A20 following
            Autophagy Activation Promotes RNF168 Nuclear Translocation and
            NF-kappaB Activation in Lupus Nephritis.
REFERENCE   3  (bases 1 to 4468)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   4  (bases 1 to 4468)
  AUTHORS   Patel,P.S., Abraham,K.J., Guturi,K.K.N., Halaby,M.J., Khan,Z.,
            Palomero,L., Ho,B., Duan,S., St-Germain,J., Algouneh,A., Mateo,F.,
            El Ghamrasni,S., Barbour,H., Barnes,D.R., Beesley,J., Sanchez,O.,
            Berman,H.K., Brown,G.W., Affar,E.B., Chenevix-Trench,G.,
            Antoniou,A.C., Arrowsmith,C.H., Raught,B., Pujana,M.A., Mekhail,K.,
            Hakem,A. and Hakem,R.
  TITLE     RNF168 regulates R-loop resolution and genomic stability in
            BRCA1/2-deficient tumors
  JOURNAL   J Clin Invest 131 (3) (2021)
   PUBMED   33529165
  REMARK    GeneRIF: RNF168 regulates R-loop resolution and genomic stability
            in BRCA1/2-deficient tumors.
REFERENCE   5  (bases 1 to 4468)
  AUTHORS   Zong,D., Adam,S., Wang,Y., Sasanuma,H., Callen,E., Murga,M.,
            Day,A., Kruhlak,M.J., Wong,N., Munro,M., Ray Chaudhuri,A.,
            Karim,B., Xia,B., Takeda,S., Johnson,N., Durocher,D. and
            Nussenzweig,A.
  TITLE     BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin
            Ubiquitylation
  JOURNAL   Mol Cell 73 (6), 1267-1281 (2019)
   PUBMED   30704900
  REMARK    GeneRIF: E3 ubiquitin ligase RNF168, in addition to its canonical
            role in inhibiting end resection, acts in a redundant manner with
            BRCA1 to load PALB2 onto damaged DNA. Loss of RNF168 negates the
            synthetic rescue of BRCA1 deficiency by 53BP1 deletion and it
            predisposes BRCA1 heterozygous mice to cancer.
REFERENCE   6  (bases 1 to 4468)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   7  (bases 1 to 4468)
  AUTHORS   Liu,C., Wang,D., Wu,J., Keller,J., Ma,T. and Yu,X.
  TITLE     RNF168 forms a functional complex with RAD6 during the DNA damage
            response
  JOURNAL   J Cell Sci 126 (Pt 9), 2042-2051 (2013)
   PUBMED   23525009
  REMARK    GeneRIF: RNF168, in complex with RAD6A or RAD6B, is activated in
            the DNA-damage-induced protein ubiquitination cascade.
REFERENCE   8  (bases 1 to 4468)
  AUTHORS   Luijsterburg,M.S., Acs,K., Ackermann,L., Wiegant,W.W.,
            Bekker-Jensen,S., Larsen,D.H., Khanna,K.K., van Attikum,H.,
            Mailand,N. and Dantuma,N.P.
  TITLE     A new non-catalytic role for ubiquitin ligase RNF8 in unfolding
            higher-order chromatin structure
  JOURNAL   EMBO J 31 (11), 2511-2527 (2012)
   PUBMED   22531782
REFERENCE   9  (bases 1 to 4468)
  AUTHORS   Bohgaki,T., Bohgaki,M., Cardoso,R., Panier,S., Zeegers,D., Li,L.,
            Stewart,G.S., Sanchez,O., Hande,M.P., Durocher,D., Hakem,A. and
            Hakem,R.
  TITLE     Genomic instability, defective spermatogenesis, immunodeficiency,
            and cancer in a mouse model of the RIDDLE syndrome
  JOURNAL   PLoS Genet 7 (4), e1001381 (2011)
   PUBMED   21552324
  REMARK    GeneRIF: Rnf168 is important for maintaining genomic integrity, and
            it cooperates with p53 in suppressing tumorigenesis.
REFERENCE   10 (bases 1 to 4468)
  AUTHORS   Ramachandran,S., Chahwan,R., Nepal,R.M., Frieder,D., Panier,S.,
            Roa,S., Zaheen,A., Durocher,D., Scharff,M.D. and Martin,A.
  TITLE     The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch
            recombination
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 809-814 (2010)
   PUBMED   20080757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665470.1, BC046815.1, BB283669.1, BQ572953.1 and AC126265.3.
            
            On Mar 12, 2008 this sequence version replaced NM_027355.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046815.1, SRR1660817.299673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB665470.1         1-28
            29-1688             BC046815.1         1-1660
            1689-1689           BB283669.1         516-516
            1690-2304           BC046815.1         1662-2276
            2305-2637           BQ572953.1         350-682
            2638-2682           BC046815.1         2610-2654
            2683-2683           BQ572953.1         728-728
            2684-3221           BC046815.1         2655-3192
            3222-3932           BC046815.1         3194-3904
            3933-4468           AC126265.3         175678-176213
FEATURES             Location/Qualifiers
     source          1..4468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.51 cM"
     gene            1..4468
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /note="ring finger protein 168"
                     /db_xref="GeneID:70238"
                     /db_xref="MGI:MGI:1917488"
     exon            1..955
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..2352
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /EC_number="2.3.2.27"
                     /note="ring fnger protein 168; RING-type E3 ubiquitin
                     transferase RNF168"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF168"
                     /protein_id="NP_081631.2"
                     /db_xref="CCDS:CCDS49825.1"
                     /db_xref="GeneID:70238"
                     /db_xref="MGI:MGI:1917488"
                     /translation="MKMAAPKTSIPSLAECQCGICMEILLEPVTLPCNHTLCNPCFQS
                     TVEKANLCCPFCRRRVSSWTRYHTRRNSLVNTDLWEIIQKHYAKECKLRISGQESKEI
                     IDECQPVRRLSEPGELRREYEEEISRVEAERQASKEEENKASEEYIQRLLAEEEEEEK
                     RQREKRRSEMEEQLRGDEELARSLSTSINSNYERNTLASPLSSRKSDPVTNKSQKKNT
                     SKQKTFGDIQKYLSPKLKPGTALACKAELEEDICKSKETDRSDTKSPVLQDTEIEKNI
                     PTLSPQTCLETQEQGSESSAGIPGPQLCVGDTKESLEGKVETVSTSPDDLCIVNDDGP
                     RATVFYSNEAAVNSSSKIENEEYSVTGVPQLTGGNRVPTESRVYHLLVEEEISDRENQ
                     ESVFEEVMDPCFSAKRRKIFIESSSDQEETEVNFTQKLIDLEHMLFERHKQEEQDRLL
                     ALQLQKEVDKEQMVPNRQKGSPDQYQLRTPSPPDRLLNRQRKNSKDRNSLQQTNADHS
                     KSPRNTKGDYWEPFKNTWKDSVNGTKMPTSTQDNCNVSKSAYTVQHRKSQRSIVQMFQ
                     R"
     exon            956..1032
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1212
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1334
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1413
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..4468
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3914..3919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /note="major polyA site"
     regulatory      4461..4466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4468
                     /gene="Rnf168"
                     /gene_synonym="3110001H15Rik"
ORIGIN      
        1 gactgagcgg ttccttgggg gaagacgtgc cgttttggcg gggaattgtg acgtccgtgg
       61 agcccgggta cctgctccgg ccgcggccag tagaccgatt ggcaggacag cgggtgcgag
      121 cggctgggtc tcgggacccg gggggtaccg cgaggtgttc cagaagctgg agcgtgggca
      181 ctggagggct gcctccaccg caacggcgag acggaagtcc cgcggcggcc cgagcccgga
      241 ttccgggcgg taccgggtgc tctgggagcg gcggtgcccg ggcttccggc tctggcaagc
      301 ccggccgcct cgcgcgtaga ggcgggtcct caccgcgtaa gaaggggagc tggatgagcg
      361 cttgtgtggc gcggggagac agaaccactc tccgccccga ggccgccgac tcccggagga
      421 acgttctttc attcccttgc tggactcagg gcataactgt tgacctgaca tcacagctcc
      481 tgcttgtctc gggcccgtgg gaactcaggc cttctggatc tcagtccgct gctgtgtgtg
      541 agagtaaaca ccaaacggct cgctgctttt ctccgttctg ggcgtgatta ggcgaaagac
      601 gactttagtc cctttctgat tttaacgttg ggtaggtctc attagcatat gaagatggct
      661 gcacctaaaa cctccatccc ttccttagcc gaatgtcagt gcgggatctg tatggaaatc
      721 ctcctagagc ctgtaaccct accttgcaac cacacgctct gtaacccatg cttccagtcc
      781 actgttgaaa aggccaatct atgctgtccc ttctgtcgtc gccgggtctc ttcgtggact
      841 cggtaccata cccgaagaaa ttctctggtc aatacagacc tgtgggagat tattcaaaaa
      901 cactatgcaa aggaatgcaa gcttagaatc tctggacaag aatcaaagga aatcattgat
      961 gagtgccagc cagttcgtcg gctcagtgaa cctggggagt tgaggcgaga atatgaagag
     1021 gagataagca gggtggaggc tgagcgacaa gccagcaagg aagaggaaaa caaagccagt
     1081 gaggagtaca tccagagatt gttggctgag gaggaggagg aggagaaaag acagagagaa
     1141 aaaagaagaa gtgagatgga agaacagctg agaggcgatg aagaactggc taggagcctg
     1201 agcaccagta tcaacagcaa ctatgagaga aataccttgg cttctccttt gagttccaga
     1261 aaatcagatc cagtcacaaa caagtcccag aagaaaaata caagtaaaca aaaaaccttt
     1321 ggagatattc aaaaatattt gtcacctaag ttgaagcctg ggaccgcctt ggcatgtaag
     1381 gctgagcttg aggaagacat ctgcaagtct aaggaaactg ataggagtga cacgaagagc
     1441 cctgtgttgc aagacacaga aattgaaaaa aatataccaa cactttctcc tcagacctgc
     1501 ctggaaactc aagaacaagg ttcggagtct tctgcaggga tacccgggcc acagttatgt
     1561 gtaggagaca ctaaagagtc ccttgaggga aaagttgaaa cagtatcaac cagtcctgat
     1621 gatttatgta ttgtaaatga tgatggacct agagccacag ttttttactc taatgaagct
     1681 gcagttaact cttctagtaa aatagaaaat gaagaatact ctgtgacagg tgtgccccag
     1741 ttaactgggg gcaacagagt tccaacagag agtagagtgt atcacttact agttgaagaa
     1801 gagatttccg acagagaaaa ccaggaatct gtatttgaag aagtcatgga tccatgtttt
     1861 tctgcaaaaa gaaggaaaat attcatcgaa tcctcctcag atcaagaaga aacagaagtg
     1921 aattttacac aaaaactgat agatttggaa catatgcttt ttgagagaca taagcaagaa
     1981 gagcaggaca gattgttagc attacaactt cagaaagagg tagataaaga gcaaatggtg
     2041 ccaaaccggc agaaaggatc cccagatcag taccagctac gcacaccctc acccccagac
     2101 aggctgctga atagacaaag gaagaattcc aaagatagga actccctaca gcaaactaat
     2161 gcagatcact caaaatctcc gaggaacaca aaaggtgact attgggagcc ctttaaaaac
     2221 acatggaagg attcagttaa tggaacaaag atgccaactt ctactcaaga taattgtaat
     2281 gtatctaaaa gtgcctatac cgtacagcat agaaagtccc agagaagcat tgttcaaatg
     2341 tttcagagat aaccaagcaa agcatgggga aagagttcta taatccagaa atgatgtatt
     2401 gcaaagctag ctcttctgtc ctaatatcct gagatgtctc acattctgct cagcaagctt
     2461 gcttactctc tgaggtttgg ttacaaagga agaatttaca aatgtgtttc tacaaaagac
     2521 ggctagtagg aaacaacctt gggaattgtt tccattgtca ataactgcag tgttctaagt
     2581 gtggcatctt tacaggtata aaaacacctt ggtcagtaca tcttcaggtg ccacttccct
     2641 ttccaaaact tttatagcct tttttttccc tctttttttt tttaaatgaa tgggtaagga
     2701 gtccacacag gtatcttcca taacactaat tagttccctt catagtttta attctaagca
     2761 ttttagcatt tcctttgaat taaaataggt aagtatcgga ctggagagat ggctcagcgg
     2821 ttaagagcgc agactgctct tctgaaggtc agctgctctt ctgaaggtcg caagttcaaa
     2881 tcccagcaac cacatgatgg ctcacaacca tccataatga gatctgatgc cctcttctgg
     2941 cctgtctgaa gacagctaca gtgtacttac atataataaa taaatcttta aaaaaaacag
     3001 gtaagtatca acatcaatta gttacagaat agctgctaga ttgtttgttt tttttaaaga
     3061 tttattaaaa aaaaaaaagc cgggtgtggt ggcgcacgcc tttaatccca gcactcggga
     3121 ggcagaggca ggcagatttc tgagttcgag gccagcctgg tctacagagt gagttccagg
     3181 acagccaggg ctatacagag aaaccctgcc tcaaaaaaaa agaaaagaaa agaaaaaaaa
     3241 aagattttat tattatacat aagtacactg tagctgactt cagacagacc agaagagggt
     3301 attagatctc attacgagtg gttgtgagcc accgtgtggt tgctgggatt tgaacttagg
     3361 accttcagca gcactcttac ctgctgagcc atctctacag ccccactgct agattgttaa
     3421 tgcaagggtt taagagtggc atgggctgag tggtggattg gtaggtaggg aatccctgga
     3481 actgaatggg taatcagaaa ctgggtccaa catggacttc aggcttcttg tagcagaaca
     3541 ttctctttaa tccctttaag tggcagaaaa tatttagagt ttacagcttt tccctccatg
     3601 gcatcttggt gtgagagggc gaattggtat atttttactg atcttgtcta gaaacaaata
     3661 aattattgta agaaaatgat actacgctct gctgtcgaac acctggcttt accatcctcg
     3721 ctgcttactg gctcagacac atgcttgtat gtgcgcacag atggaaaatg gtgtgggttt
     3781 gtcttgcatt accctgggat ccagacgaat cttgtcaagt tgagcttcta tcttttgtta
     3841 agacaactta gcaagctgta gtttcagtag attctcttct ggtgtcttgg ctccatttat
     3901 ttcctgtgaa cataataaac tgtcctaatg cagtgtttgg ctttttccac atttttgtca
     3961 tttgaatttt ttcttccgag ttttaaaact ttttttatgt ttatcttggc aatttttttt
     4021 tcctctaaaa gcaatttaac ttaatgcttt aggaagatag tgatgggact tcaaattaga
     4081 tattatcaca ttcaatcttt gtgaaatagt tcatgaccaa aaagggacta agaagaacat
     4141 tcctgtatgg tatagtgaga gtttatatat ttaccaccag tttgtccgtg ggcaatcatc
     4201 ctgattgaag ttgttttcag gtttttagtt tctctgttag ctctctgtta ttcttactgt
     4261 tgataccttt gtgttagcat tagatttttt aaattggtca ttagtgaact gctttttcct
     4321 catttttgtt ggaaaatatt agagtattaa agctgtgcag atttgaaaaa aagatgcctg
     4381 gcatgatggc acagcctaat tccagcatgt cagaggcaag ggcatctcag ttcttaaaaa
     4441 aaaaaattaa aagaatgatt aataaaaa
//
