LOCUS       NM_001033142            1795 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 166 (Rnf166), transcript variant
            1, mRNA.
ACCESSION   NM_001033142 XM_134599 XM_895075 XM_917545 XM_925000
VERSION     NM_001033142.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Oh,C.K., Choi,Y.K., Hwang,I.Y., Ko,Y.U., Chung,I.K., Yun,N. and
            Oh,Y.J.
  TITLE     RING-finger protein 166 plays a novel pro-apoptotic role in
            neurotoxin-induced neurodegeneration via ubiquitination of XIAP
  JOURNAL   Cell Death Dis 11 (10), 939 (2020)
   PUBMED   33130818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Manzanares,M., Blanco,M.J. and Nieto,M.A.
  TITLE     Snail3 orthologues in vertebrates: divergent members of the Snail
            zinc-finger gene family
  JOURNAL   Dev Genes Evol 214 (1), 47-53 (2004)
   PUBMED   14655014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114917.2.
            
            On Feb 8, 2019 this sequence version replaced NM_001033142.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151813.1, AK079883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC114917.2         74831-75042         c
            213-369             AC114917.2         69168-69324         c
            370-482             AC114917.2         67582-67694         c
            483-597             AC114917.2         67208-67322         c
            598-705             AC114917.2         66930-67037         c
            706-1795            AC114917.2         65113-66202         c
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.17 cM"
     gene            1..1795
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /note="ring finger protein 166"
                     /db_xref="GeneID:68718"
                     /db_xref="MGI:MGI:1915968"
     exon            1..212
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..771
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 313; zinc finger protein 228; RING-type E3
                     ubiquitin transferase RNF166; E3 ubiquitin-protein ligase
                     RNF166"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF166 isoform 1"
                     /protein_id="NP_001028314.1"
                     /db_xref="CCDS:CCDS22740.1"
                     /db_xref="GeneID:68718"
                     /db_xref="MGI:MGI:1915968"
                     /translation="MAMFRSLVASAQQRQPPAGPAGGDSGLEAQFSCPICLEVYHRPV
                     AIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCN
                     KKVTLAKMRAHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNL
                     DQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDY
                     SIDEEAAFQAALALSLSEN"
     exon            213..369
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     exon            370..482
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     exon            483..597
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     exon            598..705
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1795
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /note="hexamer: AATAAA"
     polyA_site      1794
                     /gene="Rnf166"
                     /gene_synonym="1110031E24Rik; Zfp313l"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgccg ggtctgccgg cctggatagg gggcggcggc ggcggcctgc cccggggatg
       61 gcgatgttcc gcagcctggt ggcctcggcg cagcagcggc agccgccggc tgggcccgcg
      121 ggcggcgaca gcggcctgga ggcgcagttc agctgtccca tctgcctgga ggtgtaccat
      181 cggccagtgg ccatcggcag ctgcggccac acgttctgcg gggagtgcct ccagccatgt
      241 ctgcaggtgc cgtcccctct gtgcccactc tgccgtctgc ccttcgaccc caagaaagtg
      301 gacaaggcca cccatgtaga gaagcaactc tcatcctaca aggcaccctg tcggggttgc
      361 aacaagaagg tgacactggc caagatgaga gcgcacattt cctcctgcct gaaggtccag
      421 gagcagatgg ctaactgccc caaattcgtc cctgtggtgc ccacatctca gcccatcccc
      481 agcaatatcc ccaaccggtc taccttcgcc tgcccctact gcggagcccg caatctggat
      541 cagcaggagc tggtgaagca ctgcgtggaa agtcaccgca gtgatcccaa ccgtgtggta
      601 tgccccatct gctcagcaat gccctggggg gaccccagct acaaaagcgc caacttcctg
      661 cagcatctgc tgcaccggca caagttctcc tacgacacct tcgtggacta cagcatcgac
      721 gaagaagctg ccttccaggc tgccctggct ctgtccctct ctgagaactg aggcacagcc
      781 tggccacccg cctcttatgg ggcagaagac acactcccgc tttaagggat agggctgttg
      841 cccttctgcc ctggcacctg cacaggagtg cgcctcacca ggccaagtgg aatgttacac
      901 aaggagagtt ggtctcagaa tccccaggct gggatcctgg ctagctggcc ccttgtcatc
      961 aagcaggacc accaggtcct ggccagcagc actgggccct cggtgcttca aggggcaagt
     1021 gctggccatt gggtcagagc aggtggctgc ctttcccaga cttggtgtct gtgtgtggag
     1081 aaggatgagg tgccctaagc tgtgcccagc agggccaggg gaagaggtgc ccagccaagg
     1141 ctgccagccc acccggtcgg tccctagctt cgcttccacc gtgagcattt ggtactggct
     1201 tttgtgatat ttaggaaccc tgcgtttttc tatcttatcc tgtgtgataa tcttttcatg
     1261 ttttctagag caaagacaaa gcagttactc ttctatcgca atacccaggt ttgactagga
     1321 agagcagtat ttttatggag catttacaaa gttatatttt taaaaaaaaa aatcaaaaac
     1381 atgtgggatg agtgtagagg gaggagcgtg ggtgtggcca gggctttgtc tgtgtgacag
     1441 gtggcgtccc caagccatgt gatctctgag gaggtggctc ctgtctggtg ctttctcttg
     1501 atgacccaga agaaacccta gcaccggcgg gccacttgct gtggctgctc ccagcagatg
     1561 taggacagcc cagacagaat ggagtccttc tgccctgccc tgtcaccttc cagagccaac
     1621 cgcatccctc ctcaggcagg gacttccctt accagtggta gagccctcaa gggccagaga
     1681 gacctgcttg gtggcaggtc aggcaagaaa acatttgtca gcatcttatt ctgttcatgg
     1741 cataaattgc tgtcttttca aaagagtttt aaataaagtg tttccaagca cccac
//
