LOCUS       NM_001405143            3518 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ring finger protein 157 (Rnf157), transcript variant
            8, mRNA.
ACCESSION   NM_001405143
VERSION     NM_001405143.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Wang,P., Zhao,J., Tan,Y., Sheng,J., He,S., Chen,Y., Nie,D., You,X.,
            Luo,J., Zhang,Y. and Hu,S.
  TITLE     RNF157 attenuates CD4+ T cell-mediated autoimmune response by
            promoting HDAC1 ubiquitination and degradation
  JOURNAL   Theranostics 13 (11), 3509-3523 (2023)
   PUBMED   37441600
  REMARK    GeneRIF: RNF157 attenuates CD4[+] T cell-mediated autoimmune
            response by promoting HDAC1 ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Kong,J.H., Young,C.B., Pusapati,G.V., Patel,C.B., Ho,S.,
            Krishnan,A., Lin,J.I., Devine,W., Moreau de Bellaing,A.,
            Athni,T.S., Aravind,L., Gunn,T.M., Lo,C.W. and Rohatgi,R.
  TITLE     A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog
            Signaling and Heart Development
  JOURNAL   Dev Cell 55 (4), 432-449 (2020)
   PUBMED   32966817
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Matz,A., Lee,S.J., Schwedhelm-Domeyer,N., Zanini,D., Holubowska,A.,
            Kannan,M., Farnworth,M., Jahn,O., Gopfert,M.C. and Stegmuller,J.
  TITLE     Regulation of neuronal survival and morphology by the E3 ubiquitin
            ligase RNF157
  JOURNAL   Cell Death Differ 22 (4), 626-642 (2015)
   PUBMED   25342469
  REMARK    GeneRIF: RNF157 has a dual role in neurons as it is also required
            for dendrite growth and maintenance for which its ligase activity
            is not critical.
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645861.12.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.104181.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AL645861.12        160692-161028       c
            338-456             AL645861.12        144184-144302       c
            457-545             AL645861.12        110280-110368       c
            546-692             AL645861.12        108249-108395       c
            693-810             AL645861.12        107808-107925       c
            811-877             AL645861.12        107238-107304       c
            878-921             AL645861.12        106931-106974       c
            922-969             AL645861.12        106664-106711       c
            970-1041            AL645861.12        103440-103511       c
            1042-1201           AL645861.12        102631-102790       c
            1202-1314           AL645861.12        102360-102472       c
            1315-1553           AL645861.12        97955-98193         c
            1554-1662           AL645861.12        97329-97437         c
            1663-1834           AL645861.12        95742-95913         c
            1835-2004           AL645861.12        95337-95506         c
            2005-2070           AL645861.12        95028-95093         c
            2071-2119           AL645861.12        93902-93950         c
            2120-3518           AL645861.12        90902-92300         c
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.17 cM"
     gene            1..3518
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /note="ring finger protein 157"
                     /db_xref="GeneID:217340"
                     /db_xref="MGI:MGI:2442484"
     exon            1..337
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2367
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /EC_number="2.3.2.27"
                     /note="isoform 8 is encoded by transcript variant 8;
                     RING-type E3 ubiquitin transferase Rnf157; E3 ubiquitin
                     ligase Rnf157"
                     /codon_start=1
                     /product="E3 ubiquitin ligase Rnf157 isoform 8"
                     /protein_id="NP_001392072.1"
                     /db_xref="GeneID:217340"
                     /db_xref="MGI:MGI:2442484"
                     /translation="MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKF
                     DSTHPEGYLFGENSDLNFLGNRPVAFPYAAPPPQEPVKTLRSLINIRKDTLRLVKCAE
                     EVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSET
                     VHYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVL
                     LGTFEKHPDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDDVSDNSAE
                     CVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGP
                     LSPSSFNPIISSQTSDSEEHSSSENIPPGYEVVSLLEALNGPLTSSPAVPPLHVLGDG
                     HLSGMLPSYGSDGYLPPVRTLSPLDRLSDCNNQGLKLKKSLSKSISQNSSVLHEEEDE
                     RSCSESDTQLSQRLSVQHPEEGLLTSRLAQGLRSLLPSPPQKVPKGVTACASLTWSTA
                     VTSSGDGSSELVIKPVHTGEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEE
                     EGEALPSPRAASRAPSEGEETPAESPDSNFAGLPAGEQDAEGNDIIEEEDRSPVREDG
                     QRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGEWQCAEHELGGRRPSARPRSP
                     RGGLGKEASAFRIETVALPGTYV"
     exon            338..456
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            457..545
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            546..692
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            693..810
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            811..877
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            878..921
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            922..969
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1041
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1201
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1314
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1553
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1662
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1834
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2004
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2070
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2119
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..3518
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /note="hexamer: AATAAA"
     polyA_site      2880
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
                     /note="major polyA site"
     polyA_site      3518
                     /gene="Rnf157"
                     /gene_synonym="2610036E23Rik; A130073L17Rik; mKIAA1917"
ORIGIN      
        1 atcacgcggt ctgaggcggc ggcggcgccc ccgggctcag ccccgcagcc ccctcaggca
       61 gaggcgccgc cgcggtgccc ggcggaggat ggtgcgcgcc gtgcgggccg ctccccgcag
      121 cctcagccgc agcagcgcct cagccgagcg ggccgcggcg ggcagccgac ccccgcaccg
      181 ggcgtgcggc cggccggcgc gctgaggctc ggacgccgga gcccgggcga cgccgcgatc
      241 gcagcggcca tgggggccct gacgagccgg cagcacgcgg gcgtggagga ggtggacatc
      301 ccgtccaatt ccgtgtaccg ctacccgccc aagtccggca gctattttgc cagccacttc
      361 atcatgggag gagagaagtt tgactccacg catccggagg gttacctgtt tggcgagaac
      421 agcgacctga acttcctggg aaacaggccg gtggcgttcc cttacgctgc cccgcctccc
      481 caagaacctg tgaagactct gagaagcctg atcaacatcc ggaaggacac gctgagactt
      541 gtcaaatgtg ctgaggaagt gaagagccac ggagaagagg caggcaaagc taaggtccac
      601 tacaatgtcg agttcacctt tgacacagat gcccgggtag ccatcaccat ctactaccag
      661 gccactgagg aattccagaa tggcattgcc agctacattc caaaagacaa cagcctgcag
      721 tcagagaccg tgcactacaa gcgaggggtg tgccagcagt tctgcctgcc ctcccatacc
      781 gtggacccct cggagtgggc cgaagaggag cttggctttg atctggaccg tgaagtctac
      841 cctctggtag tgcacgctgt ggtggatgaa ggagatgagt attttggcca ctgccacgtg
      901 cttctgggca cttttgagaa gcacccggac gggaccttct gtgtgaagcc cctcaagcag
      961 aagcaagtgg tggatggggt cagctacctt cttcaggaga tctatgggat tgaaaacaag
     1021 tacaacacac aagattccaa ggtggcagag gacgacgtca gtgacaacag cgctgagtgt
     1081 gtggtgtgtc tctctgacgt ccgcgatact ttgatcctgc cctgccggca cctctgcctc
     1141 tgcaacacct gcgcagacac cctgcgctac caggccaaca actgccccat ctgccggctg
     1201 cccttccggg cactgcttca gatccgagcc atgaggaaaa aactgggccc tctgtcccca
     1261 agcagcttta accccatcat ctcttcccag acctcggact ctgaggagca ttcatcctca
     1321 gagaacatcc ccccgggcta tgaagtggtg tctctcctcg aggccctcaa cgggcccctc
     1381 acctcgtccc cggcagtgcc tccccttcac gttcttgggg atggccacct ctcaggaatg
     1441 ctcccgtcct atggcagtga tggctacctg ccccctgtta ggacactgtc cccccttgac
     1501 cgcctgtctg actgcaacaa ccaaggactc aaactcaaaa agagtctatc caaatccatt
     1561 tcccagaatt cttctgtgct tcacgaagag gaagatgagc gctcttgcag tgagtcagac
     1621 actcagctct ctcagaggct ctcagtccag caccctgaag aggggctgtt gaccagtcgt
     1681 cttgcacagg gactccgctc tcttctacca tctcctcccc agaaggtacc taagggagta
     1741 actgcatgcg cctccctcac ctggtccaca gccgtgactt cctctgggga tgggagcagt
     1801 gagctggtga ttaaaccggt ccacactgga gaagacccag ccagcagcag cctggcccag
     1861 tcagtcatgt ccatggcttc ctcccagatc agcaccgaca cggtgtcctc catgtctggc
     1921 tcctacatcg cacctggtac agaagaagaa ggagaagccc tgccttcccc ccgagctgct
     1981 agcagggccc cttcagaagg agaggagaca ccagcagagt ccccagacag caatttcgct
     2041 ggccttccag ctggagagca ggatgcagag ggaaatgata tcatagagga agaggacaga
     2101 tcacctgtgc gagaagatgg ccagaggaca tgcgcatttc taggcatgga gtgtgacaat
     2161 aacaatgact ttgacgtcgc aagcgtgaaa gcactggaca ataagctgtg ctctgaggtc
     2221 tgcttacccg gtgagtggca gtgtgctgaa catgaacttg gtgggagacg cccctccgct
     2281 cgcccccgct ctccccgtgg aggccttgga aaagaagcct cagcttttag aatagaaacc
     2341 gtagctcttc cagggacgta cgtttgagga tcacaaggaa atctaaaagc atctgtaggt
     2401 cagtgaatgg ctttctgatc cgacgagcct taggtctcca gtgatcacac gtgcaagact
     2461 cggatcccag cggagaaggc agagggcggg gatgacttgg ttctctaagg ccccaacttc
     2521 tcagcgtgcc ctgtttcttt ctctgacctc aaacacagtc tgcaaagcag ccatgctaat
     2581 tgtacattca agcccacgca tgctagccca tgcctacaac cccacacttg gcaaacagag
     2641 gcagccccat cattgcaagc tgcaggccag gagctacgta acaagaccta cctagtctct
     2701 caaaaaataa aatcaagctt ggtgtggtgg cgcacgcctt taatcccagc actggggagg
     2761 cagaggcagg cggatttctg agttcgaggc cagcctggtc tacagaccaa gttccgtgac
     2821 agccgaagcc acacagagaa attgtcttga aaaccccaaa ataaaataag tcacagttga
     2881 gcactgactt cagtgtgccc atcctgcagc agccaagacc ctgcctggga cagatgtccc
     2941 ttacacttcc ctggatcgtc cccgcagtgt cccccactga ggacctgctt cagcttcaga
     3001 acagccactc cggggtccag tgctttactc gctcagcgaa gtagctgaag tgttaagccg
     3061 cagggccttc tgtggctgcc actctccttc agcctgtgcc acccatggtc ccagcaggcc
     3121 ctggccccat gcaagcctgc ggcaagggaa gccagttgct cgggagaaac tttctccagc
     3181 ctttctctct ttagtttgtc ctgaagatac tgcccaggtc ccgggcttcc gtgagacctg
     3241 agagacagca tcaggtcacc tgcttctccc gcacaggccc caggcgctct cccttcctgt
     3301 ccaagcatgg tggagggcgt tgatccatat ggccacctcc tgcccagtta aggctgggct
     3361 ggagctgctg gagaccaggc acgctcaccc ctgccttccc actcctggcc ttgcttccat
     3421 ccgtccattt atgttccatg tctttatgcc aagtgtaggt ctgtctgtct gtctgtctgt
     3481 ctggtttgct catttttaaa ctcatttctg ttttctga
//
