LOCUS       NM_178779               8529 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ring finger protein 152 (Rnf152), transcript variant
            1, mRNA.
ACCESSION   NM_178779
VERSION     NM_178779.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8529)
  AUTHORS   Xiong,M.G., Xu,Z.S., Li,Y.H., Wang,S.Y., Wang,Y.Y. and Ran,Y.
  TITLE     RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88
            oligomerization
  JOURNAL   EMBO Rep 21 (3), e48860 (2020)
   PUBMED   31930677
  REMARK    GeneRIF: RNF152 positively regulates TLR/IL-1R signaling by
            enhancing MyD88 oligomerization.
REFERENCE   2  (bases 1 to 8529)
  AUTHORS   Deng,L., Chen,L., Zhao,L., Xu,Y., Peng,X., Wang,X., Ding,L.,
            Jin,J., Teng,H., Wang,Y., Pan,W., Yu,F., Liao,L., Li,L., Ge,X. and
            Wang,P.
  TITLE     Ubiquitination of Rheb governs growth factor-induced mTORC1
            activation
  JOURNAL   Cell Res 29 (2), 136-150 (2019)
   PUBMED   30514904
REFERENCE   3  (bases 1 to 8529)
  AUTHORS   Wu,Y., Guo,X.P., Kanemoto,S., Maeoka,Y., Saito,A., Asada,R.,
            Matsuhisa,K., Ohtake,Y., Imaizumi,K. and Kaneko,M.
  TITLE     Sec16A, a key protein in COPII vesicle formation, regulates the
            stability and localization of the novel ubiquitin ligase RNF183
  JOURNAL   PLoS One 13 (1), e0190407 (2018)
   PUBMED   29300766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8529)
  AUTHORS   Deng,L., Jiang,C., Chen,L., Jin,J., Wei,J., Zhao,L., Chen,M.,
            Pan,W., Xu,Y., Chu,H., Wang,X., Ge,X., Li,D., Liao,L., Liu,M.,
            Li,L. and Wang,P.
  TITLE     The ubiquitination of rag A GTPase by RNF152 negatively regulates
            mTORC1 activation
  JOURNAL   Mol Cell 58 (5), 804-818 (2015)
   PUBMED   25936802
REFERENCE   5  (bases 1 to 8529)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ112559.1, AK035832.1 and AC162907.5.
            
            On May 21, 2009 this sequence version replaced NM_178779.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044638.1, SRR9219383.18796.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               CJ112559.1         1-204
            205-1496            AK035832.1         1-1292
            1497-8529           AC162907.5         127355-134387       c
FEATURES             Location/Qualifiers
     source          1..8529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 49.45 cM"
     gene            1..8529
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /note="ring finger protein 152"
                     /db_xref="GeneID:320311"
                     /db_xref="MGI:MGI:2443787"
     exon            1..368
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..491
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..8529
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..1227
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF152"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF152"
                     /protein_id="NP_848894.1"
                     /db_xref="CCDS:CCDS15204.1"
                     /db_xref="GeneID:320311"
                     /db_xref="MGI:MGI:2443787"
                     /translation="METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRT
                     SQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYML
                     PLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPPEAVEEEPDRRGV
                     VKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG"
     regulatory      8507..8512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      8529
                     /gene="Rnf152"
                     /gene_synonym="A930029B02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtccgcgga gcagagctca ctcagcctcc cgctcccttc agtgcttggg tctctggggg
       61 tgacaccaaa agcttccgct cagtgtccgg tgcctggcgg cgggtgtccg atcgtggagg
      121 cggaggacag ccgggcaggt ggagggcgcc gcctgaagcc aaaggagaga cgagcagggc
      181 tgggctgcgg gaggcgctgc cgccactctg cccgcgctgc cccgcaacct gcggcgggag
      241 gagcaggcag cagccggccc tcagcgctcg tctagcagag cgcagcgggc agtgcggacc
      301 cccgggatgc ttccgacgtt gctgcagccg ccggcggcgt aacagagccg agcctgctgc
      361 tgagagaggc tgaacaaagc tgggtctcaa tcgcgcttcc tgcttgtcag cctcttgtct
      421 cccaaacgct tactgtttcc acttgatgtc aacacgcaga agggggtgaa agggacgcgt
      481 gacagattca gaaattagca catttgtgaa tgctcgatgc cctgtgagct tgagaagagg
      541 gatccagagt ggtgacattt gagaaccggc ttctccagct tcctgttggt cctgcccttt
      601 gactcttggt ccgcgatgga gacactctcc caggattccc tgttggaatg tcagatctgt
      661 tttaattatt acagcccccg acgaaggccc aagttgttgg attgcaagca cacctgctgc
      721 tcggtgtgcc tccagcagat gaggaccagc cagaaggacg taaggtgccc ctggtgccgt
      781 ggcatcacca aattgccccc gggcttctct gtatcacaac tgcccgatga cccagaggtc
      841 ttggcagtca ttgccatacc acacacttcc gagcataccc cagtcttcat caaacttcca
      901 agcaatgggt gctacatgct gcccctgccc atctctaagg agcgtacact cctgccggga
      961 gacatgggct gccgcctgct gccagggagc cagcagaagt ctctcaccgt ggtgaccatc
     1021 cctgcagaac agcagcccct gcagggtgga gctcccccgg aggctgtgga ggaggagcct
     1081 gacagaaggg gcgtggtgaa gagctccaca tggtctggcg tgtgcactgt catcctggtg
     1141 gcctgtgttt tggtcttcct cctgggcatt gtgctacaca acatgtcctg catctctaag
     1201 cgcttcactg tgatatcctg tggttgaagt ctttcacagg gatgcctctt gtgggtgcca
     1261 acttaggggg tgagcaggtg ttggtgatgg gatccctgtg atgagatggg ggtgacactg
     1321 cacatttggt gcaagcgctg gcctgcaatt gtcacttgat tcacctaaag acaagtgcag
     1381 agggtgaggt ctcagcaaga tcccaggaga acagtttcaa gatggtgaca actatgaaga
     1441 tgtttgcatg cttcctcata attgtgtatc caatgggctg taatttatga ttttcctaaa
     1501 tcatggtctc aagttagact tttctactta gacatgaaaa tgtacatgtg ggtgcaatag
     1561 ctctctaaat acggtagacg gtaggttaaa acagatgctg tgtacacaag tagaattaaa
     1621 cctcaaatcc atgtttaaaa aacaaaaaca gtgaagaccc agagctggct cctgtgtgtg
     1681 catgtttgtg tgtgtatgct cacgtgtgtg tgcgtgcgtg cgtgtgtgtc tgtgtgtgtg
     1741 tgtgtgtgtg tatgtgtgtg tgactgaacc ctggtcttca taaacttttt atacattttg
     1801 aatggcaccc aaatcaaaat aatcaaaaca gaccttttgg ctgtttgaag aaaatatttg
     1861 cacacatgtc ttcagtgtgt tgtgctttgc caagttcctt catttctctt catctgtgat
     1921 ttaagcttgc tctgtgcttg ttaagctgga agcccaacag gcaagtgatg gacagggaaa
     1981 tatataggca atgtctaatt ccctaagaaa cctatatgcc aatctttctc aagccatctc
     2041 acaagataag aatttaaagt gtaaatattg tgaatctctg tgtgtatttt gtgtgtgtaa
     2101 ttcaatttat ctcaggtttt tgagtttttc ctgaagaatc ctgggagtaa gactttgtgg
     2161 gcgtgcataa gccaagtgtc tacaacacca gcctcctggc cggtgcctgg atctttcccc
     2221 cacatcacct ccaacatcca cttgcacttt gctgtgtata gtgatcccat gtcagtaaag
     2281 gctcagacag agcatcagaa gaactcgtca ttttccctca gtttggaggg ctttgtgtca
     2341 aagtcacaaa tgttgctaat caatggcata cctagatggg cattgtaata gacagtcctt
     2401 gatgatcttt tctttgaaag attttcctgt aagagttaac ctgcttagaa ttcaatttca
     2461 tcttgttgga actttcaaga aaatgttttg tatttcaaat gtttctactg ccaaaagtag
     2521 tacggtgaac aaaaatgctc accatgtaag tgaaccagtt tctcatgatt gctcaactat
     2581 ttttaaatgt gaatttatga agaaagatct gttagcataa aagaagcagt ccctagtctg
     2641 gctgtgtgta ttctgaaaga gttgccagcg ctatagtcct ctttgaactc tgtttgtgga
     2701 atgagtgatg tttgtcaagg actccactca gctgtgttcc tccctgctgt tctgttgaat
     2761 ccctgaaatg gtggaaaggg tgggaaaggc aaaggaaagg aaagagtggc acaggatcta
     2821 agcaaggtca gaagcagccc tggaacatgg aagcatgatt ggcctgctgg ccttcatctt
     2881 caagctgcac aacagacgtg tgctaaagtg atgactttgc agtgaaataa aacagaggaa
     2941 taacatctag agtacaacga taacaattga catgaaaatt caacatcaaa ttatgagctc
     3001 tggtttttaa aatctttcaa atttataaga cctttaggaa aaaaatgtat ctgagggctc
     3061 aaactagaaa ttaggttaaa ataccatttt atcgtgtaag ctattgggca ttatacaacg
     3121 aataatctag gatttatttg gtattaataa tttaggtatc attagctgaa tactatcctc
     3181 tattatgtaa cataatatac tgttgggtta gcatcaattt ctcaaactct caggctgctc
     3241 taatgcatgt ctgacccact ttctatttct ctcggaggag aaaacacaca tagacaaaaa
     3301 tgttgcgtaa aggatgttat gtttccaatg gatgttactc ttgcaatttt aagccaggcc
     3361 atatttaaat tcatttgtga gagatatcag cataccttcc tgtacagtag aaaatgagtg
     3421 atcctatagt acagtgtgtg aaaatgttct agttgtttag gaggctattt atagatacta
     3481 acatgtgtgt tgatatggtg tcctgtggtt tttcttgcaa agctgtatag taaaattgtc
     3541 cacagaactc ctaaaaagtt catgttagag ctgtaattaa gcaaaatcaa tctgctccct
     3601 ggtagactct tgaccttaca acctgacagt aataacccaa gtcaaagctt ttttatgtgt
     3661 gcttggtcta agagacatta tttaaaacgg ttgaaatgga ttctgcctat ggtttgcata
     3721 tgtgcttatt agggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3781 gttgtgtgtt agaggagggg gcaaggaggc ctgccaactt ctatatactt gatgtttcag
     3841 tttattctgg aatttaccca caacactaaa actttatcta tctcatgtgg ggcaagcagc
     3901 cagggcttag aatcacatgc cagtggcagg gacagcagtt gcagctgaaa ggaggctcta
     3961 gtggcttcat cttgcagatg agctcattgg ggtatgtaga gagcagtagt gtgcaggttg
     4021 taattctata gcaagaagac aagacccgtg tcctgctgtg ccgtgttatt cctcccgagg
     4081 cacaccactt tccctctcag gctatgattg tttacagagt ctgggaaggc cctgtgtcag
     4141 ctattgcttt gagggttgct tcagatatta atttcttttt agatagcttc tttttgggaa
     4201 agaaaagggg gggggttgat ttaggaatga atgaaggtat taaaagaaaa ctttcaaacc
     4261 atgtgattcg aatatttaga agtgtaaaac ataaaccagg atcctgcccc ccacatgtcc
     4321 aggacgatga gtgttgtgta aatagtaacc tataagaagc atgaatttct tctttattaa
     4381 tgatcttgat ataagcaaga gaatgcttac cgtgttaagt agagccaagt atggcacttc
     4441 atatgtcgtc tttagaaaaa ttttgtataa tgacctggga cataaattgt aatgataaag
     4501 gcaaattagt tctgaatttc agtcacacct tattatcagg aaggtctgag gctttttttt
     4561 tttttgaaac agaattaaat ttcaccctct gcattactca cagagtggat ccattggagt
     4621 ttcagctgta tgctagttca gctcttggaa ttttctaagt cagtcctgtt tgatagaact
     4681 tttgggattg atggaaattg ttctgtattt gttcagtgtt gtttagtaga gtggccacta
     4741 gccacatggc tgttaagcaa ttaggtgggg atggctgaag aaatgacttt taaatgttat
     4801 ttaattttaa gaaatttaaa attaaatatt cccatatggc ttgtgatcac attggccata
     4861 atgacatcag gaagttgact agtaacagtt tgccaaaaga aattcctttc taacttaaag
     4921 acgcttatgg gctccaaagg ggaggggtag taataaaatc tcatccattg ccctttgggg
     4981 ttattgctta gagactttaa accaaggaat gagcagtgaa gcttaaagag aactttatta
     5041 agcccctttt ctgggaccat tagctgcatg taaatctatt gtccaaagct catagctaga
     5101 cagtagctgt aaaatttttg acttgcaagc catgcatgac ctgtgctgtg aaagtgtgtg
     5161 tagggtcttg tggccaaaaa aaaaaaaaag agtcaatgtt acagaaaatc taataaataa
     5221 gagtctgatg aaatcccagt tcacttttga gctctttccc aaccgaatca ctgcatcagt
     5281 gagtgggaaa tccacaatca agcatgcatt gcggtgttta cagtgtttct atttgccctt
     5341 gaagtcagtc agtttgtcat gtatttggtg tgggcatatg tgggtgccag gctggaacaa
     5401 ggtaccactt ttagagtgag atgtgacatt gttgagtgtc tctttttaaa tttagttatc
     5461 attaaaaggt ttgaaacttt gcacaaaggc actttttaca tttttaatag ttaaggaaaa
     5521 aaaaaaaaag gaaagcgttc ctcaatgggc tttagaaact gaaaggttat tatggctgtt
     5581 ctgtagagtt actcttctgt tagtaaaggg gagtggagag tccagctcaa gatacattcc
     5641 gtataaaact cagactgtag ccgatagtct ggcacccttc cctgcttaga ttttgattta
     5701 aagatctcct gtcccttcct ttgaaaatct gtaccatgtc agaatttcct agccttcctc
     5761 ttcattgctc cccgccccag tgtagtggaa gccaactgtg cttgctttga tggaacagaa
     5821 ttgggctgag tttccaattc tgcagccctt caatagggag cactctcttt ggggctggtc
     5881 ttcaacttgt tggccaaatg gtgttttctg aagacttttc taagttagga ggccgacagt
     5941 gattcatata ctatgggtga tacgcccaga cagcaacaaa gctcctctct ccttagaaga
     6001 atggtgttat ggactaggta acattccgga accacaccag aagttggcca actcatactc
     6061 tggacctaga tggagaaatt acttcttgac attttcacca taatcaggaa gacttcacct
     6121 gaaaagtcat tctcatactg acagaaattc caggcaagag tgagatctcc aagagaattt
     6181 acccatggta tctatttgaa agagatagtt gctggatctt tttcaacctg aaactcttga
     6241 aaactaagtg gaaattcaag ccatttttcc tgatagaaat gacttgctac aactaactct
     6301 ctctctctct ctctctctct ctctctccct gtaatcggag ttaacataaa gtagaaagca
     6361 tcagcatgat tttctcatcc atggatcaca aaatgctgaa tttatatatt aatttttaaa
     6421 cagctgttat gagctccata tgccatgtca aaccaactac tttggggaat gtcttaaact
     6481 cttaagactt ctccatttat aaagaggtgg gtactcctac gtgatgtcat tgaaaaacca
     6541 ttgatcaccc atacactgag caggcagggc atttgatttc agaattctaa ataacctttc
     6601 tctttccctc cctccctccc tccctccctc cctccctccc tccctccctc cctccctccc
     6661 tcttttcctc cctccctccc tcctttcttt ctctctctct ctctctctct ctctctctct
     6721 ctcctctttt ggtccttgtt atgtttcaag attgtaaact actatctctg agatactcca
     6781 ttctgaatca atttctctga gcacttctct tgtcttgctt gttccagcca atgtcttttg
     6841 atttttctct gttcactgcc tggggtatcc ccacttgtgc atcccacact gtagtggtgc
     6901 ttgaaaatgc ttatctcatt tatctggagt ttaatctaaa aagggttttt aaaatatact
     6961 attcacattg tgttattagg gacaatcagc tattagaaca aagcactgag ggtcctcctg
     7021 agagctccaa cagtgggcct ttctcttcgt tccttacagg atgtttgtta catcctggat
     7081 ctttccctgt ttcccagatc actgatctca atgcctccct agatggagag ctgtagccca
     7141 caagacagtc tcctgtaata ttcctgccca atgagttact gtgttactct aacaggagct
     7201 tttcaaaggg actggtcact ctttaactca gcatttgctt tttgagaaca cagtagtcag
     7261 tggttggata tattggtggc aaggaaatgt gaagtagaaa gaaaagagaa acagatgtga
     7321 cagatgtcct tcagggaaca agttgatacc tatgttatct ctgtttgaac agtaagagaa
     7381 ggcagtggct gttggctagg tggacttagc catcccattg ccaaggagcc tcacctgagg
     7441 gaatggtaca gacaaaaccc tgggctctga atagatagac agacatgccc agagaaggag
     7501 aaactatttt taaaagaaag gaaagtgaaa tgggattatg ggttcaaaaa aaaaaaaaaa
     7561 gactttacac tgtatgtcag ccatggtaga agccaactga agataacctg ggatctcgac
     7621 cattctacca gggatcacct gcttaagttg aagacacaaa tggaaggtgc ttggctcatg
     7681 aggagattcc caaggagttc tcatctttcc tgtcatcctt tcagatgctt ttgggttatc
     7741 aaggctgtag aaaataccag agcctgctta tggagttggc catggagtac atataagtgt
     7801 accttgctcc tctctttgct atgaaaaagt tctagttcaa ttagtgagct gtgacttggg
     7861 tacgactact gcaaaaaaaa tagttcaata atgttgtgct tatgttcttg ctgctgccat
     7921 tattatattt atatatctca ccacttgtat gtatgacctc acttgatggt tataggtatg
     7981 gaaattgcca gcagtctggg gaagttggcc acaaactccc aatagaggac atatgtaacc
     8041 accaccatgt tcccttccat tcttaaagac ccatgtgtgg gctttctggt cttgtataac
     8101 acattgcaat cagatggtga gattagtgct gttctgaggc tgttaattct agttcctgac
     8161 ttgtttcatt tataataatg gagacagttt ctttggggaa gcttttcttt gaaagggcca
     8221 aattgcccta cagataaatg agctgccggg cagtgtagaa attcttgtcc aaatgttgcc
     8281 aaatactgac ttcatagggg atatcaagct gctgtttatt aatcggaatg tcttaaaagc
     8341 cttcctgctt gctctctctg ttatagatgg tgtcttagcc agtcccaagt ttttccaatg
     8401 aacctgattt taatacatgg tatttttgta tgctaaactg gtgtcttgtc ctttgtatat
     8461 gtggtaatgt tcattttacg actactgtta aaacacattt gctatgatta aaattcaaaa
     8521 tgatttcaa
//
