LOCUS       NM_001110197            4420 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ring finger protein 146 (Rnf146), transcript variant
            1, mRNA.
ACCESSION   NM_001110197
VERSION     NM_001110197.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4420)
  AUTHORS   Hou,S., Zhang,J., Jiang,X., Yang,Y., Shan,B., Zhang,M., Liu,C.,
            Yuan,J. and Xu,D.
  TITLE     PARP5A and RNF146 phase separation restrains RIPK1-dependent
            necroptosis
  JOURNAL   Mol Cell 84 (5), 938-954 (2024)
   PUBMED   38272024
  REMARK    GeneRIF: PARP5A and RNF146 phase separation restrains
            RIPK1-dependent necroptosis.
REFERENCE   2  (bases 1 to 4420)
  AUTHORS   Park,G., Jang,W.E., Kim,S., Gonzales,E.L., Ji,J., Choi,S., Kim,Y.,
            Park,J.H., Mohammad,H.B., Bang,G., Kang,M., Kim,S., Jeon,S.J.,
            Kim,J.Y., Kim,K.P., Shin,C.Y., An,J.Y., Kim,M.S. and Lee,Y.S.
  TITLE     Dysregulation of the Wnt/beta-catenin signaling pathway via Rnf146
            upregulation in a VPA-induced mouse model of autism spectrum
            disorder
  JOURNAL   Exp Mol Med 55 (8), 1783-1794 (2023)
   PUBMED   37524878
  REMARK    GeneRIF: Dysregulation of the Wnt/beta-catenin signaling pathway
            via Rnf146 upregulation in a VPA-induced mouse model of autism
            spectrum disorder.
REFERENCE   3  (bases 1 to 4420)
  AUTHORS   Sheng,Z., Xu,J., Li,F., Yuan,Y., Peng,X., Chen,S., Zhou,R. and
            Huang,W.
  TITLE     The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac
            hypertrophy by suppressing the LKB1/AMPK signaling pathway
  JOURNAL   Exp Cell Res 410 (1), 112954 (2022)
   PUBMED   34856161
  REMARK    GeneRIF: The RING-domain E3 ubiquitin ligase RNF146 promotes
            cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway.
REFERENCE   4  (bases 1 to 4420)
  AUTHORS   Xu,H., Li,X., Wu,X., Yang,Y., Dai,S., Lei,T., Jing,D., Luo,P. and
            Luo,E.
  TITLE     Iduna protects HT22cells by inhibiting parthanatos: The role of the
            p53-MDM2 pathway
  JOURNAL   Exp Cell Res 384 (1), 111547 (2019)
   PUBMED   31472117
  REMARK    GeneRIF: Iduna might prevent TBI by specifically inhibiting
            parthanatos and promoting mitochondrial function, with the p53-MDM2
            pathway playing a critical role.
REFERENCE   5  (bases 1 to 4420)
  AUTHORS   Kim,H., Park,J., Leem,H., Cho,M., Yoon,J.H., Maeng,H.J. and Lee,Y.
  TITLE     Rhododendrin-Induced RNF146 Expression via Estrogen Receptor beta
            Activation is Cytoprotective Against 6-OHDA-Induced Oxidative
            Stress
  JOURNAL   Int J Mol Sci 20 (7), 1772 (2019)
   PUBMED   30974833
  REMARK    GeneRIF: Rhododendrin is cytoprotective against 6-hydroxydopamine
            (6-OHDA)-induced cell death, which is largely dependent on ERbeta
            activity and RNF146 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4420)
  AUTHORS   Xu,H., Luo,P., Zhao,Y., Zhao,M., Yang,Y., Chen,T., Huo,K., Han,H.
            and Fei,Z.
  TITLE     Iduna protects HT22 cells from hydrogen peroxide-induced oxidative
            stress through interfering poly(ADP-ribose) polymerase-1-induced
            cell death (parthanatos)
  JOURNAL   Cell Signal 25 (4), 1018-1026 (2013)
   PUBMED   23333241
  REMARK    GeneRIF: Iduna acts as a potential antioxidant by improving
            mitochondrial function and inhibiting oxidative stress-induced
            parthanatos, and these protective effects are dependent on the
            involvement of ubiquitin-proteasome system.
REFERENCE   7  (bases 1 to 4420)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4420)
  AUTHORS   Kang,H.C., Lee,Y.I., Shin,J.H., Andrabi,S.A., Chi,Z., Gagne,J.P.,
            Lee,Y., Ko,H.S., Lee,B.D., Poirier,G.G., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase
            that regulates DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 108 (34), 14103-14108 (2011)
   PUBMED   21825151
REFERENCE   9  (bases 1 to 4420)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   10 (bases 1 to 4420)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050795.1, BY787516.1, BQ713250.1, AK035665.1 and BF461810.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.62813.1,
                                           SRR1660811.2108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               BC050795.1         1-416
            417-794             BY787516.1         2-379
            795-2404            BC050795.1         714-2323
            2405-2675           BQ713250.1         351-621
            2676-4400           AK035665.1         3-1727
            4401-4420           BF461810.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 16.6 cM"
     gene            1..4420
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="ring finger protein 146"
                     /db_xref="GeneID:68031"
                     /db_xref="MGI:MGI:1915281"
     exon            1..479
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     exon            480..540
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     exon            541..696
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     CDS             692..1771
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF146"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF146"
                     /protein_id="NP_001103667.1"
                     /db_xref="CCDS:CCDS48529.1"
                     /db_xref="GeneID:68031"
                     /db_xref="MGI:MGI:1915281"
                     /translation="MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQT
                     CVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGN
                     GEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNE
                     HGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVP
                     SSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPS
                     SGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRS
                     VAGGGTMSVNVRSRRPDGQCTVTEV"
     exon            697..4404
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="major polyA site"
     regulatory      2591..2596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      2612
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      4404
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
ORIGIN      
        1 gacttttctt gtgccttttt tgtataagga acaagcggta gtctctccaa gggcacggcc
       61 aaaggaaaca taggacttga cccaaggctg agttttggaa aggctcttct tcctggtact
      121 gaaggtctag cttcctccca caagccacct agatggacct ccaccagttc agaaccagga
      181 ggccacaaga tgcgccacgc agagggtgag ggaggaccgg aacagggaca aggagcagcc
      241 cggtcgcagc aagggacaga gaagagcagc agccagcgtg gggaccgcca gccagggccg
      301 ccgcgcgcgg gatcacggtg agggggcgtg gcttccgccg gcgcggcccc gccccttgag
      361 cgccgggcgg tcacgtgacg gccgcgcgcg tccccgtccg ctgcgggctc cgaagcggag
      421 gagaaaagac tgcgaggtgg ctgcggcggc ggccgagagg tgggctccgg gccggaccga
      481 gaaagggcta tgtgacattg tttttgagga tgtggaaatg gaaccgtcct ctataattag
      541 cacagagaat gaaccagcag cacgagagag aacactgcaa attagctgac agctggtgaa
      601 gaagatgctt tattctcgtg accggcgcct gtgggatctg tgatgggaat gtaagaatag
      661 cctctagagc atcacagctt cgctgaagcc aatggagatg gccggctgtg gtgaaattga
      721 tcactcaata aatatgcttc ctacaaataa gaaggcaaat gagtcctgtt ccaatactgc
      781 accttctctg acagttcctg aatgtgccat ttgtctacaa acatgtgttc accctgtcag
      841 tctgccctgt aagcatgttt tctgttatct gtgtgtaaag ggtgcttcat ggcttgggaa
      901 gcgatgtgct ctttgtcgac aagagattcc tgaggatttt cttgacaagc caaccttgtt
      961 gtcaccagaa gaacttaagg ctgcaagcag aggaaatggt gaatatgcgt ggtattatga
     1021 aggaaggaat gggtggtggc agtatgatga gcgcactagt cgggagctag aagatgcttt
     1081 ttccaaaggt aaaaagaaca cggaaatgtt aattgctgga tttctgtatg ttgctgatct
     1141 tgaaaacatg gttcaatata ggagaaatga acatggacgt cgcaggaaga ttaagcgaga
     1201 tataatagat ataccaaaga agggagtagc tggacttagg ctggactgtg acaccaatac
     1261 tgtaaatcta gcaagagaga gttctgctga tggtgcggac agtggatcag cacagactgg
     1321 agcttctgtt cagcttgcag tgccatcttc tacaaggccc ctgacatcag ttgatggtca
     1381 gttaaccagc cctgtaacac catcccctga tgcaggcatt tctttggaag actcttttgc
     1441 tcatttacaa ctcagtggag acagcatagc tgaacggagt cacagaggtg aaggagaaga
     1501 agatcatgaa tcgccatctt ctggcagagt accagatacc tccgttgaag aaacagaatc
     1561 agatgccagt agtgatagtg aggatgcccc tgtggtagtt gcacagcact ctttgaccca
     1621 acagagacct ttggttccaa atggaaacca gacagtagcc gaccagtcag accgatcagg
     1681 aactgaccga tcagttgcag ggggtgggac catgagtgtc aatgtcagat ccagaaggcc
     1741 tgatgggcag tgcacagtga cagaggttta agcaaatgtc ttccgcacca cactcaaggg
     1801 taaaatggat acctgtaaat ttctgcccac gtaacattat actcatcctt agtagtgcgt
     1861 tgtgggagtt gggggggaag ggatatggga aagacagacc tgaaattaaa atgtctaaca
     1921 tgtctctgct gaaatttatt taatgtgagg aactggggtg ttgatagttg agagctgttc
     1981 agtataacac agttttcttg acatctgttt atagtgtatt tttttaagtt tttagttctt
     2041 ttggctagtg tgtccctgtg cattaatggt cctcatctga ctcttgcact acttattttt
     2101 tctgcatgga ttggtataaa atcttcaata aaatttggca cctgtgagat atttgatatc
     2161 attatgagca ggaagcttga tgtgaatttg ggattttaaa atagatgatt aacaactata
     2221 gttggtcttc ttgagataga aatgtaaagc tgcagctaat aagtttcaga atctgtaacg
     2281 cacttcatgg tgttcccttc cataagattt gctgtcttgt ccttgtactt ggaggtttct
     2341 cttagtctgc atttttcttt ttgattaaaa aaactttata atttaataaa tactagagtt
     2401 tatcagaaat aatttgtttg agtctggaaa agggatgggg acactttggt atttgtggct
     2461 aaagagcttt tttaaaggtg aggtttgaat tgattgcatt ctattcaaac tgttccttac
     2521 tcaagaagta agtctgattt cttcagaaga gaataaggaa agagaagcta tcaatgggcg
     2581 ctgtgtttgg aataaacaaa tgtggaaaaa gatccatagg tcgtgagatt taaatttctc
     2641 aagcagctaa tatcatttat ttacatttac tttaccaggc tccatcagtg gtatttctgt
     2701 ctgggctaca agcatagtgt tatagaacca ataagcccac tttatatgga ttgacaaggg
     2761 aggaaatact ggcgaacaca gaattgagaa tttgtcccgg agaaaacaca tctgcctgtg
     2821 tttcctttaa aaagtggggt cctgtattta cacacttcta aattccctgt attcgaatta
     2881 tcacgttaac agagtgcgaa aacaaacaac aaaaaggtga ttattttgag tgtcttttac
     2941 ctcttgttga gactggttag aagttaattc ttatacagtt tttatggaac aagtaaattc
     3001 tggaatggac ataaagtttg ggttatgtgt ttctattaaa tttagttatt aaaagatagc
     3061 cacacaaaaa gttaggtatt gctcaaaaat ctggtgaaaa tgaaaaggat gcttcatgag
     3121 tctttaaatc aatactactg ctttactatt aacatgaaaa tctcagagac caatgctctg
     3181 ctactttgta tagccagtag aatggctttc actgtttagt aggtcttttg aaatagaaga
     3241 cagatggttg aaaaggccaa caaaaactcc catgacagag gggccttttt tttctttaaa
     3301 tgaagaacca tttcacatca gtatcctatg tatacagaac acacacacga aaataactaa
     3361 tatttcttac atgcctctct agtctctccc tgccttttgc ttcctatgaa ggatatatta
     3421 agttatttta aattttgttt aactttgctt ttgtaaatta tttcgactta agaaagacca
     3481 aaacagccag aaacagcagt attaacaagt gtttgggagg cggtagcagg agtgtcagga
     3541 attcacgtct acccttggcg ctacatagca agtttaagac cctctcttaa aagttagtat
     3601 gttacaaagc ataagcctgg gctaagaatt actacaggaa tgtagaaatt ggtatatgtt
     3661 aaatgataag aaagacaaca gagcactgaa ttacaatatg gagaaggccc cccgagccaa
     3721 ctacgcagat tagcagtccc ctttgaatga cttccgcagc tcatttctaa tcatctcacc
     3781 tccatgcatg ttcccctgca gcttcacctg tactacactc attttaaagg ctatttagta
     3841 tgctttcctt tcttagcaat agcctctaaa tttgcaggtc caccccacag tgtttccaaa
     3901 acgtctcgtt cattctgtaa cgcctcctct atatacagtt ctcgggcaga gcagacagat
     3961 ttttttaaac ccctaatgac ttgtggaggc ccactgacaa atttctccag ccactcttgt
     4021 gcctgttcta gagccgtagt ttcatctgag ggctgtaaga cctcatcagt caagcctata
     4081 tttaaagctt ccttggaatc cagtttgaga gtcccactta acactttgag agcttgtctg
     4141 ctgccaatga tttcaaccag acggctggta ccaccccagc ttggaactat acccatctcc
     4201 ttgtggacaa atctgatcac actttcctca gtcatcaacc tgtaaaaaca aaaataagaa
     4261 ctgtaactat ccacatgtac gagaaccatg gtctcacagg aaatcgctga tctttttagg
     4321 cagacataaa gttgttggaa aatgtcccca gctagaattt aacttaccat gtactgttca
     4381 ataaactctt gcttttaaac gtaaaaaaaa aaaaaaaaaa
//
