LOCUS       NM_001110196            4359 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ring finger protein 146 (Rnf146), transcript variant
            3, mRNA.
ACCESSION   NM_001110196
VERSION     NM_001110196.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4359)
  AUTHORS   Hou,S., Zhang,J., Jiang,X., Yang,Y., Shan,B., Zhang,M., Liu,C.,
            Yuan,J. and Xu,D.
  TITLE     PARP5A and RNF146 phase separation restrains RIPK1-dependent
            necroptosis
  JOURNAL   Mol Cell 84 (5), 938-954 (2024)
   PUBMED   38272024
  REMARK    GeneRIF: PARP5A and RNF146 phase separation restrains
            RIPK1-dependent necroptosis.
REFERENCE   2  (bases 1 to 4359)
  AUTHORS   Park,G., Jang,W.E., Kim,S., Gonzales,E.L., Ji,J., Choi,S., Kim,Y.,
            Park,J.H., Mohammad,H.B., Bang,G., Kang,M., Kim,S., Jeon,S.J.,
            Kim,J.Y., Kim,K.P., Shin,C.Y., An,J.Y., Kim,M.S. and Lee,Y.S.
  TITLE     Dysregulation of the Wnt/beta-catenin signaling pathway via Rnf146
            upregulation in a VPA-induced mouse model of autism spectrum
            disorder
  JOURNAL   Exp Mol Med 55 (8), 1783-1794 (2023)
   PUBMED   37524878
  REMARK    GeneRIF: Dysregulation of the Wnt/beta-catenin signaling pathway
            via Rnf146 upregulation in a VPA-induced mouse model of autism
            spectrum disorder.
REFERENCE   3  (bases 1 to 4359)
  AUTHORS   Sheng,Z., Xu,J., Li,F., Yuan,Y., Peng,X., Chen,S., Zhou,R. and
            Huang,W.
  TITLE     The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac
            hypertrophy by suppressing the LKB1/AMPK signaling pathway
  JOURNAL   Exp Cell Res 410 (1), 112954 (2022)
   PUBMED   34856161
  REMARK    GeneRIF: The RING-domain E3 ubiquitin ligase RNF146 promotes
            cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway.
REFERENCE   4  (bases 1 to 4359)
  AUTHORS   Xu,H., Li,X., Wu,X., Yang,Y., Dai,S., Lei,T., Jing,D., Luo,P. and
            Luo,E.
  TITLE     Iduna protects HT22cells by inhibiting parthanatos: The role of the
            p53-MDM2 pathway
  JOURNAL   Exp Cell Res 384 (1), 111547 (2019)
   PUBMED   31472117
  REMARK    GeneRIF: Iduna might prevent TBI by specifically inhibiting
            parthanatos and promoting mitochondrial function, with the p53-MDM2
            pathway playing a critical role.
REFERENCE   5  (bases 1 to 4359)
  AUTHORS   Kim,H., Park,J., Leem,H., Cho,M., Yoon,J.H., Maeng,H.J. and Lee,Y.
  TITLE     Rhododendrin-Induced RNF146 Expression via Estrogen Receptor beta
            Activation is Cytoprotective Against 6-OHDA-Induced Oxidative
            Stress
  JOURNAL   Int J Mol Sci 20 (7), 1772 (2019)
   PUBMED   30974833
  REMARK    GeneRIF: Rhododendrin is cytoprotective against 6-hydroxydopamine
            (6-OHDA)-induced cell death, which is largely dependent on ERbeta
            activity and RNF146 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4359)
  AUTHORS   Xu,H., Luo,P., Zhao,Y., Zhao,M., Yang,Y., Chen,T., Huo,K., Han,H.
            and Fei,Z.
  TITLE     Iduna protects HT22 cells from hydrogen peroxide-induced oxidative
            stress through interfering poly(ADP-ribose) polymerase-1-induced
            cell death (parthanatos)
  JOURNAL   Cell Signal 25 (4), 1018-1026 (2013)
   PUBMED   23333241
  REMARK    GeneRIF: Iduna acts as a potential antioxidant by improving
            mitochondrial function and inhibiting oxidative stress-induced
            parthanatos, and these protective effects are dependent on the
            involvement of ubiquitin-proteasome system.
REFERENCE   7  (bases 1 to 4359)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4359)
  AUTHORS   Kang,H.C., Lee,Y.I., Shin,J.H., Andrabi,S.A., Chi,Z., Gagne,J.P.,
            Lee,Y., Ko,H.S., Lee,B.D., Poirier,G.G., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase
            that regulates DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 108 (34), 14103-14108 (2011)
   PUBMED   21825151
REFERENCE   9  (bases 1 to 4359)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   10 (bases 1 to 4359)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050795.1, AK012080.1, BQ713250.1, AK035665.1 and BF461810.1.
            
            Transcript Variant: This variant (3) lacks an internal exon in the
            5' UTR, compared to variant 1. All variants encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012080.1, SRR1660813.80139.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               BC050795.1         1-402
            403-2343            AK012080.1         2-1942
            2344-2614           BQ713250.1         351-621
            2615-4339           AK035665.1         3-1727
            4340-4359           BF461810.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 16.6 cM"
     gene            1..4359
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="ring finger protein 146"
                     /db_xref="GeneID:68031"
                     /db_xref="MGI:MGI:1915281"
     exon            1..479
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     exon            480..635
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     CDS             631..1710
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF146"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF146"
                     /protein_id="NP_001103666.1"
                     /db_xref="CCDS:CCDS48529.1"
                     /db_xref="GeneID:68031"
                     /db_xref="MGI:MGI:1915281"
                     /translation="MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQT
                     CVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGN
                     GEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNE
                     HGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVP
                     SSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPS
                     SGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRS
                     VAGGGTMSVNVRSRRPDGQCTVTEV"
     exon            636..4343
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2324..2329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      2348
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="major polyA site"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
     regulatory      4319..4324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
                     /note="hexamer: AATAAA"
     polyA_site      4343
                     /gene="Rnf146"
                     /gene_synonym="2610509H23Rik; Iduna"
ORIGIN      
        1 gacttttctt gtgccttttt tgtataagga acaagcggta gtctctccaa gggcacggcc
       61 aaaggaaaca taggacttga cccaaggctg agttttggaa aggctcttct tcctggtact
      121 gaaggtctag cttcctccca caagccacct agatggacct ccaccagttc agaaccagga
      181 ggccacaaga tgcgccacgc agagggtgag ggaggaccgg aacagggaca aggagcagcc
      241 cggtcgcagc aagggacaga gaagagcagc agccagcgtg gggaccgcca gccagggccg
      301 ccgcgcgcgg gatcacggtg agggggcgtg gcttccgccg gcgcggcccc gccccttgag
      361 cgccgggcgg tcacgtgacg gccgcgcgcg tccccgtccg ctgcgggctc cgaagcggag
      421 gagaaaagac tgcgaggtgg ctgcggcggc ggccgagagg tgggctccgg gccggaccgc
      481 acagagaatg aaccagcagc acgagagaga acactgcaaa ttagctgaca gctggtgaag
      541 aagatgcttt attctcgtga ccggcgcctg tgggatctgt gatgggaatg taagaatagc
      601 ctctagagca tcacagcttc gctgaagcca atggagatgg ccggctgtgg tgaaattgat
      661 cactcaataa atatgcttcc tacaaataag aaggcaaatg agtcctgttc caatactgca
      721 ccttctctga cagttcctga atgtgccatt tgtctacaaa catgtgttca ccctgtcagt
      781 ctgccctgta agcatgtttt ctgttatctg tgtgtaaagg gtgcttcatg gcttgggaag
      841 cgatgtgctc tttgtcgaca agagattcct gaggattttc ttgacaagcc aaccttgttg
      901 tcaccagaag aacttaaggc tgcaagcaga ggaaatggtg aatatgcgtg gtattatgaa
      961 ggaaggaatg ggtggtggca gtatgatgag cgcactagtc gggagctaga agatgctttt
     1021 tccaaaggta aaaagaacac ggaaatgtta attgctggat ttctgtatgt tgctgatctt
     1081 gaaaacatgg ttcaatatag gagaaatgaa catggacgtc gcaggaagat taagcgagat
     1141 ataatagata taccaaagaa gggagtagct ggacttaggc tggactgtga caccaatact
     1201 gtaaatctag caagagagag ttctgctgat ggtgcggaca gtggatcagc acagactgga
     1261 gcttctgttc agcttgcagt gccatcttct acaaggcccc tgacatcagt tgatggtcag
     1321 ttaaccagcc ctgtaacacc atcccctgat gcaggcattt ctttggaaga ctcttttgct
     1381 catttacaac tcagtggaga cagcatagct gaacggagtc acagaggtga aggagaagaa
     1441 gatcatgaat cgccatcttc tggcagagta ccagatacct ccgttgaaga aacagaatca
     1501 gatgccagta gtgatagtga ggatgcccct gtggtagttg cacagcactc tttgacccaa
     1561 cagagacctt tggttccaaa tggaaaccag acagtagccg accagtcaga ccgatcagga
     1621 actgaccgat cagttgcagg gggtgggacc atgagtgtca atgtcagatc cagaaggcct
     1681 gatgggcagt gcacagtgac agaggtttaa gcaaatgtct tccgcaccac actcaagggt
     1741 aaaatggata cctgtaaatt tctgcccacg taacattata ctcatcctta gtagtgcgtt
     1801 gtgggagttg ggggggaagg gatatgggaa agacagacct gaaattaaaa tgtctaacat
     1861 gtctctgctg aaatttattt aatgtgagga actggggtgt tgatagttga gagctgttca
     1921 gtataacaca gttttcttga catctgttta tagtgtattt ttttaagttt ttagttcttt
     1981 tggctagtgt gtccctgtgc attaatggtc ctcatctgac tcttgcacta cttatttttt
     2041 ctgcatggat tggtataaaa tcttcaataa aatttggcac ctgtgagata tttgatatca
     2101 ttatgagcag gaagcttgat gtgaatttgg gattttaaaa tagatgatta acaactatag
     2161 ttggtcttct tgagatagaa atgtaaagct gcagctaata agtttcagaa tctgtaacgc
     2221 acttcatggt gttcccttcc ataagatttg ctgtcttgtc cttgtacttg gaggtttctc
     2281 ttagtctgca tttttctttt tgattaaaaa aactttataa tttaataaat actagagttt
     2341 atcagaaata atttgtttga gtctggaaaa gggatgggga cactttggta tttgtggcta
     2401 aagagctttt ttaaaggtga ggtttgaatt gattgcattc tattcaaact gttccttact
     2461 caagaagtaa gtctgatttc ttcagaagag aataaggaaa gagaagctat caatgggcgc
     2521 tgtgtttgga ataaacaaat gtggaaaaag atccataggt cgtgagattt aaatttctca
     2581 agcagctaat atcatttatt tacatttact ttaccaggct ccatcagtgg tatttctgtc
     2641 tgggctacaa gcatagtgtt atagaaccaa taagcccact ttatatggat tgacaaggga
     2701 ggaaatactg gcgaacacag aattgagaat ttgtcccgga gaaaacacat ctgcctgtgt
     2761 ttcctttaaa aagtggggtc ctgtatttac acacttctaa attccctgta ttcgaattat
     2821 cacgttaaca gagtgcgaaa acaaacaaca aaaaggtgat tattttgagt gtcttttacc
     2881 tcttgttgag actggttaga agttaattct tatacagttt ttatggaaca agtaaattct
     2941 ggaatggaca taaagtttgg gttatgtgtt tctattaaat ttagttatta aaagatagcc
     3001 acacaaaaag ttaggtattg ctcaaaaatc tggtgaaaat gaaaaggatg cttcatgagt
     3061 ctttaaatca atactactgc tttactatta acatgaaaat ctcagagacc aatgctctgc
     3121 tactttgtat agccagtaga atggctttca ctgtttagta ggtcttttga aatagaagac
     3181 agatggttga aaaggccaac aaaaactccc atgacagagg ggcctttttt ttctttaaat
     3241 gaagaaccat ttcacatcag tatcctatgt atacagaaca cacacacgaa aataactaat
     3301 atttcttaca tgcctctcta gtctctccct gccttttgct tcctatgaag gatatattaa
     3361 gttattttaa attttgttta actttgcttt tgtaaattat ttcgacttaa gaaagaccaa
     3421 aacagccaga aacagcagta ttaacaagtg tttgggaggc ggtagcagga gtgtcaggaa
     3481 ttcacgtcta cccttggcgc tacatagcaa gtttaagacc ctctcttaaa agttagtatg
     3541 ttacaaagca taagcctggg ctaagaatta ctacaggaat gtagaaattg gtatatgtta
     3601 aatgataaga aagacaacag agcactgaat tacaatatgg agaaggcccc ccgagccaac
     3661 tacgcagatt agcagtcccc tttgaatgac ttccgcagct catttctaat catctcacct
     3721 ccatgcatgt tcccctgcag cttcacctgt actacactca ttttaaaggc tatttagtat
     3781 gctttccttt cttagcaata gcctctaaat ttgcaggtcc accccacagt gtttccaaaa
     3841 cgtctcgttc attctgtaac gcctcctcta tatacagttc tcgggcagag cagacagatt
     3901 tttttaaacc cctaatgact tgtggaggcc cactgacaaa tttctccagc cactcttgtg
     3961 cctgttctag agccgtagtt tcatctgagg gctgtaagac ctcatcagtc aagcctatat
     4021 ttaaagcttc cttggaatcc agtttgagag tcccacttaa cactttgaga gcttgtctgc
     4081 tgccaatgat ttcaaccaga cggctggtac caccccagct tggaactata cccatctcct
     4141 tgtggacaaa tctgatcaca ctttcctcag tcatcaacct gtaaaaacaa aaataagaac
     4201 tgtaactatc cacatgtacg agaaccatgg tctcacagga aatcgctgat ctttttaggc
     4261 agacataaag ttgttggaaa atgtccccag ctagaattta acttaccatg tactgttcaa
     4321 taaactcttg cttttaaacg taaaaaaaaa aaaaaaaaa
//
