LOCUS       NM_028862               3578 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 145 (Rnf145), transcript variant
            1, mRNA.
ACCESSION   NM_028862 XM_203376
VERSION     NM_028862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3578)
  AUTHORS   Menzies,S.A., Volkmar,N., van den Boomen,D.J., Timms,R.T.,
            Dickson,A.S., Nathan,J.A. and Lehner,P.J.
  TITLE     The sterol-responsive RNF145 E3 ubiquitin ligase mediates the
            degradation of HMG-CoA reductase together with gp78 and Hrd1
  JOURNAL   Elife 7, e40009 (2018)
   PUBMED   30543180
  REMARK    GeneRIF: n the absence of both RNF145 and gp78, Hrd1, a third
            UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our
            findings reveal a critical role for the sterol-responsive RNF145 in
            HMGCR regulation and elucidate the complexity of sterol-accelerated
            HMGCR degradation
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3578)
  AUTHORS   Zhang,L., Rajbhandari,P., Priest,C., Sandhu,J., Wu,X., Temel,R.,
            Castrillo,A., de Aguiar Vallim,T.Q., Sallam,T. and Tontonoz,P.
  TITLE     Inhibition of cholesterol biosynthesis through RNF145-dependent
            ubiquitination of SCAP
  JOURNAL   Elife 6, e28766 (2017)
   PUBMED   29068315
  REMARK    GeneRIF: Mechanistic studies show that RNF145 triggers
            ubiquitination of SCAP on lysine residues within a cytoplasmic loop
            essential for COPII binding, potentially inhibiting its transport
            to Golgi and subsequent processing of SREBP-2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3578)
  AUTHORS   Cook,E.C., Nelson,J.K., Sorrentino,V., Koenis,D., Moeton,M.,
            Scheij,S., Ottenhoff,R., Bleijlevens,B., Loregger,A. and Zelcer,N.
  TITLE     Identification of the ER-resident E3 ubiquitin ligase RNF145 as a
            novel LXR-regulated gene
  JOURNAL   PLoS One 12 (2), e0172721 (2017)
   PUBMED   28231341
  REMARK    GeneRIF: we report the identification of RNF145 as an ER-resident
            E3 ubiquitin ligase that is transcriptionally controlled by LXR.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3578)
  AUTHORS   Graham,D.B., Becker,C.E., Doan,A., Goel,G., Villablanca,E.J.,
            Knights,D., Mok,A., Ng,A.C.Y., Doench,J.G., Root,D.E., Clish,C.B.
            and Xavier,R.J.
  TITLE     Functional genomics identifies negative regulatory nodes
            controlling phagocyte oxidative burst
  JOURNAL   Nat Commun 6, 7838 (2015)
   PUBMED   26194095
  REMARK    GeneRIF: implicated in proteostasis of Nox2 complex
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3578)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 3578)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3578)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   9  (bases 1 to 3578)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603913.14, AK014408.1, BB618481.1, AK043002.1 and CK624836.1.
            
            On May 10, 2018 this sequence version replaced NM_028862.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043002.1, AK014408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL603913.14        38120-38127
            9-141               AK014408.1         2-134
            142-726             BB618481.1         1-585
            727-3202            AK043002.1         706-3181
            3203-3578           CK624836.1         15-390              c
FEATURES             Location/Qualifiers
     source          1..3578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.94 cM"
     gene            1..3578
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /note="ring finger protein 145"
                     /db_xref="GeneID:74315"
                     /db_xref="MGI:MGI:1921565"
     exon            1..319
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..535
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..644
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..736
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..972
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1148
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1289
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1472
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1620
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1977
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..3578
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3556..3561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /note="hexamer: AATAAA"
     polyA_site      3578
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcggg gggcggagcc ggagcgcggg gaccaggcca tggcggccgc cgggcgctgg
       61 tgccggcgct cggcccggga gcgcctttgt cgccgcggag gatggtgacc tcacggttcg
      121 ggccgcttcc gctgcctccg cctcccgaga cgccgcagcc gaggccggac gcgggagagc
      181 cgccgctgtg agccgcgcaa accgggcccc ccgccgtcgg aaccgaagat ctcaccggag
      241 gggcgggaat cggagccggg cagcagcgga caccgccatc cccagtgccg ccccgcaggc
      301 agggaggctg cggctccagg tctgctccga ggaaacaatc caaaagcaac catggctgcg
      361 aaggagaaac tggaggcagt gctgaacgtg gccttgaggg tgccaagcat catgctgctg
      421 gatgtccttt accgctggga cgtcagctcc tttttccagc agatccaaag aagcagcctc
      481 aacaacaacc ctcttttcca gtacaaatac ttggctctta atatgcatta cgtaggttat
      541 atcttaagtg tcgtgctcct cactctgccc aggcagcatc tggtgcagct ctatttgtat
      601 tttgtgactg ccctgctcct ctatgctgga catcagatat ccagggacta cgtaaggagt
      661 gaactggagt ctgcctatga aggaccaatg tatttagaac ctctctccat gaaccgcttt
      721 accacagcct taataggtca gttagtggtg tgcaccttgt gctcctgcgt tatgaagacg
      781 aagcagatct ggctcttctc ggcacacatg cttcctctgc tggctcgcct ctgcctcgtt
      841 cctctggaga ccatcgtcat catcaacaaa tttgctatga tttttacagg attggaagtc
      901 ctgtacttcc tagggtctaa tctcctagta ccgtataacc tcgctaagtc tgcataccgg
      961 gagttagttc aggtagtgga ggtgtacggc cttctggcct tgggaatgtc cctgtggaac
     1021 cagctggtgg tgcccgtgct cttcatggtc ttctggcttg ttttatttgc tcttcagatc
     1081 tactcctact tcagcaccag agatcagcct gcatcccggg agaggcttct cttccttttc
     1141 ctgacaagca tcgccgagtg ctgcagcacg ccctactccc ttctgggctt ggtcttcacc
     1201 gtgtcctttg ttgccttggg tgttctgaca ctctgtaagt tctacctgca gggataccga
     1261 gccttcatga acgatcctgc catgaatagg gggatgacag aaggagtcac tctgctgatc
     1321 ctggcggtgc agacggggct catagaactt caggtggttc accgtgcatt cctgctcagc
     1381 atcatcctct tcatcgtcgt tgcctctatc ctgcagtcca tgttggagat cgcagatccc
     1441 attgttttgg cactgggagc atcgagagac aagagtttgt ggaaacactt ccgtgctgtg
     1501 agcctctgct tgttcctcct cgtgttccct gcgtatatgg cctacatgat ttgccagttc
     1561 ttccacatgg acttctggct tctcatcatc atctccagca gcatccttac ctctctccag
     1621 gttctgggaa cactttttat ttacgtctta tttatggttg aggaattccg caaagagccc
     1681 gtggaaaaca tggatgacgt catctactac gtgaatggca cttatcgtct gctggagttt
     1741 gttgtggccc tctgtgtggt ggcctacggc gtctcagaga ccatctttgg agagtggact
     1801 gtgatgggct ccatgatcat cttcatccat tcctactaca acgtgtggct tcgtgcccag
     1861 ctgggctgga agagtttcct tctgcgcagg gacgctgtga ataagattaa gtctctccct
     1921 gtcgcgacgc aggagcagct ggagaaacac aacgacatct gcgccatctg ttaccaggac
     1981 atgaaatccg ctgtgatcac accttgcagt catttcttcc atgcaggatg tcttaagaaa
     2041 tggctgtatg tccaggatac ctgccctctg tgtcactgcc atctcaaaaa ctcctcccag
     2101 cttccaggac tggggacaga agcggctcca cagcctcctg cgggggccga gcagaacatt
     2161 gtacttcagg aaggtcctga acccccggac catgagagtc caccagggac tgggacccag
     2221 gaaggttctg gggacagtag tgaacacatc aacagaggct cggctagcca ggagggggct
     2281 gctgatgctg gagagggtcc tcagattcca gaaggcgaag tgtgtcctgt tgagtctgcc
     2341 tagaggagaa gcaggcttgg agctctggac tgtggagaag gccacccaag gtggagttca
     2401 cactcagatc tgaggagtgg atgtaggaga ggactaggca ggaacctgac attccgagga
     2461 tctgctccag gctactcagt ggacacaccc gctctccacc ccacttcatg ctgttggaga
     2521 aattttgcaa tgtacactaa tcaaaatgta tttatatgtt ctatgctgat gttttgtaga
     2581 ggtttgccaa gaaaacttaa cctcagcaac ttcaggaatg gcccctgatt tgcgagggat
     2641 aatgaaatca ggtctgagtg cttgaaaggg gctaagagga cgcagatctg gaggtcagag
     2701 tgggaagatg aaggcagagg tggacctggc tttccccttc ccgtgggacg gggtggctct
     2761 gattggatag tgtgggtaat ggccactccc ctttccttca gttaattaaa accaccaaat
     2821 gatcctggag ttttctacag aaccgcaatg aaatcaaaga tgtagacggg actcattgac
     2881 tttcctccga gatggaggag cacggtacgt caggatgtgc ctggggaagg ggcgggcgtg
     2941 cactaggcct tgcgggtgct ctcgtgtcgc ctgagactct taaacctgat gctggagtcc
     3001 tcattatttt gatgtatatg gaacttttgt taatatattg tatactttgt tggctgtgtg
     3061 aagtaaacta aaactctagt gaacactttg gagtccactt taacaaagga gccaaagtgg
     3121 gaggggcttt agggaactga taaaggccct gggtgtactg tccaatcctg tgtaatgttt
     3181 aattcttgca actgaatcaa aagcagtgtt aaattatggc agtgtttgca ctctgggaat
     3241 gagtactgga ctgtatgacc ccactctgca aacaccactt ttgaagctgt taatacactt
     3301 tgcacccttt ctttgacaag gatgtgtcat atttaaattt ttacattcat catggctaca
     3361 ggtagaactg gggagggggg atgtaatttt tttatgggtt tttgatatga aaagaaacta
     3421 gtcatttatt tatacaataa gcttggctca aaaaaaagtg tatttcagac ttggtattcc
     3481 tactgtgggg tgtggttttc ctttgttttt agtagcaaat ttggatgtag actgacagac
     3541 atagctgaat gtcttaataa atttaaattt gaagataa
//
