LOCUS       NP_083138                663 aa            linear   ROD 27-APR-2025
DEFINITION  RING finger protein 145 isoform 1 [Mus musculus].
ACCESSION   NP_083138 XP_203376
VERSION     NP_083138.2
DBSOURCE    REFSEQ: accession NM_028862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 663)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 663)
  AUTHORS   Menzies,S.A., Volkmar,N., van den Boomen,D.J., Timms,R.T.,
            Dickson,A.S., Nathan,J.A. and Lehner,P.J.
  TITLE     The sterol-responsive RNF145 E3 ubiquitin ligase mediates the
            degradation of HMG-CoA reductase together with gp78 and Hrd1
  JOURNAL   Elife 7, e40009 (2018)
   PUBMED   30543180
  REMARK    GeneRIF: n the absence of both RNF145 and gp78, Hrd1, a third
            UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our
            findings reveal a critical role for the sterol-responsive RNF145 in
            HMGCR regulation and elucidate the complexity of sterol-accelerated
            HMGCR degradation
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 663)
  AUTHORS   Zhang,L., Rajbhandari,P., Priest,C., Sandhu,J., Wu,X., Temel,R.,
            Castrillo,A., de Aguiar Vallim,T.Q., Sallam,T. and Tontonoz,P.
  TITLE     Inhibition of cholesterol biosynthesis through RNF145-dependent
            ubiquitination of SCAP
  JOURNAL   Elife 6, e28766 (2017)
   PUBMED   29068315
  REMARK    GeneRIF: Mechanistic studies show that RNF145 triggers
            ubiquitination of SCAP on lysine residues within a cytoplasmic loop
            essential for COPII binding, potentially inhibiting its transport
            to Golgi and subsequent processing of SREBP-2.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 663)
  AUTHORS   Cook,E.C., Nelson,J.K., Sorrentino,V., Koenis,D., Moeton,M.,
            Scheij,S., Ottenhoff,R., Bleijlevens,B., Loregger,A. and Zelcer,N.
  TITLE     Identification of the ER-resident E3 ubiquitin ligase RNF145 as a
            novel LXR-regulated gene
  JOURNAL   PLoS One 12 (2), e0172721 (2017)
   PUBMED   28231341
  REMARK    GeneRIF: we report the identification of RNF145 as an ER-resident
            E3 ubiquitin ligase that is transcriptionally controlled by LXR.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 663)
  AUTHORS   Graham,D.B., Becker,C.E., Doan,A., Goel,G., Villablanca,E.J.,
            Knights,D., Mok,A., Ng,A.C.Y., Doench,J.G., Root,D.E., Clish,C.B.
            and Xavier,R.J.
  TITLE     Functional genomics identifies negative regulatory nodes
            controlling phagocyte oxidative burst
  JOURNAL   Nat Commun 6, 7838 (2015)
   PUBMED   26194095
  REMARK    GeneRIF: implicated in proteostasis of Nox2 complex
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 663)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (residues 1 to 663)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 663)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   9  (residues 1 to 663)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603913.14, AK014408.1, BB618481.1, AK043002.1 and CK624836.1.
            
            On Oct 28, 2009 this sequence version replaced NP_083138.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043002.1, AK014408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.94 cM"
     Protein         1..663
                     /product="RING finger protein 145 isoform 1"
                     /EC_number="2.3.2.27"
                     /calculated_mol_wt=74517
     Region          8..506
                     /region_name="TRC8_N"
                     /note="TRC8 N-terminal domain; pfam13705"
                     /db_xref="CDD:463960"
     Site            53..73
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            77..97
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Region          81..84
                     /region_name="YLYF motif.
                     /evidence=ECO:0000269|PubMed:29374057"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            123..143
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            146..166
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            168..188
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            205..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            225..245
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            275..295
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            316..336
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            340..360
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            384..404
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            410..430
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            460..480
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Site            482..502
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     Region          <520..627
                     /region_name="HRD1"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5243"
                     /db_xref="CDD:227568"
     Region          533..575
                     /region_name="RING-H2_RNF145"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 145 (RNF145) and similar proteins; cd16684"
                     /db_xref="CDD:319598"
     Region          587..663
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SWK7.1)"
     CDS             1..663
                     /gene="Rnf145"
                     /gene_synonym="3732413I11Rik; TMRF1"
                     /coded_by="NM_028862.4:352..2343"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24565.1"
                     /db_xref="GeneID:74315"
                     /db_xref="MGI:MGI:1921565"
ORIGIN      
        1 maakekleav lnvalrvpsi mlldvlyrwd vssffqqiqr sslnnnplfq ykylalnmhy
       61 vgyilsvvll tlprqhlvql ylyfvtalll yaghqisrdy vrselesaye gpmyleplsm
      121 nrfttaligq lvvctlcscv mktkqiwlfs ahmlpllarl clvpletivi inkfamiftg
      181 levlyflgsn llvpynlaks ayrelvqvve vygllalgms lwnqlvvpvl fmvfwlvlfa
      241 lqiysyfstr dqpasrerll flfltsiaec cstpysllgl vftvsfvalg vltlckfylq
      301 gyrafmndpa mnrgmtegvt llilavqtgl ielqvvhraf llsiilfivv asilqsmlei
      361 adpivlalga srdkslwkhf ravslclfll vfpaymaymi cqffhmdfwl liiisssilt
      421 slqvlgtlfi yvlfmveefr kepvenmddv iyyvngtyrl lefvvalcvv aygvsetifg
      481 ewtvmgsmii fihsyynvwl raqlgwksfl lrrdavnkik slpvatqeql ekhndicaic
      541 yqdmksavit pcshffhagc lkkwlyvqdt cplchchlkn ssqlpglgte aapqppagae
      601 qnivlqegpe ppdhesppgt gtqegsgdss ehinrgsasq egaadagegp qipegevcpv
      661 esa
//
