LOCUS       NM_001170643            4540 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ring finger protein 144B (Rnf144b), transcript variant
            2, mRNA.
ACCESSION   NM_001170643
VERSION     NM_001170643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4540)
  AUTHORS   Li,G., Zhang,J., Zhao,Z., Wang,J., Li,J., Xu,W., Cui,Z., Sun,P.,
            Yuan,H., Wang,T., Li,K., Bai,X., Ma,X., Li,P., Fu,Y., Cao,Y.,
            Bao,H., Li,D., Liu,Z., Zhu,N., Tang,L. and Lu,Z.
  TITLE     RNF144B negatively regulates antiviral immunity by targeting MDA5
            for autophagic degradation
  JOURNAL   EMBO Rep 25 (10), 4594-4624 (2024)
   PUBMED   39285245
  REMARK    GeneRIF: RNF144B negatively regulates antiviral immunity by
            targeting MDA5 for autophagic degradation.
REFERENCE   2  (bases 1 to 4540)
  AUTHORS   Abad,E., Sandoz,J., Romero,G., Zadra,I., Urgel-Solas,J.,
            Borredat,P., Kourtis,S., Ortet,L., Martinez,C.M., Weghorn,D.,
            Sdelci,S. and Janic,A.
  TITLE     The TP53-activated E3 ligase RNF144B is a tumour suppressor that
            prevents genomic instability
  JOURNAL   J Exp Clin Cancer Res 43 (1), 127 (2024)
   PUBMED   38685100
  REMARK    GeneRIF: The TP53-activated E3 ligase RNF144B is a tumour
            suppressor that prevents genomic instability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4540)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4540)
  AUTHORS   Guo,R., Wang,J., Tang,W. and Xiao,D.
  TITLE     Rnf144b alleviates the inflammatory responses and cardiac
            dysfunction in sepsis
  JOURNAL   ESC Heart Fail 10 (4), 2338-2344 (2023)
   PUBMED   37088470
  REMARK    GeneRIF: Rnf144b alleviates the inflammatory responses and cardiac
            dysfunction in sepsis.
REFERENCE   5  (bases 1 to 4540)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4540)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 4540)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   8  (bases 1 to 4540)
  AUTHORS   Sayan,B.S., Yang,A.L., Conforti,F., Tucci,P., Piro,M.C.,
            Browne,G.J., Agostini,M., Bernardini,S., Knight,R.A., Mak,T.W. and
            Melino,G.
  TITLE     Differential control of TAp73 and DeltaNp73 protein stability by
            the ring finger ubiquitin ligase PIR2
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 12877-12882 (2010)
   PUBMED   20615966
  REMARK    GeneRIF: PIR2, by being induced by TAp73 and degrading DeltaNp73,
            differentially regulates TAp73/DeltaNp73 stability.[PIR2]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB661852.1, AK040939.1 and AC131085.16.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052846.1, AK040939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BB661852.1         2-9
            9-2956              AK040939.1         1-2948
            2957-4540           AC131085.16        115305-116888       c
FEATURES             Location/Qualifiers
     source          1..4540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.5 cM"
     gene            1..4540
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /note="ring finger protein 144B"
                     /db_xref="GeneID:218215"
                     /db_xref="MGI:MGI:2384986"
     exon            1..118
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..309
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1050
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /EC_number="2.3.2.31"
                     /note="IBR domain containing 2; IBR domain-containing
                     protein 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF144B"
                     /protein_id="NP_001164114.1"
                     /db_xref="CCDS:CCDS26491.1"
                     /db_xref="GeneID:218215"
                     /db_xref="MGI:MGI:2384986"
                     /translation="MDSVDGLQCLTMTAENPPSGDLIPAPLVTCKLCLCEQSLDKMTM
                     LQECQCIFCTPCLKQYMVLSIREGCGSPITCPDMVCLNHGTLQETEIACLVPLDEFQL
                     YQRLKFEREVHMDPLRTWCPVADCQTVCHISAGDPGQPVLVECPSCHLKFCSCCKDAW
                     HEESSCRDSQSAMPEHGALFGTDADAPIKQCPVCRIYIERNEGCAQMMCKNCKHTFCW
                     YCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGVIALVTSPLLLL
                     ASPCIICCVCKSCRGKKKKHDPSTT"
     exon            310..414
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..475
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..674
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..819
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..909
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..4540
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /note="hexamer: AATAAA"
     polyA_site      4538
                     /gene="Rnf144b"
                     /gene_synonym="E130105P19Rik; Ibrdc2; Pir2"
                     /note="major polyA site"
ORIGIN      
        1 agggagaggg aagagaatga gagagccctt cctccgcggt gtgcccgctg ccccggctgg
       61 cccaggctgg acctgctaga gagacgccaa gcagcctgag gacttcagct ccagccaggg
      121 atagagaagg ctgaagacag gctgatggac tccgtcgatg ggctccagtg tctgaccatg
      181 actgcggaaa acccaccctc tggagacctg attcccgccc cgctcgtcac ttgcaagctc
      241 tgcctgtgtg aacagtctct ggacaagatg accatgctcc aagagtgcca gtgtatcttt
      301 tgtacaccct gcctgaaaca gtatatggtg ctgtcaatcc gagaaggctg tggatctcct
      361 atcacttgtc ctgacatggt gtgcctaaac cacgggaccc tgcaggaaac cgagattgcc
      421 tgtttggtgc ctctggatga gtttcagctg tatcagcggc tcaagtttga acgagaggtt
      481 cacatggacc ccctccggac atggtgtcct gttgcagact gccagaccgt gtgccatatt
      541 tcagccggag acccaggcca gccagtgttg gtggagtgcc cttcttgcca cctgaaattc
      601 tgctcatgtt gcaaggatgc ttggcacgag gagtcttcct gtagagacag ccagtcggcg
      661 atgccagagc atggggctct ctttggaacg gatgcggacg cccccatcaa gcagtgcccg
      721 gtttgccgca tttacattga gcgcaacgaa ggctgcgccc agatgatgtg caagaactgc
      781 aagcacacat tttgctggta ctgtctgcag aacctggaca atgacatatt cctcaggcac
      841 tatgacaaag ggccatgcag gaataagctc ggccactcga gggcatcggt aatgtggaac
      901 cgaacacagg tagtggggat ccttgtggga ttaggtgtca ttgccttggt gacctcaccc
      961 ttgctgctcc tggcctctcc ctgtataatc tgctgtgtct gcaagtcctg tcgcggcaag
     1021 aagaaaaagc atgatccatc cacaacctaa agtcacctgc gcagacatcc gggtcacatg
     1081 agacagcaca ttggtaaaag ccccacttag cagccttgcc tccttctcct tgccaaactt
     1141 tggaagtgcc tctgcccaga ctttgaacct acctgaaagc attcggtgtt ggaaaaggcc
     1201 acgcaccggg gcatgagtgt gcctgtgtat caagaagcag ccccacagtc cggactgtgt
     1261 ctgtggagca ggttgggaac tttgctttag cctgggagac tctaaaacat caccatctta
     1321 ccctccaaag gatcccacca ggctgctcat cttccatcca aaccaaggag cctgggtgaa
     1381 tactcactgt agtcatggcg gtattgccgc acttggcagc attgcaaact gagcaaacgt
     1441 ctgtgttggt tccactgcca caagacacat ggcagaggcc cagagccgga gggaaggatg
     1501 atactgcata ataacacgtt ctgtgagcag tggagccgct gcttatctca ggagctgaca
     1561 cactgactgg catgcctatg ctggctaccg cgtgtgcact tcttagcgtt tccacagtga
     1621 cttggcagaa acatagcagc tctctccccg tgtgatctca tctccaggca ggagaaactg
     1681 ccgttcagag ggagttgtcc cttcccagga agaggttgta acttgtaagg caacatggcc
     1741 tcattcagtg tctgttgttt ggcagatgtt attcttctaa ggtgaaccag tgttcaccgc
     1801 tcacagtcag ccagcagctg tggtctctaa aaagcgtttt ctacgggatg aaaggggaaa
     1861 gctccaaagc tttccttgta gacagcaggg tcctttcttg ggctctgtgg tcatattccc
     1921 aacagatcag gagttggacc agacagtgtg catcaacagt agacactgta gtccattcac
     1981 acatatagag cccatgtgac tccagctggg cacatgtgta gatatttaat ggataacaca
     2041 aaataagatt attttaaaag accttttccc tttctaggac taaaatgata tatttatcag
     2101 cataagaggg gttttttttt ggggggggtt ggttttattt acttagtaca catgtgaatt
     2161 tttgttataa agttcctaac ttactcaaga gggtagactc aaaagtcttt tacaacaacc
     2221 cctagtgcgg ttttatgcct ctgtaaagtg atattcaggt tatttacata ctttcagaca
     2281 caatgtagag cagctcttca ctcagcctaa tttagtcttg gtctcccagg agctgtccag
     2341 acaatctgag tactttctgt gctctcaaga atttcgtgtg acaacaagca atcggatgga
     2401 aacagttcag gtgtcttcag ttgctgggat ttgtgtcacc tcagtgtgat acatcctgcc
     2461 tgttatacaa ttaatcagca aataggtttt gaaaagatga gcatattttt cctctagcag
     2521 tatacagttg ccattagcaa agcagcccgg tgcttcataa gaactgtgtg tgttccacgt
     2581 taacagagac ctctcctgga agccggggag agtattcagg gcctgttctg tttcccccgg
     2641 taactaggtg actagattgt taaactgctg ctattttaga tctgttatca aagacctgtt
     2701 atcatcagcc ttgcctctgc agtgcaatgt atccctaagt ggagatgtct atatgcaagg
     2761 gatcacatgt gcggtggaat gtatcctaag tgggcatgta tgtattcagg ggatcacatg
     2821 tgcggtggaa tgtatcctaa gtgggcatgt atatattcag gggatcacat gtgtacatta
     2881 gcatctgatg tctgtacaga acattccctg gccacgtgct ttttttagtc acagtttgta
     2941 taaaacatag aactctagaa aacttctgaa tggcaaccag cccaaatcct ttcaatcatt
     3001 tattagaaaa tcttccatat aaagtggctc cgtcttctgg tgaatgtctt cagttacagc
     3061 aggaaaaaca aacctctctt ttgaaagggt atttcatatt agtctgaata taaatgacat
     3121 ctgagtggcg gacctgcaca catagtcacc ttcctccctt gaggcgaggg gcatttgtca
     3181 cagctcaggg gattacagga gctcaactga aattggattt ctctgcacgg atgtcaacag
     3241 tgacaccaag caccaccctc agtaaatttt ccaggcctgc ctggttctaa gtggggccga
     3301 tttcatgtaa cctgaaatgc tgttatctcc gaagtagaag ctgctgtgag tggatttaga
     3361 gtaaagacgg aggcaaatgc ctgggcgatt tccccggcga aactgaggga aatcgccttc
     3421 tcagagattt tttataaaag catttgtttt gaatttattt ttcagcttgg ggcggcgggt
     3481 gggggggggg gttgtttgtc aaactgattt tacataactg gatttttttt ttaatgttgc
     3541 aaagtgcctg aataatggtg tctttttcat catatagcaa aatgtgtgtg agagagtgtg
     3601 tcagaatcta ctttggtaga tggaacccaa gtgtctgtag ctctggctca tcgcagggcg
     3661 caataccagc ccaactgact ttgtttacaa agatacaagg tggcaactgt gccgggaaag
     3721 gccggtgtcc tggtgtcctc gttttgggta attagcccct gacggcttta cttacctgtc
     3781 cctcagcttc ctcctcctgc ttcaggaagg gttcctatag caagcgtttg gctgtgacaa
     3841 agcccaccag gttcacacct gggtgtaaca acccaccttc cagaaatctc actggatgca
     3901 aaggtacagc ttccagagcc tgccgctggg gttctcctct tagaacaagt tagagaagag
     3961 aggaagaaag ccattatgaa agcaaatgtt agatagcgtc ttagccaccc tgtttgttca
     4021 cagtgtgggt atttgttctg gacttgaaat ctgtactttg aaagtggcct ttggaaagca
     4081 aataagtcgg cttggatttt cttgttgtct gcagcacaaa ataatcttcc ccgtccaagt
     4141 ggaaaattct cattgatttt tttttttttt tggatgtaca aaactgtttc ttggaacgcc
     4201 aaatttcctc tttgaaatga ctcaataact aagtgtgtgc tgctttcgcc tcctgcgccc
     4261 actgctcctg aacaacctat ctctctgtcg gtgaagagat gcctttgtgg atgtgaacat
     4321 ctggctgtga gaccacagga atgccttaga ggaatggcac tttgtaaagc tgtctgaatt
     4381 gatatctaca ggctatcaca cctcctgttg gttcacgatc caggaagttt tgttgtgtgc
     4441 ttacttaaat ttactgtcgc attatataga tttccaagtc tttgggaaga aaattaactg
     4501 ttttagtctc tttagcccca ataaatgtga gcaggaaacc
//
