LOCUS       NM_001413480            5290 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus ring finger protein 144A (Rnf144a), transcript variant
            3, mRNA.
ACCESSION   NM_001413480
VERSION     NM_001413480.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5290)
  AUTHORS   Yang,B., Pei,J., Lu,C., Wang,Y., Shen,M., Qin,X., Huang,Y.,
            Yang,X., Zhao,X., Ma,S., Song,Z., Liang,Y., Wang,H. and Wang,J.
  TITLE     RNF144A promotes antiviral responses by modulating STING
            ubiquitination
  JOURNAL   EMBO Rep 24 (12), e57528 (2023)
   PUBMED   37955227
  REMARK    GeneRIF: RNF144A promotes antiviral responses by modulating STING
            ubiquitination.
REFERENCE   3  (bases 1 to 5290)
  AUTHORS   Ho,S.R., Lee,Y.C., Ittmann,M.M., Lin,F.T., Chan,K.S. and Lin,W.C.
  TITLE     RNF144A deficiency promotes PD-L1 protein stabilization and
            carcinogen-induced bladder tumorigenesis
  JOURNAL   Cancer Lett 520, 344-360 (2021)
   PUBMED   34400221
  REMARK    GeneRIF: RNF144A deficiency promotes PD-L1 protein stabilization
            and carcinogen-induced bladder tumorigenesis.
REFERENCE   4  (bases 1 to 5290)
  AUTHORS   Ho,S.R. and Lin,W.C.
  TITLE     RNF144A sustains EGFR signaling to promote EGF-dependent cell
            proliferation
  JOURNAL   J Biol Chem 293 (42), 16307-16323 (2018)
   PUBMED   30171075
REFERENCE   5  (bases 1 to 5290)
  AUTHORS   Ho,S.R., Mahanic,C.S., Lee,Y.J. and Lin,W.C.
  TITLE     RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis
            during DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 111 (26), E2646-E2655 (2014)
   PUBMED   24979766
REFERENCE   6  (bases 1 to 5290)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 5290)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156798.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2728056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC156798.2         166552-166748       c
            198-357             AC156798.2         164610-164769       c
            358-539             AC156798.2         140845-141026       c
            540-685             AC156798.2         90757-90902         c
            686-790             AC156798.2         78954-79058         c
            791-851             AC156798.2         78729-78789         c
            852-1059            AC156798.2         72403-72610         c
            1060-1207           AC156798.2         69100-69247         c
            1208-1297           AC156798.2         65471-65560         c
            1298-5290           AC156798.2         58248-62240         c
FEATURES             Location/Qualifiers
     source          1..5290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 9.69 cM"
     gene            1..5290
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /note="ring finger protein 144A"
                     /db_xref="GeneID:108089"
                     /db_xref="MGI:MGI:1344401"
     exon            1..197
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            198..357
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            358..539
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            540..685
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..1429
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /EC_number="2.3.2.31"
                     /note="isoform 1 is encoded by transcript variant 3;
                     probable E3 ubiquitin-protein ligase RNF144A;
                     ubcM4-interacting protein 4; ubiquitin-conjugating enzyme
                     7-interacting protein 4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF144A isoform 1"
                     /protein_id="NP_001400409.1"
                     /db_xref="GeneID:108089"
                     /db_xref="MGI:MGI:1344401"
                     /translation="MTTARYRPTWDLALDPLVSCKLCLGEYPAEQMTTIAQCQCIFCT
                     LCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREV
                     LFDPCRTWCPASTCQAVCQLQDIGLQTPQLVQCKACDMEFCSACKARWHPGQGCPETM
                     PITFLPGETSSAFKMEEGDAPIKRCPKCRVYIERDEGCAQMMCKNCKHAFCWYCLESL
                     DDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVL
                     CCKCKCSKGDDDPLPT"
     exon            686..790
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            791..851
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1059
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1207
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1297
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..5290
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5186..5191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /note="hexamer: AATACA"
     polyA_site      5204
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /note="major polyA site"
     regulatory      5268..5273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /note="hexamer: AATACA"
     polyA_site      5290
                     /gene="Rnf144a"
                     /gene_synonym="Rnf144; Ubce7ip4; UIP4"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcgct cgcgccccgt cgaccccgcg cgcagttctc agggcgcagg gcggggaggc
       61 ataaagggcg ctgcgctgcg gggcgggctg cacgcgggag gctgacgggg cagcggcacc
      121 cgcgagccgg caccgggcgg ggccatcaca gccacgcgca aagaggccga gcgggagccc
      181 ggaccgcgcg ggaccagccc ctggacttca tttttctaaa gatgttctaa gttctcacgt
      241 caatgcctct cacccccgtc aagggggaat tactgaaaga taaattcctg aaagaaaaca
      301 cgggtgaaaa ggagagtcca caggccacca gccagcggaa gctctggaca gttgcatgta
      361 ctttgtgttc tgctgagtct ggtgtacccg gggctgcttt tctcagttgg atggacccct
      421 agtgcagaga cctcatcctt ctacctatgg ggagaagcag ctgaatacgc ctaagcacag
      481 caggacccca agacctggct ggaagttacc acctctcctc acctctgccc ttcccacaga
      541 ctgttctgcg atgaccacag caaggtaccg gcccacctgg gacctggccc tcgacccact
      601 ggtgtcctgc aagctgtgcc tcggggaata cccagcggag cagatgacaa ccatcgccca
      661 atgccagtgc atcttctgta ccctgtgcct gaaacagtat gttgagctct tgatcaaaga
      721 agggctagaa actgcaatta gctgcccgga tgctgcctgt cccaaacagg gccaccttca
      781 ggagaatgag attgagtgta tggttgccgc agaaataatg cagagatata aaaagctaca
      841 atttgaaaga gaggtgctct ttgacccttg tcggacgtgg tgcccagcat ccacctgcca
      901 ggccgtgtgc caactccagg acatagggct gcagaccccg cagctggtac agtgcaaagc
      961 ctgtgacatg gaattctgct ctgcttgcaa agcccgctgg caccctggcc aaggctgccc
     1021 agagaccatg cccatcacat tccttcccgg agagaccagc tctgctttca agatggaaga
     1081 gggcgacgca cccatcaaac gctgccccaa gtgcagggtg tacatcgagc gggatgaggg
     1141 ctgtgcacag atgatgtgta agaactgcaa gcatgccttc tgctggtact gcctggagtc
     1201 tctggatgat gatttccttc tgatacatta tgacaagggg ccctgccgca acaagctggg
     1261 ccactcccga gcatcagtga tctggcatcg gacacaggtg gtgggaattt ttgctggatt
     1321 tgggctcctg ctcttagtgg cctccccttt cctgctcctg gccacaccct tcgtgctttg
     1381 ctgcaaatgc aagtgcagta aaggtgacga cgacccactg cccacctaga ggatggcacg
     1441 acgctggaac agaccccttc ctcgggacgt gtggctcccc tacccctacc acccctcaca
     1501 ctaaacatgt tatttgcctt atgtgcccca ttgagcttca gtgtccggct tgctgcagag
     1561 atttcaggga tggcgccagc aagtgggcag aggcccgggt gtggtctcct gggtgctgct
     1621 gaggcacggg aggcggaagt gggtgggggc atcccctcag agtcgttctg tgtctgcaga
     1681 cctggctgga ggtggcgtca gctgcatacc aggcagtctc ctccccctgg ccgtagactg
     1741 gaaatgtcaa gtttaagaga cccactggga caaagggtct ccttggcttc cagatggcac
     1801 tgtggtgtca agagaagtct tcaaggatta gactgtcttc agccagcacc tgaatatccg
     1861 acttgagaaa accaccctgt ttgtgacaac tgtttttatt cctaaaggca tttagtaaaa
     1921 ccctttttag aagactctct ccccctgtca actgagtagt gaaaaatcaa taaggtgcgt
     1981 aaaaaccatc ctatgccttt tttcgaaatg tgcattttat gaagttatag atataaatct
     2041 tttctggcct gaccatttta ttcaggagct acagaaagcc ttatgcacac tctgtgtttt
     2101 tcttggaacc tgctgtcatc agtttttgaa tgctgtgagc tgtgtactgt tacccacacg
     2161 ggccccgtgt cattgcattt ctttgaaaac actgctacat ttgaaggatt atctctagct
     2221 tcacagcatt gccctttgcc ccagttcagc tcacagggcg cgtcccttca gtcctctctc
     2281 ccgggtgaca tcagatgcct ttgcgcatct ttaaaccgga tgttctcctc tgaactaatt
     2341 ttactccgag tgactctatt ttgattccat gcccaacttt ttaggtaggc atcaaggaga
     2401 cagtgtcatc tatctctagg gaacacttgg aggctggctt agagctttct gaagtctatg
     2461 cattgttaaa atgttttaag taatttgaaa aatcatgtgg ctcacacact ctgaaccctg
     2521 ctaaccagtt tgttcttgct aggtgaaaaa aggagagaga aagaataaaa aaggaataaa
     2581 ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa
     2641 ggaaggagag acccttctgt ttcacttaat ttttctgatg tgcagagttt gtgaattgat
     2701 ccttccctgg gctatgtgac agttacatat caacaaagag caagttagta agaagacaca
     2761 ggtattcctt aaatcgtctc tgaaaatagg gagcagtgct ttctctcaga gttggctttc
     2821 atagtccagt gtgcttccca ggagatgtag agatttgggg agggggtggc tgggcatttg
     2881 actactgcag gaacatcctt aggggctgtc tgtatgactc ttcgtttatg ggtcaatgtt
     2941 aagccctaac agacactccc tgcagggcaa tggcataatt ctctttattt ttaattgaca
     3001 gtgagtaact gaggtaaaac agaaccactg gtctctcatc ctctggtact gattttcttt
     3061 attaagctaa agccatttag agtctcagtc ctcatcaaaa ccacactcaa aaagtccccc
     3121 tggtagttgc aaattacagg tgtgacttct gctgggtgaa gcctaggtct tgatgctctg
     3181 tggtgagaaa ctggtcagta gctgagattt gagacctcaa gcctgcagtt tgtatgagat
     3241 gttatccagt caccacccct taaaatgcct gtcaggaatc tcagctgtcc tgggccctgg
     3301 ctccttcttg ccttgccttg attgctgctg tctgatttgt tcagtgacat tctgtctttg
     3361 cggtggggga ggctgcagtt caagctccct aatcaaagat ggggtcccct tatgtctagg
     3421 agactcctct ggatgtccac acacctctgt aaccccacct gtgctcacac agcagcctat
     3481 agtgggcttc ctaagcacat ggctggcaca agcgggaatt gtggggacat gggccaaact
     3541 gtatcctgtc tgccctgagt ctttgtacac ttactcagtt ggcttcagta ataaaaccta
     3601 acttgtccat tccctataga aacaccagta agatcacgtt gaaatatata aacttatgta
     3661 ttgtcgcccg agggagtcct ctaagtagag gttaccacat gcgtttacta tggacattca
     3721 gcttgagcca attgtggttt gaaatgcata tgcaacagaa gaggtggccc ccgatgaagc
     3781 tggcctctct gtcggtccta agaagcccga gggcctctgt gaccagtctc atttctgttg
     3841 ctcagtgtgg tacctcagaa ctgaaaatgg agttccctga gacagactgt tttcctgatg
     3901 gaagaagagc tggccttgta gagaaggctc agagtggcgg gctatggggc tgttccgtaa
     3961 gacttcactg agcactcgct ggtctgtggg ttatccgcag ctgaccctgc tacagaatct
     4021 ccctgggtgt gcttatctct gccaaattca ttcttgcacc ttgtgtcctg ggggatgagg
     4081 cgtcacattc tcccccagag tgatgccagc agtggctaag tcatgatagg tgttcgtgga
     4141 ggactgggtg acagctcctt gcagggacag gggaattgga tttcatgagt ttcactaccc
     4201 agagtgtgga accaaaactt gcccacccat cccgctttcc tgcctatctt gaggagagca
     4261 aatcttccct atagtttatt atttcataaa gcagatgtga gactctgacc agttccccac
     4321 tgaaaacagt gcacgtgaga ggaaggatag tgaggctgga aaattggctt caaggtgaaa
     4381 ttatcttttc cattggaatt agaaagggga aagattattt tatgagttag aagagaagag
     4441 tttcccttgg tagtctttaa agattaaggg attagaaaaa aaagggagga cttattttgt
     4501 atacttccca gatttccact gattaataaa tatacctgtg aatatatata tgtagatcac
     4561 aatgaaattt tcaagggaaa ccattttgca tgtataccgt tttatgaagg tttccttaaa
     4621 taaaataaat accaaagctt gtttctccct cacaatgaac ccaaaccctt atgaagttaa
     4681 atgaggtgaa gaaatttggc tattgccaaa aactcaacca ggagggaagg gcttatgttc
     4741 aaacaattac tgatgccctg tgactagggg aacacgtcct tttggtagtt aaaaccccat
     4801 ggtctccagc cttcctgact tgtataatcc tgtcttccaa gatcccaggg cccttccgtt
     4861 aggtgtagct gtgtgccacg tgcctgactt ttcttttgta ctttgcttac tttgccttgg
     4921 gtatatttta atcttgtata aaacaaaaat gcatgtgtcg gtcatgcgca cgtgcacacg
     4981 tagacattct gtatttgaca aatggtggta agaccaaaaa aacaaacaaa caaaaaaaaa
     5041 aacaagaaga gaattgcatt tgtggttttg cagcgtgagt acactttgta ccactaacac
     5101 tgtgatgtat aagagctgtc tgaatgcctt ttcatgttgt gatttgtact ctagaatcct
     5161 atggaaacat ttggtttata atttcaatac atattttaaa tgtattgtgt cttatgtagt
     5221 ctgtctcccc tttcgaaggg atatcttttt aaaggtattt tggctggaat acaggtgatt
     5281 attttgtaaa
//
